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The map label for this gene is sdhA [H]

Identifier: 119945914

GI number: 119945914

Start: 2740382

End: 2742148

Strand: Reverse

Name: sdhA [H]

Synonym: Ping_2254

Alternate gene names: 119945914

Gene position: 2742148-2740382 (Counterclockwise)

Preceding gene: 119945915

Following gene: 119945913

Centisome position: 60.14

GC content: 44.43

Gene sequence:

>1767_bases
GTGAGTTTACCGATTCGTGAATTTGATGCTATTGTGATTGGTGCGGGTGGCGCAGGTATGCGCGCAGCACTTTCCATTTC
AGAAGAAGGCAAAAGTTGTGCCTTAATAAGTAAAGTTTTTCCAACCCGCTCTCATACTGTTTCAGCGCAAGGCGGTATTA
CTGTCGCATTGGGTAATGCCCATGAAGATGATTGGCAGTATCACATGTATGATACCGTTAAGGGCTCTGATTATATCGGT
GACCAGGACGCTATTGAGTATATGTGTAAAATCGGGCCTGAAGTTGTACGCGAGCTTGAACATATGGGCTTGCCTTTTTC
TCGTTTTGAAGACGGCAGTATTTACCAGCGTCCCTTTGGCGGGCAGTCTAAAGAATATGGTCAAGGTCAAGCATCTCGTA
CTGCGGCAGCTGCCGACCGTACTGGTCATGCTTTATTACACACACTTTATCAGCAGAATATTAAAAATAAAACCACCGTT
TTTTCTGAGTGGTATGCACTTGATTTAGTAAAAAATGATGACGGTGATGTTGTTGGCTGTACTGCTATTGATATTGAGTC
TGGCGAAGTAGTGATGTTTAAAGCACAGGCGACCGTGCTTGCAACGGGTGGAGCAGGTCGTATTTACGCCTCTACCACTA
ATGCACATATTAACACCGGCGATGGTGTTGGCATGGCGCTGCGTGCGGGTGTTCCAGTGCAGGATATGGAAATGTGGCAG
TTCCATCCGACTGGCATTGCTGGTGCAGGTACACTAGTAACAGAAGGCTGTCGTGGTGAAGGTGGTTATCTGCTTAATAA
AGATGGCGAACGTTTTATGGAACGTTATGCGCCAAATGCCAAAGATTTAGCAGGGCGCGATGTTGTTGCCCGTGCAATGA
TGATTGAAATTCGTGAAGGTCGCGGTTGCGAGGGGCCGTGGGGCGTACACCTTAAATTAAAACTAGACCACTTAGGTAAA
GATGTTTTAGAGTCGAGATTACCAGGTGTTATGGAATTATCACGTACTTTTGCGCATGTTGATCCTGTTAAAGAGCCTAT
TCCAGTTATTCCAACCTGTCATTATCAAATGGGTGGCGTACCAACAACAGTCAATGGTCAAGTGCTTAAATTGGATGAAA
ACGGTAAAGATGTAGAAGTTAAAGGACTCTTTGCAGTCGGTGAAATAGCATGCGTATCAGTACACGGTTCTAACCGCTTA
GGTGGTAATTCACTGTTAGACTTAGTGGTATTTGGCCGTGCGACAGGTAAACATTTGGGTGTGGTGCTTGCGCAAGAAAA
CACAGCTAAGGAGCCTACCCAGGAAAATATTGATGCTACACTGGAACGTTTTAACCGTTGGGAAAAAGGTAACGGCACTG
AATGTCCAAATCAAATCAGAAAAGATCTGCAGCAGTGTATGCAAAACAATTTCTCTGTCTTTAGAGATGGTGAGGCAATG
GCCGAAGGCTTAGCTGAACTGAAAGTACTGCGTGAGCGTTTGAAAAATGCAAAATTAGACGATAAAAGTACCGAATTTAA
CACTAACCGCATTGAATGTTTAGAGCTTGATAACTTGATGGAAACTGCATTTTCAACTGCCATGGCCGCTAATTTTAGAA
CGGAAAGTCGAGGCGCACACAGCCGCTTTGATTACCCGGATCGGGATGATAAAAGTTGGCTATGCCACAGCATCTTTAAT
CCTGAAACCGAAGAGATGTGTAAGCGTGATGTTAATATGAAACCAGTATTGCGTGAACCTTTCCCTCCTAAAGCACGTGT
TTATTAA

Upstream 100 bases:

>100_bases
GTTAAAAATGCTTTGTTGCGTGCTGCATTACAGTTTTTATTAACGTCAACGGCATTTGTCTATGTTATTTTTGGTTTTGT
AATTTTGTGGGGTGTTTAAG

Downstream 100 bases:

>100_bases
AAAGGCTATTGTTATGCAAGTGAAATTTTCTATTTATCGTTATAACCCTGATGTTGATAACGCGCCCTATATGCAAGATA
TGTCTTTAGATATTGCAGAG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MSLPIREFDAIVIGAGGAGMRAALSISEEGKSCALISKVFPTRSHTVSAQGGITVALGNAHEDDWQYHMYDTVKGSDYIG
DQDAIEYMCKIGPEVVRELEHMGLPFSRFEDGSIYQRPFGGQSKEYGQGQASRTAAAADRTGHALLHTLYQQNIKNKTTV
FSEWYALDLVKNDDGDVVGCTAIDIESGEVVMFKAQATVLATGGAGRIYASTTNAHINTGDGVGMALRAGVPVQDMEMWQ
FHPTGIAGAGTLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARAMMIEIREGRGCEGPWGVHLKLKLDHLGK
DVLESRLPGVMELSRTFAHVDPVKEPIPVIPTCHYQMGGVPTTVNGQVLKLDENGKDVEVKGLFAVGEIACVSVHGSNRL
GGNSLLDLVVFGRATGKHLGVVLAQENTAKEPTQENIDATLERFNRWEKGNGTECPNQIRKDLQQCMQNNFSVFRDGEAM
AEGLAELKVLRERLKNAKLDDKSTEFNTNRIECLELDNLMETAFSTAMAANFRTESRGAHSRFDYPDRDDKSWLCHSIFN
PETEEMCKRDVNMKPVLREPFPPKARVY

Sequences:

>Translated_588_residues
MSLPIREFDAIVIGAGGAGMRAALSISEEGKSCALISKVFPTRSHTVSAQGGITVALGNAHEDDWQYHMYDTVKGSDYIG
DQDAIEYMCKIGPEVVRELEHMGLPFSRFEDGSIYQRPFGGQSKEYGQGQASRTAAAADRTGHALLHTLYQQNIKNKTTV
FSEWYALDLVKNDDGDVVGCTAIDIESGEVVMFKAQATVLATGGAGRIYASTTNAHINTGDGVGMALRAGVPVQDMEMWQ
FHPTGIAGAGTLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARAMMIEIREGRGCEGPWGVHLKLKLDHLGK
DVLESRLPGVMELSRTFAHVDPVKEPIPVIPTCHYQMGGVPTTVNGQVLKLDENGKDVEVKGLFAVGEIACVSVHGSNRL
GGNSLLDLVVFGRATGKHLGVVLAQENTAKEPTQENIDATLERFNRWEKGNGTECPNQIRKDLQQCMQNNFSVFRDGEAM
AEGLAELKVLRERLKNAKLDDKSTEFNTNRIECLELDNLMETAFSTAMAANFRTESRGAHSRFDYPDRDDKSWLCHSIFN
PETEEMCKRDVNMKPVLREPFPPKARVY
>Mature_587_residues
SLPIREFDAIVIGAGGAGMRAALSISEEGKSCALISKVFPTRSHTVSAQGGITVALGNAHEDDWQYHMYDTVKGSDYIGD
QDAIEYMCKIGPEVVRELEHMGLPFSRFEDGSIYQRPFGGQSKEYGQGQASRTAAAADRTGHALLHTLYQQNIKNKTTVF
SEWYALDLVKNDDGDVVGCTAIDIESGEVVMFKAQATVLATGGAGRIYASTTNAHINTGDGVGMALRAGVPVQDMEMWQF
HPTGIAGAGTLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARAMMIEIREGRGCEGPWGVHLKLKLDHLGKD
VLESRLPGVMELSRTFAHVDPVKEPIPVIPTCHYQMGGVPTTVNGQVLKLDENGKDVEVKGLFAVGEIACVSVHGSNRLG
GNSLLDLVVFGRATGKHLGVVLAQENTAKEPTQENIDATLERFNRWEKGNGTECPNQIRKDLQQCMQNNFSVFRDGEAMA
EGLAELKVLRERLKNAKLDDKSTEFNTNRIECLELDNLMETAFSTAMAANFRTESRGAHSRFDYPDRDDKSWLCHSIFNP
ETEEMCKRDVNMKPVLREPFPPKARVY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=552, Percent_Identity=53.804347826087, Blast_Score=546, Evalue=1e-155,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=78.4013605442177, Blast_Score=936, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=570, Percent_Identity=41.0526315789474, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1788928, Length=562, Percent_Identity=30.6049822064057, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17550100, Length=599, Percent_Identity=49.5826377295492, Blast_Score=532, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17505833, Length=594, Percent_Identity=48.3164983164983, Blast_Score=531, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI71986328, Length=322, Percent_Identity=31.055900621118, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322701, Length=555, Percent_Identity=54.0540540540541, Blast_Score=586, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6322416, Length=593, Percent_Identity=52.4451939291737, Blast_Score=575, Evalue=1e-165,
Organism=Drosophila melanogaster, GI17137288, Length=549, Percent_Identity=53.9162112932605, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24655642, Length=549, Percent_Identity=53.9162112932605, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24655647, Length=549, Percent_Identity=53.9162112932605, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24663005, Length=614, Percent_Identity=47.0684039087948, Blast_Score=538, Evalue=1e-153,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64573; Mature: 64442

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPIREFDAIVIGAGGAGMRAALSISEEGKSCALISKVFPTRSHTVSAQGGITVALGNA
CCCCCCCCCEEEEECCCCCCEEEEEECCCCCCEEEHHHHCCCCCCEEECCCCEEEEECCC
HEDDWQYHMYDTVKGSDYIGDQDAIEYMCKIGPEVVRELEHMGLPFSRFEDGSIYQRPFG
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCHHHCCCCCEEECCCC
GQSKEYGQGQASRTAAAADRTGHALLHTLYQQNIKNKTTVFSEWYALDLVKNDDGDVVGC
CCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECEEEEEEEECCCCCEEEE
TAIDIESGEVVMFKAQATVLATGGAGRIYASTTNAHINTGDGVGMALRAGVPVQDMEMWQ
EEEEECCCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCEEEECCCCCCCCHHEE
FHPTGIAGAGTLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARAMMIEIREG
ECCCCCCCCCHHEECCCCCCCCEEECCCHHHHHHHHCCCHHHHCCHHHHHHHHHEEEECC
RGCEGPWGVHLKLKLDHLGKDVLESRLPGVMELSRTFAHVDPVKEPIPVIPTCHYQMGGV
CCCCCCCEEEEEEEHHHCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PTTVNGQVLKLDENGKDVEVKGLFAVGEIACVSVHGSNRLGGNSLLDLVVFGRATGKHLG
CEECCCEEEEECCCCCEEEEEEEEEECEEEEEEEECCCCCCCHHHEEEEEECCCCCCEEE
VVLAQENTAKEPTQENIDATLERFNRWEKGNGTECPNQIRKDLQQCMQNNFSVFRDGEAM
EEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCHHH
AEGLAELKVLRERLKNAKLDDKSTEFNTNRIECLELDNLMETAFSTAMAANFRTESRGAH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCC
SRFDYPDRDDKSWLCHSIFNPETEEMCKRDVNMKPVLREPFPPKARVY
CCCCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLPIREFDAIVIGAGGAGMRAALSISEEGKSCALISKVFPTRSHTVSAQGGITVALGNA
CCCCCCCCEEEEECCCCCCEEEEEECCCCCCEEEHHHHCCCCCCEEECCCCEEEEECCC
HEDDWQYHMYDTVKGSDYIGDQDAIEYMCKIGPEVVRELEHMGLPFSRFEDGSIYQRPFG
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCHHHCCCCCEEECCCC
GQSKEYGQGQASRTAAAADRTGHALLHTLYQQNIKNKTTVFSEWYALDLVKNDDGDVVGC
CCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECEEEEEEEECCCCCEEEE
TAIDIESGEVVMFKAQATVLATGGAGRIYASTTNAHINTGDGVGMALRAGVPVQDMEMWQ
EEEEECCCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCEEEECCCCCCCCHHEE
FHPTGIAGAGTLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARAMMIEIREG
ECCCCCCCCCHHEECCCCCCCCEEECCCHHHHHHHHCCCHHHHCCHHHHHHHHHEEEECC
RGCEGPWGVHLKLKLDHLGKDVLESRLPGVMELSRTFAHVDPVKEPIPVIPTCHYQMGGV
CCCCCCCEEEEEEEHHHCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PTTVNGQVLKLDENGKDVEVKGLFAVGEIACVSVHGSNRLGGNSLLDLVVFGRATGKHLG
CEECCCEEEEECCCCCEEEEEEEEEECEEEEEEEECCCCCCCHHHEEEEEECCCCCCEEE
VVLAQENTAKEPTQENIDATLERFNRWEKGNGTECPNQIRKDLQQCMQNNFSVFRDGEAM
EEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCHHH
AEGLAELKVLRERLKNAKLDDKSTEFNTNRIECLELDNLMETAFSTAMAANFRTESRGAH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCC
SRFDYPDRDDKSWLCHSIFNPETEEMCKRDVNMKPVLREPFPPKARVY
CCCCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]