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The map label for this gene is gap [H]

Identifier: 119945687

GI number: 119945687

Start: 2436481

End: 2437932

Strand: Direct

Name: gap [H]

Synonym: Ping_2004

Alternate gene names: 119945687

Gene position: 2436481-2437932 (Clockwise)

Preceding gene: 119945685

Following gene: 119945690

Centisome position: 53.44

GC content: 39.19

Gene sequence:

>1452_bases
ATGAACCAAGTTATTTCTAATACCTGTATGCAAGATTGGTCAGATCGTGAATCGACAGTAGAAACTATGATTCCAATGAT
TGGCGCTTTGTACCGTAAAAAGAACATTGTTACCTCTATATACGGTCGCCCAATTATAAATCGTTCTGTTATTGACCTAT
TGAAAGCCCATCGCTTTGTTCGTCATATGGAAGACAAGGAGCTTTCTGTACTAGAGACGTTTCCAATCATTAATGCAATG
ATGTCGATGGATTTAGATCGCGCTCATGTTGATGTGGGTAAGCTTGCGGTTAAATTCCGTAACGAAGTGAATGGTAGTGA
TCTTGAGGCTTTCTTGAATAAAGAGCTTAATGATGCGCTTGGTCAAAATAGCCCTGCGACGAAAGAAAATCGTGATGTAG
TGCTTTATGGTTTTGGTCGTATTGGTCGTTTGTTAGCACGCCTTATTATTGAAAGATCAGGCGGTGGTAATGGTTTACGT
TTACGTGCAATTGTGGTTCGTAAAGGTAAAGGAAATGATCTTGAGAAGCGTGCAAGTCTATTGCGTCGGGATTCTATCCA
CGGCTCTTTCCGAGGAACTATATCTATAGACAAAGAAAAGAATGCGATTATTGCTAACGGTAATTACATTCAGGTTATCT
ATTCAGACGCCCCCGAAAATGCTGATTATGAAGCATTTGGCATTGAAAACGCATTAGTTATTGATAATACCGGTATCTGG
CGTGATCAAGCTGGTCTAGAACGTCATTTGCAAGCAAAAGGGGTTTCTCGTGTATTATTGACAGCTCCAGGTAAGGGGGA
TATTAAGAACATTGTTTACGGTATTAATAATAACGTGATTGAAGATACGGATACTATATTATCAGCAGCTTCTTGTACGA
CTAATGCTATTACGCCAATATTGAAAATGATCGATAACGAATACGGTATTATTAATGGTCACGTAGAAACGATCCACTCT
TATACTAACGATCAAAACTTAATTGATAACTATCACGAAGGTGATCGACGTGGTCGTGCCGCTGCATTGAATATGGTCAT
TACAGAAACAGGTGCTGCTTCTGCCGTTGCTAAAGCATTTCCTGAAATGGAAGGTTTACTAACGGGTAACTCTATTCGTG
TTCCTACACCAAATGTATCTATGGCTATCTTATCTTTGAACCTAAAAAGTGATATTACGACTGATGGTGTTAATGCTTTC
CTTCGTAAAATGTCTTTGTACTCTTCAGTTCAAAAGCAAATCGATTGGGTTAACTCTTCAGAGGTTGTATCAACCGATTT
CGTTGGTAACTCACATGCAGGTATTGTCGATGCGCAAGCAACGATTACCAGTGATAAACGTGTTAATTTATATGTTTGGT
ATGATAATGAGTTTGGTTATAGTCATCAGGTCATTCGGATTGCACAGCAGATGTGTGGGGTGTTTTACCCAACGTATCCT
ATTGTGAAATAG

Upstream 100 bases:

>100_bases
AAAGCGAACCAAACAGGCATAATTTATACCTAATTTTGATATAATGGGTAGTTATATAGCTCTTTGTCATAAAATATTGT
TAAAAATGAAAGGTAGACGC

Downstream 100 bases:

>100_bases
AGCTTAAGCAGAAAGACTTTAATTATTATTGCGACATAAAAAATGTTGTTCTAACGTAGGAAATATAGCATAACCACATA
TTTTGTTGTGTAAAATATGT

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNQVISNTCMQDWSDRESTVETMIPMIGALYRKKNIVTSIYGRPIINRSVIDLLKAHRFVRHMEDKELSVLETFPIINAM
MSMDLDRAHVDVGKLAVKFRNEVNGSDLEAFLNKELNDALGQNSPATKENRDVVLYGFGRIGRLLARLIIERSGGGNGLR
LRAIVVRKGKGNDLEKRASLLRRDSIHGSFRGTISIDKEKNAIIANGNYIQVIYSDAPENADYEAFGIENALVIDNTGIW
RDQAGLERHLQAKGVSRVLLTAPGKGDIKNIVYGINNNVIEDTDTILSAASCTTNAITPILKMIDNEYGIINGHVETIHS
YTNDQNLIDNYHEGDRRGRAAALNMVITETGAASAVAKAFPEMEGLLTGNSIRVPTPNVSMAILSLNLKSDITTDGVNAF
LRKMSLYSSVQKQIDWVNSSEVVSTDFVGNSHAGIVDAQATITSDKRVNLYVWYDNEFGYSHQVIRIAQQMCGVFYPTYP
IVK

Sequences:

>Translated_483_residues
MNQVISNTCMQDWSDRESTVETMIPMIGALYRKKNIVTSIYGRPIINRSVIDLLKAHRFVRHMEDKELSVLETFPIINAM
MSMDLDRAHVDVGKLAVKFRNEVNGSDLEAFLNKELNDALGQNSPATKENRDVVLYGFGRIGRLLARLIIERSGGGNGLR
LRAIVVRKGKGNDLEKRASLLRRDSIHGSFRGTISIDKEKNAIIANGNYIQVIYSDAPENADYEAFGIENALVIDNTGIW
RDQAGLERHLQAKGVSRVLLTAPGKGDIKNIVYGINNNVIEDTDTILSAASCTTNAITPILKMIDNEYGIINGHVETIHS
YTNDQNLIDNYHEGDRRGRAAALNMVITETGAASAVAKAFPEMEGLLTGNSIRVPTPNVSMAILSLNLKSDITTDGVNAF
LRKMSLYSSVQKQIDWVNSSEVVSTDFVGNSHAGIVDAQATITSDKRVNLYVWYDNEFGYSHQVIRIAQQMCGVFYPTYP
IVK
>Mature_483_residues
MNQVISNTCMQDWSDRESTVETMIPMIGALYRKKNIVTSIYGRPIINRSVIDLLKAHRFVRHMEDKELSVLETFPIINAM
MSMDLDRAHVDVGKLAVKFRNEVNGSDLEAFLNKELNDALGQNSPATKENRDVVLYGFGRIGRLLARLIIERSGGGNGLR
LRAIVVRKGKGNDLEKRASLLRRDSIHGSFRGTISIDKEKNAIIANGNYIQVIYSDAPENADYEAFGIENALVIDNTGIW
RDQAGLERHLQAKGVSRVLLTAPGKGDIKNIVYGINNNVIEDTDTILSAASCTTNAITPILKMIDNEYGIINGHVETIHS
YTNDQNLIDNYHEGDRRGRAAALNMVITETGAASAVAKAFPEMEGLLTGNSIRVPTPNVSMAILSLNLKSDITTDGVNAF
LRKMSLYSSVQKQIDWVNSSEVVSTDFVGNSHAGIVDAQATITSDKRVNLYVWYDNEFGYSHQVIRIAQQMCGVFYPTYP
IVK

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7657116, Length=338, Percent_Identity=34.6153846153846, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI7669492, Length=339, Percent_Identity=35.3982300884956, Blast_Score=178, Evalue=1e-44,
Organism=Escherichia coli, GI1788079, Length=336, Percent_Identity=36.0119047619048, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1789295, Length=346, Percent_Identity=31.7919075144509, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17534677, Length=342, Percent_Identity=33.9181286549708, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17534679, Length=342, Percent_Identity=33.6257309941521, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17568413, Length=342, Percent_Identity=34.2105263157895, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI32566163, Length=342, Percent_Identity=34.2105263157895, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322409, Length=343, Percent_Identity=34.9854227405248, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6322468, Length=342, Percent_Identity=33.9181286549708, Blast_Score=182, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6321631, Length=346, Percent_Identity=34.1040462427746, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI85725000, Length=338, Percent_Identity=36.094674556213, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI22023983, Length=338, Percent_Identity=36.094674556213, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI17933600, Length=338, Percent_Identity=35.5029585798817, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI18110149, Length=338, Percent_Identity=35.5029585798817, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI19922412, Length=331, Percent_Identity=34.1389728096677, Blast_Score=170, Evalue=2e-42,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 53501; Mature: 53501

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQVISNTCMQDWSDRESTVETMIPMIGALYRKKNIVTSIYGRPIINRSVIDLLKAHRFV
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
RHMEDKELSVLETFPIINAMMSMDLDRAHVDVGKLAVKFRNEVNGSDLEAFLNKELNDAL
HHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GQNSPATKENRDVVLYGFGRIGRLLARLIIERSGGGNGLRLRAIVVRKGKGNDLEKRASL
CCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCHHHHHHH
LRRDSIHGSFRGTISIDKEKNAIIANGNYIQVIYSDAPENADYEAFGIENALVIDNTGIW
HHHHCCCCCEEEEEEECCCCCEEEECCCEEEEEECCCCCCCCEEEECCCCEEEEECCCCC
RDQAGLERHLQAKGVSRVLLTAPGKGDIKNIVYGINNNVIEDTDTILSAASCTTNAITPI
CCHHHHHHHHHHCCCCEEEEECCCCCCHHHEEEECCCCCCCCHHHHHHHHHCCHHHHHHH
LKMIDNEYGIINGHVETIHSYTNDQNLIDNYHEGDRRGRAAALNMVITETGAASAVAKAF
HHHHCCCCCEEECHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHHH
PEMEGLLTGNSIRVPTPNVSMAILSLNLKSDITTDGVNAFLRKMSLYSSVQKQIDWVNSS
HHHHCEECCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
EVVSTDFVGNSHAGIVDAQATITSDKRVNLYVWYDNEFGYSHQVIRIAQQMCGVFYPTYP
CEEEEECCCCCCCCEEECEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCC
IVK
CCC
>Mature Secondary Structure
MNQVISNTCMQDWSDRESTVETMIPMIGALYRKKNIVTSIYGRPIINRSVIDLLKAHRFV
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
RHMEDKELSVLETFPIINAMMSMDLDRAHVDVGKLAVKFRNEVNGSDLEAFLNKELNDAL
HHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GQNSPATKENRDVVLYGFGRIGRLLARLIIERSGGGNGLRLRAIVVRKGKGNDLEKRASL
CCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCHHHHHHH
LRRDSIHGSFRGTISIDKEKNAIIANGNYIQVIYSDAPENADYEAFGIENALVIDNTGIW
HHHHCCCCCEEEEEEECCCCCEEEECCCEEEEEECCCCCCCCEEEECCCCEEEEECCCCC
RDQAGLERHLQAKGVSRVLLTAPGKGDIKNIVYGINNNVIEDTDTILSAASCTTNAITPI
CCHHHHHHHHHHCCCCEEEEECCCCCCHHHEEEECCCCCCCCHHHHHHHHHCCHHHHHHH
LKMIDNEYGIINGHVETIHSYTNDQNLIDNYHEGDRRGRAAALNMVITETGAASAVAKAF
HHHHCCCCCEEECHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHHH
PEMEGLLTGNSIRVPTPNVSMAILSLNLKSDITTDGVNAFLRKMSLYSSVQKQIDWVNSS
HHHHCEECCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
EVVSTDFVGNSHAGIVDAQATITSDKRVNLYVWYDNEFGYSHQVIRIAQQMCGVFYPTYP
CEEEEECCCCCCCCEEECEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCC
IVK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8508805; 10360571; 2401296; 7877172 [H]