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The map label for this gene is htpG [H]

Identifier: 120598526

GI number: 120598526

Start: 1966018

End: 1967931

Strand: Direct

Name: htpG [H]

Synonym: Sputw3181_1709

Alternate gene names: 120598526

Gene position: 1966018-1967931 (Clockwise)

Preceding gene: 120598525

Following gene: 120598527

Centisome position: 41.76

GC content: 47.13

Gene sequence:

>1914_bases
ATGTCACAACAAGAAACTCATGGTTTTCAAACTGAAGTCAAACAGCTGTTGCATTTGATGATCCATTCTTTGTACTCCAA
CAAAGAAATTTTCTTGCGTGAACTGGTCTCCAACGCTGCGGATGCGGCCGATAAGCTGCGTTACCTCGCGTTGACCAATG
ACGCATTATATGAAGGTGACGGTGAGCTGCGTGTGCGCATTAGTGCAGACAAAGATAAAGGCACAGTGACCATCGAAGAT
AATGGTGTGGGTATGACCCGTGATGGCGTGATTGAGCATTTAGGCACTATTGCAAAATCAGGCACCGCCGAATTCTTCAA
AAACCTCTCTGGCGAAGCCTCAAAGGACTCGCAGTTAATTGGTCAGTTCGGTGTGGGTTTCTACTCCGCCTTTATAGTGG
CGAAAAAAGTCACCGTTCGCACCCGTGCCGCCGGCCATAAGGCCGATGAAGCAGTATTGTGGGAATCGGAAGGTGAGGGT
AGTTTCACCGTTGAAACCATCACTAAGGCGAGCCGTGGTACTGAAATCACCCTGCACCTACGTGATGAAGAAAAAGAGTT
TGCCGATGATTGGCGCCTACGTTCTATCATCACTAAATACTCAGATCATATCTCTGTGCCCGTAGAGATGTGGCAGGAAG
GCACACCAGAGCGCGACGGTCCAGACGGCGAAAAAATTCCTGCAACCGAAGGTTACTGGAAAGTTATGAACAAGGCGACA
GCCCTGTGGATGCGCAATAAGTCTGAGATTAGCGACGAAGAATATCAAGAATTTTATAAGCACATTTCCCATGACTACAC
AGACGCATTACTGTGGAGCCACAACCGCGTAGAAGGTAAGCAAGAATATACTAACCTCTTGTATATTCCTTCAAAAGCGC
CATGGGATCTGTGGAATCGTGACCGTAAACACGGTCTAAAACTGTTTGTGCAACGTGTGTTTATTATGGATGACGCAGAG
CAATTTATGCCATCTTACCTGCGTTTTGTGCAGGGCTTAATTGACTCAAACGATCTGCCGCTGAACGTCTCCCGCGAAAT
TTTGCAGGACAATCACATTACCAAAGCGATGCGCACTGGTATCACTAAGCGCGTGCTGGGTATGTTGGAGAAACTGGCGA
AAGACGATGCGGAAAAATATCAACAGTTCTGGGCTGAATTTGGCCAAGTGTTAAAAGAAGGACCCGCAGAAGATTTCGCA
AACCGTGAACGTATTGCTGGCTTACTGCGTTTTGCTTCAACCCACACGGGTAGCGCTGCGCCGACTGTGTCACTCGATGA
CTACATCAGCCGTATGAAAGAAGGCCAAACGAAGATTTACTATATTGTTGCCGACAGCTATGACGCCGCCGCTAACAGTC
CACATTTAGAGTTATTGCGCAAAAAAGACATTGAAGTATTACTGATGTCTGAGCGTATCGATGAGTGGTTAATCAACCAC
TTAACAGAGTACAAAGAAAAACAATTGCACTCAGTGACTCGTGGTGAACTTGAACTTGGCGAACTGGAAGATGCAGCGGA
GAAGGAAGCACAGGAGAAACTTGCCGAGGAGTCTGCTCCTCTTATCGAGCGTATTAAAGCTGCACTAGGTACAAAGGTTG
CCGATGTGAAAGTGACCTCTCGTTTAACTGACACCCCAGCCTGTGTGGTCACGGGTGAAGGCGAAATGTCGACGCAAATG
ATCAAGCTGATGCAAGCTGCCGGTCAACCCGTGCCGGAAGTGAAGCCAACATTTGAGGTAAACCCTGCGCACCCATTAGT
GTCGCGCTTAAATGATCTTCAAGATGAAACCGCTTTTGCGGATTGGTCAAACTTACTGTTACAACAGGCGCAATTATCTG
AAAAAGGTAGCCTTGCGGATCCATCGGCCTTTATTAAGCTGATGAACCAAATGTTACTGGCAAATATGAAGTAA

Upstream 100 bases:

>100_bases
TCGTTTTATTCCTTGCCCTTGAAAAGCAAATTTGCAGCCCCATTTAAGTAAGCACTGAGCGTTACTTTTACCAAATTGCG
TAACAAATAAGGAAAATTTC

Downstream 100 bases:

