Click here to switch to the map view.

The map label for this gene is polC [H]

Identifier: 119945580

GI number: 119945580

Start: 2291243

End: 2291857

Strand: Direct

Name: polC [H]

Synonym: Ping_1885

Alternate gene names: 119945580

Gene position: 2291243-2291857 (Clockwise)

Preceding gene: 119945579

Following gene: 119945583

Centisome position: 50.25

GC content: 38.05

Gene sequence:

>615_bases
ATGTCTGATGCTAAAAATATTGTTATATTTGATTTTGAAACAACAGGTTTATCGCCAAAAATGGGTGATCGACCAATTGA
AATAGGAGCAGTGCGGATCAAAAATGGTCTGTTAGTTGAGCGGTTTCAGGCATTAATGCACCCGGGCATAAGAATCAGTT
CTTTTATTGAAAACTTTACCGGTATCAGTAATAAAATGCTGGCAGAAGCTAAGCCTTGTGCAGAGGTGATGGGGCGCTTT
TGTGATTTTATCGGCTCTGATAATCTTGTTGCCCATAATGCCTCCTTTGATAAACGTTTTTTAGATGCTGAATTACACAG
AATATCAAGGGGTTACTCCGGACAAATTAGTTGTTCAATGCTTTTAGCAAGAAGAGTTCTTCGAGATGCACCTAACCATA
AACTGGGCACGTTAGTTGATTATTTAAATATTCAAACAGAAGGGGTCTATCACCGGGCTTTATTCGACTCAGAAATGACC
GCTAATGTTTGGTTGGCCATGATTAATAAAATTCAGCAGCATTATAAAATGAAAACGATTCCCTTCGCATTAATGCAAAA
GTTATGTAAAACCCCTGCTGCATTCGCGCATCGGACTATTTTAAATTGGAAATAA

Upstream 100 bases:

>100_bases
GAATCTACCAAAAAAGCAGTTTTAAAATTACGTGAATAATTTTCCCGCAAAAACCATAAAATAATTTTTATTCTTTGAAG
TAAAAAAATGAAACAGTAAA

Downstream 100 bases:

>100_bases
TTTATCGAGCATGACAAATCCAACTGATTATAATTGAACTATAAATAATGAACTATAAAGGTGATTATCCTTGCTAATTA
GAAGAATTAATCATTTTATT

Product: DNA polymerase III, epsilon subunit

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MSDAKNIVIFDFETTGLSPKMGDRPIEIGAVRIKNGLLVERFQALMHPGIRISSFIENFTGISNKMLAEAKPCAEVMGRF
CDFIGSDNLVAHNASFDKRFLDAELHRISRGYSGQISCSMLLARRVLRDAPNHKLGTLVDYLNIQTEGVYHRALFDSEMT
ANVWLAMINKIQQHYKMKTIPFALMQKLCKTPAAFAHRTILNWK

Sequences:

>Translated_204_residues
MSDAKNIVIFDFETTGLSPKMGDRPIEIGAVRIKNGLLVERFQALMHPGIRISSFIENFTGISNKMLAEAKPCAEVMGRF
CDFIGSDNLVAHNASFDKRFLDAELHRISRGYSGQISCSMLLARRVLRDAPNHKLGTLVDYLNIQTEGVYHRALFDSEMT
ANVWLAMINKIQQHYKMKTIPFALMQKLCKTPAAFAHRTILNWK
>Mature_203_residues
SDAKNIVIFDFETTGLSPKMGDRPIEIGAVRIKNGLLVERFQALMHPGIRISSFIENFTGISNKMLAEAKPCAEVMGRFC
DFIGSDNLVAHNASFDKRFLDAELHRISRGYSGQISCSMLLARRVLRDAPNHKLGTLVDYLNIQTEGVYHRALFDSEMTA
NVWLAMINKIQQHYKMKTIPFALMQKLCKTPAAFAHRTILNWK

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2176

COG function: function code L; DNA polymerase III, alpha subunit (gram-positive type)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

Organism=Escherichia coli, GI1786409, Length=170, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR023223
- InterPro:   IPR016027
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 23092; Mature: 22961

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAKNIVIFDFETTGLSPKMGDRPIEIGAVRIKNGLLVERFQALMHPGIRISSFIENFT
CCCCCEEEEEEEECCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHH
GISNKMLAEAKPCAEVMGRFCDFIGSDNLVAHNASFDKRFLDAELHRISRGYSGQISCSM
CCCHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHH
LLARRVLRDAPNHKLGTLVDYLNIQTEGVYHRALFDSEMTANVWLAMINKIQQHYKMKTI
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
PFALMQKLCKTPAAFAHRTILNWK
HHHHHHHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure 
SDAKNIVIFDFETTGLSPKMGDRPIEIGAVRIKNGLLVERFQALMHPGIRISSFIENFT
CCCCEEEEEEEECCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHH
GISNKMLAEAKPCAEVMGRFCDFIGSDNLVAHNASFDKRFLDAELHRISRGYSGQISCSM
CCCHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHH
LLARRVLRDAPNHKLGTLVDYLNIQTEGVYHRALFDSEMTANVWLAMINKIQQHYKMKTI
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
PFALMQKLCKTPAAFAHRTILNWK
HHHHHHHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]