Click here to switch to the map view.

The map label for this gene is moaA

Identifier: 119945837

GI number: 119945837

Start: 2651806

End: 2652825

Strand: Reverse

Name: moaA

Synonym: Ping_2177

Alternate gene names: 119945837

Gene position: 2652825-2651806 (Counterclockwise)

Preceding gene: 119945842

Following gene: 119945836

Centisome position: 58.18

GC content: 38.73

Gene sequence:

>1020_bases
ATGTCTTTGCCTCCCGTATTTGGAAAGGAACTTAACATGAGCCAACAACTTATTGATAACTTCGATCGGAAGTTTGAATA
CTTACGCCTGTCGATAACCGATGTCTGTAATTTTAAATGTAATTATTGTCTGCCCGATGGATATCAGCGAACCCATGAAA
AACAGTTTTTGAGCAAGCAGGAGATAACCAACTTAGTCAATGCTTTCGCCGAACTGGGTGCTAAAAAAGTACGTATAACA
GGTGGAGAACCCGCTTTACGCAAAGATTTTCCGAAAATAATTGAAGCCATTGCCACTATCCCTGGCATCCAAAAAGTAGC
CACTACGACTAACGGTTACAATTTAAGCAGTCATGCTCAAGCGTGGTTTGATGCTGGTCTTGATTCGATTAACGTCAGCG
TCGACAGCTTAGATGCAAAAACTTTTCACCTTATTACCGGGAAAAATATATTTCAAAAAGTCATGCAGGGCGTCAATGCT
TCGGTCAAAGCGGGTTTTAAACAGGTTAAGATTAACAGTGTGTTAATGAAGGGTCTTAATGATATTGACATTGATTTGTA
TATTAACTGGATAAAAGATCAACCCATTCAATTACGTTTTATTGAATTAATGCAGACAGAAGATAACGGTGAATTCTTTA
ATAAACATCACCTTTCTGGTGAATGGATTAAACAAAATCTGTTAGAAAATGGCTGGACGCAAAAACAGTCCTTAAGTCAT
GACGGACCTGCACAAATTTTTTACCATCCTGATTATCTGGGGGAGATTGGTTTAATCATGCCCTACAGTAAAGATTTTTG
TAAAAGCTGTAATCGTTTAAGGGTTTCATCGGTAGGTCGGCTGCATTTGTGTTTATTCGGTGAAGAAGGAGTTGATTTAC
GGGATCTTTTAGGAACATCTGCAGATAAAGAAAAGCTTAAACAACGAATAGTAGAATCACTGAAAAGCAAAAAAGTGAGT
CATTATTTGGCAGATGGAGAATCGGGAGGAACGCCGCACCTTGCATCAATTGGCGGTTAA

Upstream 100 bases:

>100_bases
GCTCCGAGCTTAATAAAACTAAGTTTCCTTTTTAAGGTAAATAAGTCTGTTAAGCCGCTTGTCTGACATTTTGGTCAGCG
CAAGAAGGGTAAAGAGAGAA

Downstream 100 bases:

>100_bases
ACTTGGATTGTTAGCATAATCATAATATGTCCCAAGGGGCTCTGTTCCGAATAATGATTGTTCGCTTTATTTATGCTTAA
TGCTTTGTAATTTAAAGTAT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSLPPVFGKELNMSQQLIDNFDRKFEYLRLSITDVCNFKCNYCLPDGYQRTHEKQFLSKQEITNLVNAFAELGAKKVRIT
GGEPALRKDFPKIIEAIATIPGIQKVATTTNGYNLSSHAQAWFDAGLDSINVSVDSLDAKTFHLITGKNIFQKVMQGVNA
SVKAGFKQVKINSVLMKGLNDIDIDLYINWIKDQPIQLRFIELMQTEDNGEFFNKHHLSGEWIKQNLLENGWTQKQSLSH
DGPAQIFYHPDYLGEIGLIMPYSKDFCKSCNRLRVSSVGRLHLCLFGEEGVDLRDLLGTSADKEKLKQRIVESLKSKKVS
HYLADGESGGTPHLASIGG

Sequences:

>Translated_339_residues
MSLPPVFGKELNMSQQLIDNFDRKFEYLRLSITDVCNFKCNYCLPDGYQRTHEKQFLSKQEITNLVNAFAELGAKKVRIT
GGEPALRKDFPKIIEAIATIPGIQKVATTTNGYNLSSHAQAWFDAGLDSINVSVDSLDAKTFHLITGKNIFQKVMQGVNA
SVKAGFKQVKINSVLMKGLNDIDIDLYINWIKDQPIQLRFIELMQTEDNGEFFNKHHLSGEWIKQNLLENGWTQKQSLSH
DGPAQIFYHPDYLGEIGLIMPYSKDFCKSCNRLRVSSVGRLHLCLFGEEGVDLRDLLGTSADKEKLKQRIVESLKSKKVS
HYLADGESGGTPHLASIGG
>Mature_338_residues
SLPPVFGKELNMSQQLIDNFDRKFEYLRLSITDVCNFKCNYCLPDGYQRTHEKQFLSKQEITNLVNAFAELGAKKVRITG
GEPALRKDFPKIIEAIATIPGIQKVATTTNGYNLSSHAQAWFDAGLDSINVSVDSLDAKTFHLITGKNIFQKVMQGVNAS
VKAGFKQVKINSVLMKGLNDIDIDLYINWIKDQPIQLRFIELMQTEDNGEFFNKHHLSGEWIKQNLLENGWTQKQSLSHD
GPAQIFYHPDYLGEIGLIMPYSKDFCKSCNRLRVSSVGRLHLCLFGEEGVDLRDLLGTSADKEKLKQRIVESLKSKKVSH
YLADGESGGTPHLASIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family

