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The map label for this gene is gpwA [H]

Identifier: 120598150

GI number: 120598150

Start: 1509728

End: 1510267

Strand: Direct

Name: gpwA [H]

Synonym: Sputw3181_1327

Alternate gene names: 120598150

Gene position: 1509728-1510267 (Clockwise)

Preceding gene: 120598149

Following gene: 120598151

Centisome position: 32.06

GC content: 39.44

Gene sequence:

>540_bases
ATGAATAAATTCACTCTAATATTAGCAGCGACAGCAAGCATCATTAGTGTGGGAGCCATGGCCGCCACTTGCCCAAATTA
TCTCGATCTGGAAGTACGTAAATTACATTCAGAGGATAAAATTAATCTGTGTGAGTTGACTCAAGGTAAACCCGTATTGA
TCGTCAATACTGCCAGTAACTGTGGCTATACCTCACAGTTTAAATCCCTAGAAGCTATTAATAAGGAATATAAAGACAAA
GGATTAGTTGTGATAGGTTTCCCATCGGATGATTTTTTTCAAGAAGAAAATGATGAGAAAGACACGGCGAAGGTATGTTA
CATCAATTATGGTGTGACTTTTACTATGTTGGCCACATCGCCGGTCCGAGGAAATGATGCAAACAGTGTATTTAAATACT
TGGCCGAAAAAACGGGTGCGCCAAAGTGGAATTTCTATAAGTATGTTGTCAGTGGTGACGGTACAGTTGTACAGCAGTTC
AATTCAAAAGTGAAACCCGATAGTGCCGAACTTAAACAGGCTATTGAATCGGTTCTTTAA

Upstream 100 bases:

>100_bases
TTAGTCAGTGCTTACTATGAGCCTAACCCTAGCTTTTATTTTTAATTCAATATGATCTTTATCTCGAGCATTTACGTAAT
GCCAGATAAAGGAGAAAACA

Downstream 100 bases:

>100_bases
TTTTAATACGTTAAATTATTTAAGAGGCTGTTTTGGCTAAATTTTCAGGATTATCAAAAGACATTGGGCATGCAAAGCGC
GGCAGGGTTGGTGTACTGTT

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MNKFTLILAATASIISVGAMAATCPNYLDLEVRKLHSEDKINLCELTQGKPVLIVNTASNCGYTSQFKSLEAINKEYKDK
GLVVIGFPSDDFFQEENDEKDTAKVCYINYGVTFTMLATSPVRGNDANSVFKYLAEKTGAPKWNFYKYVVSGDGTVVQQF
NSKVKPDSAELKQAIESVL

Sequences:

>Translated_179_residues
MNKFTLILAATASIISVGAMAATCPNYLDLEVRKLHSEDKINLCELTQGKPVLIVNTASNCGYTSQFKSLEAINKEYKDK
GLVVIGFPSDDFFQEENDEKDTAKVCYINYGVTFTMLATSPVRGNDANSVFKYLAEKTGAPKWNFYKYVVSGDGTVVQQF
NSKVKPDSAELKQAIESVL
>Mature_179_residues
MNKFTLILAATASIISVGAMAATCPNYLDLEVRKLHSEDKINLCELTQGKPVLIVNTASNCGYTSQFKSLEAINKEYKDK
GLVVIGFPSDDFFQEENDEKDTAKVCYINYGVTFTMLATSPVRGNDANSVFKYLAEKTGAPKWNFYKYVVSGDGTVVQQF
NSKVKPDSAELKQAIESVL

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=128, Percent_Identity=35.9375, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI192455698, Length=139, Percent_Identity=30.2158273381295, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI4557629, Length=141, Percent_Identity=30.4964539007092, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI1788003, Length=157, Percent_Identity=31.8471337579618, Blast_Score=86, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17535473, Length=142, Percent_Identity=35.2112676056338, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17506887, Length=160, Percent_Identity=30.625, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193210707, Length=156, Percent_Identity=33.974358974359, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319721, Length=139, Percent_Identity=46.0431654676259, Blast_Score=118, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6322228, Length=139, Percent_Identity=43.1654676258993, Blast_Score=112, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322826, Length=139, Percent_Identity=40.2877697841727, Blast_Score=93, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24656772, Length=162, Percent_Identity=30.8641975308642, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24656767, Length=162, Percent_Identity=30.8641975308642, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24656777, Length=162, Percent_Identity=30.8641975308642, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 19732; Mature: 19732

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKFTLILAATASIISVGAMAATCPNYLDLEVRKLHSEDKINLCELTQGKPVLIVNTASN
CCCEEEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEECCCCCEEEEECCCC
CGYTSQFKSLEAINKEYKDKGLVVIGFPSDDFFQEENDEKDTAKVCYINYGVTFTMLATS
CCCHHHHHHHHHHHHHHHHCCEEEEECCCCHHHCCCCCCCCCEEEEEEECCEEEEEEEEC
PVRGNDANSVFKYLAEKTGAPKWNFYKYVVSGDGTVVQQFNSKVKPDSAELKQAIESVL
CCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEHHHCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNKFTLILAATASIISVGAMAATCPNYLDLEVRKLHSEDKINLCELTQGKPVLIVNTASN
CCCEEEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEECCCCCEEEEECCCC
CGYTSQFKSLEAINKEYKDKGLVVIGFPSDDFFQEENDEKDTAKVCYINYGVTFTMLATS
CCCHHHHHHHHHHHHHHHHCCEEEEECCCCHHHCCCCCCCCCEEEEEEECCEEEEEEEEC
PVRGNDANSVFKYLAEKTGAPKWNFYKYVVSGDGTVVQQFNSKVKPDSAELKQAIESVL
CCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEHHHCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA