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The map label for this gene is thlA [H]

Identifier: 119946052

GI number: 119946052

Start: 2941097

End: 2942323

Strand: Reverse

Name: thlA [H]

Synonym: Ping_2401

Alternate gene names: 119946052

Gene position: 2942323-2941097 (Counterclockwise)

Preceding gene: 119946053

Following gene: 119946051

Centisome position: 64.53

GC content: 46.21

Gene sequence:

>1227_bases
ATGATGTCACTGAATTTTAACAATCTGAAAGAAGGTAATCTTATGAAAGATGTCGTTATCGTAAGTGCAAAACGCACTGC
AATTGGTTCTTATCTCGGTGTATTCAATAATGTATCACCCATCGATCTGGCTGTCACAGCGGTAAAATCTGCCTTGGAGG
CCGCAAATGTAACACCACAACAAGTCGATAATCTGATTTTTGGTCATGTCTTTTCAGCAGGTCTTGGTCAGAACCCCGCT
CGCCAAATAGCTAAATTTGCAGGTATTCCCGATCAGGCAACCGCCAATGTGGTCTCAATGGTATGCGGATCCGGATTAAA
AGCGGTGATGGATGCGGTGCTGCAAATCCAAACGGGCGAATCAGAAATCGTTGTTGCTGGCGGTACAGAATCGATGTCTA
ATGCAGTATATACCCTTGATTCACATCGCACAGGCGCGAAAACGGGTAACTCTCAACTGACTGATATTGTACTTAAGGAT
GGCTTAATTGATGCGTTTAGTGGTTTTCATATGGGCATTACCGCTGAAAATTTAGCGAAAAAATACCAAATCTCCCGCGA
AGAGCAGGATGCATACGCGCTTCAATCTCAACAGCGCGCAGAAACAGCGATAACATCCGGCAGATTTAAAAATGAGATTG
CTGCGCACATTATCTCAACGCGCGGTGGTGATACCATTGTTGATAGTGATGAATACCCGCGTTTCGGGATACCACTTAAG
GTTATCAGTAAAGCACGTCCAGCCTTTAAAAAAGATGGCACAGTGACGGCCGCAAATGCATCGGGTTTAAATGATGGTGC
AGCTGCCGTCGTTCTTATGAGTAAAGAAAAAGCGCTGGCACTGGGGTTAACACCTATGGTCACTATTCGTGCGCAAGGTG
CAGCTGGGGTTGATCCTGATATTATGGGGTATGGCCCCGTGCCGGCAACACAAAAAGCGCTGAAAAAAGCTGGCCTGACG
GTTCAAGACTTGAATTTGGTTGAAGCAAATGAAGCATTTGCATCTCAATGCCTGTCTGTTATCAAAGGCCTGGGTCTAGA
CCCTGCTATTACAAATGTAAACGGCGGCGCAATTTCTCTTGGTCATCCGGTCGGAGCCAGCGGTGCACGCATACTTGTCA
CCCTGCTTCACGAACTGACTAAGCGAAAAGAACGCTACGGACTGGCGACATTGTGTATCGGTGGAGGTCAAGGTGTTGCG
CTGCTTGTTGAAAATGAAAATAGATAA

Upstream 100 bases:

>100_bases
CAGAAAAAACAGACCCCAGAACAATGAAATAAATCTAATCGACAGACATCCTCCTGCTACCAATGAATCATTATGTTTAA
AATTCAAGGTACTGAAGGCA

Downstream 100 bases:

>100_bases
AAAGGGACATTATAGAATTTAAAATCATTAGTGTTACTGTGCCAATCTATGTGCGTTATGACTGAAGATAAGAGTAAAAG
TAATACCACCAGACGGTCAT

Product: acetyl-CoA acetyltransferases

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MMSLNFNNLKEGNLMKDVVIVSAKRTAIGSYLGVFNNVSPIDLAVTAVKSALEAANVTPQQVDNLIFGHVFSAGLGQNPA
RQIAKFAGIPDQATANVVSMVCGSGLKAVMDAVLQIQTGESEIVVAGGTESMSNAVYTLDSHRTGAKTGNSQLTDIVLKD
GLIDAFSGFHMGITAENLAKKYQISREEQDAYALQSQQRAETAITSGRFKNEIAAHIISTRGGDTIVDSDEYPRFGIPLK
VISKARPAFKKDGTVTAANASGLNDGAAAVVLMSKEKALALGLTPMVTIRAQGAAGVDPDIMGYGPVPATQKALKKAGLT
VQDLNLVEANEAFASQCLSVIKGLGLDPAITNVNGGAISLGHPVGASGARILVTLLHELTKRKERYGLATLCIGGGQGVA
LLVENENR

Sequences:

>Translated_408_residues
MMSLNFNNLKEGNLMKDVVIVSAKRTAIGSYLGVFNNVSPIDLAVTAVKSALEAANVTPQQVDNLIFGHVFSAGLGQNPA
RQIAKFAGIPDQATANVVSMVCGSGLKAVMDAVLQIQTGESEIVVAGGTESMSNAVYTLDSHRTGAKTGNSQLTDIVLKD
GLIDAFSGFHMGITAENLAKKYQISREEQDAYALQSQQRAETAITSGRFKNEIAAHIISTRGGDTIVDSDEYPRFGIPLK
VISKARPAFKKDGTVTAANASGLNDGAAAVVLMSKEKALALGLTPMVTIRAQGAAGVDPDIMGYGPVPATQKALKKAGLT
VQDLNLVEANEAFASQCLSVIKGLGLDPAITNVNGGAISLGHPVGASGARILVTLLHELTKRKERYGLATLCIGGGQGVA
LLVENENR
>Mature_408_residues
MMSLNFNNLKEGNLMKDVVIVSAKRTAIGSYLGVFNNVSPIDLAVTAVKSALEAANVTPQQVDNLIFGHVFSAGLGQNPA
RQIAKFAGIPDQATANVVSMVCGSGLKAVMDAVLQIQTGESEIVVAGGTESMSNAVYTLDSHRTGAKTGNSQLTDIVLKD
GLIDAFSGFHMGITAENLAKKYQISREEQDAYALQSQQRAETAITSGRFKNEIAAHIISTRGGDTIVDSDEYPRFGIPLK
VISKARPAFKKDGTVTAANASGLNDGAAAVVLMSKEKALALGLTPMVTIRAQGAAGVDPDIMGYGPVPATQKALKKAGLT
VQDLNLVEANEAFASQCLSVIKGLGLDPAITNVNGGAISLGHPVGASGARILVTLLHELTKRKERYGLATLCIGGGQGVA
LLVENENR

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=53.1969309462916, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=45.088161209068, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=43.0025445292621, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=41.0579345088161, Blast_Score=248, Evalue=9e-66,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=34.8837209302326, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=30.690537084399, Blast_Score=145, Evalue=6e-35,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=52.8061224489796, Blast_Score=401, Evalue=1e-113,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=53.8071065989848, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=38.9027431421446, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI48994986, Length=408, Percent_Identity=42.156862745098, Blast_Score=257, Evalue=8e-70,
Organism=Escherichia coli, GI1788683, Length=424, Percent_Identity=33.4905660377358, Blast_Score=191, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=43.4782608695652, Blast_Score=312, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI17535921, Length=392, Percent_Identity=40.3061224489796, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI25147385, Length=391, Percent_Identity=39.1304347826087, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=31.2941176470588, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=31.0432569974555, Blast_Score=163, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6325229, Length=401, Percent_Identity=42.3940149625935, Blast_Score=283, Evalue=4e-77,
Organism=Saccharomyces cerevisiae, GI6322031, Length=398, Percent_Identity=38.1909547738693, Blast_Score=207, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=50, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24640423, Length=395, Percent_Identity=42.5316455696203, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=40.920716112532, Blast_Score=275, Evalue=3e-74,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=33.0188679245283, Blast_Score=190, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42544; Mature: 42544

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSLNFNNLKEGNLMKDVVIVSAKRTAIGSYLGVFNNVSPIDLAVTAVKSALEAANVTPQ
CCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHH
QVDNLIFGHVFSAGLGQNPARQIAKFAGIPDQATANVVSMVCGSGLKAVMDAVLQIQTGE
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHEEECCC
SEIVVAGGTESMSNAVYTLDSHRTGAKTGNSQLTDIVLKDGLIDAFSGFHMGITAENLAK
CEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHCCHHHHHCCCCCCCCHHHHHH
KYQISREEQDAYALQSQQRAETAITSGRFKNEIAAHIISTRGGDTIVDSDEYPRFGIPLK
HHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHH
VISKARPAFKKDGTVTAANASGLNDGAAAVVLMSKEKALALGLTPMVTIRAQGAAGVDPD
HHHHCCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCEEEECCCCEEEEEECCCCCCCCC
IMGYGPVPATQKALKKAGLTVQDLNLVEANEAFASQCLSVIKGLGLDPAITNVNGGAISL
CCCCCCCCHHHHHHHHHCCEEEECCEEEHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEE
GHPVGASGARILVTLLHELTKRKERYGLATLCIGGGQGVALLVENENR
CCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEEEEECCCC
>Mature Secondary Structure
MMSLNFNNLKEGNLMKDVVIVSAKRTAIGSYLGVFNNVSPIDLAVTAVKSALEAANVTPQ
CCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHH
QVDNLIFGHVFSAGLGQNPARQIAKFAGIPDQATANVVSMVCGSGLKAVMDAVLQIQTGE
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHEEECCC
SEIVVAGGTESMSNAVYTLDSHRTGAKTGNSQLTDIVLKDGLIDAFSGFHMGITAENLAK
CEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHCCHHHHHCCCCCCCCHHHHHH
KYQISREEQDAYALQSQQRAETAITSGRFKNEIAAHIISTRGGDTIVDSDEYPRFGIPLK
HHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHH
VISKARPAFKKDGTVTAANASGLNDGAAAVVLMSKEKALALGLTPMVTIRAQGAAGVDPD
HHHHCCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCEEEECCCCEEEEEECCCCCCCCC
IMGYGPVPATQKALKKAGLTVQDLNLVEANEAFASQCLSVIKGLGLDPAITNVNGGAISL
CCCCCCCCHHHHHHHHHCCEEEECCEEEHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEE
GHPVGASGARILVTLLHELTKRKERYGLATLCIGGGQGVALLVENENR
CCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]