Homologues:

Organism=Homo sapiens, GI116734668, Length=308, Percent_Identity=34.4155844155844, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI22027536, Length=308, Percent_Identity=34.4155844155844, Blast_Score=202, Evalue=3e-52,
Organism=Escherichia coli, GI1786999, Length=329, Percent_Identity=55.6231003039514, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI32566329, Length=314, Percent_Identity=35.9872611464968, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI32566331, Length=322, Percent_Identity=35.7142857142857, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17561210, Length=314, Percent_Identity=35.9872611464968, Blast_Score=190, Evalue=7e-49,
Organism=Drosophila melanogaster, GI28574490, Length=316, Percent_Identity=31.6455696202532, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI28574488, Length=316, Percent_Identity=31.6455696202532, Blast_Score=191, Evalue=6e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAA_PSYIN (A1SWQ3)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943517.1
- ProteinModelPortal:   A1SWQ3
- SMR:   A1SWQ3
- STRING:   A1SWQ3
- GeneID:   4625332
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_2177
- eggNOG:   COG2896
- HOGENOM:   HBG529885
- OMA:   ILQARIF
- PhylomeDB:   A1SWQ3
- ProtClustDB:   PRK00164
- BioCyc:   PING357804:PING_2177-MONOMER
- HAMAP:   MF_01225_B
- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR010505
- InterPro:   IPR007197
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00729
- TIGRFAMs:   TIGR02666

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM

EC number: NA

Molecular weight: Translated: 38072; Mature: 37941

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: BINDING 29-29 BINDING 42-42 BINDING 78-78 BINDING 82-82 BINDING 109-109 BINDING 133-133 BINDING 170-170 BINDING 204-204

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPPVFGKELNMSQQLIDNFDRKFEYLRLSITDVCNFKCNYCLPDGYQRTHEKQFLSKQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEHHHHHCCEECCCCCCCHHHHHHHHHHHHH
EITNLVNAFAELGAKKVRITGGEPALRKDFPKIIEAIATIPGIQKVATTTNGYNLSSHAQ
HHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHH
AWFDAGLDSINVSVDSLDAKTFHLITGKNIFQKVMQGVNASVKAGFKQVKINSVLMKGLN
HHHHCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCCC
DIDIDLYINWIKDQPIQLRFIELMQTEDNGEFFNKHHLSGEWIKQNLLENGWTQKQSLSH
CCEEEEEEEEECCCCCEEEEEEEHHCCCCCCHHHHHCCCHHHHHHHHHHCCCCCHHHCCC
DGPAQIFYHPDYLGEIGLIMPYSKDFCKSCNRLRVSSVGRLHLCLFGEEGVDLRDLLGTS
CCCCEEEECCCCCCCCCEECCCCHHHHHHHCCEECCCCCEEEEEEECCCCCCHHHHHCCC
ADKEKLKQRIVESLKSKKVSHYLADGESGGTPHLASIGG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLPPVFGKELNMSQQLIDNFDRKFEYLRLSITDVCNFKCNYCLPDGYQRTHEKQFLSKQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHEEEHHHHHCCEECCCCCCCHHHHHHHHHHHHH
EITNLVNAFAELGAKKVRITGGEPALRKDFPKIIEAIATIPGIQKVATTTNGYNLSSHAQ
HHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHH
AWFDAGLDSINVSVDSLDAKTFHLITGKNIFQKVMQGVNASVKAGFKQVKINSVLMKGLN
HHHHCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCCC
DIDIDLYINWIKDQPIQLRFIELMQTEDNGEFFNKHHLSGEWIKQNLLENGWTQKQSLSH
CCEEEEEEEEECCCCCEEEEEEEHHCCCCCCHHHHHCCCHHHHHHHHHHCCCCCHHHCCC
DGPAQIFYHPDYLGEIGLIMPYSKDFCKSCNRLRVSSVGRLHLCLFGEEGVDLRDLLGTS
CCCCEEEECCCCCCCCCEECCCCHHHHHHHCCEECCCCCEEEEEEECCCCCCHHHHHCCC
ADKEKLKQRIVESLKSKKVSHYLADGESGGTPHLASIGG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA