Click here to switch to the map view.

The map label for this gene is gabT [H]

Identifier: 119945584

GI number: 119945584

Start: 2295030

End: 2296337

Strand: Direct

Name: gabT [H]

Synonym: Ping_1889

Alternate gene names: 119945584

Gene position: 2295030-2296337 (Clockwise)

Preceding gene: 119945583

Following gene: 119945588

Centisome position: 50.33

GC content: 44.57

Gene sequence:

>1308_bases
ATGTCAAATGAAACATTACAAAATAGAAAAACAAAAGTTATCGCACGCGGTCAGGGTAATACTTATCCGATTTATGTCGA
CCATGCAAAAAATGCTGAAATTTGGGATGTTGAAGGCAACCGCTATATTGATTTTGGTGCCGGTATTGCGGTCTGTAACA
CTGGCCACAGCCACCCTAAAGTTATCGCTGCCGTTAAACAGCAAGTGGATAAATTCAGCCATACCTGTGTGATGGTTAAT
CCCTATGAAGTAGCTGTCGAGCTGGCTGAAAAATTAACCAAGCTGGCACCAGGTAATTCCCCTAAAAAAGCCATTTTTGT
AACTACAGGTGCGGAAGCGGTTGAAAACTGTGTGAAGATTGCCCGTGCCCATACGGGTCGTCGTGGCGTCATTGCATTTA
ATGGCGGTTTCCATGGCCGTACTAATTTGACCATGGCACTAACGGGTAAAGTTACCCCGTACAAAAACCTGTTCGGTCCA
TTCCCAGCAGATATCTTCCATGCCCCTTTCCCAATGGAGCACCATGATGTCTCAGTAAAAGATTCATTAAAAGCATTACA
AAACTTATTCAAAGTGGATATTTGCCCAAGCGATGTTGCTGCTATTATTGTTGAGCCGGTACAAGGCGAGGGCGGATTTT
ACGCGGCGCCGACTGAATTTTTACAGGCATTACGTAAAATTTGTGACCAACATGGCATTGTCTTAATTGCCGATGAAATT
CAGACTGGTTTTGGTCGTACGGGTAAAATGTTTGCCTTTGAACATGCGGGTGTTGAAGCTGACTTAATGACCATGGCAAA
AGGGATTGCCGGTGGTTTTCCTCTTTCTGCGGTTGTGGGTAAAAGTGAGATCATGGATGCACCTTTACCGGGTGGTCTTG
GCGGAACTTATGGCGGCTCGCCGGTTGCATGTGCGGCGGCATTAGCGGTACTGGAGGTGATGGAAGAAGAAAACCTTGTA
CAACGTTCAGTGCAAATTGGTGAACGCTTTAATCAACGTCTGAACCTGCTAAAAACGCAGCGCCCCGATCTTGTTTTAGA
TGTGAGAAACCAAGGCTCAATGATTGCAATTGAGTTTGTCAAAAATGGTGATCCGGAGCAACCCAATACCGAATTAACCC
AAGCTATTATTGCTAATGCTGCTCAACACGGGTTAGTACTTTTAGCCTGTGGATTTTACGGCAATGTAGTCCGTTTTCTT
CCTCCACTGACTATATCTGATGCCGTGGTTGAAGAAGGTTTAAATAACTTTACCGCGTTATTTGAAAGCCTAACAGCTGA
GTCTGAAGAGAAGCGAAAAGTAGGTTAA

Upstream 100 bases:

>100_bases
TAAGCAACTTAACTAAGTTACCTAACTAAGTTACCTAACTAAGTAATCCTTTGTCCATTATCGCCGATTAAGCAATAAAT
AAAATATTAGGAATAAAATC

Downstream 100 bases:

