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The map label for this gene is 119946225

Identifier: 119946225

GI number: 119946225

Start: 3172265

End: 3173662

Strand: Direct

Name: 119946225

Synonym: Ping_2586

Alternate gene names: NA

Gene position: 3172265-3173662 (Clockwise)

Preceding gene: 119946221

Following gene: 119946226

Centisome position: 69.57

GC content: 39.27

Gene sequence:

>1398_bases
ATGGCTTTTATCCAATCATTTGGGGCTGCTGAGACAGTTACCGGATCATGCCATCTTTTACAGCTTAAAAATGGATCTAA
CATTTTAATTGATTGCGGTTATTTTCAGGGGAGCAAAGAAGAGCAAACATTTGAACCTTTTGGTTTTGATCCTAAAAAAG
TGGATATTTTACTGATTACCCATGCGCATTTAGATCATGTCGGACGCATTCCTAAACTTATCAAGGAGGGCTTTAACGGC
AAAGTTATCGCCTCAAGAGCGAGCATGGATCTGGCCGAAGTTATCTTAATGGATAGCGCTAAAATTGCTGAGGAGGACTA
TAAAATAGCACTTAAAAAAGCCAAACGATCCGGTAATGAAAAACAGGTTAGACCGCCTATTTACAGCATTGATGATGCAA
AAGCCGTCTTTGATTTAACTATCCAATATGCACAGTACAATAAAAGCATTCAACTTACGCCTGAGGTAAAAGTTACTTTT
CGTAATGCAGGACATATCCTTGGCTCGGCAACCGTGCAAATCGAGTTTACTGAAGCAGGTCTCTCCAAATCAGTTGTATT
TAGTGGGGACTTAGGCGGTCGGCGAGACTTAATTATGCCCGCCCCCTCTTTTGCTAAACAAGCCGATGCTCTTTATATTG
AATCAACCTACGGAGATCGTGATCATCGCGGTTTAAAGGAAACGGTTGATGAATTTAAAGAAATCATTATCAAGACCTTA
AATAATAAGGGTAATGTATTGATCCCCTCCTTTGCGATTGAACGCACGCAAGAAATTTTGCTGCTGCTAAAGCAAATGTA
TTACGACAAAGAGTTGCCCAAATGCCAAGTATTTTTAGATTCGCCAATGGCTATGCGTGCCACGCAAATTTATACCCGTT
ATCATTCTGAATTAAATGAGCCTGCCAAAAAATTGCTTGAGCGTGACGGCACTATTTTTGACTTTCCCTATCTGCAATAT
GCACTCAAAAACCAAGATTCAATGCTGATTAATAACATAGAAAGCGGCTGCATTATCATTGCCGGGAGTGGTATGTGCAC
CGGTGGGCGGATTTTGCAGCACTTTAAACATCGTCTATGGGATGCGCGTAACAGTGTCATCTTTGTTGGTTATCAAGTGC
AGGATACCTTAGGACGAAAAATGATTGATGGAGCAGAAACAATCCAGCTTTATCACGAAAATATTAAAGTAAATGCGCAG
ATACATATGATTAACGGATTTTCTGCCCATGCTGATCAAAGCGATCTTTTAGCTTGGATAAGCGAATTTGAAAAACTCGA
TAAAGTATTTTTAATACATGGAGAACCTGACAAACAGGCGATTTTTAAACAAATCATTGAAGAGCAGTTACATAAACCCA
CACATATTGTTAAATATGCGGAACAAATTTATATTTAA

Upstream 100 bases:

>100_bases
CAGTTAAATATCAGTTTAATATCATCAATACCTGATGAATTTTAAGCGAATAAATACAGGCATGCTACAGTTAAAAGTGT
ATCAACAATGGAGGTGCTTT

Downstream 100 bases:

>100_bases
CAGTGCGGGCAAACTAATCTCTTTAATAAACGCGACTAAGCGACGCTAACTACCTCGAAGGTTCCTAGAAAGCAAAAAGC
CCGTAACACCTTTAAATGTT

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MAFIQSFGAAETVTGSCHLLQLKNGSNILIDCGYFQGSKEEQTFEPFGFDPKKVDILLITHAHLDHVGRIPKLIKEGFNG
KVIASRASMDLAEVILMDSAKIAEEDYKIALKKAKRSGNEKQVRPPIYSIDDAKAVFDLTIQYAQYNKSIQLTPEVKVTF
RNAGHILGSATVQIEFTEAGLSKSVVFSGDLGGRRDLIMPAPSFAKQADALYIESTYGDRDHRGLKETVDEFKEIIIKTL
NNKGNVLIPSFAIERTQEILLLLKQMYYDKELPKCQVFLDSPMAMRATQIYTRYHSELNEPAKKLLERDGTIFDFPYLQY
ALKNQDSMLINNIESGCIIIAGSGMCTGGRILQHFKHRLWDARNSVIFVGYQVQDTLGRKMIDGAETIQLYHENIKVNAQ
IHMINGFSAHADQSDLLAWISEFEKLDKVFLIHGEPDKQAIFKQIIEEQLHKPTHIVKYAEQIYI

Sequences:

>Translated_465_residues
MAFIQSFGAAETVTGSCHLLQLKNGSNILIDCGYFQGSKEEQTFEPFGFDPKKVDILLITHAHLDHVGRIPKLIKEGFNG
KVIASRASMDLAEVILMDSAKIAEEDYKIALKKAKRSGNEKQVRPPIYSIDDAKAVFDLTIQYAQYNKSIQLTPEVKVTF
RNAGHILGSATVQIEFTEAGLSKSVVFSGDLGGRRDLIMPAPSFAKQADALYIESTYGDRDHRGLKETVDEFKEIIIKTL
NNKGNVLIPSFAIERTQEILLLLKQMYYDKELPKCQVFLDSPMAMRATQIYTRYHSELNEPAKKLLERDGTIFDFPYLQY
ALKNQDSMLINNIESGCIIIAGSGMCTGGRILQHFKHRLWDARNSVIFVGYQVQDTLGRKMIDGAETIQLYHENIKVNAQ
IHMINGFSAHADQSDLLAWISEFEKLDKVFLIHGEPDKQAIFKQIIEEQLHKPTHIVKYAEQIYI
>Mature_464_residues
AFIQSFGAAETVTGSCHLLQLKNGSNILIDCGYFQGSKEEQTFEPFGFDPKKVDILLITHAHLDHVGRIPKLIKEGFNGK
VIASRASMDLAEVILMDSAKIAEEDYKIALKKAKRSGNEKQVRPPIYSIDDAKAVFDLTIQYAQYNKSIQLTPEVKVTFR
NAGHILGSATVQIEFTEAGLSKSVVFSGDLGGRRDLIMPAPSFAKQADALYIESTYGDRDHRGLKETVDEFKEIIIKTLN
NKGNVLIPSFAIERTQEILLLLKQMYYDKELPKCQVFLDSPMAMRATQIYTRYHSELNEPAKKLLERDGTIFDFPYLQYA
LKNQDSMLINNIESGCIIIAGSGMCTGGRILQHFKHRLWDARNSVIFVGYQVQDTLGRKMIDGAETIQLYHENIKVNAQI
HMINGFSAHADQSDLLAWISEFEKLDKVFLIHGEPDKQAIFKQIIEEQLHKPTHIVKYAEQIYI

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=474, Percent_Identity=26.5822784810127, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI7706427, Length=446, Percent_Identity=27.5784753363229, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI32564696, Length=487, Percent_Identity=27.3100616016427, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI32566029, Length=455, Percent_Identity=27.6923076923077, Blast_Score=137, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323307, Length=454, Percent_Identity=26.6519823788546, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21358523, Length=474, Percent_Identity=28.2700421940928, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24648013, Length=457, Percent_Identity=27.1334792122538, Blast_Score=143, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 52555; Mature: 52424

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFIQSFGAAETVTGSCHLLQLKNGSNILIDCGYFQGSKEEQTFEPFGFDPKKVDILLIT
CCCHHHCCCCCEECCCEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEE
HAHLDHVGRIPKLIKEGFNGKVIASRASMDLAEVILMDSAKIAEEDYKIALKKAKRSGNE
EHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
KQVRPPIYSIDDAKAVFDLTIQYAQYNKSIQLTPEVKVTFRNAGHILGSATVQIEFTEAG
CCCCCCCCCCCCCCEEEEEEEEEECCCCCEEECCCEEEEEECCCCEEEEEEEEEEEECCC
LSKSVVFSGDLGGRRDLIMPAPSFAKQADALYIESTYGDRDHRGLKETVDEFKEIIIKTL
CCCEEEEECCCCCCCCEEECCCHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHC
NNKGNVLIPSFAIERTQEILLLLKQMYYDKELPKCQVFLDSPMAMRATQIYTRYHSELNE
CCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCH
PAKKLLERDGTIFDFPYLQYALKNQDSMLINNIESGCIIIAGSGMCTGGRILQHFKHRLW
HHHHHHHCCCCEEECHHHHHHHCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHH
DARNSVIFVGYQVQDTLGRKMIDGAETIQLYHENIKVNAQIHMINGFSAHADQSDLLAWI
CCCCCEEEEEEEEHHHHHHHHHCCHHHHEEEECCEEEEEEEEEEECCCCCCCHHHHHHHH
SEFEKLDKVFLIHGEPDKQAIFKQIIEEQLHKPTHIVKYAEQIYI
HHHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AFIQSFGAAETVTGSCHLLQLKNGSNILIDCGYFQGSKEEQTFEPFGFDPKKVDILLIT
CCHHHCCCCCEECCCEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEE
HAHLDHVGRIPKLIKEGFNGKVIASRASMDLAEVILMDSAKIAEEDYKIALKKAKRSGNE
EHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
KQVRPPIYSIDDAKAVFDLTIQYAQYNKSIQLTPEVKVTFRNAGHILGSATVQIEFTEAG
CCCCCCCCCCCCCCEEEEEEEEEECCCCCEEECCCEEEEEECCCCEEEEEEEEEEEECCC
LSKSVVFSGDLGGRRDLIMPAPSFAKQADALYIESTYGDRDHRGLKETVDEFKEIIIKTL
CCCEEEEECCCCCCCCEEECCCHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHC
NNKGNVLIPSFAIERTQEILLLLKQMYYDKELPKCQVFLDSPMAMRATQIYTRYHSELNE
CCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCH
PAKKLLERDGTIFDFPYLQYALKNQDSMLINNIESGCIIIAGSGMCTGGRILQHFKHRLW
HHHHHHHCCCCEEECHHHHHHHCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHH
DARNSVIFVGYQVQDTLGRKMIDGAETIQLYHENIKVNAQIHMINGFSAHADQSDLLAWI
CCCCCEEEEEEEEHHHHHHHHHCCHHHHEEEECCEEEEEEEEEEECCCCCCCHHHHHHHH
SEFEKLDKVFLIHGEPDKQAIFKQIIEEQLHKPTHIVKYAEQIYI
HHHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA