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The map label for this gene is merR [H]

Identifier: 119945632

GI number: 119945632

Start: 2366752

End: 2367159

Strand: Direct

Name: merR [H]

Synonym: Ping_1943

Alternate gene names: 119945632

Gene position: 2366752-2367159 (Clockwise)

Preceding gene: 119945618

Following gene: 119945633

Centisome position: 51.91

GC content: 37.5

Gene sequence:

>408_bases
ATGTCCTTTACAATTGGGAGGTTAGCGCAGCTAGCGGGTGTCAATATTGAAACTATTCGCTTTTATGAACGCAGAGGTTT
ATTGATACAGCCGATAAAACCATTAACGGGTTATCGGCAATACGATGACCAAGCGCTCAGCCGCATTCGATTTATTAAAC
GTGCTCAGGAGGTTGGCTTTACCTTAAGTGAAATACAAAGCTTGCTTGATATTGAATCTAATAACTGCAATAAAGTACAA
CATTTAGCGATGGAAAAGCTGACCTTAACGCGACAAAAAATAACTGATCTGCAACATCTTGAAAAGTCACTTCAACATTT
AGTCACACAATGTGAAATAACTCAGAATAAAACTCACTGCCCCATTGTGGACTCTTTCAATAACGCTTCTTCTTTAAATA
AAAAATAA

Upstream 100 bases:

>100_bases
ACACATAAACGTTTCTTACCTGTATAAATGAATAGAAAATTAATGGGTTTGGTATAACATACCCTAGCGATAATATATTC
AATAAATTTAGTGAGAAAGT

Downstream 100 bases:

>100_bases
CCTTTATTTCACGAACCCTATTGACTCCCTACTTGGGTACGGCATGTATAGTTAATCTATTATACAAGCAGAGAGTTAAG
CAATGAACCAGGTACCAGCA

Product: transcriptional regulator of MerR family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 135; Mature: 134

Protein sequence:

>135_residues
MSFTIGRLAQLAGVNIETIRFYERRGLLIQPIKPLTGYRQYDDQALSRIRFIKRAQEVGFTLSEIQSLLDIESNNCNKVQ
HLAMEKLTLTRQKITDLQHLEKSLQHLVTQCEITQNKTHCPIVDSFNNASSLNKK

Sequences:

>Translated_135_residues
MSFTIGRLAQLAGVNIETIRFYERRGLLIQPIKPLTGYRQYDDQALSRIRFIKRAQEVGFTLSEIQSLLDIESNNCNKVQ
HLAMEKLTLTRQKITDLQHLEKSLQHLVTQCEITQNKTHCPIVDSFNNASSLNKK
>Mature_134_residues
SFTIGRLAQLAGVNIETIRFYERRGLLIQPIKPLTGYRQYDDQALSRIRFIKRAQEVGFTLSEIQSLLDIESNNCNKVQH
LAMEKLTLTRQKITDLQHLEKSLQHLVTQCEITQNKTHCPIVDSFNNASSLNKK

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=134, Percent_Identity=31.3432835820896, Blast_Score=82, Evalue=1e-17,
Organism=Escherichia coli, GI1786695, Length=129, Percent_Identity=27.906976744186, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15557; Mature: 15426

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTIGRLAQLAGVNIETIRFYERRGLLIQPIKPLTGYRQYDDQALSRIRFIKRAQEVGF
CCCCHHHHHHHHCCCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
TLSEIQSLLDIESNNCNKVQHLAMEKLTLTRQKITDLQHLEKSLQHLVTQCEITQNKTHC
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PIVDSFNNASSLNKK
CCCCCCCCCCCCCCC
>Mature Secondary Structure 
SFTIGRLAQLAGVNIETIRFYERRGLLIQPIKPLTGYRQYDDQALSRIRFIKRAQEVGF
CCCHHHHHHHHCCCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
TLSEIQSLLDIESNNCNKVQHLAMEKLTLTRQKITDLQHLEKSLQHLVTQCEITQNKTHC
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PIVDSFNNASSLNKK
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6091128; 2551364 [H]