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The map label for this gene is tdh

Identifier: 119945549

GI number: 119945549

Start: 2252697

End: 2253731

Strand: Direct

Name: tdh

Synonym: Ping_1853

Alternate gene names: 119945549

Gene position: 2252697-2253731 (Clockwise)

Preceding gene: 119945548

Following gene: 119945550

Centisome position: 49.41

GC content: 44.54

Gene sequence:

>1035_bases
ATGAAAATAAAAGCGCTAGCAAAATTAAAACCAGAAGTGGGCATTTGGATGACCACAGTCGATAAGCCTGAGCCCGGGCA
TAATGATTTGTTGATTAAAATCCATAAAACAGCCATTTGTGGTACCGATATCCATATTTATAACTGGGATGAATGGTCAC
AAAATACGATTCCTGTTCCAATGGTTGTCGGCCATGAATATGTCGGTGAAGTAGTTGGAATGGGCCAGGAGGTTCGCGGA
TTTAGCGTTGGTGACAGGGTATCGGGCGAAGGCCATATTACCTGCGGACATTGTCGTAACTGCCGGGCAGGGCGGACGCA
TCTTTGCCGTAATACTATTGGTGTGGGGGTTAATCGCACGGGTGCATTTGCAGAGTATTTAGTTATTCCGGCTTTTAATG
CCTTTAAAATACCCGCAGGTATTTCCGATGATTTAGCATCTATCTTTGACCCCTTTGGTAATGCAGTGCACAGCGCTTTA
TCCTTTGATGTTGTTGGTGAAGACGTGCTTATTACCGGTGCCGGCCCTATTGGTATTATGGCGGCTGCAGTTGCGAAACA
TGCTGGTGCGCGTTATGTGGTGATAACGGATATTAATGAATATCGATTAGATCTGGCCAGAAAAATGGGCGTGACCCGCG
CGGTTAATGTCGCCCAGCAAAAACTCGAAGATGTTATAGCACAACTGGGCATGACGGAAGGTTTTGATGTTGGACTCGAG
ATGTCCGGTGCGCCCGTCGCCTTTAATAGTATGCTTAAAAATATGAGCCACGGCGGTAAGATTGCACTGTTAGGTATTCC
ACCTTCTGATATGTCCATTGATTGGAATATGGTTATTTTTAAAGGGCTGGTTATTAAAGGAATTTATGGCCGGGAGATGT
TTGAAACCTGGTATAAAATGGCCAGTTTAATACAATCCGGTTTAGATTTGGATCCCATTATAACTCATACTTTCCCCGTG
GATAAATTCCAGGAGGGCTTTGATATGATGCGTTCGGGTAAATCGGGAAAAGTCATACTGGACTGGTCTATTTAG

Upstream 100 bases:

>100_bases
GCAAATGTCTGCCGCACATACAACTAAGCAGCTTGATTATGCGATTGATGTCTTTATTGAAGTTGGTAAAGAGATGGGCT
TAATTTAATTGGAGAGCAAA

Downstream 100 bases:

>100_bases
TGGTAGCTGACGAGAGCCGTTTACAATATGGAAAGTGATGAATAAACAACTTTTTGATTATTGTCAACGCCTGCTAAAGA
AACACGATCAGGGGGGAGCG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MKIKALAKLKPEVGIWMTTVDKPEPGHNDLLIKIHKTAICGTDIHIYNWDEWSQNTIPVPMVVGHEYVGEVVGMGQEVRG
FSVGDRVSGEGHITCGHCRNCRAGRTHLCRNTIGVGVNRTGAFAEYLVIPAFNAFKIPAGISDDLASIFDPFGNAVHSAL
SFDVVGEDVLITGAGPIGIMAAAVAKHAGARYVVITDINEYRLDLARKMGVTRAVNVAQQKLEDVIAQLGMTEGFDVGLE
MSGAPVAFNSMLKNMSHGGKIALLGIPPSDMSIDWNMVIFKGLVIKGIYGREMFETWYKMASLIQSGLDLDPIITHTFPV
DKFQEGFDMMRSGKSGKVILDWSI

Sequences:

>Translated_344_residues
MKIKALAKLKPEVGIWMTTVDKPEPGHNDLLIKIHKTAICGTDIHIYNWDEWSQNTIPVPMVVGHEYVGEVVGMGQEVRG
FSVGDRVSGEGHITCGHCRNCRAGRTHLCRNTIGVGVNRTGAFAEYLVIPAFNAFKIPAGISDDLASIFDPFGNAVHSAL
SFDVVGEDVLITGAGPIGIMAAAVAKHAGARYVVITDINEYRLDLARKMGVTRAVNVAQQKLEDVIAQLGMTEGFDVGLE
MSGAPVAFNSMLKNMSHGGKIALLGIPPSDMSIDWNMVIFKGLVIKGIYGREMFETWYKMASLIQSGLDLDPIITHTFPV
DKFQEGFDMMRSGKSGKVILDWSI
>Mature_344_residues
MKIKALAKLKPEVGIWMTTVDKPEPGHNDLLIKIHKTAICGTDIHIYNWDEWSQNTIPVPMVVGHEYVGEVVGMGQEVRG
FSVGDRVSGEGHITCGHCRNCRAGRTHLCRNTIGVGVNRTGAFAEYLVIPAFNAFKIPAGISDDLASIFDPFGNAVHSAL
SFDVVGEDVLITGAGPIGIMAAAVAKHAGARYVVITDINEYRLDLARKMGVTRAVNVAQQKLEDVIAQLGMTEGFDVGLE
MSGAPVAFNSMLKNMSHGGKIALLGIPPSDMSIDWNMVIFKGLVIKGIYGREMFETWYKMASLIQSGLDLDPIITHTFPV
DKFQEGFDMMRSGKSGKVILDWSI

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=325, Percent_Identity=27.3846153846154, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4501929, Length=355, Percent_Identity=26.7605633802817, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI34577061, Length=357, Percent_Identity=26.890756302521, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI4501933, Length=355, Percent_Identity=26.7605633802817, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI156523966, Length=377, Percent_Identity=24.6684350132626, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI262073058, Length=352, Percent_Identity=25.5681818181818, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI71743840, Length=353, Percent_Identity=26.0623229461756, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4501939, Length=371, Percent_Identity=24.5283018867925, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI71565152, Length=386, Percent_Identity=25.1295336787565, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI71565154, Length=376, Percent_Identity=24.7340425531915, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI194239674, Length=345, Percent_Identity=24.3478260869565, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI13236495, Length=345, Percent_Identity=24.3478260869565, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=83.2352941176471, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI1788073, Length=315, Percent_Identity=30.4761904761905, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1788075, Length=370, Percent_Identity=30.2702702702703, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87082125, Length=353, Percent_Identity=30.5949008498584, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI226510992, Length=326, Percent_Identity=30.0613496932515, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787863, Length=330, Percent_Identity=27.2727272727273, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788407, Length=343, Percent_Identity=26.2390670553936, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790718, Length=324, Percent_Identity=25, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1786825, Length=378, Percent_Identity=28.3068783068783, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI87081918, Length=267, Percent_Identity=29.5880149812734, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786552, Length=379, Percent_Identity=27.1767810026385, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786518, Length=351, Percent_Identity=24.5014245014245, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=336, Percent_Identity=30.6547619047619, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17562878, Length=210, Percent_Identity=36.1904761904762, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71988145, Length=329, Percent_Identity=25.2279635258359, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=334, Percent_Identity=26.6467065868263, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=293, Percent_Identity=25.5972696245734, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=378, Percent_Identity=24.6031746031746, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=306, Percent_Identity=29.4117647058824, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319955, Length=306, Percent_Identity=29.0849673202614, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323099, Length=322, Percent_Identity=29.5031055900621, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319258, Length=299, Percent_Identity=28.0936454849498, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319257, Length=270, Percent_Identity=27.7777777777778, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=332, Percent_Identity=28.9156626506024, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=26.0053619302949, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=330, Percent_Identity=28.4848484848485, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=330, Percent_Identity=27.5757575757576, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=272, Percent_Identity=27.9411764705882, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319949, Length=303, Percent_Identity=27.7227722772277, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323980, Length=259, Percent_Identity=30.5019305019305, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17737897, Length=322, Percent_Identity=26.3975155279503, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI17137530, Length=322, Percent_Identity=25.4658385093168, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17737895, Length=356, Percent_Identity=26.9662921348315, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45551930, Length=340, Percent_Identity=25.5882352941176, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550770, Length=340, Percent_Identity=25.5882352941176, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221457811, Length=340, Percent_Identity=25.5882352941176, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TDH_PSYIN (A1SVW5)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943229.1
- ProteinModelPortal:   A1SVW5
- SMR:   A1SVW5
- STRING:   A1SVW5
- GeneID:   4625040
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1853
- eggNOG:   COG1063
- HOGENOM:   HBG753318
- OMA:   VITHMIT
- PhylomeDB:   A1SVW5
- ProtClustDB:   PRK05396
- BioCyc:   PING357804:PING_1853-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00627
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695
- TIGRFAMs:   TIGR00692

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.103

Molecular weight: Translated: 37406; Mature: 37406

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKALAKLKPEVGIWMTTVDKPEPGHNDLLIKIHKTAICGTDIHIYNWDEWSQNTIPVP
CCCCCHHHCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCCCCCCCCE
MVVGHEYVGEVVGMGQEVRGFSVGDRVSGEGHITCGHCRNCRAGRTHLCRNTIGVGVNRT
EEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCC
GAFAEYLVIPAFNAFKIPAGISDDLASIFDPFGNAVHSALSFDVVGEDVLITGAGPIGIM
CCHHHEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHH
AAAVAKHAGARYVVITDINEYRLDLARKMGVTRAVNVAQQKLEDVIAQLGMTEGFDVGLE
HHHHHHHCCCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
MSGAPVAFNSMLKNMSHGGKIALLGIPPSDMSIDWNMVIFKGLVIKGIYGREMFETWYKM
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHEEHHHHHCCCCCHHHHHHHHHH
ASLIQSGLDLDPIITHTFPVDKFQEGFDMMRSGKSGKVILDWSI
HHHHHCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure
MKIKALAKLKPEVGIWMTTVDKPEPGHNDLLIKIHKTAICGTDIHIYNWDEWSQNTIPVP
CCCCCHHHCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCCCCCCCCE
MVVGHEYVGEVVGMGQEVRGFSVGDRVSGEGHITCGHCRNCRAGRTHLCRNTIGVGVNRT
EEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCC
GAFAEYLVIPAFNAFKIPAGISDDLASIFDPFGNAVHSALSFDVVGEDVLITGAGPIGIM
CCHHHEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHH
AAAVAKHAGARYVVITDINEYRLDLARKMGVTRAVNVAQQKLEDVIAQLGMTEGFDVGLE
HHHHHHHCCCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
MSGAPVAFNSMLKNMSHGGKIALLGIPPSDMSIDWNMVIFKGLVIKGIYGREMFETWYKM
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHEEHHHHHCCCCCHHHHHHHHHH
ASLIQSGLDLDPIITHTFPVDKFQEGFDMMRSGKSGKVILDWSI
HHHHHCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA