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The map label for this gene is mro [H]

Identifier: 120598767

GI number: 120598767

Start: 2258304

End: 2259359

Strand: Direct

Name: mro [H]

Synonym: Sputw3181_1952

Alternate gene names: 120598767

Gene position: 2258304-2259359 (Clockwise)

Preceding gene: 120598766

Following gene: 120598768

Centisome position: 47.96

GC content: 37.5

Gene sequence:

>1056_bases
ATGTCACTCTCAATCTCTACACAACAATTAACGCATAGCACCTTCCCTGCACCATTAGAGTTAATAACATTAACGAATAG
TCATGGTTTGGAAGTAGTGTTATCGAGTTATGGTGCAAGTATTTGGTCTGTCAAACTCTATGAAAAAGAAGATAAAACCA
TTGATCTCAGTTTGAGTTATCAGAATATTCAAGATTGGGCAATAAACCCTTATTATTTTGGTATTACTGCAGGCCGCGTT
GCAAATCGAATTGGTGGAGCTGCATTTTCTTTAAAGGGTCAAACCATTGTATTAACCCCGAATGAAGGTAATAACCAACT
TCACGGTGGTCCGCAAGGCTTAAGTCACTGTGTTTGGCAATGTGAAACTAAGCAATATTCCGATGCTGTTGGTGCCATTT
TTAGGATACAGAGTCCTGATGGTGATCAAGGTTATCCTGGGGATTTATCCGTAACAGTCGAATATCGCCTTAGTGAAAGC
AATGAGTTAATCCTGATTTACGATGCTCTATCAGACCAAACCACTCCGGTTTGTCTCACAAATCATGCCTATTGGAATCT
CGCATCTGACAAGCAACATGGCATCTTAGGCCATAACTTACAACTCAATGCGAGTCATATTTTAGCCTTAGATTCTGAGC
AAATTCCTACGGGTGAATTGGTTTTAGTCGATGATACCCCCTTCGATTTTCGTCAAATAAAATCCATATCTGAAGATATT
CATAAATTAAGTAATGGTTATGACCACTATTTTGTGATGTCGAAGGATATAGACAATACCTCATGCTTAAAAACCATCGC
CACATTAATCGAACCTATTTCAGGACGTGAATTGGAAATCAGCACTACAGAATTAGGTGTGCAATTTTATAGTGGTAACT
TTTTAGATGGTACGCGGCTTGATAATCATGGAAAACCGTTAAATCAATATCAAGGTTTATGTTTAGAAACCCATGGTTAT
CCTAATGCCGTCAATATTGCTCATTTTCCGAGTGTTATGTTAGAGGAAAATAAACCCTATAAACAAATAACGGTGCATAG
ATTTAAAAATATTTAA

Upstream 100 bases:

>100_bases
ATTAACAATAAAGTCTTTGTTGATTAAGTCGTCATTATCTTACATAGATAGCTGAGGATGAGTGCTGAGAAAACTTATTA
TAAAAGGTGAAAGCACTCAT

Downstream 100 bases:

>100_bases
TTTAAACCGTGTGTGACACTTTAGTCATATAACGAATTAGTCATATTAGTTTAATTGAGTTTGATCTTCTGCATTAAGAA
GGTCTGGGGATTGCTGTTAT

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSLSISTQQLTHSTFPAPLELITLTNSHGLEVVLSSYGASIWSVKLYEKEDKTIDLSLSYQNIQDWAINPYYFGITAGRV
ANRIGGAAFSLKGQTIVLTPNEGNNQLHGGPQGLSHCVWQCETKQYSDAVGAIFRIQSPDGDQGYPGDLSVTVEYRLSES
NELILIYDALSDQTTPVCLTNHAYWNLASDKQHGILGHNLQLNASHILALDSEQIPTGELVLVDDTPFDFRQIKSISEDI
HKLSNGYDHYFVMSKDIDNTSCLKTIATLIEPISGRELEISTTELGVQFYSGNFLDGTRLDNHGKPLNQYQGLCLETHGY
PNAVNIAHFPSVMLEENKPYKQITVHRFKNI

Sequences:

>Translated_351_residues
MSLSISTQQLTHSTFPAPLELITLTNSHGLEVVLSSYGASIWSVKLYEKEDKTIDLSLSYQNIQDWAINPYYFGITAGRV
ANRIGGAAFSLKGQTIVLTPNEGNNQLHGGPQGLSHCVWQCETKQYSDAVGAIFRIQSPDGDQGYPGDLSVTVEYRLSES
NELILIYDALSDQTTPVCLTNHAYWNLASDKQHGILGHNLQLNASHILALDSEQIPTGELVLVDDTPFDFRQIKSISEDI
HKLSNGYDHYFVMSKDIDNTSCLKTIATLIEPISGRELEISTTELGVQFYSGNFLDGTRLDNHGKPLNQYQGLCLETHGY
PNAVNIAHFPSVMLEENKPYKQITVHRFKNI
>Mature_350_residues
SLSISTQQLTHSTFPAPLELITLTNSHGLEVVLSSYGASIWSVKLYEKEDKTIDLSLSYQNIQDWAINPYYFGITAGRVA
NRIGGAAFSLKGQTIVLTPNEGNNQLHGGPQGLSHCVWQCETKQYSDAVGAIFRIQSPDGDQGYPGDLSVTVEYRLSESN
ELILIYDALSDQTTPVCLTNHAYWNLASDKQHGILGHNLQLNASHILALDSEQIPTGELVLVDDTPFDFRQIKSISEDIH
KLSNGYDHYFVMSKDIDNTSCLKTIATLIEPISGRELEISTTELGVQFYSGNFLDGTRLDNHGKPLNQYQGLCLETHGYP
NAVNIAHFPSVMLEENKPYKQITVHRFKNI

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=320, Percent_Identity=36.875, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1786971, Length=338, Percent_Identity=33.4319526627219, Blast_Score=191, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17557428, Length=334, Percent_Identity=31.7365269461078, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI115533334, Length=334, Percent_Identity=31.7365269461078, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6319493, Length=343, Percent_Identity=25.9475218658892, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322004, Length=359, Percent_Identity=27.2980501392758, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324399, Length=349, Percent_Identity=24.6418338108883, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583720, Length=363, Percent_Identity=33.6088154269972, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24659048, Length=343, Percent_Identity=34.9854227405248, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24668278, Length=348, Percent_Identity=35.0574712643678, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24668282, Length=363, Percent_Identity=31.9559228650138, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24641876, Length=341, Percent_Identity=28.7390029325513, Blast_Score=149, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 39008; Mature: 38877

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSISTQQLTHSTFPAPLELITLTNSHGLEVVLSSYGASIWSVKLYEKEDKTIDLSLSY
CCCCCCHHHHHCCCCCCCEEEEEEECCCCCEEEEECCCCEEEEEEEEECCCCEEEEEEEE
QNIQDWAINPYYFGITAGRVANRIGGAAFSLKGQTIVLTPNEGNNQLHGGPQGLSHCVWQ
CCCCCCCCCCEEEEEEHHHHHHHCCCEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHEE
CETKQYSDAVGAIFRIQSPDGDQGYPGDLSVTVEYRLSESNELILIYDALSDQTTPVCLT
ECCHHHCCCCEEEEEEECCCCCCCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCEEEE
NHAYWNLASDKQHGILGHNLQLNASHILALDSEQIPTGELVLVDDTPFDFRQIKSISEDI
CCEEEEECCCCCCCEECCCEEECCCEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHH
HKLSNGYDHYFVMSKDIDNTSCLKTIATLIEPISGRELEISTTELGVQFYSGNFLDGTRL
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEHEEEEEEECCCCCCCCEE
DNHGKPLNQYQGLCLETHGYPNAVNIAHFPSVMLEENKPYKQITVHRFKNI
CCCCCCHHHHCCEEEEECCCCCEEEHHHCCCEEECCCCCHHHEEHHHHCCC
>Mature Secondary Structure 
SLSISTQQLTHSTFPAPLELITLTNSHGLEVVLSSYGASIWSVKLYEKEDKTIDLSLSY
CCCCCHHHHHCCCCCCCEEEEEEECCCCCEEEEECCCCEEEEEEEEECCCCEEEEEEEE
QNIQDWAINPYYFGITAGRVANRIGGAAFSLKGQTIVLTPNEGNNQLHGGPQGLSHCVWQ
CCCCCCCCCCEEEEEEHHHHHHHCCCEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHEE
CETKQYSDAVGAIFRIQSPDGDQGYPGDLSVTVEYRLSESNELILIYDALSDQTTPVCLT
ECCHHHCCCCEEEEEEECCCCCCCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCEEEE
NHAYWNLASDKQHGILGHNLQLNASHILALDSEQIPTGELVLVDDTPFDFRQIKSISEDI
CCEEEEECCCCCCCEECCCEEECCCEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHH
HKLSNGYDHYFVMSKDIDNTSCLKTIATLIEPISGRELEISTTELGVQFYSGNFLDGTRL
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEHEEEEEEECCCCCCCCEE
DNHGKPLNQYQGLCLETHGYPNAVNIAHFPSVMLEENKPYKQITVHRFKNI
CCCCCCHHHHCCEEEEECCCCCEEEHHHCCCEEECCCCCHHHEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]