Click here to switch to the map view.

The map label for this gene is ttcA1 [H]

Identifier: 120598865

GI number: 120598865

Start: 2365978

End: 2366910

Strand: Direct

Name: ttcA1 [H]

Synonym: Sputw3181_2056

Alternate gene names: 120598865

Gene position: 2365978-2366910 (Clockwise)

Preceding gene: 120598864

Following gene: 120598868

Centisome position: 50.25

GC content: 42.34

Gene sequence:

>933_bases
ATGTCTGAAGAATTATCGAAAAAACACACTACCCGTCTTAATAAATTACAAAAGCGTTTGCGTCGTGAGGTGGGGAGTGC
CATCGCAGATTACAATATGATTGAGGATGGCGACCGTGTTATGTGTTGCTTAAGTGGTGGCAAAGACAGTTATGCTATGC
TCGATATTCTAATGAATTTACAGCAACGTGCGCCTATTCAATTTGAAATTATTGCCGTCAATTTAGATCAAAAGCAGCCA
GGCTTCCCAGAGGATATTCTTCCCGCTTATCTCGATAAACTCAAGGTGCCTTATCATATCCTCGAAAAAGACACATATTC
TATCGTGAAGGATAAGATCCCTGAGGGCAAAACAACATGTTCACTGTGCTCTCGTCTTCGCCGTGGTACGCTGTATGGCT
TTGCACAACGTATTGGTGCAACTAAAATTGCTCTTGGTCACCATAGAGATGACATCATTGAAACCCTGTTTCTAAATATG
TTTTTTGGCGGGAAAATGAAAGCAATGCCCCCTAAATTACTTTCTGATGATGGCGCCAACATTGTGATACGGCCCCTAGC
CTATTGTCGTGAGAAAGATTTAGAGGAATATGCACAGCTTAAACAGTTTCCAATCATCCCTTGTAATCTCTGTGGTTCAC
AGGAAAATTTAAAACGTGCCGCGGTTAAAGATATGCTTAATCAATGGGATCGACAATATCCTGGCCGTATTGAAACCATT
TTTACTGCCATGCAGAACACGGCTCCATCACAGGGTGTCGATCGTGAACAGTTTGATTTTATTTCTTTAAAGCGCGATCC
CGATGTACCAATGACTGGTGACGTTGCCGAGGCTGATTTACCCGCCTTCGATTTTCTAGATATTGCTAACAGCGGTCATA
TCGATTTAGATGCTGCGCAGCGTATCGATGTTGTCAGCTTTTATGAAGCTTAA

Upstream 100 bases:

>100_bases
GAAGAAACCTAAACCACACGGCTCTTTACCCCGCATGAGATAGCTGGAATAATACGCGCCCTGAAACTCAGTTACTGGGC
GCTTTTTTATGTTGGAAGCT

Downstream 100 bases:

>100_bases
ACAATATCCACTAAAGCAAACCATGCTTTAAGCTAAAAAGCCCACATAATGTGGGCTTTTTGGTCATAATTTTAGGTGAA
ATAATGTTATTTTACCCAAG

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSEELSKKHTTRLNKLQKRLRREVGSAIADYNMIEDGDRVMCCLSGGKDSYAMLDILMNLQQRAPIQFEIIAVNLDQKQP
GFPEDILPAYLDKLKVPYHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLFLNM
FFGGKMKAMPPKLLSDDGANIVIRPLAYCREKDLEEYAQLKQFPIIPCNLCGSQENLKRAAVKDMLNQWDRQYPGRIETI
FTAMQNTAPSQGVDREQFDFISLKRDPDVPMTGDVAEADLPAFDFLDIANSGHIDLDAAQRIDVVSFYEA

Sequences:

>Translated_310_residues
MSEELSKKHTTRLNKLQKRLRREVGSAIADYNMIEDGDRVMCCLSGGKDSYAMLDILMNLQQRAPIQFEIIAVNLDQKQP
GFPEDILPAYLDKLKVPYHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLFLNM
FFGGKMKAMPPKLLSDDGANIVIRPLAYCREKDLEEYAQLKQFPIIPCNLCGSQENLKRAAVKDMLNQWDRQYPGRIETI
FTAMQNTAPSQGVDREQFDFISLKRDPDVPMTGDVAEADLPAFDFLDIANSGHIDLDAAQRIDVVSFYEA
>Mature_309_residues
SEELSKKHTTRLNKLQKRLRREVGSAIADYNMIEDGDRVMCCLSGGKDSYAMLDILMNLQQRAPIQFEIIAVNLDQKQPG
FPEDILPAYLDKLKVPYHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLFLNMF
FGGKMKAMPPKLLSDDGANIVIRPLAYCREKDLEEYAQLKQFPIIPCNLCGSQENLKRAAVKDMLNQWDRQYPGRIETIF
TAMQNTAPSQGVDREQFDFISLKRDPDVPMTGDVAEADLPAFDFLDIANSGHIDLDAAQRIDVVSFYEA

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=275, Percent_Identity=68.3636363636364, Blast_Score=407, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI193211090, Length=249, Percent_Identity=33.7349397590361, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17540090, Length=191, Percent_Identity=30.8900523560209, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24651972, Length=234, Percent_Identity=26.9230769230769, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 35115; Mature: 34984

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEELSKKHTTRLNKLQKRLRREVGSAIADYNMIEDGDRVMCCLSGGKDSYAMLDILMNL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
QQRAPIQFEIIAVNLDQKQPGFPEDILPAYLDKLKVPYHILEKDTYSIVKDKIPEGKTTC
HHCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHH
SLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLFLNMFFGGKMKAMPPKLLSDDGAN
HHHHHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCC
IVIRPLAYCREKDLEEYAQLKQFPIIPCNLCGSQENLKRAAVKDMLNQWDRQYPGRIETI
EEEHHHHHHHHCCHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
FTAMQNTAPSQGVDREQFDFISLKRDPDVPMTGDVAEADLPAFDFLDIANSGHIDLDAAQ
HHHHHHCCCCCCCCHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEECCHHH
RIDVVSFYEA
HCCHHHHCCC
>Mature Secondary Structure 
SEELSKKHTTRLNKLQKRLRREVGSAIADYNMIEDGDRVMCCLSGGKDSYAMLDILMNL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
QQRAPIQFEIIAVNLDQKQPGFPEDILPAYLDKLKVPYHILEKDTYSIVKDKIPEGKTTC
HHCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHH
SLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLFLNMFFGGKMKAMPPKLLSDDGAN
HHHHHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCC
IVIRPLAYCREKDLEEYAQLKQFPIIPCNLCGSQENLKRAAVKDMLNQWDRQYPGRIETI
EEEHHHHHHHHCCHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
FTAMQNTAPSQGVDREQFDFISLKRDPDVPMTGDVAEADLPAFDFLDIANSGHIDLDAAQ
HHHHHHCCCCCCCCHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEECCHHH
RIDVVSFYEA
HCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA