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The map label for this gene is hemH2 [H]

Identifier: 120598151

GI number: 120598151

Start: 1510300

End: 1511313

Strand: Direct

Name: hemH2 [H]

Synonym: Sputw3181_1328

Alternate gene names: 120598151

Gene position: 1510300-1511313 (Clockwise)

Preceding gene: 120598150

Following gene: 120598156

Centisome position: 32.08

GC content: 41.32

Gene sequence:

>1014_bases
TTGGCTAAATTTTCAGGATTATCAAAAGACATTGGGCATGCAAAGCGCGGCAGGGTTGGTGTACTGTTACTTAATCTGGG
TACACCAGATGCTCCAACAGCATCGGCAGTAAGACGTTATTTAGCTGAGTTTTTATCCGATCCTCGTGTAGTAGAAATTC
CTAAATTAATTTGGATGTTAATTTTACATGGGATTATTTTGCGAGTTCGTCCGGCTAAATCGGCGGCTCTATACGAAAAA
GTATGGACCCAAGCGGGTTCGCCTTTAATGGATATCAGTTTGCGCCAAACGGCAAAACTTACGGATAAGCTAGCATCTGA
GGGAATAGATGTATCTGTGCATTTAGCCATGCGTTATGGAAATCCTTCGGTTGCCAGCACATTGCAAAATATGCACAAGC
AAGGGGTTGATAAGATTGTTGTATTGCCTTTGTATCCTCAATATGCGGCGCCGACGACAGGCTCTGCTTTTGATGCGATA
GCAAAAGAGTTATCCCAATGGCGTTATATTCCATCACTTCATTTTATTAATACTTATCATGACCATCCCGATTTTATTGA
GGCTTTAGCTGAGTCAATTCGAGTTGATTTTGAAAATCAAGGCAAGCCTGAAAAGCTGGTATTGTCATACCATGGTATGC
CAGAAAGGAACTTGCATTTAGGTGATCCTTATTATTGTTTTTGTGCAAAAACTACACGCTTAGTAACTGAAAAGCTTGGA
TTAAGTCAGGATGAGTTTGTGATGACTTTTCAATCTCGCTTTGGTAAAGCTAAATGGCTACAACCTTACACCGATGCCAC
GATGCAAGCATTACCCAATGCGGGTGTTCGTGATGTTGCTATTGTCTGTCCGGCATTTAGTGCCGATTGCCTCGAAACAT
TAGAAGAAATTGTTGGTGAAAATGGCCATATTTTTACCGAGGCAGGAGGGAATAAGTTCCGTTATATTCCGGCACTTAAC
GATGATGATGCACACATTACTATGATGGCAAATCTTGTCAGGCCTTACTTATAA

Upstream 100 bases:

>100_bases
AGCAGTTCAATTCAAAAGTGAAACCCGATAGTGCCGAACTTAAACAGGCTATTGAATCGGTTCTTTAATTTTAATACGTT
AAATTATTTAAGAGGCTGTT

Downstream 100 bases:

>100_bases
CCTGACGTAGCTTAGCCCTATGAAAATAAAAAAGGATAAGGCAACTTATCCTTTTTTAGATCTAGCGACCAAATTGGTTT
TCGAAATAGCTTTCTATGAT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 2; Protoheme ferro-lyase 2 [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MAKFSGLSKDIGHAKRGRVGVLLLNLGTPDAPTASAVRRYLAEFLSDPRVVEIPKLIWMLILHGIILRVRPAKSAALYEK
VWTQAGSPLMDISLRQTAKLTDKLASEGIDVSVHLAMRYGNPSVASTLQNMHKQGVDKIVVLPLYPQYAAPTTGSAFDAI
AKELSQWRYIPSLHFINTYHDHPDFIEALAESIRVDFENQGKPEKLVLSYHGMPERNLHLGDPYYCFCAKTTRLVTEKLG
LSQDEFVMTFQSRFGKAKWLQPYTDATMQALPNAGVRDVAIVCPAFSADCLETLEEIVGENGHIFTEAGGNKFRYIPALN
DDDAHITMMANLVRPYL

Sequences:

>Translated_337_residues
MAKFSGLSKDIGHAKRGRVGVLLLNLGTPDAPTASAVRRYLAEFLSDPRVVEIPKLIWMLILHGIILRVRPAKSAALYEK
VWTQAGSPLMDISLRQTAKLTDKLASEGIDVSVHLAMRYGNPSVASTLQNMHKQGVDKIVVLPLYPQYAAPTTGSAFDAI
AKELSQWRYIPSLHFINTYHDHPDFIEALAESIRVDFENQGKPEKLVLSYHGMPERNLHLGDPYYCFCAKTTRLVTEKLG
LSQDEFVMTFQSRFGKAKWLQPYTDATMQALPNAGVRDVAIVCPAFSADCLETLEEIVGENGHIFTEAGGNKFRYIPALN
DDDAHITMMANLVRPYL
>Mature_336_residues
AKFSGLSKDIGHAKRGRVGVLLLNLGTPDAPTASAVRRYLAEFLSDPRVVEIPKLIWMLILHGIILRVRPAKSAALYEKV
WTQAGSPLMDISLRQTAKLTDKLASEGIDVSVHLAMRYGNPSVASTLQNMHKQGVDKIVVLPLYPQYAAPTTGSAFDAIA
KELSQWRYIPSLHFINTYHDHPDFIEALAESIRVDFENQGKPEKLVLSYHGMPERNLHLGDPYYCFCAKTTRLVTEKLGL
SQDEFVMTFQSRFGKAKWLQPYTDATMQALPNAGVRDVAIVCPAFSADCLETLEEIVGENGHIFTEAGGNKFRYIPALND
DDAHITMMANLVRPYL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=335, Percent_Identity=25.6716417910448, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI60499025, Length=333, Percent_Identity=25.8258258258258, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=48.1366459627329, Blast_Score=309, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6324750, Length=338, Percent_Identity=26.6272189349112, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17864156, Length=348, Percent_Identity=24.1379310344828, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24651774, Length=277, Percent_Identity=23.826714801444, Blast_Score=85, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 37518; Mature: 37386

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKFSGLSKDIGHAKRGRVGVLLLNLGTPDAPTASAVRRYLAEFLSDPRVVEIPKLIWML
CCCCCCCCHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHH
ILHGIILRVRPAKSAALYEKVWTQAGSPLMDISLRQTAKLTDKLASEGIDVSVHLAMRYG
HHHHHHEEECCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
NPSVASTLQNMHKQGVDKIVVLPLYPQYAAPTTGSAFDAIAKELSQWRYIPSLHFINTYH
CCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
DHPDFIEALAESIRVDFENQGKPEKLVLSYHGMPERNLHLGDPYYCFCAKTTRLVTEKLG
CCHHHHHHHHHHHEECCCCCCCCCEEEEEECCCCCCCEECCCCEEEEECHHHHHHHHHHC
LSQDEFVMTFQSRFGKAKWLQPYTDATMQALPNAGVRDVAIVCPAFSADCLETLEEIVGE
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCC
NGHIFTEAGGNKFRYIPALNDDDAHITMMANLVRPYL
CCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
AKFSGLSKDIGHAKRGRVGVLLLNLGTPDAPTASAVRRYLAEFLSDPRVVEIPKLIWML
CCCCCCCHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHH
ILHGIILRVRPAKSAALYEKVWTQAGSPLMDISLRQTAKLTDKLASEGIDVSVHLAMRYG
HHHHHHEEECCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
NPSVASTLQNMHKQGVDKIVVLPLYPQYAAPTTGSAFDAIAKELSQWRYIPSLHFINTYH
CCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
DHPDFIEALAESIRVDFENQGKPEKLVLSYHGMPERNLHLGDPYYCFCAKTTRLVTEKLG
CCHHHHHHHHHHHEECCCCCCCCCEEEEEECCCCCCCEECCCCEEEEECHHHHHHHHHHC
LSQDEFVMTFQSRFGKAKWLQPYTDATMQALPNAGVRDVAIVCPAFSADCLETLEEIVGE
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCC
NGHIFTEAGGNKFRYIPALNDDDAHITMMANLVRPYL
CCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]