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The map label for this gene is clpA [H]

Identifier: 120598598

GI number: 120598598

Start: 2052739

End: 2055006

Strand: Direct

Name: clpA [H]

Synonym: Sputw3181_1782

Alternate gene names: 120598598

Gene position: 2052739-2055006 (Clockwise)

Preceding gene: 120598597

Following gene: 120598602

Centisome position: 43.6

GC content: 47.05

Gene sequence:

>2268_bases
ATGCTGAACAAAGATCTGGAAGTCACCTTAAATCTGGCGTTTCAGCAAGCCAGAGACGCGCGTCACGAGTATATGACAGT
GGAACATCTGTTATTAGCTCTCATCGACAATCCAGCGGCTCAAGAAGCGTTAATCGCCTGTGGAGCGAATCTAGATAAAC
TCAGAGATGAAGTGGCAAGCTTTATCCAACAAACAACCCCAATCATTGCCGATATTGATGATGACAAAGAAACTCAGCCG
ACGCTTGGGTTCCAGCGAGTGCTGCAACGGGCAGTATTCCATGTGCAGTCATCGGGCCGCAATGAAGTGAACGGCGCTAA
CGTTTTAGTCGCTATTTTCAGCGAACAAGAATCCCAAGCCGTGTACTTGCTGCGCCGTTGCGATATTAGTCGCCTAGACG
TAGTGAATTTTATTTCCCATGGTTTCGCCAAAAATGATGATACTGAGTCACATCAAGATCAAGAACGCATAGAAGATCAA
AGTGAAGGCAGTGAAGAACGCAGCATGTTGTCGCAATTTGCGGCCAACTTAAACCAACTTGCAAAGCAAGGGATTATTGA
TCCACTGATTGGCCGCGATCAGGAAATTGAGCGCGCGATTCAAACCCTGTGCCGTCGCCGTAAAAATAATCCACTGTTAG
TGGGTGAGGCGGGTGTGGGGAAAACGGCGATTGCCGAAGGGCTGGCGTATCGGATTGTGAATAAACAAGTGCCCGATGTA
ATGCTTGAAGCCACGGTGTATTCCTTGGATTTAGGTTCATTGCTTGCAGGCACTAAGTATCGCGGCGACTTTGAAAAACG
CTTTAAGAACTTGTTAAAAGAACTTGCGGCGGATAAGCATGCCATCCTATTCATCGATGAGATCCATACCATTATCGGTG
CGGGCGCGGCCTCTGGCGGCGTAATGGATGCCTCTAATCTGCTGAAACCTTTGCTATCTAGCGGTAATTTGCGCTGCATG
GGCTCGACGACTTTCCAAGAATATCAAAGTATTTTTGAGAAAGACCGTGCGCTGGCACGTCGTTTCCAAAAGGTGGATAT
TAATGAGCCTTCAGTGGAAGAAACCACGAAGATTTTGATGGGGCTTAAGTCTAAATACGAAGAATATCATGGCGTTCGTT
ATACTCAGGCCGCGATTAGCAGCGCTGCAGTATTATCGGCCAAGCACATTAATGACAGGCATTTACCCGATAAAGCTATC
GATGTGATCGATGAAGCGGGGGCTCGTATGGTGATGTTGCCTATGAGCAAGCGTAAAAAGACCATAGGCCAAGCCGAAAT
TGAGTCCATTGTAGCTAAAATGGCGCGCATCCCTGAGAAGTCAGTATCTGCCACAGATAAGGACTTACTGCGTAATCTTG
AGCGTAACCTTAAGATGGTGGTCTTTGGTCAAGATAAAGCCATTGAGACCTTAAGCTCAGCCATTCGTTTATCGCGAAGT
GGTTTGGGCACAGATAAAAAACCTGTCGGCAGTTTCTTATTCGCCGGTCCCACTGGTGTGGGTAAAACCGAGGTTACCAA
TCAACTGGCTACCTGTTTAGGGATGAAACTGGTGCGCTTTGATATGTCGGAGTACATGGAAAGCCACACAGTGTCACGCT
TAATTGGGGCACCTCCAGGTTATGTGGGTTATGACCAAGGTGGATTGCTGACAGATGCTGTGATTAAAAATCCGCACTGT
GTCGTGCTATTGGATGAAATTGAGAAGGCCCACCGTGATGTCTATAACTTGCTGTTGCAGGTGATGGACCACGGCACTTT
GACCGATAATAATGGTCGTAAGGCTGACTTCAGACACGTGACTTTGGTGATGACCACTAACGCGGGGGTACAGGAGACTA
TTCGTAAGTCGATTGGCTTTACCCAGCAAGATCATACCCAAGATGCGTTATCTGAAATTAATCGAGTATTTTCGCCAGAA
TTTCGAAATCGTCTCGATTCCATCATTTGGTTCAACCATTTGGATATGACGATTATTGCCAAAGTGGTCGATAAATTCTT
GGTGGAATTACAGGCTCAGTTGGATGCAAAACACGTCATCTTGGACGTCAGCGACGAAGCCAGAACCTTACTCGCCGAGA
AAGGCTACGATAAGAACATGGGCGCGCGTCCAATGGCTCGGGTCGTGACCGAATTGATCAAACGTCCATTAGCGGATGAG
ATTTTATTTGGTGCCTTAGAGTCGGGTGGTGTGGCTTACGTGGATGTCAAAGAGGGTGAAATTGCTATTCGCACAGAGCG
TCATGAAAAAGTGGCTTCTAAGGCTTAA

Upstream 100 bases:

>100_bases
AATCAATTTGCAAGACAAAACCAACATCCGTTACTGTGTTCGTTAGAGAAAGCATAAAACCGCTTTACTCTGTAGTCTGT
TGTTAATTTTGGGGGTGCTT

Downstream 100 bases:

>100_bases
CTCGGCCTAAAGGTGAGTTTTGTCCATAAAAATGGCTGCAATTGCAGCCATTTTTCTTATCTTTCGCCAACAAAAAAACC
CGGCCTTGCCGGGTTTTTAA

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 755; Mature: 755

Protein sequence:

>755_residues
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVASFIQQTTPIIADIDDDKETQP
TLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQAVYLLRRCDISRLDVVNFISHGFAKNDDTESHQDQERIEDQ
SEGSEERSMLSQFAANLNQLAKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNKQVPDV
MLEATVYSLDLGSLLAGTKYRGDFEKRFKNLLKELAADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGNLRCM
GSTTFQEYQSIFEKDRALARRFQKVDINEPSVEETTKILMGLKSKYEEYHGVRYTQAAISSAAVLSAKHINDRHLPDKAI
DVIDEAGARMVMLPMSKRKKTIGQAEIESIVAKMARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIETLSSAIRLSRS
GLGTDKKPVGSFLFAGPTGVGKTEVTNQLATCLGMKLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHC
VVLLDEIEKAHRDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPE
FRNRLDSIIWFNHLDMTIIAKVVDKFLVELQAQLDAKHVILDVSDEARTLLAEKGYDKNMGARPMARVVTELIKRPLADE
ILFGALESGGVAYVDVKEGEIAIRTERHEKVASKA

Sequences:

>Translated_755_residues
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVASFIQQTTPIIADIDDDKETQP
TLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQAVYLLRRCDISRLDVVNFISHGFAKNDDTESHQDQERIEDQ
SEGSEERSMLSQFAANLNQLAKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNKQVPDV
MLEATVYSLDLGSLLAGTKYRGDFEKRFKNLLKELAADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGNLRCM
GSTTFQEYQSIFEKDRALARRFQKVDINEPSVEETTKILMGLKSKYEEYHGVRYTQAAISSAAVLSAKHINDRHLPDKAI
DVIDEAGARMVMLPMSKRKKTIGQAEIESIVAKMARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIETLSSAIRLSRS
GLGTDKKPVGSFLFAGPTGVGKTEVTNQLATCLGMKLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHC
VVLLDEIEKAHRDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPE
FRNRLDSIIWFNHLDMTIIAKVVDKFLVELQAQLDAKHVILDVSDEARTLLAEKGYDKNMGARPMARVVTELIKRPLADE
ILFGALESGGVAYVDVKEGEIAIRTERHEKVASKA
>Mature_755_residues
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVASFIQQTTPIIADIDDDKETQP
TLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQAVYLLRRCDISRLDVVNFISHGFAKNDDTESHQDQERIEDQ
SEGSEERSMLSQFAANLNQLAKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNKQVPDV
MLEATVYSLDLGSLLAGTKYRGDFEKRFKNLLKELAADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGNLRCM
GSTTFQEYQSIFEKDRALARRFQKVDINEPSVEETTKILMGLKSKYEEYHGVRYTQAAISSAAVLSAKHINDRHLPDKAI
DVIDEAGARMVMLPMSKRKKTIGQAEIESIVAKMARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIETLSSAIRLSRS
GLGTDKKPVGSFLFAGPTGVGKTEVTNQLATCLGMKLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHC
VVLLDEIEKAHRDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPE
FRNRLDSIIWFNHLDMTIIAKVVDKFLVELQAQLDAKHVILDVSDEARTLLAEKGYDKNMGARPMARVVTELIKRPLADE
ILFGALESGGVAYVDVKEGEIAIRTERHEKVASKA

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=297, Percent_Identity=31.3131313131313, Blast_Score=146, Evalue=7e-35,
Organism=Escherichia coli, GI1787109, Length=732, Percent_Identity=70.2185792349727, Blast_Score=1072, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=408, Percent_Identity=41.9117647058824, Blast_Score=283, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6320464, Length=320, Percent_Identity=49.0625, Blast_Score=280, Evalue=7e-76,
Organism=Saccharomyces cerevisiae, GI6323002, Length=410, Percent_Identity=38.0487804878049, Blast_Score=254, Evalue=5e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83780; Mature: 83780

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVAS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
FIQQTTPIIADIDDDKETQPTLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQA
HHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHH
VYLLRRCDISRLDVVNFISHGFAKNDDTESHQDQERIEDQSEGSEERSMLSQFAANLNQL
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNKQVPDV
HHHCCCCHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHH
MLEATVYSLDLGSLLAGTKYRGDFEKRFKNLLKELAADKHAILFIDEIHTIIGAGAASGG
HHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCC
VMDASNLLKPLLSSGNLRCMGSTTFQEYQSIFEKDRALARRFQKVDINEPSVEETTKILM
CCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKSKYEEYHGVRYTQAAISSAAVLSAKHINDRHLPDKAIDVIDEAGARMVMLPMSKRKK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCHHHHH
TIGQAEIESIVAKMARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIETLSSAIRLSRS
HHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHC
GLGTDKKPVGSFLFAGPTGVGKTEVTNQLATCLGMKLVRFDMSEYMESHTVSRLIGAPPG
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGYDQGGLLTDAVIKNPHCVVLLDEIEKAHRDVYNLLLQVMDHGTLTDNNGRKADFRHV
CCCCCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEE
TLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPEFRNRLDSIIWFNHLDMTIIA
EEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
KVVDKFLVELQAQLDAKHVILDVSDEARTLLAEKGYDKNMGARPMARVVTELIKRPLADE
HHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHH
ILFGALESGGVAYVDVKEGEIAIRTERHEKVASKA
HHHHHHCCCCEEEEEECCCCEEEEEHHHHHHHCCC
>Mature Secondary Structure
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVAS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
FIQQTTPIIADIDDDKETQPTLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQA
HHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHH
VYLLRRCDISRLDVVNFISHGFAKNDDTESHQDQERIEDQSEGSEERSMLSQFAANLNQL
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNKQVPDV
HHHCCCCHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHH
MLEATVYSLDLGSLLAGTKYRGDFEKRFKNLLKELAADKHAILFIDEIHTIIGAGAASGG
HHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCC
VMDASNLLKPLLSSGNLRCMGSTTFQEYQSIFEKDRALARRFQKVDINEPSVEETTKILM
CCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKSKYEEYHGVRYTQAAISSAAVLSAKHINDRHLPDKAIDVIDEAGARMVMLPMSKRKK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCHHHHH
TIGQAEIESIVAKMARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIETLSSAIRLSRS
HHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHC
GLGTDKKPVGSFLFAGPTGVGKTEVTNQLATCLGMKLVRFDMSEYMESHTVSRLIGAPPG
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGYDQGGLLTDAVIKNPHCVVLLDEIEKAHRDVYNLLLQVMDHGTLTDNNGRKADFRHV
CCCCCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEE
TLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPEFRNRLDSIIWFNHLDMTIIA
EEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
KVVDKFLVELQAQLDAKHVILDVSDEARTLLAEKGYDKNMGARPMARVVTELIKRPLADE
HHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHH
ILFGALESGGVAYVDVKEGEIAIRTERHEKVASKA
HHHHHHCCCCEEEEEECCCCEEEEEHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]