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The map label for this gene is ykoD [H]

Identifier: 120596914

GI number: 120596914

Start: 99594

End: 100940

Strand: Direct

Name: ykoD [H]

Synonym: Sputw3181_0081

Alternate gene names: 120596914

Gene position: 99594-100940 (Clockwise)

Preceding gene: 120596912

Following gene: 120596915

Centisome position: 2.12

GC content: 45.58

Gene sequence:

>1347_bases
ATGAAACTTCTAGAAACCCAAGATGTTAGCTTTAACTATGGTTGTCAGTTAACTACCATATTTCAGGAGGTTAACCTCAG
CATTCGCACTGGCCAATGCCATTGTGTGAGTGGACCTACGGGGTCGGGTAAATCGAGCCTACTAAACCTCCTTGCGGGCG
TATTGACTCGTCCGCATGAGGGGGATATTTGGCGGCACCCTGAGCTAGTCACAGGTTTGGTTATGCAGGATCCACAACTC
CAACTACTTCGGCAAACGGTCGGTGCAGAAGTCGCCTTTGCATTGGAGAATTTTGGTATTCCTGCCGAGAGTATGCTGCC
AAAAGTGCAGTTAGCATTGAGGCGAGTCGGGTTATTTCTGAGCCTTGATACCCAAGTGAGTACGCTTTCCCTTGGGCAAA
AATATCGGCTGATGATCGCTTCCCAACTGGTATGTGAACCACATTTGCTGTTACTCGATGAGCCTTGGGCACAGCTTGAT
AATCATGGTGTAAGCGAACTGTTGGGGGTTATGCGGAATTTACTGCAAGAGGGTATGGCGTTGGTATTGGTTGAACATAA
CGCCCATGCTTTTGCCGATATTATCCAGCATTACTGGCAGTTAGAGCGGGGCAAACTCTCCGAAGGGATTTATCCTGCCA
CTGATTCAGCGCAAGTTGAGGTATTTAAGTGGCAAAACTACTGTAAACGAGAACACTTAGGTAAAGTACTCGTGAAGGCT
GATGCGTTTGATTTTGGTTACGATAATAACCCTGTTTTATTTAGTTGCCCGCAGGGATTTCAACTACAGTCAGGGGAGAT
TGTGACATTAGTTGGCGATAACGCTTCAGGTAAAACGAGTCTACTAAAAATCCTCGCCGGGGTGCTTAATATAAGACAAA
GACTACCTATCAAAGTGTTAGGAAGAAGGCCAAAACTCGGCGTGTATGGGGCAGAACTTGGCTTATTAATGCAAAGACCA
AGTCGACAACTGTTTGAAACCAGCGTGCTAGCCGAGATGCAATTTCGTTTAAAGCGATTTAAGCTTCCGAAGGAACGCGC
AATCCAAATATTAGATGAGCTAGCGTTATCCTCTTTAGCAGAATTATCCCCCCACAAACTGTCCTACGGCCAACAACACT
TGATCGCCTTAGCATCCATTGTTTGTTTACGTCCTCGGGTGTTGTTATTGGATGACCCTTTAGCGGGTATGGATAAAGAT
TACTACGGTAAAGTTTGGCACCTGCTGACAGGTCTAAGCTCTCAAGGCAGTGCCATTTTACTCAGTAGCCATAGAAACAT
TAAACATGATGCAGTTTCACGACAATGGAGTTTGCGTAATAGGCAATTGGTGTTGGAATCAATGTAG

Upstream 100 bases:

>100_bases
TGCTTAACCACGGATGGTAACGATATTTGCATCTATCAGGTCATCAGGTGGTAGTGAGAAGAGTTTAAATATCCTATTGA
TATCAATTGGCAGGTTTAAA

Downstream 100 bases:

>100_bases
ATGGGTAATGAATAGTTTCGAATGTTTGACACTTCAGCAGGACGATAAGCTTTAAAGTGTTAACCAATGATAACCATTAT
GTTATTTCCCTCCCGTTATT

Product: ABC transporter-like protein

Products: ADP; phosphate; ribose [Cytoplasm]; D-allose [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MKLLETQDVSFNYGCQLTTIFQEVNLSIRTGQCHCVSGPTGSGKSSLLNLLAGVLTRPHEGDIWRHPELVTGLVMQDPQL
QLLRQTVGAEVAFALENFGIPAESMLPKVQLALRRVGLFLSLDTQVSTLSLGQKYRLMIASQLVCEPHLLLLDEPWAQLD
NHGVSELLGVMRNLLQEGMALVLVEHNAHAFADIIQHYWQLERGKLSEGIYPATDSAQVEVFKWQNYCKREHLGKVLVKA
DAFDFGYDNNPVLFSCPQGFQLQSGEIVTLVGDNASGKTSLLKILAGVLNIRQRLPIKVLGRRPKLGVYGAELGLLMQRP
SRQLFETSVLAEMQFRLKRFKLPKERAIQILDELALSSLAELSPHKLSYGQQHLIALASIVCLRPRVLLLDDPLAGMDKD
YYGKVWHLLTGLSSQGSAILLSSHRNIKHDAVSRQWSLRNRQLVLESM

Sequences:

>Translated_448_residues
MKLLETQDVSFNYGCQLTTIFQEVNLSIRTGQCHCVSGPTGSGKSSLLNLLAGVLTRPHEGDIWRHPELVTGLVMQDPQL
QLLRQTVGAEVAFALENFGIPAESMLPKVQLALRRVGLFLSLDTQVSTLSLGQKYRLMIASQLVCEPHLLLLDEPWAQLD
NHGVSELLGVMRNLLQEGMALVLVEHNAHAFADIIQHYWQLERGKLSEGIYPATDSAQVEVFKWQNYCKREHLGKVLVKA
DAFDFGYDNNPVLFSCPQGFQLQSGEIVTLVGDNASGKTSLLKILAGVLNIRQRLPIKVLGRRPKLGVYGAELGLLMQRP
SRQLFETSVLAEMQFRLKRFKLPKERAIQILDELALSSLAELSPHKLSYGQQHLIALASIVCLRPRVLLLDDPLAGMDKD
YYGKVWHLLTGLSSQGSAILLSSHRNIKHDAVSRQWSLRNRQLVLESM
>Mature_448_residues
MKLLETQDVSFNYGCQLTTIFQEVNLSIRTGQCHCVSGPTGSGKSSLLNLLAGVLTRPHEGDIWRHPELVTGLVMQDPQL
QLLRQTVGAEVAFALENFGIPAESMLPKVQLALRRVGLFLSLDTQVSTLSLGQKYRLMIASQLVCEPHLLLLDEPWAQLD
NHGVSELLGVMRNLLQEGMALVLVEHNAHAFADIIQHYWQLERGKLSEGIYPATDSAQVEVFKWQNYCKREHLGKVLVKA
DAFDFGYDNNPVLFSCPQGFQLQSGEIVTLVGDNASGKTSLLKILAGVLNIRQRLPIKVLGRRPKLGVYGAELGLLMQRP
SRQLFETSVLAEMQFRLKRFKLPKERAIQILDELALSSLAELSPHKLSYGQQHLIALASIVCLRPRVLLLDDPLAGMDKD
YYGKVWHLLTGLSSQGSAILLSSHRNIKHDAVSRQWSLRNRQLVLESM

Specific function: Part of the ABC transporter complex YkoCDEF that could transport hydroxymethylpyrimidine (HMP) and/or thiamine. Could also transport other HMP-containing products. Responsible for energy coupling to the transport system (Probable) [H]

COG id: COG1122

COG function: function code P; ABC-type cobalt transport system, ATPase component

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI46592915, Length=184, Percent_Identity=27.1739130434783, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI46592956, Length=184, Percent_Identity=27.1739130434783, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI46592964, Length=184, Percent_Identity=27.1739130434783, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI46592898, Length=184, Percent_Identity=27.1739130434783, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI46592971, Length=184, Percent_Identity=27.1739130434783, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI46592978, Length=180, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI215820660, Length=276, Percent_Identity=25.7246376811594, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI20143975, Length=276, Percent_Identity=25.7246376811594, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790525, Length=448, Percent_Identity=24.1071428571429, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788506, Length=480, Percent_Identity=24.5833333333333, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1789991, Length=482, Percent_Identity=25.7261410788382, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790190, Length=435, Percent_Identity=24.5977011494253, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1787029, Length=230, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87081709, Length=184, Percent_Identity=31.5217391304348, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI48994943, Length=461, Percent_Identity=24.0780911062907, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788225, Length=235, Percent_Identity=28.936170212766, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786563, Length=191, Percent_Identity=32.4607329842932, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788210, Length=449, Percent_Identity=23.8307349665924, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788897, Length=448, Percent_Identity=23.8839285714286, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1786872, Length=162, Percent_Identity=28.3950617283951, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788761, Length=224, Percent_Identity=29.4642857142857, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI48995001, Length=465, Percent_Identity=23.4408602150538, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789873, Length=204, Percent_Identity=27.9411764705882, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786398, Length=213, Percent_Identity=28.6384976525822, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787370, Length=180, Percent_Identity=32.2222222222222, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788165, Length=189, Percent_Identity=31.2169312169312, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787105, Length=255, Percent_Identity=25.0980392156863, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87081834, Length=216, Percent_Identity=29.6296296296296, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87082267, Length=168, Percent_Identity=29.7619047619048, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789672, Length=172, Percent_Identity=25, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787089, Length=227, Percent_Identity=27.3127753303965, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87081791, Length=197, Percent_Identity=26.9035532994924, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790467, Length=173, Percent_Identity=30.635838150289, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1786319, Length=195, Percent_Identity=24.6153846153846, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1787164, Length=218, Percent_Identity=29.3577981651376, Blast_Score=62, Evalue=9e-11,
Organism=Escherichia coli, GI1787547, Length=184, Percent_Identity=28.2608695652174, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI161076682, Length=226, Percent_Identity=28.7610619469027, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574744, Length=191, Percent_Identity=29.8429319371728, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161076684, Length=226, Percent_Identity=28.7610619469027, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24581617, Length=226, Percent_Identity=28.7610619469027, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24581615, Length=226, Percent_Identity=28.7610619469027, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24581191, Length=172, Percent_Identity=27.906976744186, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24581189, Length=172, Percent_Identity=27.906976744186, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24581193, Length=172, Percent_Identity=27.906976744186, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24581195, Length=172, Percent_Identity=27.906976744186, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19920532, Length=183, Percent_Identity=30.0546448087432, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24580930, Length=183, Percent_Identity=30.0546448087432, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI85724864, Length=184, Percent_Identity=28.804347826087, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24580555, Length=184, Percent_Identity=28.804347826087, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI85816269, Length=184, Percent_Identity=28.804347826087, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24580553, Length=184, Percent_Identity=28.804347826087, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 50037; Mature: 50037

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLETQDVSFNYGCQLTTIFQEVNLSIRTGQCHCVSGPTGSGKSSLLNLLAGVLTRPHE
CCCCCCCCCCCCCCCCCEEEHHHHCCEEECCEEEEECCCCCCCHHHHHHHHHHHHCCCCC
GDIWRHPELVTGLVMQDPQLQLLRQTVGAEVAFALENFGIPAESMLPKVQLALRRVGLFL
CCCCCCCHHHHHHHCCCHHHHHHHHHHCCHHEEHHHHCCCCHHHHHHHHHHHHHHHCEEE
SLDTQVSTLSLGQKYRLMIASQLVCEPHLLLLDEPWAQLDNHGVSELLGVMRNLLQEGMA
EECCCHHHHHCCHHHHHHHHHHHHCCCCEEEECCCHHHHCCCCHHHHHHHHHHHHHCCEE
LVLVEHNAHAFADIIQHYWQLERGKLSEGIYPATDSAQVEVFKWQNYCKREHLGKVLVKA
EEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHEEEEE
DAFDFGYDNNPVLFSCPQGFQLQSGEIVTLVGDNASGKTSLLKILAGVLNIRQRLPIKVL
CCEECCCCCCCEEEECCCCCEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHEE
GRRPKLGVYGAELGLLMQRPSRQLFETSVLAEMQFRLKRFKLPKERAIQILDELALSSLA
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ELSPHKLSYGQQHLIALASIVCLRPRVLLLDDPLAGMDKDYYGKVWHLLTGLSSQGSAIL
HCCCCHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEE
LSSHRNIKHDAVSRQWSLRNRQLVLESM
EECCCCCCHHHHHHHHHCCCCEEEECCC
>Mature Secondary Structure
MKLLETQDVSFNYGCQLTTIFQEVNLSIRTGQCHCVSGPTGSGKSSLLNLLAGVLTRPHE
CCCCCCCCCCCCCCCCCEEEHHHHCCEEECCEEEEECCCCCCCHHHHHHHHHHHHCCCCC
GDIWRHPELVTGLVMQDPQLQLLRQTVGAEVAFALENFGIPAESMLPKVQLALRRVGLFL
CCCCCCCHHHHHHHCCCHHHHHHHHHHCCHHEEHHHHCCCCHHHHHHHHHHHHHHHCEEE
SLDTQVSTLSLGQKYRLMIASQLVCEPHLLLLDEPWAQLDNHGVSELLGVMRNLLQEGMA
EECCCHHHHHCCHHHHHHHHHHHHCCCCEEEECCCHHHHCCCCHHHHHHHHHHHHHCCEE
LVLVEHNAHAFADIIQHYWQLERGKLSEGIYPATDSAQVEVFKWQNYCKREHLGKVLVKA
EEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHEEEEE
DAFDFGYDNNPVLFSCPQGFQLQSGEIVTLVGDNASGKTSLLKILAGVLNIRQRLPIKVL
CCEECCCCCCCEEEECCCCCEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHEE
GRRPKLGVYGAELGLLMQRPSRQLFETSVLAEMQFRLKRFKLPKERAIQILDELALSSLA
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ELSPHKLSYGQQHLIALASIVCLRPRVLLLDDPLAGMDKDYYGKVWHLLTGLSSQGSAIL
HCCCCHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEE
LSSHRNIKHDAVSRQWSLRNRQLVLESM
EECCCCCCHHHHHHHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; ribose [Periplasm]; D-allose [Periplasm]; ATP [C]

Specific reaction: ATP + H2O + ribose [Periplasm] = ADP + phosphate + ribose [Cytoplasm] D-allose [Periplasm] + ATP + H2O = D-allose [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]