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The map label for this gene is msrA [H]

Identifier: 120598933

GI number: 120598933

Start: 2449039

End: 2449518

Strand: Direct

Name: msrA [H]

Synonym: Sputw3181_2125

Alternate gene names: 120598933

Gene position: 2449039-2449518 (Clockwise)

Preceding gene: 120598927

Following gene: 120598936

Centisome position: 52.01

GC content: 45.83

Gene sequence:

>480_bases
ATGGCGTTAGCAACCTTTGGTGCCGGCTGTTTCTGGGGCGTAGAGTATTTTTTTAGACAAGTGAATGGCGTACTAAATGC
CACCTGTGGATATATGGGTGGCAATAATGCCGCCACTACTTATGAAGAAGTGAAAAAAGGTAAAACAGGCCATGCCGAAG
TGGTGCAAGTGGAATTTGACCCAGCCCTTGTCAGTTATGAAGACTTGCTCGATGTATTTTGGAAAAACCACAATCCAACG
AGTCTGAACATGCAAGGCGGAGATATTGGTACTCAGTACCGCAGCACCATTTTCTTCCACGACCGTGAACAAAAGGCCGC
GGCAGAAGCCTCAAAGTTGGCTTTTGCCCGCTCGGGCCGTTGGGGATTACGCCATATAGTGACTGAGATAGTGCCACTGC
AACAGTTCCATGTGGCTGAGGAATGCCATCAAAATTATATTGATAAGAACAACTTACCAAGTTGTCATATCGAATATTAA

Upstream 100 bases:

>100_bases
GCACACCACAACAATTGCATAAAATTTTACAGCCATACTTGCTTTTAATCCTCTGTTTAATCACAATCCTTAGCCATCTA
GACTTCTATTGGATTTAATT

Downstream 100 bases:

>100_bases
TACGAGTTAGCCTTAAATCGGGCCAAATAAAAAACGCACTCACGGATTAACATGAGTGCGTTTTTTATCTCTGAAAAGCT
CACTTAAGCGTTTAGTGCCT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MALATFGAGCFWGVEYFFRQVNGVLNATCGYMGGNNAATTYEEVKKGKTGHAEVVQVEFDPALVSYEDLLDVFWKNHNPT
SLNMQGGDIGTQYRSTIFFHDREQKAAAEASKLAFARSGRWGLRHIVTEIVPLQQFHVAEECHQNYIDKNNLPSCHIEY

Sequences:

>Translated_159_residues
MALATFGAGCFWGVEYFFRQVNGVLNATCGYMGGNNAATTYEEVKKGKTGHAEVVQVEFDPALVSYEDLLDVFWKNHNPT
SLNMQGGDIGTQYRSTIFFHDREQKAAAEASKLAFARSGRWGLRHIVTEIVPLQQFHVAEECHQNYIDKNNLPSCHIEY
>Mature_158_residues
ALATFGAGCFWGVEYFFRQVNGVLNATCGYMGGNNAATTYEEVKKGKTGHAEVVQVEFDPALVSYEDLLDVFWKNHNPTS
LNMQGGDIGTQYRSTIFFHDREQKAAAEASKLAFARSGRWGLRHIVTEIVPLQQFHVAEECHQNYIDKNNLPSCHIEY

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=149, Percent_Identity=45.6375838926174, Blast_Score=126, Evalue=6e-30,
Organism=Homo sapiens, GI208609995, Length=149, Percent_Identity=45.6375838926174, Blast_Score=126, Evalue=9e-30,
Organism=Homo sapiens, GI208609993, Length=104, Percent_Identity=47.1153846153846, Blast_Score=91, Evalue=6e-19,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=49.3421052631579, Blast_Score=142, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=35.3741496598639, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320881, Length=156, Percent_Identity=37.1794871794872, Blast_Score=108, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24664627, Length=145, Percent_Identity=41.3793103448276, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24664631, Length=145, Percent_Identity=40.6896551724138, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI45553131, Length=138, Percent_Identity=39.8550724637681, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 17883; Mature: 17752

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALATFGAGCFWGVEYFFRQVNGVLNATCGYMGGNNAATTYEEVKKGKTGHAEVVQVEFD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECC
PALVSYEDLLDVFWKNHNPTSLNMQGGDIGTQYRSTIFFHDREQKAAAEASKLAFARSGR
CCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHEEEEEECCHHHHHHHHHHHHHHCCCC
WGLRHIVTEIVPLQQFHVAEECHQNYIDKNNLPSCHIEY
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
>Mature Secondary Structure 
ALATFGAGCFWGVEYFFRQVNGVLNATCGYMGGNNAATTYEEVKKGKTGHAEVVQVEFD
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECC
PALVSYEDLLDVFWKNHNPTSLNMQGGDIGTQYRSTIFFHDREQKAAAEASKLAFARSGR
CCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHEEEEEECCHHHHHHHHHHHHHHCCCC
WGLRHIVTEIVPLQQFHVAEECHQNYIDKNNLPSCHIEY
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]