>100_bases
TTAGCCTATCTTCTTCACAAAACCCTGTTCGCACATGGATAGTTTGCGCGTGGATCGGGTTTTGTGCATGAGCATTTCAA
TGATACTTATCAAAAGCGCC

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSNETLQNRKTKVIARGQGNTYPIYVDHAKNAEIWDVEGNRYIDFGAGIAVCNTGHSHPKVIAAVKQQVDKFSHTCVMVN
PYEVAVELAEKLTKLAPGNSPKKAIFVTTGAEAVENCVKIARAHTGRRGVIAFNGGFHGRTNLTMALTGKVTPYKNLFGP
FPADIFHAPFPMEHHDVSVKDSLKALQNLFKVDICPSDVAAIIVEPVQGEGGFYAAPTEFLQALRKICDQHGIVLIADEI
QTGFGRTGKMFAFEHAGVEADLMTMAKGIAGGFPLSAVVGKSEIMDAPLPGGLGGTYGGSPVACAAALAVLEVMEEENLV
QRSVQIGERFNQRLNLLKTQRPDLVLDVRNQGSMIAIEFVKNGDPEQPNTELTQAIIANAAQHGLVLLACGFYGNVVRFL
PPLTISDAVVEEGLNNFTALFESLTAESEEKRKVG

Sequences:

>Translated_435_residues
MSNETLQNRKTKVIARGQGNTYPIYVDHAKNAEIWDVEGNRYIDFGAGIAVCNTGHSHPKVIAAVKQQVDKFSHTCVMVN
PYEVAVELAEKLTKLAPGNSPKKAIFVTTGAEAVENCVKIARAHTGRRGVIAFNGGFHGRTNLTMALTGKVTPYKNLFGP
FPADIFHAPFPMEHHDVSVKDSLKALQNLFKVDICPSDVAAIIVEPVQGEGGFYAAPTEFLQALRKICDQHGIVLIADEI
QTGFGRTGKMFAFEHAGVEADLMTMAKGIAGGFPLSAVVGKSEIMDAPLPGGLGGTYGGSPVACAAALAVLEVMEEENLV
QRSVQIGERFNQRLNLLKTQRPDLVLDVRNQGSMIAIEFVKNGDPEQPNTELTQAIIANAAQHGLVLLACGFYGNVVRFL
PPLTISDAVVEEGLNNFTALFESLTAESEEKRKVG
>Mature_434_residues
SNETLQNRKTKVIARGQGNTYPIYVDHAKNAEIWDVEGNRYIDFGAGIAVCNTGHSHPKVIAAVKQQVDKFSHTCVMVNP
YEVAVELAEKLTKLAPGNSPKKAIFVTTGAEAVENCVKIARAHTGRRGVIAFNGGFHGRTNLTMALTGKVTPYKNLFGPF
PADIFHAPFPMEHHDVSVKDSLKALQNLFKVDICPSDVAAIIVEPVQGEGGFYAAPTEFLQALRKICDQHGIVLIADEIQ
TGFGRTGKMFAFEHAGVEADLMTMAKGIAGGFPLSAVVGKSEIMDAPLPGGLGGTYGGSPVACAAALAVLEVMEEENLVQ
RSVQIGERFNQRLNLLKTQRPDLVLDVRNQGSMIAIEFVKNGDPEQPNTELTQAIIANAAQHGLVLLACGFYGNVVRFLP
PLTISDAVVEEGLNNFTALFESLTAESEEKRKVG

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=402, Percent_Identity=33.3333333333333, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI13994255, Length=445, Percent_Identity=32.8089887640449, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI37574042, Length=429, Percent_Identity=28.6713286713287, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI284507298, Length=317, Percent_Identity=32.4921135646688, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI24119277, Length=424, Percent_Identity=27.3584905660377, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI226442705, Length=434, Percent_Identity=28.3410138248848, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI226442709, Length=397, Percent_Identity=28.9672544080605, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI188536080, Length=456, Percent_Identity=26.3157894736842, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI38679950, Length=456, Percent_Identity=26.3157894736842, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI38679946, Length=456, Percent_Identity=26.3157894736842, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI1789016, Length=421, Percent_Identity=52.0190023752969, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1787560, Length=410, Percent_Identity=56.5853658536585, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1789759, Length=395, Percent_Identity=36.4556962025316, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=37.6847290640394, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI145693181, Length=380, Percent_Identity=34.7368421052632, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1786991, Length=352, Percent_Identity=33.2386363636364, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786349, Length=348, Percent_Identity=31.3218390804598, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI25144271, Length=401, Percent_Identity=32.4189526184539, Blast_Score=195, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI32564660, Length=407, Percent_Identity=32.6781326781327, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71992977, Length=451, Percent_Identity=29.7117516629712, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI25144274, Length=284, Percent_Identity=32.7464788732394, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17541228, Length=432, Percent_Identity=24.3055555555556, Blast_Score=115, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6324432, Length=413, Percent_Identity=32.9297820823245, Blast_Score=220, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6323470, Length=450, Percent_Identity=30.8888888888889, Blast_Score=206, Evalue=8e-54,
Organism=Saccharomyces cerevisiae, GI6324386, Length=363, Percent_Identity=25.8953168044077, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321456, Length=439, Percent_Identity=25.9681093394077, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI161085790, Length=438, Percent_Identity=32.4200913242009, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI28574759, Length=413, Percent_Identity=33.6561743341404, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI21357415, Length=402, Percent_Identity=30.8457711442786, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI21356575, Length=427, Percent_Identity=31.615925058548, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI281366494, Length=449, Percent_Identity=25.3897550111359, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24667139, Length=449, Percent_Identity=25.3897550111359, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24667143, Length=449, Percent_Identity=25.3897550111359, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 46826; Mature: 46695

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNETLQNRKTKVIARGQGNTYPIYVDHAKNAEIWDVEGNRYIDFGAGIAVCNTGHSHPK
CCCCHHCCCCEEEEECCCCCEEEEEEECCCCCEEEECCCCEEEEECCCEEEECCCCCCHH
VIAAVKQQVDKFSHTCVMVNPYEVAVELAEKLTKLAPGNSPKKAIFVTTGAEAVENCVKI
HHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHH
ARAHTGRRGVIAFNGGFHGRTNLTMALTGKVTPYKNLFGPFPADIFHAPFPMEHHDVSVK
HHHCCCCCEEEEECCCCCCCCEEEEEEECCCCCHHHHCCCCCHHHHCCCCCCCCCCCCHH
DSLKALQNLFKVDICPSDVAAIIVEPVQGEGGFYAAPTEFLQALRKICDQHGIVLIADEI
HHHHHHHHHHEECCCCCCEEEEEEEEECCCCCEEECHHHHHHHHHHHHHHCCEEEEEECC
QTGFGRTGKMFAFEHAGVEADLMTMAKGIAGGFPLSAVVGKSEIMDAPLPGGLGGTYGGS
CCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHCHHHHCCCCCCCCCCCCCCCC
PVACAAALAVLEVMEEENLVQRSVQIGERFNQRLNLLKTQRPDLVLDVRNQGSMIAIEFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEE
KNGDPEQPNTELTQAIIANAAQHGLVLLACGFYGNVVRFLPPLTISDAVVEEGLNNFTAL
CCCCCCCCCHHHHHHHHHHHHHCCEEEEEECHHHHHHHHCCCCCHHHHHHHHCHHHHHHH
FESLTAESEEKRKVG
HHHHHCCCHHHHCCC
>Mature Secondary Structure 
SNETLQNRKTKVIARGQGNTYPIYVDHAKNAEIWDVEGNRYIDFGAGIAVCNTGHSHPK
CCCHHCCCCEEEEECCCCCEEEEEEECCCCCEEEECCCCEEEEECCCEEEECCCCCCHH
VIAAVKQQVDKFSHTCVMVNPYEVAVELAEKLTKLAPGNSPKKAIFVTTGAEAVENCVKI
HHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHH
ARAHTGRRGVIAFNGGFHGRTNLTMALTGKVTPYKNLFGPFPADIFHAPFPMEHHDVSVK
HHHCCCCCEEEEECCCCCCCCEEEEEEECCCCCHHHHCCCCCHHHHCCCCCCCCCCCCHH
DSLKALQNLFKVDICPSDVAAIIVEPVQGEGGFYAAPTEFLQALRKICDQHGIVLIADEI
HHHHHHHHHHEECCCCCCEEEEEEEEECCCCCEEECHHHHHHHHHHHHHHCCEEEEEECC
QTGFGRTGKMFAFEHAGVEADLMTMAKGIAGGFPLSAVVGKSEIMDAPLPGGLGGTYGGS
CCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHCHHHHCCCCCCCCCCCCCCCC
PVACAAALAVLEVMEEENLVQRSVQIGERFNQRLNLLKTQRPDLVLDVRNQGSMIAIEFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEE
KNGDPEQPNTELTQAIIANAAQHGLVLLACGFYGNVVRFLPPLTISDAVVEEGLNNFTAL
CCCCCCCCCHHHHHHHHHHHHHCCEEEEEECHHHHHHHHCCCCCHHHHHHHHCHHHHHHH
FESLTAESEEKRKVG
HHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]