>100_bases
AAAATTTGGGGCCCATGGACGTTATTGCTCAAATGGGCCCCAACTATTTTTGAGCTTATCTCAGTTTTAACTTAGTTATG
TTTTAGCTTAAGCATGTTAA

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G [H]

Number of amino acids: Translated: 637; Mature: 636

Protein sequence:

>637_residues
MSQQETHGFQTEVKQLLHLMIHSLYSNKEIFLRELVSNAADAADKLRYLALTNDALYEGDGELRVRISADKDKGTVTIED
NGVGMTRDGVIEHLGTIAKSGTAEFFKNLSGEASKDSQLIGQFGVGFYSAFIVAKKVTVRTRAAGHKADEAVLWESEGEG
SFTVETITKASRGTEITLHLRDEEKEFADDWRLRSIITKYSDHISVPVEMWQEGTPERDGPDGEKIPATEGYWKVMNKAT
ALWMRNKSEISDEEYQEFYKHISHDYTDALLWSHNRVEGKQEYTNLLYIPSKAPWDLWNRDRKHGLKLFVQRVFIMDDAE
QFMPSYLRFVQGLIDSNDLPLNVSREILQDNHITKAMRTGITKRVLGMLEKLAKDDAEKYQQFWAEFGQVLKEGPAEDFA
NRERIAGLLRFASTHTGSAAPTVSLDDYISRMKEGQTKIYYIVADSYDAAANSPHLELLRKKDIEVLLMSERIDEWLINH
LTEYKEKQLHSVTRGELELGELEDAAEKEAQEKLAEESAPLIERIKAALGTKVADVKVTSRLTDTPACVVTGEGEMSTQM
IKLMQAAGQPVPEVKPTFEVNPAHPLVSRLNDLQDETAFADWSNLLLQQAQLSEKGSLADPSAFIKLMNQMLLANMK

Sequences:

>Translated_637_residues
MSQQETHGFQTEVKQLLHLMIHSLYSNKEIFLRELVSNAADAADKLRYLALTNDALYEGDGELRVRISADKDKGTVTIED
NGVGMTRDGVIEHLGTIAKSGTAEFFKNLSGEASKDSQLIGQFGVGFYSAFIVAKKVTVRTRAAGHKADEAVLWESEGEG
SFTVETITKASRGTEITLHLRDEEKEFADDWRLRSIITKYSDHISVPVEMWQEGTPERDGPDGEKIPATEGYWKVMNKAT
ALWMRNKSEISDEEYQEFYKHISHDYTDALLWSHNRVEGKQEYTNLLYIPSKAPWDLWNRDRKHGLKLFVQRVFIMDDAE
QFMPSYLRFVQGLIDSNDLPLNVSREILQDNHITKAMRTGITKRVLGMLEKLAKDDAEKYQQFWAEFGQVLKEGPAEDFA
NRERIAGLLRFASTHTGSAAPTVSLDDYISRMKEGQTKIYYIVADSYDAAANSPHLELLRKKDIEVLLMSERIDEWLINH
LTEYKEKQLHSVTRGELELGELEDAAEKEAQEKLAEESAPLIERIKAALGTKVADVKVTSRLTDTPACVVTGEGEMSTQM
IKLMQAAGQPVPEVKPTFEVNPAHPLVSRLNDLQDETAFADWSNLLLQQAQLSEKGSLADPSAFIKLMNQMLLANMK
>Mature_636_residues
SQQETHGFQTEVKQLLHLMIHSLYSNKEIFLRELVSNAADAADKLRYLALTNDALYEGDGELRVRISADKDKGTVTIEDN
GVGMTRDGVIEHLGTIAKSGTAEFFKNLSGEASKDSQLIGQFGVGFYSAFIVAKKVTVRTRAAGHKADEAVLWESEGEGS
FTVETITKASRGTEITLHLRDEEKEFADDWRLRSIITKYSDHISVPVEMWQEGTPERDGPDGEKIPATEGYWKVMNKATA
LWMRNKSEISDEEYQEFYKHISHDYTDALLWSHNRVEGKQEYTNLLYIPSKAPWDLWNRDRKHGLKLFVQRVFIMDDAEQ
FMPSYLRFVQGLIDSNDLPLNVSREILQDNHITKAMRTGITKRVLGMLEKLAKDDAEKYQQFWAEFGQVLKEGPAEDFAN
RERIAGLLRFASTHTGSAAPTVSLDDYISRMKEGQTKIYYIVADSYDAAANSPHLELLRKKDIEVLLMSERIDEWLINHL
TEYKEKQLHSVTRGELELGELEDAAEKEAQEKLAEESAPLIERIKAALGTKVADVKVTSRLTDTPACVVTGEGEMSTQMI
KLMQAAGQPVPEVKPTFEVNPAHPLVSRLNDLQDETAFADWSNLLLQQAQLSEKGSLADPSAFIKLMNQMLLANMK

Specific function: Molecular chaperone. Has ATPase activity [H]

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family [H]

Homologues:

