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The map label for this gene is fhs [H]

Identifier: 120597458

GI number: 120597458

Start: 684185

End: 685897

Strand: Direct

Name: fhs [H]

Synonym: Sputw3181_0627

Alternate gene names: 120597458

Gene position: 684185-685897 (Clockwise)

Preceding gene: 120597457

Following gene: 120597460

Centisome position: 14.53

GC content: 48.04

Gene sequence:

>1713_bases
ATGCTGACCGATATGGAGATTTCAAGCCGTGCCAGTTTAACAAATGTGGCAGAGCTTGGCGCAGAGTTAGGCTTATTACC
GGAAGAAATGCTTCTATTTGGTAGCACAAAAGCTAAGGTAGATTTAAGTGTTCAGCAGCGTTTAGCGGGTCAAAGTCGGG
GAAAACTGATTATTGTCACTGCTGTCACCCCAACACCCCACGGTGAAGGTAAAACAGTGACAAGTATTGGGCTAACTCAA
TCCTTAAAGGCCATAGGTAAAAAAGCCTGTGCCTGCATTCGCCAACCGAGTATGGGGCCCGTCTTTGGCGTCAAAGGTGG
CGCAGCGGGTGGCGGTTATGCACAGGTTGTACCTATGCAGGAACTTAACTTGCATTTAACGGGTGATATTCATGCTGTCA
GCAGTGCCCATAATTTAGGTGCCGCCGCGATTGCGGCGAGGCTTTTCCATGAGTCACGTTTAGGTAAAGTGGAATTTGAG
GCGCAATCTGGACAAGCCTTTTTGGATATCGATCCTGCGCAGATCCGCTGGCATAGGGTGCTTGACCATAATGATCGTTG
TCTGCGACAGGTCCAGGTTGGACTGGGGGAAAACAACGGTCCTGTATATGAGTCTGGTTTTGATATTACGGCTGCATCTG
AATTAATGGCTATTTTGGCCTTGAGCGCTAATTTGGCGGATATGCGGGCCCGCATTGGGCGATTAGTTCTAGCACTTAAT
CGCCAAGGGCAGGTGATAAGCGCAGAAGATTTAGGGGTCGCAGGCGCTATGACGGCGATTATGGTGGATGCGATTAAACC
CACATTGATGCAGACCTTAAATGGCGCACCATGCCTCATTCATGCAGGCCCCTTTGCCAATATTGCCCACGGAAACTCCT
CGATTATTGCCGATGATATCGCTTTAAAACTTGTGGACTATGTGATCACCGAAGGGGGCTTTGGTTCCGATATGGGATTC
GAGAAGTTCTGTAATATCAAGGTGCGTCAGTCCGGGCAAGTCCCAAGTGCCGCGGTGTTAGTGACGACATTAAAAGCGCT
TAAGGCAAATAGCGGTATTGAGTCAGACACAGATATCAATACTCCTGATGAGATTCGTCTAGAGGCAGGATTTGCTAATT
TACACTGGCATATTAACAATGTGGCACGCTATGGCATTCCCGTCGTCGTGGCAATCAATCGCTTTGCCACGGATACCGAA
GCTGAGTTGCAATGGTTAATCAACGCCGTTAACCAAACTGCGGCATTTGGTTGTGAGGTCAGTGATGCTTTTAGCCAAGG
TGAAGCGGGGGCTATTGAACTTGCATATACTGTGGTTCGCGCCGCTGACACTCAGAGCCAGTTTAGGTTGTTATATCCGG
ATGATGCTTCTTTAGAGGCTAAGTTATCCACTTTAGCTGAGGTTGGTTATGGTGCGGCGGGCATCAGTCTCTCGGATGAA
GCTAAGCAACAAGTGAGGGAGTTTACCTCACTCGGTTATGCTTATTTACCTGTGTGTATGGCAAAAACACCCCTATCGAT
TAGTCACGATCCTATGCAAAAGGGCGTCCCGAAAGATTTTATTGTGCCAATCCGCGCTTTAGTGCTGAATGCGGGGGCGG
GTTTTGTTACAGCATTAGTGGGCAATGTGATGACAATGCCTGGTCTTGGTATAAAGCCAGGTTATCTCAAGATTGATATT
GATGAGGCTGGAGAGATTATTGGTTTAGGTTAG

Upstream 100 bases:

>100_bases
TCTCTTAAGATCAATCACCTAATATCCGCCATATTCAAGCGATGTTGTTTATTACAATCACACCTATTTATCCGGAATAC
TTCAAAGGAGAAACCGACGC

Downstream 100 bases:

>100_bases
GTGCTGAGGTTGTCATCGCTAGTGCTTAAAATGAATGGTATCGCAGTGGGTTGATTGTTTGTTACCATGGATTGGGCCTG
ATTTTAGGCTTGCATAATAG

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MLTDMEISSRASLTNVAELGAELGLLPEEMLLFGSTKAKVDLSVQQRLAGQSRGKLIIVTAVTPTPHGEGKTVTSIGLTQ
SLKAIGKKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQELNLHLTGDIHAVSSAHNLGAAAIAARLFHESRLGKVEFE
AQSGQAFLDIDPAQIRWHRVLDHNDRCLRQVQVGLGENNGPVYESGFDITAASELMAILALSANLADMRARIGRLVLALN
RQGQVISAEDLGVAGAMTAIMVDAIKPTLMQTLNGAPCLIHAGPFANIAHGNSSIIADDIALKLVDYVITEGGFGSDMGF
EKFCNIKVRQSGQVPSAAVLVTTLKALKANSGIESDTDINTPDEIRLEAGFANLHWHINNVARYGIPVVVAINRFATDTE
AELQWLINAVNQTAAFGCEVSDAFSQGEAGAIELAYTVVRAADTQSQFRLLYPDDASLEAKLSTLAEVGYGAAGISLSDE
AKQQVREFTSLGYAYLPVCMAKTPLSISHDPMQKGVPKDFIVPIRALVLNAGAGFVTALVGNVMTMPGLGIKPGYLKIDI
DEAGEIIGLG

Sequences:

>Translated_570_residues
MLTDMEISSRASLTNVAELGAELGLLPEEMLLFGSTKAKVDLSVQQRLAGQSRGKLIIVTAVTPTPHGEGKTVTSIGLTQ
SLKAIGKKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQELNLHLTGDIHAVSSAHNLGAAAIAARLFHESRLGKVEFE
AQSGQAFLDIDPAQIRWHRVLDHNDRCLRQVQVGLGENNGPVYESGFDITAASELMAILALSANLADMRARIGRLVLALN
RQGQVISAEDLGVAGAMTAIMVDAIKPTLMQTLNGAPCLIHAGPFANIAHGNSSIIADDIALKLVDYVITEGGFGSDMGF
EKFCNIKVRQSGQVPSAAVLVTTLKALKANSGIESDTDINTPDEIRLEAGFANLHWHINNVARYGIPVVVAINRFATDTE
AELQWLINAVNQTAAFGCEVSDAFSQGEAGAIELAYTVVRAADTQSQFRLLYPDDASLEAKLSTLAEVGYGAAGISLSDE
AKQQVREFTSLGYAYLPVCMAKTPLSISHDPMQKGVPKDFIVPIRALVLNAGAGFVTALVGNVMTMPGLGIKPGYLKIDI
DEAGEIIGLG
>Mature_570_residues
MLTDMEISSRASLTNVAELGAELGLLPEEMLLFGSTKAKVDLSVQQRLAGQSRGKLIIVTAVTPTPHGEGKTVTSIGLTQ
SLKAIGKKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQELNLHLTGDIHAVSSAHNLGAAAIAARLFHESRLGKVEFE
AQSGQAFLDIDPAQIRWHRVLDHNDRCLRQVQVGLGENNGPVYESGFDITAASELMAILALSANLADMRARIGRLVLALN
RQGQVISAEDLGVAGAMTAIMVDAIKPTLMQTLNGAPCLIHAGPFANIAHGNSSIIADDIALKLVDYVITEGGFGSDMGF
EKFCNIKVRQSGQVPSAAVLVTTLKALKANSGIESDTDINTPDEIRLEAGFANLHWHINNVARYGIPVVVAINRFATDTE
AELQWLINAVNQTAAFGCEVSDAFSQGEAGAIELAYTVVRAADTQSQFRLLYPDDASLEAKLSTLAEVGYGAAGISLSDE
AKQQVREFTSLGYAYLPVCMAKTPLSISHDPMQKGVPKDFIVPIRALVLNAGAGFVTALVGNVMTMPGLGIKPGYLKIDI
DEAGEIIGLG

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=617, Percent_Identity=47.8119935170178, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI36796743, Length=617, Percent_Identity=47.8119935170178, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI310124614, Length=85, Percent_Identity=47.0588235294118, Blast_Score=86, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17568737, Length=621, Percent_Identity=47.8260869565217, Blast_Score=520, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17568739, Length=621, Percent_Identity=47.8260869565217, Blast_Score=520, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6319558, Length=629, Percent_Identity=43.2432432432432, Blast_Score=467, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6321643, Length=627, Percent_Identity=44.8165869218501, Blast_Score=466, Evalue=1e-132,
Organism=Drosophila melanogaster, GI62472483, Length=617, Percent_Identity=43.7601296596434, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45551871, Length=617, Percent_Identity=43.7601296596434, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24645718, Length=617, Percent_Identity=43.7601296596434, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI17137370, Length=617, Percent_Identity=43.7601296596434, Blast_Score=456, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 60138; Mature: 60138

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00721 FTHFS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTDMEISSRASLTNVAELGAELGLLPEEMLLFGSTKAKVDLSVQQRLAGQSRGKLIIVT
CCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHEECCCCCEEEHHHHHHHCCCCCCCEEEEE
AVTPTPHGEGKTVTSIGLTQSLKAIGKKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQ
EECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEHH
ELNLHLTGDIHAVSSAHNLGAAAIAARLFHESRLGKVEFEAQSGQAFLDIDPAQIRWHRV
HCCEEEECCEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCHHHHHEEHH
LDHNDRCLRQVQVGLGENNGPVYESGFDITAASELMAILALSANLADMRARIGRLVLALN
HCCCHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEC
RQGQVISAEDLGVAGAMTAIMVDAIKPTLMQTLNGAPCLIHAGPFANIAHGNSSIIADDI
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCCEEHHHH
ALKLVDYVITEGGFGSDMGFEKFCNIKVRQSGQVPSAAVLVTTLKALKANSGIESDTDIN
HHHHHHHHHCCCCCCCCCCHHHHCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
TPDEIRLEAGFANLHWHINNVARYGIPVVVAINRFATDTEAELQWLINAVNQTAAFGCEV
CCCCEEEEECEEEEEEEECCHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCC
SDAFSQGEAGAIELAYTVVRAADTQSQFRLLYPDDASLEAKLSTLAEVGYGAAGISLSDE
HHHHCCCCCCEEEEHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHH
AKQQVREFTSLGYAYLPVCMAKTPLSISHDPMQKGVPKDFIVPIRALVLNAGAGFVTALV
HHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCHHHHHHH
GNVMTMPGLGIKPGYLKIDIDEAGEIIGLG
HHHHHCCCCCCCCCEEEEEECCCCCEEECC
>Mature Secondary Structure
MLTDMEISSRASLTNVAELGAELGLLPEEMLLFGSTKAKVDLSVQQRLAGQSRGKLIIVT
CCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHEECCCCCEEEHHHHHHHCCCCCCCEEEEE
AVTPTPHGEGKTVTSIGLTQSLKAIGKKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQ
EECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEHH
ELNLHLTGDIHAVSSAHNLGAAAIAARLFHESRLGKVEFEAQSGQAFLDIDPAQIRWHRV
HCCEEEECCEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCHHHHHEEHH
LDHNDRCLRQVQVGLGENNGPVYESGFDITAASELMAILALSANLADMRARIGRLVLALN
HCCCHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEC
RQGQVISAEDLGVAGAMTAIMVDAIKPTLMQTLNGAPCLIHAGPFANIAHGNSSIIADDI
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCCEEHHHH
ALKLVDYVITEGGFGSDMGFEKFCNIKVRQSGQVPSAAVLVTTLKALKANSGIESDTDIN
HHHHHHHHHCCCCCCCCCCHHHHCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
TPDEIRLEAGFANLHWHINNVARYGIPVVVAINRFATDTEAELQWLINAVNQTAAFGCEV
CCCCEEEEECEEEEEEEECCHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCC
SDAFSQGEAGAIELAYTVVRAADTQSQFRLLYPDDASLEAKLSTLAEVGYGAAGISLSDE
HHHHCCCCCCEEEEHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHH
AKQQVREFTSLGYAYLPVCMAKTPLSISHDPMQKGVPKDFIVPIRALVLNAGAGFVTALV
HHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCHHHHHHH
GNVMTMPGLGIKPGYLKIDIDEAGEIIGLG
HHHHHCCCCCCCCCEEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA