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The map label for this gene is panE [H]

Identifier: 119945922

GI number: 119945922

Start: 2748050

End: 2748949

Strand: Direct

Name: panE [H]

Synonym: Ping_2262

Alternate gene names: 119945922

Gene position: 2748050-2748949 (Clockwise)

Preceding gene: 119945920

Following gene: 119945928

Centisome position: 60.27

GC content: 40.0

Gene sequence:

>900_bases
ATGTGGCAAATTATAGGTGCGGGCGCAATAGGTTGTTTATGGGCCGCTAACTTATTGCGGATCAGAGAAAAAGTCCAGCT
TATCACTCGCCGCCCCTGCACAGCTAACCTCCTGCAATATCAGGATTTATTAAAGCAGCAGTTTACTTTTCCTATAACGA
CCAGTACATCACTCAGCAGTACTTCTGATCCTGTCTTAGTCTGCGTGAAAGCAACACAAGTGATACCCGCCATTACAACA
CATCTAGCCTCAATAGATGCAGAGCAGGCTATTATTTTAATGCATAACGGCATGGGCTGTGCTGAGCAGGTAGCAAAATT
ATTACCTGACAATCCAATTATCTGCGCAACAACGGCAAATGCAAGTTTACTGCATTCTCCATTAAATATTGAGCAAACGG
GCAAAGGTGTCACCTACTTGGGAGCCTACAACAATAAGGGAAAACTGTTTCAATCATTACAGGTGCCTCTGAATTCTGCC
CTTACCAATACCTGCTGGTGTGAGGATGTTAATGAAAAATTATGGCTTAAACTAATCATCAATATGGCTATCAATCCATT
AACAGCCATTCATCAAATAAAAAATGGACAATTAAAAGAGTCTTTTTTTCAAACGCAAATCAACAGTCTGGTAAATGAAA
GCTTAGCAGTGGCTAACGCTGAAGGTGTTACCTTTAAAAAAGAGGAAATATTAGCAATTATTCAACAGGTAATAACATTA
ACAGCAGAAAATCTTTCCTCCATGAACCGGGACATTTTTTATCGAAGACACACTGAAAATGAGTTTATTGCGGGTTATTT
ATTAAAATCAGCCACCTTTAAGCAGATTCATACCCCGACAATTATGCGCCTTTATCAACAAATAAAGGCATTGGAGCAAG
CCGCTCTTGCCGAACAATGA

Upstream 100 bases:

>100_bases
TATCCTGTTTTTTATTAAAAATTTAATAACGCTAAGTTACCAGAAAACTTCAATTTCATCTATGTTATGATCTTTAAAAT
AATTATTTCAGGCTGAAAAT

Downstream 100 bases:

>100_bases
TAGCCAAATAATACATCTTGAAATTTTGCCAACGTTAACCTGATGCGGGATTAAGACATGATTTAAAGCTGCTGATAATG
AAAAACATGATCTGATAAGC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MWQIIGAGAIGCLWAANLLRIREKVQLITRRPCTANLLQYQDLLKQQFTFPITTSTSLSSTSDPVLVCVKATQVIPAITT
HLASIDAEQAIILMHNGMGCAEQVAKLLPDNPIICATTANASLLHSPLNIEQTGKGVTYLGAYNNKGKLFQSLQVPLNSA
LTNTCWCEDVNEKLWLKLIINMAINPLTAIHQIKNGQLKESFFQTQINSLVNESLAVANAEGVTFKKEEILAIIQQVITL
TAENLSSMNRDIFYRRHTENEFIAGYLLKSATFKQIHTPTIMRLYQQIKALEQAALAEQ

Sequences:

>Translated_299_residues
MWQIIGAGAIGCLWAANLLRIREKVQLITRRPCTANLLQYQDLLKQQFTFPITTSTSLSSTSDPVLVCVKATQVIPAITT
HLASIDAEQAIILMHNGMGCAEQVAKLLPDNPIICATTANASLLHSPLNIEQTGKGVTYLGAYNNKGKLFQSLQVPLNSA
LTNTCWCEDVNEKLWLKLIINMAINPLTAIHQIKNGQLKESFFQTQINSLVNESLAVANAEGVTFKKEEILAIIQQVITL
TAENLSSMNRDIFYRRHTENEFIAGYLLKSATFKQIHTPTIMRLYQQIKALEQAALAEQ
>Mature_299_residues
MWQIIGAGAIGCLWAANLLRIREKVQLITRRPCTANLLQYQDLLKQQFTFPITTSTSLSSTSDPVLVCVKATQVIPAITT
HLASIDAEQAIILMHNGMGCAEQVAKLLPDNPIICATTANASLLHSPLNIEQTGKGVTYLGAYNNKGKLFQSLQVPLNSA
LTNTCWCEDVNEKLWLKLIINMAINPLTAIHQIKNGQLKESFFQTQINSLVNESLAVANAEGVTFKKEEILAIIQQVITL
TAENLSSMNRDIFYRRHTENEFIAGYLLKSATFKQIHTPTIMRLYQQIKALEQAALAEQ

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=293, Percent_Identity=32.0819112627986, Blast_Score=140, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33151; Mature: 33151

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWQIIGAGAIGCLWAANLLRIREKVQLITRRPCTANLLQYQDLLKQQFTFPITTSTSLSS
CCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEECCCCCCC
TSDPVLVCVKATQVIPAITTHLASIDAEQAIILMHNGMGCAEQVAKLLPDNPIICATTAN
CCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEEECCC
ASLLHSPLNIEQTGKGVTYLGAYNNKGKLFQSLQVPLNSALTNTCWCEDVNEKLWLKLII
HHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHCCHHHHHCCCHHHCCCHHHHHHHHHH
NMAINPLTAIHQIKNGQLKESFFQTQINSLVNESLAVANAEGVTFKKEEILAIIQQVITL
HHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHH
TAENLSSMNRDIFYRRHTENEFIAGYLLKSATFKQIHTPTIMRLYQQIKALEQAALAEQ
HHHHHHHHCHHHEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MWQIIGAGAIGCLWAANLLRIREKVQLITRRPCTANLLQYQDLLKQQFTFPITTSTSLSS
CCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEECCCCCCC
TSDPVLVCVKATQVIPAITTHLASIDAEQAIILMHNGMGCAEQVAKLLPDNPIICATTAN
CCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEEECCC
ASLLHSPLNIEQTGKGVTYLGAYNNKGKLFQSLQVPLNSALTNTCWCEDVNEKLWLKLII
HHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHCCHHHHHCCCHHHCCCHHHHHHHHHH
NMAINPLTAIHQIKNGQLKESFFQTQINSLVNESLAVANAEGVTFKKEEILAIIQQVITL
HHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHH
TAENLSSMNRDIFYRRHTENEFIAGYLLKSATFKQIHTPTIMRLYQQIKALEQAALAEQ
HHHHHHHHCHHHEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]