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The map label for this gene is typA [H]

Identifier: 120597098

GI number: 120597098

Start: 291326

End: 293137

Strand: Direct

Name: typA [H]

Synonym: Sputw3181_0267

Alternate gene names: 120597098

Gene position: 291326-293137 (Clockwise)

Preceding gene: 120597096

Following gene: 120597100

Centisome position: 6.19

GC content: 47.41

Gene sequence:

>1812_bases
GTGCTAGAGAATTTACGTAACATCGCCATTATTGCACACGTTGACCATGGCAAAACGACCCTGGTAGACAAGTTGCTGTC
GCAATCAGGAACCCTTGCAACCCGGGGAGAAGCTACTGAGCGGGTGATGGACTCCAACGATCTTGAGAAGGAACGTGGAA
TCACGATTCTGGCAAAGAATACTGCCATCAAGTGGAACGATTATCGTATCAACATCGTTGATACCCCAGGCCACGCCGAC
TTCGGTGGTGAGGTTGAGCGTGTTCTGTCTATGGTTGACTCAGTATTATTGCTGGTTGATGCCGTTGATGGTCCAATGCC
ACAGACTCGCTTCGTAACCAAAAAAGCGTTCGCCCAAGGCCTAAAGCCAATCGTTGTTATCAACAAAATTGATCGTCCAG
GTGCTCGCCCTGATTGGGTTATCGACCAAGTGTTCGACCTGTTCGACAACTTAGGTGCGACCGACGAACAATTAGATTTC
CCAATCGTTTACGCTTCAGCGTTAAACGGTTTTGCAACTTTAGATCCAGATGTCGTCAGTGAAGATATGACGCCACTGTT
CCAAACTATCGTTGAAAAAGTCTCTTTCCCTGATGCTGACGCCGATGGCGCGTTCCAGATGCAAATTTCACAGCTCGATT
ACAACTCTTATGTAGGTGTGATCGGTGTGGGCCGTATCAATCGTGGTAGCATCAAAACTAACCAACAAGTGACTATCATC
GGTGCCGATGGTAAGACGCGTAACGGTAAAATGGGCCAAGTATTAGGTTACATGGGCCTTGACCGTACTGAGGTTGAGGT
TGCTAATGCTGGCGATATCGTGGCGATTACGGGTTTAGGCGAACTGAAAATCTCTGATACTGTCTGTGCCGCTGGTAATG
TAGAAGCGCTGCCGCCACTGTCTGTTGATGAGCCTACACTGACCATGACTTTCCAAGTCAACACTTCACCTTTCGCAGGT
AAAGAAGGTAAGTATGTGACTTCACGTAACATTCTTGAGCGTTTACAACAAGAATTAGTCCACAACGTGGCACTGCGTGT
TGAAGAAACTGACAGCCCAGATCGCTTCCGCGTATCAGGCCGTGGTGAATTGCATTTATCAATTTTGATTGAAAACATGC
GTCGCGAAGGTTACGAGTTAGCCGTATCACGTCCAGAAGTGATTCTGAAAACCATTGACGGTGAACTGTGTGAACCATTT
GAAACGTTGACCGTTGACGTTGAAGAAGAACATCAAGGCACAGTGATCGAGAAGTTGGGTACCCGTAAAGCTGAAATGAA
AGATATGCAGCTTGATGGTAAAGGTCGTGTACGTATCGACTTCATCATCCCAAGCCGTGGTTTGATTGGTTTCCAAACTG
AGTTTATGACTGCTACTTCAGGTACTGGTTTAATCTACCACTCGTTCGACCATTACGGTCCACATAAAGGTGGCGATATT
GGTCAACGCGCTAACGGCGTATTGATCTCTAACGCAACGGGTAAGGCGTTGACCTTCGCACTGTTCGGTCTACAGGATCG
TGGTCGTCTCTTTATCGGCCATGCGGCTGAAGTCTACGAAGGCCAAGTGGTTGGTATCCACGCTCGCTCAAACGATCTAA
CAGTTAACTGTTTGAAAGGTAAGCAGCTAACCAACATGCGTGCCTCTGGTACTGACGAAGCGCAAGTGCTGACTACGCCA
ATTACCATGACGCTTGAGCAAGCGCTTGAGTTTATTGATGATGACGAATTAGTTGAAGTGACGCCGAAAAGCATCCGTGT
TCGTAAGAGACACTTGACTGAAAACGATCGTAAGCGCAATAACCGCGGTTAA

Upstream 100 bases:

>100_bases
TGGAGTAGAATGGCACGCTTTTTTATGGCGACTCAACGTAGATTGCTGTAACGAATATTGTAATATCCCCTATTTTTGTT
TGATGGTAAGAGGTTTATCC

Downstream 100 bases:

>100_bases
CAAAAGCGGCTTACTTCGGTGAGCCACCTTATGAAAGCCCCGTTAAAGAAATTTGACGGGGCTTTTTTATTTTACGTTTC
AAGCTTGTTCACTGATGGCG

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: Tyrosine phosphorylated protein A [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MLENLRNIAIIAHVDHGKTTLVDKLLSQSGTLATRGEATERVMDSNDLEKERGITILAKNTAIKWNDYRINIVDTPGHAD
FGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTKKAFAQGLKPIVVINKIDRPGARPDWVIDQVFDLFDNLGATDEQLDF
PIVYASALNGFATLDPDVVSEDMTPLFQTIVEKVSFPDADADGAFQMQISQLDYNSYVGVIGVGRINRGSIKTNQQVTII
GADGKTRNGKMGQVLGYMGLDRTEVEVANAGDIVAITGLGELKISDTVCAAGNVEALPPLSVDEPTLTMTFQVNTSPFAG
KEGKYVTSRNILERLQQELVHNVALRVEETDSPDRFRVSGRGELHLSILIENMRREGYELAVSRPEVILKTIDGELCEPF
ETLTVDVEEEHQGTVIEKLGTRKAEMKDMQLDGKGRVRIDFIIPSRGLIGFQTEFMTATSGTGLIYHSFDHYGPHKGGDI
GQRANGVLISNATGKALTFALFGLQDRGRLFIGHAAEVYEGQVVGIHARSNDLTVNCLKGKQLTNMRASGTDEAQVLTTP
ITMTLEQALEFIDDDELVEVTPKSIRVRKRHLTENDRKRNNRG

Sequences:

>Translated_603_residues
MLENLRNIAIIAHVDHGKTTLVDKLLSQSGTLATRGEATERVMDSNDLEKERGITILAKNTAIKWNDYRINIVDTPGHAD
FGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTKKAFAQGLKPIVVINKIDRPGARPDWVIDQVFDLFDNLGATDEQLDF
PIVYASALNGFATLDPDVVSEDMTPLFQTIVEKVSFPDADADGAFQMQISQLDYNSYVGVIGVGRINRGSIKTNQQVTII
GADGKTRNGKMGQVLGYMGLDRTEVEVANAGDIVAITGLGELKISDTVCAAGNVEALPPLSVDEPTLTMTFQVNTSPFAG
KEGKYVTSRNILERLQQELVHNVALRVEETDSPDRFRVSGRGELHLSILIENMRREGYELAVSRPEVILKTIDGELCEPF
ETLTVDVEEEHQGTVIEKLGTRKAEMKDMQLDGKGRVRIDFIIPSRGLIGFQTEFMTATSGTGLIYHSFDHYGPHKGGDI
GQRANGVLISNATGKALTFALFGLQDRGRLFIGHAAEVYEGQVVGIHARSNDLTVNCLKGKQLTNMRASGTDEAQVLTTP
ITMTLEQALEFIDDDELVEVTPKSIRVRKRHLTENDRKRNNRG
>Mature_603_residues
MLENLRNIAIIAHVDHGKTTLVDKLLSQSGTLATRGEATERVMDSNDLEKERGITILAKNTAIKWNDYRINIVDTPGHAD
FGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTKKAFAQGLKPIVVINKIDRPGARPDWVIDQVFDLFDNLGATDEQLDF
PIVYASALNGFATLDPDVVSEDMTPLFQTIVEKVSFPDADADGAFQMQISQLDYNSYVGVIGVGRINRGSIKTNQQVTII
GADGKTRNGKMGQVLGYMGLDRTEVEVANAGDIVAITGLGELKISDTVCAAGNVEALPPLSVDEPTLTMTFQVNTSPFAG
KEGKYVTSRNILERLQQELVHNVALRVEETDSPDRFRVSGRGELHLSILIENMRREGYELAVSRPEVILKTIDGELCEPF
ETLTVDVEEEHQGTVIEKLGTRKAEMKDMQLDGKGRVRIDFIIPSRGLIGFQTEFMTATSGTGLIYHSFDHYGPHKGGDI
GQRANGVLISNATGKALTFALFGLQDRGRLFIGHAAEVYEGQVVGIHARSNDLTVNCLKGKQLTNMRASGTDEAQVLTTP
ITMTLEQALEFIDDDELVEVTPKSIRVRKRHLTENDRKRNNRG

Specific function: Probably interacts with the ribosomes in a GTP dependent manner. GTPase that mediates interactions between enteropathogenic E.coli (EPEC) and epithelial cells [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=516, Percent_Identity=26.1627906976744, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=43.609022556391, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI18390331, Length=147, Percent_Identity=42.1768707482993, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI4503483, Length=147, Percent_Identity=40.1360544217687, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI25306287, Length=171, Percent_Identity=34.5029239766082, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI19923640, Length=171, Percent_Identity=34.5029239766082, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI25306283, Length=171, Percent_Identity=34.5029239766082, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=40.5405405405405, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=40.5405405405405, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=40.5405405405405, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI34147630, Length=264, Percent_Identity=27.6515151515151, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=36.7647058823529, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=36.7647058823529, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=31.0077519379845, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI48994988, Length=603, Percent_Identity=77.6119402985075, Blast_Score=977, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=502, Percent_Identity=29.0836653386454, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1789738, Length=152, Percent_Identity=38.1578947368421, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1790835, Length=212, Percent_Identity=30.188679245283, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789737, Length=286, Percent_Identity=29.020979020979, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790412, Length=286, Percent_Identity=29.020979020979, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789559, Length=137, Percent_Identity=36.4963503649635, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17557151, Length=235, Percent_Identity=33.6170212765957, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17556745, Length=447, Percent_Identity=27.5167785234899, Blast_Score=119, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=40.7692307692308, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=40.7692307692308, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17533571, Length=178, Percent_Identity=37.0786516853933, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17506493, Length=159, Percent_Identity=37.7358490566038, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17552882, Length=179, Percent_Identity=34.0782122905028, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17556456, Length=286, Percent_Identity=29.020979020979, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI25141371, Length=245, Percent_Identity=29.7959183673469, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=583, Percent_Identity=27.958833619211, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324707, Length=147, Percent_Identity=40.1360544217687, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=147, Percent_Identity=40.1360544217687, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323098, Length=179, Percent_Identity=37.9888268156425, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324761, Length=273, Percent_Identity=28.9377289377289, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322359, Length=151, Percent_Identity=39.0728476821192, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324166, Length=142, Percent_Identity=37.3239436619718, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI78706572, Length=559, Percent_Identity=27.5491949910555, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24582462, Length=178, Percent_Identity=38.2022471910112, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574573, Length=139, Percent_Identity=39.568345323741, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24585711, Length=151, Percent_Identity=39.0728476821192, Blast_Score=106, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24585713, Length=151, Percent_Identity=39.0728476821192, Blast_Score=106, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24585709, Length=151, Percent_Identity=39.0728476821192, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI221458488, Length=161, Percent_Identity=39.1304347826087, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281363316, Length=321, Percent_Identity=28.6604361370716, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17864358, Length=321, Percent_Identity=28.6604361370716, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21357743, Length=190, Percent_Identity=34.2105263157895, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI19921738, Length=304, Percent_Identity=29.2763157894737, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28572034, Length=129, Percent_Identity=37.984496124031, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 66263; Mature: 66263

