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The map label for this gene is proC [H]

Identifier: 119946662

GI number: 119946662

Start: 3740848

End: 3741672

Strand: Direct

Name: proC [H]

Synonym: Ping_3041

Alternate gene names: 119946662

Gene position: 3740848-3741672 (Clockwise)

Preceding gene: 119946661

Following gene: 119946663

Centisome position: 82.04

GC content: 43.64

Gene sequence:

>825_bases
ATGTTACATAAGAAAATTACCTTTATTGGTGCCGGCAACATGGCCGGCAGTATAATCAGCGGATTAGCTAAATCTGGCTA
TCCTGCGGATTTGATCTGTGCATGTGCACCCAGTGCGAACAATACACAAAAACTAGCAGACCAATTTTCAATTCAGGCCA
GCCAAGACAATGTGACTGCAGTCGATTGGGCCGAAGTTATTGTGCTAGGCGTTAAACCGCAAATGATGGCAGATGTTTGT
CAGGCGATGGTTGACCAGGGCGCAGATTTTAGCAATAAGTTAGTTATCTCCATTGCGGCTGGTATCTCTGTACAGCGCCT
GCAGTCTTTATTAGGCGAGAAAGCCCAAATTATTCGCACTATGCCTAATACCCCAAGCTTATTACAAAAAGGAATGACCG
GGTTATTTGCATCGGAACAGGTAAGCGAAGAATATAAAACCTTTGCGGGCGACTTGATGTCAGCTGTGGGTGAGACAGTC
TGGGTAAAAGAAGAAAGCATGATTAATTCCGTTATCGCCGCGTCAGGATCTTCACCTGCGTACTTCTTCCTGTTTATGGA
AGCGATGCAGACAAAAGCAATAGAAATGGGCTTTGATCCGGAACAAGCACGTTTATTAGTGTCGCAAGCCGCACTGGGCA
GCATTGAAATGGTCAAACAAAACCCAGATATCTCTATTGGTAAGCTTCGTGAAAACGTCACTTCTAAAGAAGGATCAACT
GCAAAAGCGCTTGATACTTTTAATGAATTACAATTAACTGAAATCGTCGCTAAAGCGATGCAGGCAGCTTCTGATCGTGG
TGAAGAAATGGAAAAATTATTCTAA

Upstream 100 bases:

>100_bases
TGGACTAGACATGCTTGCCCATACCTTACTTAAAAAAAAGCCCTTGCACTGGAACAGTTGATTTATGTTTAAAGTCACAA
AGGGCGTCAGGAGAAATAAA

Downstream 100 bases:

>100_bases
ACTTCAGTTCATAAAATAGAGAGAAAGTATAATGAATGCAGTAAATTTTTTAGCGGAGACCCTGTTTGATCTTTATATCA
TGATCGTATTATTACGTATC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MLHKKITFIGAGNMAGSIISGLAKSGYPADLICACAPSANNTQKLADQFSIQASQDNVTAVDWAEVIVLGVKPQMMADVC
QAMVDQGADFSNKLVISIAAGISVQRLQSLLGEKAQIIRTMPNTPSLLQKGMTGLFASEQVSEEYKTFAGDLMSAVGETV
WVKEESMINSVIAASGSSPAYFFLFMEAMQTKAIEMGFDPEQARLLVSQAALGSIEMVKQNPDISIGKLRENVTSKEGST
AKALDTFNELQLTEIVAKAMQAASDRGEEMEKLF

Sequences:

>Translated_274_residues
MLHKKITFIGAGNMAGSIISGLAKSGYPADLICACAPSANNTQKLADQFSIQASQDNVTAVDWAEVIVLGVKPQMMADVC
QAMVDQGADFSNKLVISIAAGISVQRLQSLLGEKAQIIRTMPNTPSLLQKGMTGLFASEQVSEEYKTFAGDLMSAVGETV
WVKEESMINSVIAASGSSPAYFFLFMEAMQTKAIEMGFDPEQARLLVSQAALGSIEMVKQNPDISIGKLRENVTSKEGST
AKALDTFNELQLTEIVAKAMQAASDRGEEMEKLF
>Mature_274_residues
MLHKKITFIGAGNMAGSIISGLAKSGYPADLICACAPSANNTQKLADQFSIQASQDNVTAVDWAEVIVLGVKPQMMADVC
QAMVDQGADFSNKLVISIAAGISVQRLQSLLGEKAQIIRTMPNTPSLLQKGMTGLFASEQVSEEYKTFAGDLMSAVGETV
WVKEESMINSVIAASGSSPAYFFLFMEAMQTKAIEMGFDPEQARLLVSQAALGSIEMVKQNPDISIGKLRENVTSKEGST
AKALDTFNELQLTEIVAKAMQAASDRGEEMEKLF

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=277, Percent_Identity=28.5198555956679, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI24797097, Length=277, Percent_Identity=28.5198555956679, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI21361454, Length=277, Percent_Identity=29.2418772563177, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI198041662, Length=273, Percent_Identity=25.6410256410256, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786585, Length=273, Percent_Identity=35.5311355311355, Blast_Score=144, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17569021, Length=266, Percent_Identity=31.203007518797, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17540664, Length=291, Percent_Identity=28.1786941580756, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320861, Length=268, Percent_Identity=25.7462686567164, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21358587, Length=276, Percent_Identity=31.5217391304348, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24648116, Length=283, Percent_Identity=28.6219081272085, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=32.3529411764706, Blast_Score=87, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29348; Mature: 29348

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHKKITFIGAGNMAGSIISGLAKSGYPADLICACAPSANNTQKLADQFSIQASQDNVTA
CCCCEEEEEECCCHHHHHHHHHHHCCCCHHEEEEECCCCCCHHHHHHHHHCCCCCCCCEE
VDWAEVIVLGVKPQMMADVCQAMVDQGADFSNKLVISIAAGISVQRLQSLLGEKAQIIRT
ECHHHEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCHHHHHHC
MPNTPSLLQKGMTGLFASEQVSEEYKTFAGDLMSAVGETVWVKEESMINSVIAASGSSPA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHCCCCCCH
YFFLFMEAMQTKAIEMGFDPEQARLLVSQAALGSIEMVKQNPDISIGKLRENVTSKEGST
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHCCCCCH
AKALDTFNELQLTEIVAKAMQAASDRGEEMEKLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLHKKITFIGAGNMAGSIISGLAKSGYPADLICACAPSANNTQKLADQFSIQASQDNVTA
CCCCEEEEEECCCHHHHHHHHHHHCCCCHHEEEEECCCCCCHHHHHHHHHCCCCCCCCEE
VDWAEVIVLGVKPQMMADVCQAMVDQGADFSNKLVISIAAGISVQRLQSLLGEKAQIIRT
ECHHHEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCHHHHHHC
MPNTPSLLQKGMTGLFASEQVSEEYKTFAGDLMSAVGETVWVKEESMINSVIAASGSSPA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHCCCCCCH
YFFLFMEAMQTKAIEMGFDPEQARLLVSQAALGSIEMVKQNPDISIGKLRENVTSKEGST
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHCCCCCH
AKALDTFNELQLTEIVAKAMQAASDRGEEMEKLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]