Organism=Homo sapiens, GI20149594, Length=681, Percent_Identity=37.7386196769457, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI4507677, Length=686, Percent_Identity=37.4635568513119, Blast_Score=418, Evalue=1e-116,
Organism=Homo sapiens, GI155722983, Length=638, Percent_Identity=34.012539184953, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI154146191, Length=408, Percent_Identity=38.4803921568627, Blast_Score=269, Evalue=6e-72,
Organism=Homo sapiens, GI153792590, Length=408, Percent_Identity=38.4803921568627, Blast_Score=268, Evalue=2e-71,
Organism=Escherichia coli, GI1786679, Length=635, Percent_Identity=68.9763779527559, Blast_Score=894, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559162, Length=668, Percent_Identity=38.622754491018, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17542208, Length=665, Percent_Identity=37.593984962406, Blast_Score=410, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI115535205, Length=647, Percent_Identity=31.3755795981453, Blast_Score=317, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI115535167, Length=445, Percent_Identity=34.8314606741573, Blast_Score=263, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6323840, Length=680, Percent_Identity=37.7941176470588, Blast_Score=444, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6325016, Length=684, Percent_Identity=37.280701754386, Blast_Score=439, Evalue=1e-124,
Organism=Drosophila melanogaster, GI17647529, Length=684, Percent_Identity=38.1578947368421, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI21357739, Length=677, Percent_Identity=36.4844903988183, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24586016, Length=647, Percent_Identity=34.4667697063369, Blast_Score=362, Evalue=1e-100,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568 [H]

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90 [H]

EC number: NA

Molecular weight: Translated: 71944; Mature: 71813

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00298 HSP90

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQETHGFQTEVKQLLHLMIHSLYSNKEIFLRELVSNAADAADKLRYLALTNDALYEGD
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEECCCEEECC
GELRVRISADKDKGTVTIEDNGVGMTRDGVIEHLGTIAKSGTAEFFKNLSGEASKDSQLI
CCEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHH
GQFGVGFYSAFIVAKKVTVRTRAAGHKADEAVLWESEGEGSFTVETITKASRGTEITLHL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEHHHHHHCCCCCEEEEEE
RDEEKEFADDWRLRSIITKYSDHISVPVEMWQEGTPERDGPDGEKIPATEGYWKVMNKAT
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
ALWMRNKSEISDEEYQEFYKHISHDYTDALLWSHNRVEGKQEYTNLLYIPSKAPWDLWNR
HHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHCCEEEECCCCCCCHHHH
DRKHGLKLFVQRVFIMDDAEQFMPSYLRFVQGLIDSNDLPLNVSREILQDNHITKAMRTG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHH
ITKRVLGMLEKLAKDDAEKYQQFWAEFGQVLKEGPAEDFANRERIAGLLRFASTHTGSAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
PTVSLDDYISRMKEGQTKIYYIVADSYDAAANSPHLELLRKKDIEVLLMSERIDEWLINH
CCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHH
LTEYKEKQLHSVTRGELELGELEDAAEKEAQEKLAEESAPLIERIKAALGTKVADVKVTS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHEEEEHH
RLTDTPACVVTGEGEMSTQMIKLMQAAGQPVPEVKPTFEVNPAHPLVSRLNDLQDETAFA
HCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHH
DWSNLLLQQAQLSEKGSLADPSAFIKLMNQMLLANMK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SQQETHGFQTEVKQLLHLMIHSLYSNKEIFLRELVSNAADAADKLRYLALTNDALYEGD
CCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEECCCEEECC
GELRVRISADKDKGTVTIEDNGVGMTRDGVIEHLGTIAKSGTAEFFKNLSGEASKDSQLI
CCEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHH
GQFGVGFYSAFIVAKKVTVRTRAAGHKADEAVLWESEGEGSFTVETITKASRGTEITLHL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEHHHHHHCCCCCEEEEEE
RDEEKEFADDWRLRSIITKYSDHISVPVEMWQEGTPERDGPDGEKIPATEGYWKVMNKAT
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
ALWMRNKSEISDEEYQEFYKHISHDYTDALLWSHNRVEGKQEYTNLLYIPSKAPWDLWNR
HHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHCCEEEECCCCCCCHHHH
DRKHGLKLFVQRVFIMDDAEQFMPSYLRFVQGLIDSNDLPLNVSREILQDNHITKAMRTG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHH
ITKRVLGMLEKLAKDDAEKYQQFWAEFGQVLKEGPAEDFANRERIAGLLRFASTHTGSAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
PTVSLDDYISRMKEGQTKIYYIVADSYDAAANSPHLELLRKKDIEVLLMSERIDEWLINH
CCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHH
LTEYKEKQLHSVTRGELELGELEDAAEKEAQEKLAEESAPLIERIKAALGTKVADVKVTS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHEEEEHH
RLTDTPACVVTGEGEMSTQMIKLMQAAGQPVPEVKPTFEVNPAHPLVSRLNDLQDETAFA
HCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHH
DWSNLLLQQAQLSEKGSLADPSAFIKLMNQMLLANMK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA