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The map label for this gene is czcD [H]

Identifier: 120597994

GI number: 120597994

Start: 1321777

End: 1322694

Strand: Direct

Name: czcD [H]

Synonym: Sputw3181_1171

Alternate gene names: 120597994

Gene position: 1321777-1322694 (Clockwise)

Preceding gene: 120597993

Following gene: 120597995

Centisome position: 28.07

GC content: 45.42

Gene sequence:

>918_bases
GTGAGTCTTAATGCACCAGCACAACCATTCATATATCAAAGACGACAGCGACAACCGGATCGCTATGGCTTTTTTCTTAA
TGTGGGTTTTACCCTAATTGAGTTTATCGGCGGTTGGTTAACCAACAGCACAGCAATTATGGCAGATGCAGTGCATGACC
TGGGTGATAGCTTATCTATTGGCAGTGCATGGCTGTTGAACCGGCTTGGCCGAAAGTCTGCAAACCGACAATTTACTTAC
GGCTACCGCAGATTGTCATTGTTTGGCGCCTTAATTAACGGCTTGGTATTGATTGCCGGATCGGTTTGGGTACTGACTGA
GGCAATACCGCGGCTGGCTAACCCGGTAATGCCAGTGACAGAGGGAATGCTGGCTTTAGCTGTGCTGGGTGTTGCAGTCA
ATGGCTTTGCCGCTTACCGCTTGAGCAAAGGAAATACACTGAATGAAAAAGTGCTGAATTGGCATTTGCTTGAAGACGTT
CTTGGGTGGGTTGCAGTTTTGGTTGTGGCTATTGTGCTGCAATTTGTGGATTGGCCTATCCTTGACCCTTTGCTTTCTAT
TGGTTTCACCTTATTTATTTTGGTTAATGTTTTACGAAACCTCAGCACAACTGCGCGTTTATTTCTGCAAGCCGCGCCAG
ATAGCAAATTGCAAAATGAAATCCAAGATACTTTGCTGAAAATTGATGAGTTAGACAGCATTCATCACCTGCATCTCTGG
TCGCTTGATGGTGAACATCATGTACTCACCGCACATGTGGTAACCAATGCCAGCAAGGCATTTACTGCAAACCATTATGC
CGATATTAAGCTGCGTATTGCTAACGCATTGGAGCAGTTTGATTTAGCACATACCACGATAGAGCTGGAGTTAACACAAG
AACATTGTCGGGATGAATTCCCGGATAAGGTGCAGTGA

Upstream 100 bases:

>100_bases
TAGCTGCAACTCGAAGCGCACGGTAGAGCACTGTGGTATTTTAAAACAATTGAATGAAGCCGTTAGTCAAACCAACTAAG
TTGTTATCAGCAATAAATAG

Downstream 100 bases:

>100_bases
AGTGACCGTCATTACAACGTTAGGTTTATTTATCATTACTGCAATAGCAGAAATTGTCGGTTGCTATTTGCCTTACTTGT
GGCTGAAAAAAGGAGCTTCA

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSLNAPAQPFIYQRRQRQPDRYGFFLNVGFTLIEFIGGWLTNSTAIMADAVHDLGDSLSIGSAWLLNRLGRKSANRQFTY
GYRRLSLFGALINGLVLIAGSVWVLTEAIPRLANPVMPVTEGMLALAVLGVAVNGFAAYRLSKGNTLNEKVLNWHLLEDV
LGWVAVLVVAIVLQFVDWPILDPLLSIGFTLFILVNVLRNLSTTARLFLQAAPDSKLQNEIQDTLLKIDELDSIHHLHLW
SLDGEHHVLTAHVVTNASKAFTANHYADIKLRIANALEQFDLAHTTIELELTQEHCRDEFPDKVQ

Sequences:

>Translated_305_residues
MSLNAPAQPFIYQRRQRQPDRYGFFLNVGFTLIEFIGGWLTNSTAIMADAVHDLGDSLSIGSAWLLNRLGRKSANRQFTY
GYRRLSLFGALINGLVLIAGSVWVLTEAIPRLANPVMPVTEGMLALAVLGVAVNGFAAYRLSKGNTLNEKVLNWHLLEDV
LGWVAVLVVAIVLQFVDWPILDPLLSIGFTLFILVNVLRNLSTTARLFLQAAPDSKLQNEIQDTLLKIDELDSIHHLHLW
SLDGEHHVLTAHVVTNASKAFTANHYADIKLRIANALEQFDLAHTTIELELTQEHCRDEFPDKVQ
>Mature_304_residues
SLNAPAQPFIYQRRQRQPDRYGFFLNVGFTLIEFIGGWLTNSTAIMADAVHDLGDSLSIGSAWLLNRLGRKSANRQFTYG
YRRLSLFGALINGLVLIAGSVWVLTEAIPRLANPVMPVTEGMLALAVLGVAVNGFAAYRLSKGNTLNEKVLNWHLLEDVL
GWVAVLVVAIVLQFVDWPILDPLLSIGFTLFILVNVLRNLSTTARLFLQAAPDSKLQNEIQDTLLKIDELDSIHHLHLWS
LDGEHHVLTAHVVTNASKAFTANHYADIKLRIANALEQFDLAHTTIELELTQEHCRDEFPDKVQ

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=295, Percent_Identity=27.7966101694915, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI21359890, Length=275, Percent_Identity=26.1818181818182, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI64762489, Length=279, Percent_Identity=26.8817204301075, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI289803013, Length=279, Percent_Identity=25.089605734767, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI289803009, Length=279, Percent_Identity=25.089605734767, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI289803007, Length=279, Percent_Identity=25.089605734767, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI289803003, Length=279, Percent_Identity=25.089605734767, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI20070323, Length=262, Percent_Identity=26.3358778625954, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI21361112, Length=295, Percent_Identity=25.7627118644068, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786966, Length=282, Percent_Identity=30.8510638297872, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32564488, Length=308, Percent_Identity=25.3246753246753, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17555794, Length=249, Percent_Identity=24.8995983935743, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17555796, Length=249, Percent_Identity=24.4979919678715, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193210990, Length=305, Percent_Identity=24.9180327868852, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320411, Length=167, Percent_Identity=26.9461077844311, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324892, Length=110, Percent_Identity=37.2727272727273, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34056; Mature: 33925

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLNAPAQPFIYQRRQRQPDRYGFFLNVGFTLIEFIGGWLTNSTAIMADAVHDLGDSLSI
CCCCCCCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
GSAWLLNRLGRKSANRQFTYGYRRLSLFGALINGLVLIAGSVWVLTEAIPRLANPVMPVT
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
EGMLALAVLGVAVNGFAAYRLSKGNTLNEKVLNWHLLEDVLGWVAVLVVAIVLQFVDWPI
HHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LDPLLSIGFTLFILVNVLRNLSTTARLFLQAAPDSKLQNEIQDTLLKIDELDSIHHLHLW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEE
SLDGEHHVLTAHVVTNASKAFTANHYADIKLRIANALEQFDLAHTTIELELTQEHCRDEF
EECCCCEEEEEEEHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECHHHHHCCC
PDKVQ
CCCCC
>Mature Secondary Structure 
SLNAPAQPFIYQRRQRQPDRYGFFLNVGFTLIEFIGGWLTNSTAIMADAVHDLGDSLSI
CCCCCCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
GSAWLLNRLGRKSANRQFTYGYRRLSLFGALINGLVLIAGSVWVLTEAIPRLANPVMPVT
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
EGMLALAVLGVAVNGFAAYRLSKGNTLNEKVLNWHLLEDVLGWVAVLVVAIVLQFVDWPI
HHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LDPLLSIGFTLFILVNVLRNLSTTARLFLQAAPDSKLQNEIQDTLLKIDELDSIHHLHLW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEE
SLDGEHHVLTAHVVTNASKAFTANHYADIKLRIANALEQFDLAHTTIELELTQEHCRDEF
EECCCCEEEEEEEHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECHHHHHCCC
PDKVQ
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]