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The map label for this gene is gyrB [H]

Identifier: 119947311

GI number: 119947311

Start: 4528020

End: 4530449

Strand: Direct

Name: gyrB [H]

Synonym: Ping_3717

Alternate gene names: 119947311

Gene position: 4528020-4530449 (Clockwise)

Preceding gene: 119947310

Following gene: 119947312

Centisome position: 99.31

GC content: 41.48

Gene sequence:

>2430_bases
ATGGCTGAAAATAGTTATGATTCGTCAAGTATTAAAGTACTAAAAGGGTTAGATGCGGTTCGCAAACGCCCTGGCATGTA
TATTGGCGACACAGATGATGGCACCGGTTTACATCATATGGTTTTTGAGGTTTTAGATAACTCAATTGATGAAACATTGG
CGGGTTTTTGTACTGATATTATTACTACAATCCATACCGACGGCTCAGTTTCTGTACGTGATGATGGCCGCGGTATTCCT
GTTGATATGCATGAAGAAGAGGGTGTTTCAGCAGCCGAAGTTATTATGACCGTGTTACACGCCGGTGGTAAGTTTGATGA
TAACTCTTACAAAGTTTCCGGTGGTCTGCATGGTGTGGGTGTTTCCGTGGTTAATGCGCTTTCAGAAAAGCTGCGCTTAA
CGGTTAAACGCCATGGTCATATTTATCAACAAACTTATATTCATGGTGTGCCCGAGGCACCCATCGCCATTATTGGTGAT
ACTGAACAAACTGGTACAGAACTGCGTTTTTGGCCTAGTAAAGAAACCTTCTCTGACACACTGTTTCACTACGATATTCT
GGCAAAAAGATTACGTGAGCTTTCTTTCTTAAACTCCGGTGTGTCAATCAAACTTTTTGATAAACGCGAAGAAGATAAGT
CGGATCATTTTCATTATGAAGGTGGTATTGAAGCCTTTGTTAATTATTTAAATAAAAACAAAACCCCTATTCACCAGAAG
ATTTTTCACTTCTCAACAGATCATGAAGATGGCACTAATGTAGAAGTGGCAATGCAGTGGAATGATGGTTTTCAGGAAAA
CATCTACTGTTTTACCAATAATATCCCGCAAAAAGATGGTGGTTCTCATTTAACCGGTTTCCGTGGTGCATTAACTCGTA
CCTTAAATAATTACATGGAAAAGGAAATGGGTAAGGTTAAAAACGCGAAGAATAAAACAGCCACTGAAGGCGGTGATTCA
CGCGAAGGTTTAACCGCTGTTATATCCGTAAAAGTGCCGGATCCTAAGTTCTCTTCACAAACAAAAGACCGTTTAGTTTC
ATCTGAAGTACGACCTGTTGTCGAAGGTGCAATGAATGAACATCTGCAGGAATTTTTACTGGAAAATCCTGCTGAAGCCA
GAATTATAACGGGTAAAATTATTGATGCCGCACGAGCACGTGAGGCAGCCCGTAAAGCCCGTGATATGACACGCCGTAAA
GGTGCCTTAGATTTGGCTGGTTTACCCGGAAAACTGGCTGATTGCCAGGAAAAAGATCCCGCTCTTTCTGAACTCTATAT
TGTGGAAGGGGACTCCGCTGGCGGCAGCGCTAAGCAGGGACGTTCGCGTAAAAACCAGGCGATATTACCGCTTAAAGGTA
AAATCCTGAATGTTGAAAAAGCACGCTTTGATAAAATGCTTTCTTCCCAGGAAGTAGCAACCTTAATCACAGCCTTAGGT
TGTGGTATTGGCCGCGATGAATATAATCCGGAAAAAACCCGTTATCATCATATTATTATTATGACCGATGCCGATGTCGA
TGGTTCTCACATCCGGACATTGTTACTGACCTTTTTCTTCCGTCAAATGCCGGAATTAATTGAAAATGGTTATATCTATA
TTGCTCAACCGCCTTTATATAAAATTAAAAAAGGTAAGCAGGAAGATTACGTTAAAGATGAAGCTGCAATGCAGGCATTC
TTAACCCGGTTAGCAATGGAAAATTCATCACTGCATATAAATTCCGATGCACCCGGTATTTCCGGCATCGAACTGGAAAG
TATGATTCAGCGTTACCGTAGTGTTCAAGATACTATTACACGTTTATCTCGCCGTTATCCCTCTGCGATGTTAAATAAGC
TTATCTATAAACCTGAACTCACGGCCGATAATCTGGCTAATTATTCGCTTGTCTCAGAATGGGCAAACGATATTGTCGCA
ACCTTAAATCGAGAAGATTTAGGTGGCACAATTTATAAAACTGAAGTCATTAAATCTGAAGATGAACTGACCAACAATGT
GATTGTTATCGTGCGTAAACATGGTGTGGATAACCGCTATCAGCTTGATGAAGAGTTTTTTGGATCATCCGGTTACAAAT
CTTTGGTTTCATTGGGTAATGAAATACAGAACCTTCTGGAAGAGGGTGCATATATAAAACGTGGTGAGCGCAGAAAAGAA
GTTAAGAACTTTATTGAAGCGGTAAACTGGTTAATGCATGAAGCAAAACGTGGCCTTTATATACAGCGTTATAAAGGGCT
GGGAGAGATGAACCCTGGCCAGCTATGGGAAACCACGATGGATCCTAGTGCGCGCCGTATGCTGCAGGTAACAATCCAGG
ATGCGGTGGGTGCTGACCAACTGTTCTCGACCTTAATGGGCGATCATGTTGAACCTAGACGTGAGTTTATAGAAAAAAAT
GCACTGCGGGCTGAAAACTTAGATATCTAA

Upstream 100 bases:

>100_bases
GTGTTATTGCAGCAGAAAATATTGATCGATTATTTGGACAGGAACAGACTGTGTTTCACGTGGAGCACGGTAAGATTACA
GTAGAATAGGTGAAAGTTTG

Downstream 100 bases:

>100_bases
TAATAAGCCAAAATAAAACACCATAAAATGCCCGTCAGTTTGCTACTGACGGGCATTTTTTTTAGCCTGCAAAACATCTC
AGTAATACTAAAAGCATTAA

Product: DNA gyrase, B subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 809; Mature: 808

Protein sequence:

>809_residues
MAENSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVLDNSIDETLAGFCTDIITTIHTDGSVSVRDDGRGIP
VDMHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLRLTVKRHGHIYQQTYIHGVPEAPIAIIGD
TEQTGTELRFWPSKETFSDTLFHYDILAKRLRELSFLNSGVSIKLFDKREEDKSDHFHYEGGIEAFVNYLNKNKTPIHQK
IFHFSTDHEDGTNVEVAMQWNDGFQENIYCFTNNIPQKDGGSHLTGFRGALTRTLNNYMEKEMGKVKNAKNKTATEGGDS
REGLTAVISVKVPDPKFSSQTKDRLVSSEVRPVVEGAMNEHLQEFLLENPAEARIITGKIIDAARAREAARKARDMTRRK
GALDLAGLPGKLADCQEKDPALSELYIVEGDSAGGSAKQGRSRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALG
CGIGRDEYNPEKTRYHHIIIMTDADVDGSHIRTLLLTFFFRQMPELIENGYIYIAQPPLYKIKKGKQEDYVKDEAAMQAF
LTRLAMENSSLHINSDAPGISGIELESMIQRYRSVQDTITRLSRRYPSAMLNKLIYKPELTADNLANYSLVSEWANDIVA
TLNREDLGGTIYKTEVIKSEDELTNNVIVIVRKHGVDNRYQLDEEFFGSSGYKSLVSLGNEIQNLLEEGAYIKRGERRKE
VKNFIEAVNWLMHEAKRGLYIQRYKGLGEMNPGQLWETTMDPSARRMLQVTIQDAVGADQLFSTLMGDHVEPRREFIEKN
ALRAENLDI

Sequences:

>Translated_809_residues
MAENSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVLDNSIDETLAGFCTDIITTIHTDGSVSVRDDGRGIP
VDMHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLRLTVKRHGHIYQQTYIHGVPEAPIAIIGD
TEQTGTELRFWPSKETFSDTLFHYDILAKRLRELSFLNSGVSIKLFDKREEDKSDHFHYEGGIEAFVNYLNKNKTPIHQK
IFHFSTDHEDGTNVEVAMQWNDGFQENIYCFTNNIPQKDGGSHLTGFRGALTRTLNNYMEKEMGKVKNAKNKTATEGGDS
REGLTAVISVKVPDPKFSSQTKDRLVSSEVRPVVEGAMNEHLQEFLLENPAEARIITGKIIDAARAREAARKARDMTRRK
GALDLAGLPGKLADCQEKDPALSELYIVEGDSAGGSAKQGRSRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALG
CGIGRDEYNPEKTRYHHIIIMTDADVDGSHIRTLLLTFFFRQMPELIENGYIYIAQPPLYKIKKGKQEDYVKDEAAMQAF
LTRLAMENSSLHINSDAPGISGIELESMIQRYRSVQDTITRLSRRYPSAMLNKLIYKPELTADNLANYSLVSEWANDIVA
TLNREDLGGTIYKTEVIKSEDELTNNVIVIVRKHGVDNRYQLDEEFFGSSGYKSLVSLGNEIQNLLEEGAYIKRGERRKE
VKNFIEAVNWLMHEAKRGLYIQRYKGLGEMNPGQLWETTMDPSARRMLQVTIQDAVGADQLFSTLMGDHVEPRREFIEKN
ALRAENLDI
>Mature_808_residues
AENSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVLDNSIDETLAGFCTDIITTIHTDGSVSVRDDGRGIPV
DMHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLRLTVKRHGHIYQQTYIHGVPEAPIAIIGDT
EQTGTELRFWPSKETFSDTLFHYDILAKRLRELSFLNSGVSIKLFDKREEDKSDHFHYEGGIEAFVNYLNKNKTPIHQKI
FHFSTDHEDGTNVEVAMQWNDGFQENIYCFTNNIPQKDGGSHLTGFRGALTRTLNNYMEKEMGKVKNAKNKTATEGGDSR
EGLTAVISVKVPDPKFSSQTKDRLVSSEVRPVVEGAMNEHLQEFLLENPAEARIITGKIIDAARAREAARKARDMTRRKG
ALDLAGLPGKLADCQEKDPALSELYIVEGDSAGGSAKQGRSRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGC
GIGRDEYNPEKTRYHHIIIMTDADVDGSHIRTLLLTFFFRQMPELIENGYIYIAQPPLYKIKKGKQEDYVKDEAAMQAFL
TRLAMENSSLHINSDAPGISGIELESMIQRYRSVQDTITRLSRRYPSAMLNKLIYKPELTADNLANYSLVSEWANDIVAT
LNREDLGGTIYKTEVIKSEDELTNNVIVIVRKHGVDNRYQLDEEFFGSSGYKSLVSLGNEIQNLLEEGAYIKRGERRKEV
KNFIEAVNWLMHEAKRGLYIQRYKGLGEMNPGQLWETTMDPSARRMLQVTIQDAVGADQLFSTLMGDHVEPRREFIEKNA
LRAENLDI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=552, Percent_Identity=26.0869565217391, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI19913406, Length=559, Percent_Identity=25.2236135957066, Blast_Score=126, Evalue=9e-29,
Organism=Escherichia coli, GI48994957, Length=807, Percent_Identity=70.6319702602231, Blast_Score=1167, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=565, Percent_Identity=38.0530973451327, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17535065, Length=535, Percent_Identity=25.607476635514, Blast_Score=137, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI212645845, Length=509, Percent_Identity=25.147347740668, Blast_Score=122, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI212645657, Length=154, Percent_Identity=34.4155844155844, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=592, Percent_Identity=24.6621621621622, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17136538, Length=544, Percent_Identity=25.9191176470588, Blast_Score=127, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 90697; Mature: 90566

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAENSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVLDNSIDETLAGFCTDI
CCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ITTIHTDGSVSVRDDGRGIPVDMHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVG
HHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHH
VSVVNALSEKLRLTVKRHGHIYQQTYIHGVPEAPIAIIGDTEQTGTELRFWPSKETFSDT
HHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEECCCCCCCCCEEECCCCCHHHHH
LFHYDILAKRLRELSFLNSGVSIKLFDKREEDKSDHFHYEGGIEAFVNYLNKNKTPIHQK
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEECCCHHHHHHHHHCCCCCHHHH
IFHFSTDHEDGTNVEVAMQWNDGFQENIYCFTNNIPQKDGGSHLTGFRGALTRTLNNYME
HHHCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
KEMGKVKNAKNKTATEGGDSREGLTAVISVKVPDPKFSSQTKDRLVSSEVRPVVEGAMNE
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
HLQEFLLENPAEARIITGKIIDAARAREAARKARDMTRRKGALDLAGLPGKLADCQEKDP
HHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCC
ALSELYIVEGDSAGGSAKQGRSRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALG
CCEEEEEEECCCCCCCCHHCCCCCCCEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHHH
CGIGRDEYNPEKTRYHHIIIMTDADVDGSHIRTLLLTFFFRQMPELIENGYIYIAQPPLY
CCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCH
KIKKGKQEDYVKDEAAMQAFLTRLAMENSSLHINSDAPGISGIELESMIQRYRSVQDTIT
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
RLSRRYPSAMLNKLIYKPELTADNLANYSLVSEWANDIVATLNREDLGGTIYKTEVIKSE
HHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCEEEEHHHHCCH
DELTNNVIVIVRKHGVDNRYQLDEEFFGSSGYKSLVSLGNEIQNLLEEGAYIKRGERRKE
HHCCCCEEEEEEECCCCCCEECCHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHCCHHHHH
VKNFIEAVNWLMHEAKRGLYIQRYKGLGEMNPGQLWETTMDPSARRMLQVTIQDAVGADQ
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCHHH
LFSTLMGDHVEPRREFIEKNALRAENLDI
HHHHHHCCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AENSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVLDNSIDETLAGFCTDI
CCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ITTIHTDGSVSVRDDGRGIPVDMHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVG
HHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHH
VSVVNALSEKLRLTVKRHGHIYQQTYIHGVPEAPIAIIGDTEQTGTELRFWPSKETFSDT
HHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEECCCCCCCCCEEECCCCCHHHHH
LFHYDILAKRLRELSFLNSGVSIKLFDKREEDKSDHFHYEGGIEAFVNYLNKNKTPIHQK
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEECCCHHHHHHHHHCCCCCHHHH
IFHFSTDHEDGTNVEVAMQWNDGFQENIYCFTNNIPQKDGGSHLTGFRGALTRTLNNYME
HHHCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
KEMGKVKNAKNKTATEGGDSREGLTAVISVKVPDPKFSSQTKDRLVSSEVRPVVEGAMNE
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
HLQEFLLENPAEARIITGKIIDAARAREAARKARDMTRRKGALDLAGLPGKLADCQEKDP
HHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCC
ALSELYIVEGDSAGGSAKQGRSRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALG
CCEEEEEEECCCCCCCCHHCCCCCCCEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHHH
CGIGRDEYNPEKTRYHHIIIMTDADVDGSHIRTLLLTFFFRQMPELIENGYIYIAQPPLY
CCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCH
KIKKGKQEDYVKDEAAMQAFLTRLAMENSSLHINSDAPGISGIELESMIQRYRSVQDTIT
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
RLSRRYPSAMLNKLIYKPELTADNLANYSLVSEWANDIVATLNREDLGGTIYKTEVIKSE
HHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCEEEEHHHHCCH
DELTNNVIVIVRKHGVDNRYQLDEEFFGSSGYKSLVSLGNEIQNLLEEGAYIKRGERRKE
HHCCCCEEEEEEECCCCCCEECCHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHCCHHHHH
VKNFIEAVNWLMHEAKRGLYIQRYKGLGEMNPGQLWETTMDPSARRMLQVTIQDAVGADQ
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCHHH
LFSTLMGDHVEPRREFIEKNALRAENLDI
HHHHHHCCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]