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The map label for this gene is pdhR [H]

Identifier: 119946549

GI number: 119946549

Start: 3613116

End: 3613865

Strand: Reverse

Name: pdhR [H]

Synonym: Ping_2928

Alternate gene names: 119946549

Gene position: 3613865-3613116 (Counterclockwise)

Preceding gene: 119946551

Following gene: 119946548

Centisome position: 79.26

GC content: 41.73

Gene sequence:

>750_bases
ATGACTTACGCAAAAATCAAACAACCCAAACTTGCGGATGTGATTGAAAATCGTCTTGAAAGCATGATTCTAGATGGCTC
TTTGGAGCTCGGTGAAAAATTACCTTCGGAACGTGAACTGGCTAAACAGTTTGATGTCTCTCGCCCTTCACTGCGTGAAG
CGATGCAGCGCTTAGAGTCAAAAGGGTTACTTAACCGTCGTCAAGGCGGCGGGACCTATGTTAAAGAAGAATTACGTCAG
CGTTTAACTGATCCCTTATTTGAACTGTTAAATACCCATCCTGAATCTCAATATGACTTACTTGAGTTTCGTTATGCACT
GGAAGGCGTTTCTGCGTATTACGCAGCCCTGCGTGGTACTTCTGCTGATTTTGAAAAAATCAAAAATAGTTTTGCAGCGA
TTGAAAAATCCCGTCAAACACGCGATCTAGAAAAAGAGGTTCAGCATGTTGCACAGTTTTATCTGTCTGTAATAGAGGCT
TCTCACAACGTGGTTTTTTTACATTTAGCGCGTGGAATTCAACCTCTGCTGGAAAAAAATATCGCCGATAATGTACAGCA
ACTTTATGGTTATCCTGAAGTGGCTGATAAAATTCATCAGCATCGTCTGCAGCTGCTTGACGCGATTCTATCCAAGCAAC
CCGCAAGTGCACAACAAGCATCAGCACAGCATTTAAGTTATATTGAAGAAACACGTCTTGTGATGTTACGTGAAGAGAGT
TTATTTAAACGCGCATTAGGGCGTTTTTAA

Upstream 100 bases:

>100_bases
CACTAGACGTCTGCTAAAATAATTGTTAATTTAGATGGCTAAAAGTTAAATGGTAATACCAATTAACTTGCTGGCAAAGT
TTCTGTTTATTAAGGACATT

Downstream 100 bases:

>100_bases
CTTGCTAAAAAAACAGCTCAATCAAGTAACTATTTATATTACTTATTGCCGAGACGGCATTATCCAAAACGTGTTTTAAA
ACAGGTAATGGTTAATCTAA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTYAKIKQPKLADVIENRLESMILDGSLELGEKLPSERELAKQFDVSRPSLREAMQRLESKGLLNRRQGGGTYVKEELRQ
RLTDPLFELLNTHPESQYDLLEFRYALEGVSAYYAALRGTSADFEKIKNSFAAIEKSRQTRDLEKEVQHVAQFYLSVIEA
SHNVVFLHLARGIQPLLEKNIADNVQQLYGYPEVADKIHQHRLQLLDAILSKQPASAQQASAQHLSYIEETRLVMLREES
LFKRALGRF

Sequences:

>Translated_249_residues
MTYAKIKQPKLADVIENRLESMILDGSLELGEKLPSERELAKQFDVSRPSLREAMQRLESKGLLNRRQGGGTYVKEELRQ
RLTDPLFELLNTHPESQYDLLEFRYALEGVSAYYAALRGTSADFEKIKNSFAAIEKSRQTRDLEKEVQHVAQFYLSVIEA
SHNVVFLHLARGIQPLLEKNIADNVQQLYGYPEVADKIHQHRLQLLDAILSKQPASAQQASAQHLSYIEETRLVMLREES
LFKRALGRF
>Mature_248_residues
TYAKIKQPKLADVIENRLESMILDGSLELGEKLPSERELAKQFDVSRPSLREAMQRLESKGLLNRRQGGGTYVKEELRQR
LTDPLFELLNTHPESQYDLLEFRYALEGVSAYYAALRGTSADFEKIKNSFAAIEKSRQTRDLEKEVQHVAQFYLSVIEAS
HNVVFLHLARGIQPLLEKNIADNVQQLYGYPEVADKIHQHRLQLLDAILSKQPASAQQASAQHLSYIEETRLVMLREESL
FKRALGRF

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=233, Percent_Identity=56.6523605150215, Blast_Score=266, Evalue=8e-73,
Organism=Escherichia coli, GI1790032, Length=226, Percent_Identity=36.283185840708, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1789353, Length=226, Percent_Identity=32.3008849557522, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1790780, Length=217, Percent_Identity=29.9539170506912, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI87082208, Length=236, Percent_Identity=27.5423728813559, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1789621, Length=236, Percent_Identity=29.2372881355932, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28585; Mature: 28454

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYAKIKQPKLADVIENRLESMILDGSLELGEKLPSERELAKQFDVSRPSLREAMQRLES
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHH
KGLLNRRQGGGTYVKEELRQRLTDPLFELLNTHPESQYDLLEFRYALEGVSAYYAALRGT
HCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
SADFEKIKNSFAAIEKSRQTRDLEKEVQHVAQFYLSVIEASHNVVFLHLARGIQPLLEKN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHH
IADNVQQLYGYPEVADKIHQHRLQLLDAILSKQPASAQQASAQHLSYIEETRLVMLREES
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFKRALGRF
HHHHHHCCC
>Mature Secondary Structure 
TYAKIKQPKLADVIENRLESMILDGSLELGEKLPSERELAKQFDVSRPSLREAMQRLES
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHH
KGLLNRRQGGGTYVKEELRQRLTDPLFELLNTHPESQYDLLEFRYALEGVSAYYAALRGT
HCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
SADFEKIKNSFAAIEKSRQTRDLEKEVQHVAQFYLSVIEASHNVVFLHLARGIQPLLEKN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHH
IADNVQQLYGYPEVADKIHQHRLQLLDAILSKQPASAQQASAQHLSYIEETRLVMLREES
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFKRALGRF
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]