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The map label for this gene is tlpA [H]

Identifier: 120597062

GI number: 120597062

Start: 252340

End: 254295

Strand: Direct

Name: tlpA [H]

Synonym: Sputw3181_0230

Alternate gene names: 120597062

Gene position: 252340-254295 (Clockwise)

Preceding gene: 120597052

Following gene: 120597064

Centisome position: 5.36

GC content: 46.22

Gene sequence:

>1956_bases
ATGGGTTTTACTCGTAAAATTCAGCTTATCAGTTTATTAATTGTCCTATTACCCCTCATTTTTGCTACAGCAATAGTAAC
TTATATTGCTCGGGATGAATTGTTTGCCGAGGCTCAGTCTCGTTTAGTGGCTGTGCGTGAGATCAAGCAGCGGCAAATTG
TGAGTATGTTTCAGGACTTTTCCGATAATCTTCAGGCCGTCAGCGCCGTAATCGCCAGCCAAAAAAACCTCGATACTCTT
ACCGACATAGATCAAACCTTGCAGTCCTTAAATAAATCTCTCGGTTTTTATGATCTGTTTATTATTCGTGATGATGGCAC
CGTTTTATATACAGTTGAGAAAGAGTCTGATTTCGGTACCAATTTGCGTACAGGGCCCTTCCATGATTCTGGATTAGCAC
AATTATTTAATAAGGCATTGGGATCGGCGGGTACTGTATTGTTGCAAGATTTTTCCGCATACGCGCCTTCAAATGGTCAA
CCAGCGGCATTTATTGGCCAGTCGATTCAGTTCAATCAGCAAAGGTTAGTCGTGGCGGCTCAGGTATCTATCGACCGCAT
TAATCGAGTTATGCAAATTCGTGAAGGTATGGGGCAAAGCGGTGAAACTTATCTCATAGGTCCAAATAATCGTATGCGCT
CCGATTCTTTTCTCGACCCAGTTAATCGCACTGTTACGGCTTCTTTTGCGGGAACGGTAGCTCAGAATGGTGTCGATACA
CAAGCGGTCAAAGAGGCGCTGGCAGGTAAAACAGGGGTGATGCAAGTGAGTGATTACAATAATAATCCTGTATTATCTGC
TTATTCTCCCGTCGTTGAGCTTGGTTTACGTTGGGGGTTGATGGCTGAAATTGATGTGAGTGAAATTGCAGCTCCCGCCT
ACCGCATGCTGTTTATTGGTTTATCTGTATGTGTGGCCGCCTTAGTGTTGGCGTTCGCTGCCGCGAAGTTAGTCACAGGA
TTTGTATTAAAGCCGCTCGGCGGTGAGCCTGAGGACATGTGCAACTTGACCAGTATGATCGCCTCTGGTGATTTAACTCA
TCATTTACCGCATATTCAAACGGATAATCACCTGATGAGTTGGTTGGCGCGGATGCAAACTAAGCTTAAAGAAATCATCA
GTCAGCTGGTGGGTGTTGGGCATGAACTTGAATCCGCCGCCGAACAAAACTCTGCAGCTATGAGTCAAGCCGATTGCAGT
ATTCAGATGCAGGCTAAAGAAACCGATATGTTGGCCACTGCAGTTGAAGAAATGAGTTATGCCGCAGCCGAAATCAGCAC
CAATACGATGAGGTCCTCCGATGAAGTGTCTGCCTGTACCCATTCGAGTGAAATTCTTTCACAAAACTTAGCCAGTACTC
GTAAAAGCTTAAAAGTAACCTTGAACAGTTTTGCGACTATTCATCAACAGGTGGGCAGTCTTGAGGCGGATAGTCAGAAA
ATCGGTTCAGTATTGGCGGTGATAAATGCGATTGCAGAACAAACTAATCTCTTGTCTCTTAATGCGGCGATTGAAGCTGC
GAGAGCTGGCGAGCATGGTCGTGGATTTGCGGTGGTGGCCGATGAGGTGCGTCAGTTAGCGGTGAAGGTTCAGTTAGCAA
CTCAGGATATTGGGCAAGTGTTAAAAGGTATTCAGCAACAGTCAGGTGTGCTGGCGTTGCATAGCGTAACGTGTTCCACT
GAAGCCTCTAAAACTGCAGAAGATGCCGATGGAATGCAAGCGGCTGTGGATGATATTGCTTTGCGCTTAGAAACCTTAAA
GGCATTAATGATTCAAACCGCAACCGCTGCGGAAGAACAAACAACGGTTTCAGCGACGATTGCGCAGGGAATTGCTGGCT
TAAGCGTGGCGGCGGAGGAAAATAGTGCGGCTATCAGCCAAGTGGCAGCGAGTACGCGGAGTCTGTTGGGGTTAGCAAAT
CAGCTTGGTTTAACAACGGCACAGTTTAAGGTGTAG

Upstream 100 bases:

>100_bases
CTACTTTGTTTCGCTGAGATTCTTCTCCTATAGTGTTATGGCAGGTTTGATTCTGTAAAGAGCGAAGGAATAGAATTCGA
AGCATGACAAGGAGTCCTCC

Downstream 100 bases:

>100_bases
GTATTTTTCGCTGCATTTACAGTGTTCTCACCTTAGTTGGTGCTGTAAATGTGACTGAGCTCGATGTTGTATATCCGCCA
GAAATGGAGCTCTGGCGGAT

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 651; Mature: 650

Protein sequence:

>651_residues
MGFTRKIQLISLLIVLLPLIFATAIVTYIARDELFAEAQSRLVAVREIKQRQIVSMFQDFSDNLQAVSAVIASQKNLDTL
TDIDQTLQSLNKSLGFYDLFIIRDDGTVLYTVEKESDFGTNLRTGPFHDSGLAQLFNKALGSAGTVLLQDFSAYAPSNGQ
PAAFIGQSIQFNQQRLVVAAQVSIDRINRVMQIREGMGQSGETYLIGPNNRMRSDSFLDPVNRTVTASFAGTVAQNGVDT
QAVKEALAGKTGVMQVSDYNNNPVLSAYSPVVELGLRWGLMAEIDVSEIAAPAYRMLFIGLSVCVAALVLAFAAAKLVTG
FVLKPLGGEPEDMCNLTSMIASGDLTHHLPHIQTDNHLMSWLARMQTKLKEIISQLVGVGHELESAAEQNSAAMSQADCS
IQMQAKETDMLATAVEEMSYAAAEISTNTMRSSDEVSACTHSSEILSQNLASTRKSLKVTLNSFATIHQQVGSLEADSQK
IGSVLAVINAIAEQTNLLSLNAAIEAARAGEHGRGFAVVADEVRQLAVKVQLATQDIGQVLKGIQQQSGVLALHSVTCST
EASKTAEDADGMQAAVDDIALRLETLKALMIQTATAAEEQTTVSATIAQGIAGLSVAAEENSAAISQVAASTRSLLGLAN
QLGLTTAQFKV

Sequences:

>Translated_651_residues
MGFTRKIQLISLLIVLLPLIFATAIVTYIARDELFAEAQSRLVAVREIKQRQIVSMFQDFSDNLQAVSAVIASQKNLDTL
TDIDQTLQSLNKSLGFYDLFIIRDDGTVLYTVEKESDFGTNLRTGPFHDSGLAQLFNKALGSAGTVLLQDFSAYAPSNGQ
PAAFIGQSIQFNQQRLVVAAQVSIDRINRVMQIREGMGQSGETYLIGPNNRMRSDSFLDPVNRTVTASFAGTVAQNGVDT
QAVKEALAGKTGVMQVSDYNNNPVLSAYSPVVELGLRWGLMAEIDVSEIAAPAYRMLFIGLSVCVAALVLAFAAAKLVTG
FVLKPLGGEPEDMCNLTSMIASGDLTHHLPHIQTDNHLMSWLARMQTKLKEIISQLVGVGHELESAAEQNSAAMSQADCS
IQMQAKETDMLATAVEEMSYAAAEISTNTMRSSDEVSACTHSSEILSQNLASTRKSLKVTLNSFATIHQQVGSLEADSQK
IGSVLAVINAIAEQTNLLSLNAAIEAARAGEHGRGFAVVADEVRQLAVKVQLATQDIGQVLKGIQQQSGVLALHSVTCST
EASKTAEDADGMQAAVDDIALRLETLKALMIQTATAAEEQTTVSATIAQGIAGLSVAAEENSAAISQVAASTRSLLGLAN
QLGLTTAQFKV
>Mature_650_residues
GFTRKIQLISLLIVLLPLIFATAIVTYIARDELFAEAQSRLVAVREIKQRQIVSMFQDFSDNLQAVSAVIASQKNLDTLT
DIDQTLQSLNKSLGFYDLFIIRDDGTVLYTVEKESDFGTNLRTGPFHDSGLAQLFNKALGSAGTVLLQDFSAYAPSNGQP
AAFIGQSIQFNQQRLVVAAQVSIDRINRVMQIREGMGQSGETYLIGPNNRMRSDSFLDPVNRTVTASFAGTVAQNGVDTQ
AVKEALAGKTGVMQVSDYNNNPVLSAYSPVVELGLRWGLMAEIDVSEIAAPAYRMLFIGLSVCVAALVLAFAAAKLVTGF
VLKPLGGEPEDMCNLTSMIASGDLTHHLPHIQTDNHLMSWLARMQTKLKEIISQLVGVGHELESAAEQNSAAMSQADCSI
QMQAKETDMLATAVEEMSYAAAEISTNTMRSSDEVSACTHSSEILSQNLASTRKSLKVTLNSFATIHQQVGSLEADSQKI
GSVLAVINAIAEQTNLLSLNAAIEAARAGEHGRGFAVVADEVRQLAVKVQLATQDIGQVLKGIQQQSGVLALHSVTCSTE
ASKTAEDADGMQAAVDDIALRLETLKALMIQTATAAEEQTTVSATIAQGIAGLSVAAEENSAAISQVAASTRSLLGLANQ
LGLTTAQFKV

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788194, Length=277, Percent_Identity=29.9638989169675, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1787690, Length=378, Percent_Identity=28.042328042328, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI2367378, Length=267, Percent_Identity=28.0898876404494, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1789453, Length=157, Percent_Identity=35.6687898089172, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788195, Length=136, Percent_Identity=37.5, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 69450; Mature: 69319

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFTRKIQLISLLIVLLPLIFATAIVTYIARDELFAEAQSRLVAVREIKQRQIVSMFQDF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDNLQAVSAVIASQKNLDTLTDIDQTLQSLNKSLGFYDLFIIRDDGTVLYTVEKESDFGT
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEECCCCCCC
NLRTGPFHDSGLAQLFNKALGSAGTVLLQDFSAYAPSNGQPAAFIGQSIQFNQQRLVVAA
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEEEEE
QVSIDRINRVMQIREGMGQSGETYLIGPNNRMRSDSFLDPVNRTVTASFAGTVAQNGVDT
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHEEHHHHHHHHCCCCCH
QAVKEALAGKTGVMQVSDYNNNPVLSAYSPVVELGLRWGLMAEIDVSEIAAPAYRMLFIG
HHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHH
LSVCVAALVLAFAAAKLVTGFVLKPLGGEPEDMCNLTSMIASGDLTHHLPHIQTDNHLMS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHH
WLARMQTKLKEIISQLVGVGHELESAAEQNSAAMSQADCSIQMQAKETDMLATAVEEMSY
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHH
AAAEISTNTMRSSDEVSACTHSSEILSQNLASTRKSLKVTLNSFATIHQQVGSLEADSQK
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IGSVLAVINAIAEQTNLLSLNAAIEAARAGEHGRGFAVVADEVRQLAVKVQLATQDIGQV
HHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
LKGIQQQSGVLALHSVTCSTEASKTAEDADGMQAAVDDIALRLETLKALMIQTATAAEEQ
HHHHHHHCCEEEEEEEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
TTVSATIAQGIAGLSVAAEENSAAISQVAASTRSLLGLANQLGLTTAQFKV
HHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
GFTRKIQLISLLIVLLPLIFATAIVTYIARDELFAEAQSRLVAVREIKQRQIVSMFQDF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDNLQAVSAVIASQKNLDTLTDIDQTLQSLNKSLGFYDLFIIRDDGTVLYTVEKESDFGT
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEECCCCCCC
NLRTGPFHDSGLAQLFNKALGSAGTVLLQDFSAYAPSNGQPAAFIGQSIQFNQQRLVVAA
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEEEEE
QVSIDRINRVMQIREGMGQSGETYLIGPNNRMRSDSFLDPVNRTVTASFAGTVAQNGVDT
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHEEHHHHHHHHCCCCCH
QAVKEALAGKTGVMQVSDYNNNPVLSAYSPVVELGLRWGLMAEIDVSEIAAPAYRMLFIG
HHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHH
LSVCVAALVLAFAAAKLVTGFVLKPLGGEPEDMCNLTSMIASGDLTHHLPHIQTDNHLMS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHH
WLARMQTKLKEIISQLVGVGHELESAAEQNSAAMSQADCSIQMQAKETDMLATAVEEMSY
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHH
AAAEISTNTMRSSDEVSACTHSSEILSQNLASTRKSLKVTLNSFATIHQQVGSLEADSQK
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IGSVLAVINAIAEQTNLLSLNAAIEAARAGEHGRGFAVVADEVRQLAVKVQLATQDIGQV
HHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
LKGIQQQSGVLALHSVTCSTEASKTAEDADGMQAAVDDIALRLETLKALMIQTATAAEEQ
HHHHHHHCCEEEEEEEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
TTVSATIAQGIAGLSVAAEENSAAISQVAASTRSLLGLANQLGLTTAQFKV
HHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]