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The map label for this gene is gltA [H]

Identifier: 119945917

GI number: 119945917

Start: 2743829

End: 2745124

Strand: Direct

Name: gltA [H]

Synonym: Ping_2257

Alternate gene names: 119945917

Gene position: 2743829-2745124 (Clockwise)

Preceding gene: 119945905

Following gene: 119945918

Centisome position: 60.18

GC content: 40.59

Gene sequence:

>1296_bases
ATGTCTGAACAAAAAGCAATACTTCAATTACCTGGACAAGAAGCAATAGAACTACCAATCATGAAAGGGACTGCCGGTAA
TGATGTCATTGATATTCGAAGCTTAGGGAAAGCAGGTTATTTTACCTATGACCCCGGTTTTCTAGCAACAGCTTCTTGTG
AATCAGCAATAACCTTCATAGATGGCGACAAGGGAATCCTATTACATCGCGGCTATGGAATTGAAGAATTAGCTGAAAAA
TCTGACTACCTCGAAGTTTGTTATTTACTGTTAAATGGCCAATTTCCTGACCAGGAACAGTCAGAAAAATTCCATCATGT
TATATTACACCATACAATGATTCACGAACAGTTAGCAAAACTGTACCAAGGTTTCCGTCGCGATTCTCATCCAATGGCAA
TCATGTGTGGTGTTGTTGGCGCATTATCAGCTTTCTACCATGACTCTCTTGATGTTACCAACGAAACTCATCGTGAAATT
ACCGCTTACCGTCTAATTTCTAAAATGCCAACCTTAGCGGCCATGTCCTATAAATATTCAAATGGTCAGCCCTTTGTTTA
CCCTGACAATAGCCTTTCATATGCAGGTAATTTCCTGAAAATGATGTTTGCTGTTCCCTGCGAGGAGTTCAAAGTAAACC
CCGTACTTGAACGTGCGATGGATAAAATATTTATCCTGCATGCAGACCATGAACAAAATGCGTCTACTTCTACCGTCCGT
CTGGCTGGTTCATCGGGTGCTAACCCATTTGCGTGTATTGCCGCAGGTATCGCATCTTTATGGGGTCCTGCACATGGTGG
CGCCAATGAAGCTTGTTTGAATATGTTAGAAGAAATCGGCAGTGTTGAAAACATTCCTGAATATATCGATAAAGCAAAAG
ATAAAAATGACCCATTCCGCTTAATGGGCTTTGGACATCGGGTCTATAAAAATCACGATCCCCGTGCAACTGTTATGCGA
AAAGCCTGTCACGAAGTATTAGATGATCTGAACATTAATGATCCTCTTCTTGACGTTGCTATGGAGCTTGAAAGAATTGC
GCTTGAAGACCCATATTTTGTAGAGAAAAAACTCTACCCGAATGTGGATTTTTATTCTGGTCTGGTACTGCGGGCAATGG
GTATTCCTAAATCAATGTTTACGGTTATTTTTGCGATTTCCCGTACTATTGGTTGGATATCACATTGGAAAGAGATGTTA
GATCAACCTGGACTGAAAATTGGACGACCACGTCAGTTATATACTGGTGAAGTTGGACTAAAAATTGATGACGTTAAAAA
TCGTTCTAACACATAG

Upstream 100 bases:

>100_bases
TGAACTGTTAAAATTGACAAGGCTAAATTTAGCCTGTAAAAATATGCGGGTTAAATTCTTGTAATGCTTGTAATTCTTAA
AAGAAATGGAGATAGAACAA

Downstream 100 bases:

>100_bases
CAAATGAATAAGAAGTGATCAGAATTACTGTTGAAAGCGACACTAGCTGTTTTGCTAGGACTCATTTATCCGGTTCAATA
CTTGATCATTTTTGTTATAC

Product: citrate synthase I

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSEQKAILQLPGQEAIELPIMKGTAGNDVIDIRSLGKAGYFTYDPGFLATASCESAITFIDGDKGILLHRGYGIEELAEK
SDYLEVCYLLLNGQFPDQEQSEKFHHVILHHTMIHEQLAKLYQGFRRDSHPMAIMCGVVGALSAFYHDSLDVTNETHREI
TAYRLISKMPTLAAMSYKYSNGQPFVYPDNSLSYAGNFLKMMFAVPCEEFKVNPVLERAMDKIFILHADHEQNASTSTVR
LAGSSGANPFACIAAGIASLWGPAHGGANEACLNMLEEIGSVENIPEYIDKAKDKNDPFRLMGFGHRVYKNHDPRATVMR
KACHEVLDDLNINDPLLDVAMELERIALEDPYFVEKKLYPNVDFYSGLVLRAMGIPKSMFTVIFAISRTIGWISHWKEML
DQPGLKIGRPRQLYTGEVGLKIDDVKNRSNT

Sequences:

>Translated_431_residues
MSEQKAILQLPGQEAIELPIMKGTAGNDVIDIRSLGKAGYFTYDPGFLATASCESAITFIDGDKGILLHRGYGIEELAEK
SDYLEVCYLLLNGQFPDQEQSEKFHHVILHHTMIHEQLAKLYQGFRRDSHPMAIMCGVVGALSAFYHDSLDVTNETHREI
TAYRLISKMPTLAAMSYKYSNGQPFVYPDNSLSYAGNFLKMMFAVPCEEFKVNPVLERAMDKIFILHADHEQNASTSTVR
LAGSSGANPFACIAAGIASLWGPAHGGANEACLNMLEEIGSVENIPEYIDKAKDKNDPFRLMGFGHRVYKNHDPRATVMR
KACHEVLDDLNINDPLLDVAMELERIALEDPYFVEKKLYPNVDFYSGLVLRAMGIPKSMFTVIFAISRTIGWISHWKEML
DQPGLKIGRPRQLYTGEVGLKIDDVKNRSNT
>Mature_430_residues
SEQKAILQLPGQEAIELPIMKGTAGNDVIDIRSLGKAGYFTYDPGFLATASCESAITFIDGDKGILLHRGYGIEELAEKS
DYLEVCYLLLNGQFPDQEQSEKFHHVILHHTMIHEQLAKLYQGFRRDSHPMAIMCGVVGALSAFYHDSLDVTNETHREIT
AYRLISKMPTLAAMSYKYSNGQPFVYPDNSLSYAGNFLKMMFAVPCEEFKVNPVLERAMDKIFILHADHEQNASTSTVRL
AGSSGANPFACIAAGIASLWGPAHGGANEACLNMLEEIGSVENIPEYIDKAKDKNDPFRLMGFGHRVYKNHDPRATVMRK
ACHEVLDDLNINDPLLDVAMELERIALEDPYFVEKKLYPNVDFYSGLVLRAMGIPKSMFTVIFAISRTIGWISHWKEMLD
QPGLKIGRPRQLYTGEVGLKIDDVKNRSNT

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=417, Percent_Identity=27.3381294964029, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1786939, Length=416, Percent_Identity=73.0769230769231, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI1786527, Length=357, Percent_Identity=29.6918767507003, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17555174, Length=388, Percent_Identity=27.0618556701031, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319850, Length=350, Percent_Identity=28.2857142857143, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324328, Length=387, Percent_Identity=27.390180878553, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325257, Length=412, Percent_Identity=25.4854368932039, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24640126, Length=392, Percent_Identity=27.8061224489796, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24640124, Length=392, Percent_Identity=27.8061224489796, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21356863, Length=402, Percent_Identity=25.8706467661692, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48221; Mature: 48090

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQKAILQLPGQEAIELPIMKGTAGNDVIDIRSLGKAGYFTYDPGFLATASCESAITFI
CCCCCCHHCCCCCHHEEEEEEECCCCCCEEEHHHCCCCCCEEECCCCEEECCCCCEEEEE
DGDKGILLHRGYGIEELAEKSDYLEVCYLLLNGQFPDQEQSEKFHHVILHHTMIHEQLAK
ECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LYQGFRRDSHPMAIMCGVVGALSAFYHDSLDVTNETHREITAYRLISKMPTLAAMSYKYS
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHEEEEC
NGQPFVYPDNSLSYAGNFLKMMFAVPCEEFKVNPVLERAMDKIFILHADHEQNASTSTVR
CCCEEEECCCCHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHEEEEEECCCCCCCCCCEEE
LAGSSGANPFACIAAGIASLWGPAHGGANEACLNMLEEIGSVENIPEYIDKAKDKNDPFR
EECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEE
LMGFGHRVYKNHDPRATVMRKACHEVLDDLNINDPLLDVAMELERIALEDPYFVEKKLYP
EEECCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCC
NVDFYSGLVLRAMGIPKSMFTVIFAISRTIGWISHWKEMLDQPGLKIGRPRQLYTGEVGL
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCC
KIDDVKNRSNT
EEECCCCCCCC
>Mature Secondary Structure 
SEQKAILQLPGQEAIELPIMKGTAGNDVIDIRSLGKAGYFTYDPGFLATASCESAITFI
CCCCCHHCCCCCHHEEEEEEECCCCCCEEEHHHCCCCCCEEECCCCEEECCCCCEEEEE
DGDKGILLHRGYGIEELAEKSDYLEVCYLLLNGQFPDQEQSEKFHHVILHHTMIHEQLAK
ECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LYQGFRRDSHPMAIMCGVVGALSAFYHDSLDVTNETHREITAYRLISKMPTLAAMSYKYS
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHEEEEC
NGQPFVYPDNSLSYAGNFLKMMFAVPCEEFKVNPVLERAMDKIFILHADHEQNASTSTVR
CCCEEEECCCCHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHEEEEEECCCCCCCCCCEEE
LAGSSGANPFACIAAGIASLWGPAHGGANEACLNMLEEIGSVENIPEYIDKAKDKNDPFR
EECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEE
LMGFGHRVYKNHDPRATVMRKACHEVLDDLNINDPLLDVAMELERIALEDPYFVEKKLYP
EEECCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCC
NVDFYSGLVLRAMGIPKSMFTVIFAISRTIGWISHWKEMLDQPGLKIGRPRQLYTGEVGL
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCC
KIDDVKNRSNT
EEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]