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The map label for this gene is ltaE [H]

Identifier: 119945952

GI number: 119945952

Start: 2786305

End: 2787318

Strand: Direct

Name: ltaE [H]

Synonym: Ping_2292

Alternate gene names: 119945952

Gene position: 2786305-2787318 (Clockwise)

Preceding gene: 119945950

Following gene: 119945954

Centisome position: 61.11

GC content: 44.97

Gene sequence:

>1014_bases
ATGATTGATTTTCGTTCTGATACAGTCACCCTTCCATCGCCCGCTATGCTGCAGGCGATGATCTATGCCCCGGTGGGTGA
TGACGTTTATGGTGACGATCCAACCGTCAATGATTTAGAACAATGGGCTGCAGAACGTCATGGTTTTGAAGCTGCCATTT
TCTGCACCTCCGGCACGCAGGCAAATCTATTGGCGTTGATGGCACACTGTGAACGCGGTGATGAATACCTTTGCGGTCAG
CAGGCACATAATTATAAATTTGAAGGCGGTGGTGCGGCAGTATTAGGATCGATTCAGCCACAGCCTATCGAAAATGAAAA
TGATGGTTCCCTTTCCTTTGCAAAACTCGCCTCGGCCATTAAGCCTGTCGATCCGCATTTTGCCCGTACCACATTATTAA
GTCTTGAAAATACGATCAATGGAAAAGTGCTCTCACTTGCTTATCTGCAACAGGCTCGCACATTCGTGAACCTTCATGGA
TTACAGCTGCACCTTGACGGTGCCCGGGTATATAACGCAGCCATTGCATTAGCCGTTGATATTAAAGAAATCAGTCAATA
TTTTGATTCAATGAGCATCTGTTTATCAAAAGGGTTAGGGGCTCCGATCGGTTCACTCTTGTTAGGTGATAAGAAATTAA
TCGCAAAAGCCCGTCGCTGGCGTAAAGTGTTGGGCGGTGGGATGCGTCAGGTGGGTATTTTAGCGGCGGCAGGTAAATAT
GCCTTAACAGAGAATGTAACCCGTTTAGCAGAAGATCATGCTAATGCGCATTATCTTGCCCAGCAGTTATCATTACTCGA
AGGTTTTACGGTCAATCCGGCATTAGTACAAACCAATATGGTTTTTGCCAAACTTGATCCGGCGATCAATCAGCAAAAAT
TACAGGATACGTTAAAAGAGCAGGGTATAATATTGAGCACAGGGAACCCGGTTCGTTTAGTGACTCATTTGGGTATTAGT
CGAATCGACATTGAGACTTTTTTAACCGCGTTAAAACAGGCTTTAAAACCTTAA

Upstream 100 bases:

>100_bases
GCAATGGATTGTTTTGCATCTCATTAGGTGTACTATTTAGGCATACAAAAAACGGATAATAACCAAAACAAATCATAATA
CCAAAGGAGAAAAATAACTA

Downstream 100 bases:

>100_bases
TAAATGGACGCGGCGCCGCTTTTCAGAGCGGGTATTATCCCGGGAAACAGGTGCTAGGGCCTGTTTCCATTGTCGCCTGC
CAATTGATCTAATAATTTAA

Product: threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MIDFRSDTVTLPSPAMLQAMIYAPVGDDVYGDDPTVNDLEQWAAERHGFEAAIFCTSGTQANLLALMAHCERGDEYLCGQ
QAHNYKFEGGGAAVLGSIQPQPIENENDGSLSFAKLASAIKPVDPHFARTTLLSLENTINGKVLSLAYLQQARTFVNLHG
LQLHLDGARVYNAAIALAVDIKEISQYFDSMSICLSKGLGAPIGSLLLGDKKLIAKARRWRKVLGGGMRQVGILAAAGKY
ALTENVTRLAEDHANAHYLAQQLSLLEGFTVNPALVQTNMVFAKLDPAINQQKLQDTLKEQGIILSTGNPVRLVTHLGIS
RIDIETFLTALKQALKP

Sequences:

>Translated_337_residues
MIDFRSDTVTLPSPAMLQAMIYAPVGDDVYGDDPTVNDLEQWAAERHGFEAAIFCTSGTQANLLALMAHCERGDEYLCGQ
QAHNYKFEGGGAAVLGSIQPQPIENENDGSLSFAKLASAIKPVDPHFARTTLLSLENTINGKVLSLAYLQQARTFVNLHG
LQLHLDGARVYNAAIALAVDIKEISQYFDSMSICLSKGLGAPIGSLLLGDKKLIAKARRWRKVLGGGMRQVGILAAAGKY
ALTENVTRLAEDHANAHYLAQQLSLLEGFTVNPALVQTNMVFAKLDPAINQQKLQDTLKEQGIILSTGNPVRLVTHLGIS
RIDIETFLTALKQALKP
>Mature_337_residues
MIDFRSDTVTLPSPAMLQAMIYAPVGDDVYGDDPTVNDLEQWAAERHGFEAAIFCTSGTQANLLALMAHCERGDEYLCGQ
QAHNYKFEGGGAAVLGSIQPQPIENENDGSLSFAKLASAIKPVDPHFARTTLLSLENTINGKVLSLAYLQQARTFVNLHG
LQLHLDGARVYNAAIALAVDIKEISQYFDSMSICLSKGLGAPIGSLLLGDKKLIAKARRWRKVLGGGMRQVGILAAAGKY
ALTENVTRLAEDHANAHYLAQQLSLLEGFTVNPALVQTNMVFAKLDPAINQQKLQDTLKEQGIILSTGNPVRLVTHLGIS
RIDIETFLTALKQALKP

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=321, Percent_Identity=58.8785046728972, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI193206522, Length=345, Percent_Identity=39.7101449275362, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI193206520, Length=345, Percent_Identity=39.7101449275362, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI193206524, Length=345, Percent_Identity=39.7101449275362, Blast_Score=236, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6320789, Length=343, Percent_Identity=36.734693877551, Blast_Score=189, Evalue=5e-49,
Organism=Drosophila melanogaster, GI21355439, Length=307, Percent_Identity=46.2540716612378, Blast_Score=246, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 36493; Mature: 36493

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDFRSDTVTLPSPAMLQAMIYAPVGDDVYGDDPTVNDLEQWAAERHGFEAAIFCTSGTQ
CCCCCCCEEECCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCC
ANLLALMAHCERGDEYLCGQQAHNYKFEGGGAAVLGSIQPQPIENENDGSLSFAKLASAI
HHHHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHH
KPVDPHFARTTLLSLENTINGKVLSLAYLQQARTFVNLHGLQLHLDGARVYNAAIALAVD
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCEEEEECCHHHHHHHHHEEEE
IKEISQYFDSMSICLSKGLGAPIGSLLLGDKKLIAKARRWRKVLGGGMRQVGILAAAGKY
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCH
ALTENVTRLAEDHANAHYLAQQLSLLEGFTVNPALVQTNMVFAKLDPAINQQKLQDTLKE
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHCEEEEECCCCCCHHHHHHHHHH
QGIILSTGNPVRLVTHLGISRIDIETFLTALKQALKP
CCEEEECCCCEEEHHHCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDFRSDTVTLPSPAMLQAMIYAPVGDDVYGDDPTVNDLEQWAAERHGFEAAIFCTSGTQ
CCCCCCCEEECCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCC
ANLLALMAHCERGDEYLCGQQAHNYKFEGGGAAVLGSIQPQPIENENDGSLSFAKLASAI
HHHHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHH
KPVDPHFARTTLLSLENTINGKVLSLAYLQQARTFVNLHGLQLHLDGARVYNAAIALAVD
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCEEEEECCHHHHHHHHHEEEE
IKEISQYFDSMSICLSKGLGAPIGSLLLGDKKLIAKARRWRKVLGGGMRQVGILAAAGKY
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCH
ALTENVTRLAEDHANAHYLAQQLSLLEGFTVNPALVQTNMVFAKLDPAINQQKLQDTLKE
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHCEEEEECCCCCCHHHHHHHHHH
QGIILSTGNPVRLVTHLGISRIDIETFLTALKQALKP
CCEEEECCCCEEEHHHCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]