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLENLRNIAIIAHVDHGKTTLVDKLLSQSGTLATRGEATERVMDSNDLEKERGITILAKN
CCCCCCEEEEEEEECCCCHHHHHHHHHCCCCEEECCCHHHHHHCCCCCHHHCCEEEEEEC
TAIKWNDYRINIVDTPGHADFGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTKKAFAQG
CEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
LKPIVVINKIDRPGARPDWVIDQVFDLFDNLGATDEQLDFPIVYASALNGFATLDPDVVS
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHHHHH
EDMTPLFQTIVEKVSFPDADADGAFQMQISQLDYNSYVGVIGVGRINRGSIKTNQQVTII
HHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCCCCCCCEEEEE
GADGKTRNGKMGQVLGYMGLDRTEVEVANAGDIVAITGLGELKISDTVCAAGNVEALPPL
ECCCCCCCCCHHHHHHHCCCCCCEEEEECCCCEEEEECCCCEEECCEEECCCCCCCCCCC
SVDEPTLTMTFQVNTSPFAGKEGKYVTSRNILERLQQELVHNVALRVEETDSPDRFRVSG
CCCCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEECC
RGELHLSILIENMRREGYELAVSRPEVILKTIDGELCEPFETLTVDVEEEHQGTVIEKLG
CCCEEEEEEEEHHHCCCEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHC
TRKAEMKDMQLDGKGRVRIDFIIPSRGLIGFQTEFMTATSGTGLIYHSFDHYGPHKGGDI
CCCHHHHHEEECCCCCEEEEEEECCCCCEEEEEEEEEECCCCEEEEECCCCCCCCCCCCC
GQRANGVLISNATGKALTFALFGLQDRGRLFIGHAAEVYEGQVVGIHARSNDLTVNCLKG
CCCCCCEEEECCCCCEEEEEEEEECCCCCEEEECCHHHHCCEEEEEEECCCCEEEEEECC
KQLTNMRASGTDEAQVLTTPITMTLEQALEFIDDDELVEVTPKSIRVRKRHLTENDRKRN
CEECCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCHHHCC
NRG
CCC
>Mature Secondary Structure
MLENLRNIAIIAHVDHGKTTLVDKLLSQSGTLATRGEATERVMDSNDLEKERGITILAKN
CCCCCCEEEEEEEECCCCHHHHHHHHHCCCCEEECCCHHHHHHCCCCCHHHCCEEEEEEC
TAIKWNDYRINIVDTPGHADFGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTKKAFAQG
CEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
LKPIVVINKIDRPGARPDWVIDQVFDLFDNLGATDEQLDFPIVYASALNGFATLDPDVVS
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHHHHH
EDMTPLFQTIVEKVSFPDADADGAFQMQISQLDYNSYVGVIGVGRINRGSIKTNQQVTII
HHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCCCCCCCEEEEE
GADGKTRNGKMGQVLGYMGLDRTEVEVANAGDIVAITGLGELKISDTVCAAGNVEALPPL
ECCCCCCCCCHHHHHHHCCCCCCEEEEECCCCEEEEECCCCEEECCEEECCCCCCCCCCC
SVDEPTLTMTFQVNTSPFAGKEGKYVTSRNILERLQQELVHNVALRVEETDSPDRFRVSG
CCCCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEECC
RGELHLSILIENMRREGYELAVSRPEVILKTIDGELCEPFETLTVDVEEEHQGTVIEKLG
CCCEEEEEEEEHHHCCCEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHC
TRKAEMKDMQLDGKGRVRIDFIIPSRGLIGFQTEFMTATSGTGLIYHSFDHYGPHKGGDI
CCCHHHHHEEECCCCCEEEEEEECCCCCEEEEEEEEEECCCCEEEEECCCCCCCCCCCCC
GQRANGVLISNATGKALTFALFGLQDRGRLFIGHAAEVYEGQVVGIHARSNDLTVNCLKG
CCCCCCEEEECCCCCEEEEEEEEECCCCCEEEECCHHHHCCEEEEEEECCCCEEEEEECC
KQLTNMRASGTDEAQVLTTPITMTLEQALEFIDDDELVEVTPKSIRVRKRHLTENDRKRN
CEECCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCHHHCC
NRG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9622352 [H]