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The map label for this gene is cobS [H]

Identifier: 120597978

GI number: 120597978

Start: 1305573

End: 1306649

Strand: Direct

Name: cobS [H]

Synonym: Sputw3181_1155

Alternate gene names: 120597978

Gene position: 1305573-1306649 (Clockwise)

Preceding gene: 120597977

Following gene: 120597979

Centisome position: 27.73

GC content: 50.05

Gene sequence:

>1077_bases
ATGATAGAGCGAGCTGAACTCTTACATACACAGCCATACCACAATCAACACACCACCCGACGGGGACTTCATTCCCTGTT
GGGGCATGGGGCCTCGTTAAAACTAATGAGGTTTACCATGACAGAACAATCCCCATTTTTGGTTCAAGTGAATCAAGCGT
TTAATGTCCCGGCTCCTGATGCTTTCGTTCTGGAAGGATATGGTGCCGACACTACCCATCCAAACATTCCCGTTCGCAAG
GACGAGTATGTTTTTAGAAAAGAAGACTTACGTGACGTATTGGCGTTCTTGTCTCACCCAGACGGTGACGGTTTGTATAT
TACAGGCCCCACGGGATGCGGTAAGACCTCGCTAATTTGCCAAGTTGCTTCTCGATTGAATTGGCCTGTTCAGCAAATTA
CTGCGCACGGTCGATTGGAGTTGTCCGATCTTATCGGTCACCACACGCTGGTTAATGGCAACATGACCTTTGTGTATGGA
CCGCTGGCACTGGCTGTAAAGCATGGCCATTTACTGATCATTAATGAAATGGATCTTGCTGAGCCTGCTGAACTGGCTGG
GCTGAATGACATTTTGGAAGGTGCCCCGTTGGTCATCGCACAAAATGGCGGTGAGATCATCATGCCACATAACAAGTTTC
GTTTTATCGCTACCGGCAACAGTGCGGGCAGCGGTGACCAAACGGGCTTGTATCAAGGCGTGCTTCAACAGAATTTGGCT
TTTCTTGATCGCTTTAGAATCATCGAAGCGACCTATGCAGAGCCTTCTGTAGAGGAAGCCATTCTGGAGAACGTTGCGCC
GGGCTTGCCAGAAGTCTTTCGCCAAAAAATGGTGAAAGTGGCTGGTGACATTCGCCGTCTATTTATTGGGGGCGCGGATG
GCGGCGCTGAGCTTAGTATCACCATGTCCACTCGGACCTTGGTGCGCTGGGCAAAGTTAACACTTGCTTTTAAAGGCGCT
CCTAACGCAGTGGAGTATGCACTGGTTCGGTCTTTGACGGCTCGTGCTGAGTTGGAGCAACGTGAAGCCATTCACCGTAT
TGCCGCTGATGTCTTCGGTGACCACTGGGAGGATTGA

Upstream 100 bases:

>100_bases
ACTTTTAACGTTCACTTGGAGCCGATTTCGGCTCCTTTCTCATGCGCTTACATCGAGTGCATCAGAAAGCAGTTTCACTC
GTAGCCAATGCTGGGTACGA

Downstream 100 bases:

>100_bases
TGATGGAAAAGTGCTTTGCTCTTTACCGTTACAGTCATTCTGATGGGACAGCCAAAGAATGGGCCATTTACGTTGGATCA
AATACCCAGGAGATTGAAGT

Product: ATPase

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobS [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MIERAELLHTQPYHNQHTTRRGLHSLLGHGASLKLMRFTMTEQSPFLVQVNQAFNVPAPDAFVLEGYGADTTHPNIPVRK
DEYVFRKEDLRDVLAFLSHPDGDGLYITGPTGCGKTSLICQVASRLNWPVQQITAHGRLELSDLIGHHTLVNGNMTFVYG
PLALAVKHGHLLIINEMDLAEPAELAGLNDILEGAPLVIAQNGGEIIMPHNKFRFIATGNSAGSGDQTGLYQGVLQQNLA
FLDRFRIIEATYAEPSVEEAILENVAPGLPEVFRQKMVKVAGDIRRLFIGGADGGAELSITMSTRTLVRWAKLTLAFKGA
PNAVEYALVRSLTARAELEQREAIHRIAADVFGDHWED

Sequences:

>Translated_358_residues
MIERAELLHTQPYHNQHTTRRGLHSLLGHGASLKLMRFTMTEQSPFLVQVNQAFNVPAPDAFVLEGYGADTTHPNIPVRK
DEYVFRKEDLRDVLAFLSHPDGDGLYITGPTGCGKTSLICQVASRLNWPVQQITAHGRLELSDLIGHHTLVNGNMTFVYG
PLALAVKHGHLLIINEMDLAEPAELAGLNDILEGAPLVIAQNGGEIIMPHNKFRFIATGNSAGSGDQTGLYQGVLQQNLA
FLDRFRIIEATYAEPSVEEAILENVAPGLPEVFRQKMVKVAGDIRRLFIGGADGGAELSITMSTRTLVRWAKLTLAFKGA
PNAVEYALVRSLTARAELEQREAIHRIAADVFGDHWED
>Mature_358_residues
MIERAELLHTQPYHNQHTTRRGLHSLLGHGASLKLMRFTMTEQSPFLVQVNQAFNVPAPDAFVLEGYGADTTHPNIPVRK
DEYVFRKEDLRDVLAFLSHPDGDGLYITGPTGCGKTSLICQVASRLNWPVQQITAHGRLELSDLIGHHTLVNGNMTFVYG
PLALAVKHGHLLIINEMDLAEPAELAGLNDILEGAPLVIAQNGGEIIMPHNKFRFIATGNSAGSGDQTGLYQGVLQQNLA
FLDRFRIIEATYAEPSVEEAILENVAPGLPEVFRQKMVKVAGDIRRLFIGGADGGAELSITMSTRTLVRWAKLTLAFKGA
PNAVEYALVRSLTARAELEQREAIHRIAADVFGDHWED

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG0714

COG function: function code R; MoxR-like ATPases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24415404, Length=232, Percent_Identity=30.1724137931034, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI57863273, Length=223, Percent_Identity=26.9058295964126, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI57863271, Length=223, Percent_Identity=26.9058295964126, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25145616, Length=253, Percent_Identity=28.8537549407115, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323135, Length=288, Percent_Identity=26.0416666666667, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161076560, Length=209, Percent_Identity=30.1435406698565, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161076562, Length=209, Percent_Identity=30.1435406698565, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011704
- InterPro:   IPR006537 [H]

Pfam domain/function: PF07728 AAA_5 [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 39353; Mature: 39353

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIERAELLHTQPYHNQHTTRRGLHSLLGHGASLKLMRFTMTEQSPFLVQVNQAFNVPAPD
CCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCC
AFVLEGYGADTTHPNIPVRKDEYVFRKEDLRDVLAFLSHPDGDGLYITGPTGCGKTSLIC
EEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
QVASRLNWPVQQITAHGRLELSDLIGHHTLVNGNMTFVYGPLALAVKHGHLLIINEMDLA
HHHHHCCCCHHHHHCCCCEEHHHHHCCEEEECCCEEEEECCEEEEEECCCEEEEECCCCC
EPAELAGLNDILEGAPLVIAQNGGEIIMPHNKFRFIATGNSAGSGDQTGLYQGVLQQNLA
CCHHHCCHHHHHCCCCEEEEECCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHH
FLDRFRIIEATYAEPSVEEAILENVAPGLPEVFRQKMVKVAGDIRRLFIGGADGGAELSI
HHHHHHHEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCEEEE
TMSTRTLVRWAKLTLAFKGAPNAVEYALVRSLTARAELEQREAIHRIAADVFGDHWED
EECHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIERAELLHTQPYHNQHTTRRGLHSLLGHGASLKLMRFTMTEQSPFLVQVNQAFNVPAPD
CCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCC
AFVLEGYGADTTHPNIPVRKDEYVFRKEDLRDVLAFLSHPDGDGLYITGPTGCGKTSLIC
EEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
QVASRLNWPVQQITAHGRLELSDLIGHHTLVNGNMTFVYGPLALAVKHGHLLIINEMDLA
HHHHHCCCCHHHHHCCCCEEHHHHHCCEEEECCCEEEEECCEEEEEECCCEEEEECCCCC
EPAELAGLNDILEGAPLVIAQNGGEIIMPHNKFRFIATGNSAGSGDQTGLYQGVLQQNLA
CCHHHCCHHHHHCCCCEEEEECCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHH
FLDRFRIIEATYAEPSVEEAILENVAPGLPEVFRQKMVKVAGDIRRLFIGGADGGAELSI
HHHHHHHEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCEEEE
TMSTRTLVRWAKLTLAFKGAPNAVEYALVRSLTARAELEQREAIHRIAADVFGDHWED
EECHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]