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The map label for this gene is kbl [C]

Identifier: 119945548

GI number: 119945548

Start: 2251491

End: 2252684

Strand: Direct

Name: kbl [C]

Synonym: Ping_1852

Alternate gene names: 119945548

Gene position: 2251491-2252684 (Clockwise)

Preceding gene: 119945547

Following gene: 119945549

Centisome position: 49.38

GC content: 41.88

Gene sequence:

>1194_bases
ATGTCTAATAAATTCTATCAACAAATCAATCAACAAATCGAACAAGTCAAAAATGATGGCCTTTATAAATCAGAGCGAAT
TATTACATCAGCTCAACAAGCCTTAGTATCAATAGCAAGTGGTGAGCAGGTGCTTAATTTTTGTGCCAATAACTATCTTG
GTTTAGCAAACCATCCTGAGTTGATTGCAGCTGCTAAAAAAGGGCTGGATCAACAAGGTTTTGGTATGGCCTCCGTACGT
TTTATTTGCGGTACTCAAGACAAGCATAAAGCTTTGGAAGCCAAGCTCTCTGGCTTTTTAGGCATGGAAGATACGATTCT
TTATACTTCCTGTTTTGACGCTAATACCGGTTTATTTGAAACTATTTTGAATGCCGATGATGCCATTATTTCAGATGCGT
TAAATCATGCTTCTATTATAGATGGTGTACGTTTATGCAAAGCTAAACGTTTCCGTTATGCAAATAATAATATGGCTGAA
TTAGAAGAGCAGTTAATCGCCGCAGAAAAAGCCGGTGCGCGCAATACATTGATTGTGACCGATGGTGTCTTTTCAATGGA
TGGGGTAGTCGCCAATTTACCAGCCATTTGTGATTTGGCTGATAAATATGATGCATTGGTGATGGTTGATGATTCTCATG
CTGTTGGTTTTATGGGTGCCAATGGTCGTGGTACCCATGAATATCATAATGTAATGGGGCGTATTGATATTATTACCGGC
ACCTTAGGTAAAGCTATGGGGGGCGCATCCGGTGGTTATACAGCGGGCAAAAAAGAAGTGATTGATTGGTTACGCCAACG
CTCGCGTCCTTATCTTTTTTCAAACTCGCTTGCCCCTGCGATTGTTGCAGCTTCCATTGAGGTGCTCGACTTATTGGCTA
AAAGTCACGCGCTGCGTGAAAAACTTTGGGAAAACTCTGCGCACTTTCGTCGCCGCATGACTGAAGCGGGTTTTACCATG
GGTGGCAGTGACCATGCTATTATTCCTATTATGTTGGGGGATGCAAAAATAGCCGCCGAGTTTGCGGAAAGAGCCCTGTT
GAAAAAAGTTTATGTGGTGGCTTTCTCGTTTCCTGTTGTACCAAAAGATCAGGCACGTATCCGTACGCAAATGTCTGCCG
CACATACAACTAAGCAGCTTGATTATGCGATTGATGTCTTTATTGAAGTTGGTAAAGAGATGGGCTTAATTTAA

Upstream 100 bases:

>100_bases
AATCATTGTAAATATATTTACAATGATTTGTCTCCCATACTCTCTGTTTTAATATAAAATAGTTAAATAATTTTCTGCTA
AATCAATATCGTGGTGTGTC

Downstream 100 bases:

>100_bases
TTGGAGAGCAAAATGAAAATAAAAGCGCTAGCAAAATTAAAACCAGAAGTGGGCATTTGGATGACCACAGTCGATAAGCC
TGAGCCCGGGCATAATGATT

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MSNKFYQQINQQIEQVKNDGLYKSERIITSAQQALVSIASGEQVLNFCANNYLGLANHPELIAAAKKGLDQQGFGMASVR
FICGTQDKHKALEAKLSGFLGMEDTILYTSCFDANTGLFETILNADDAIISDALNHASIIDGVRLCKAKRFRYANNNMAE
LEEQLIAAEKAGARNTLIVTDGVFSMDGVVANLPAICDLADKYDALVMVDDSHAVGFMGANGRGTHEYHNVMGRIDIITG
TLGKAMGGASGGYTAGKKEVIDWLRQRSRPYLFSNSLAPAIVAASIEVLDLLAKSHALREKLWENSAHFRRRMTEAGFTM
GGSDHAIIPIMLGDAKIAAEFAERALLKKVYVVAFSFPVVPKDQARIRTQMSAAHTTKQLDYAIDVFIEVGKEMGLI

Sequences:

>Translated_397_residues
MSNKFYQQINQQIEQVKNDGLYKSERIITSAQQALVSIASGEQVLNFCANNYLGLANHPELIAAAKKGLDQQGFGMASVR
FICGTQDKHKALEAKLSGFLGMEDTILYTSCFDANTGLFETILNADDAIISDALNHASIIDGVRLCKAKRFRYANNNMAE
LEEQLIAAEKAGARNTLIVTDGVFSMDGVVANLPAICDLADKYDALVMVDDSHAVGFMGANGRGTHEYHNVMGRIDIITG
TLGKAMGGASGGYTAGKKEVIDWLRQRSRPYLFSNSLAPAIVAASIEVLDLLAKSHALREKLWENSAHFRRRMTEAGFTM
GGSDHAIIPIMLGDAKIAAEFAERALLKKVYVVAFSFPVVPKDQARIRTQMSAAHTTKQLDYAIDVFIEVGKEMGLI
>Mature_396_residues
SNKFYQQINQQIEQVKNDGLYKSERIITSAQQALVSIASGEQVLNFCANNYLGLANHPELIAAAKKGLDQQGFGMASVRF
ICGTQDKHKALEAKLSGFLGMEDTILYTSCFDANTGLFETILNADDAIISDALNHASIIDGVRLCKAKRFRYANNNMAEL
EEQLIAAEKAGARNTLIVTDGVFSMDGVVANLPAICDLADKYDALVMVDDSHAVGFMGANGRGTHEYHNVMGRIDIITGT
LGKAMGGASGGYTAGKKEVIDWLRQRSRPYLFSNSLAPAIVAASIEVLDLLAKSHALREKLWENSAHFRRRMTEAGFTMG
GSDHAIIPIMLGDAKIAAEFAERALLKKVYVVAFSFPVVPKDQARIRTQMSAAHTTKQLDYAIDVFIEVGKEMGLI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=389, Percent_Identity=51.413881748072, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI284448556, Length=416, Percent_Identity=48.5576923076923, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI4758668, Length=365, Percent_Identity=36.986301369863, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI4502025, Length=406, Percent_Identity=31.0344827586207, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI40316939, Length=406, Percent_Identity=31.0344827586207, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI119220554, Length=366, Percent_Identity=34.9726775956284, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI83977442, Length=366, Percent_Identity=33.3333333333333, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI83977440, Length=366, Percent_Identity=33.3333333333333, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI83977444, Length=403, Percent_Identity=31.2655086848635, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI5454084, Length=261, Percent_Identity=29.1187739463602, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1790046, Length=397, Percent_Identity=69.7732997481108, Blast_Score=602, Evalue=1e-173,
Organism=Escherichia coli, GI1786993, Length=352, Percent_Identity=33.2386363636364, Blast_Score=184, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI71994529, Length=399, Percent_Identity=54.8872180451128, Blast_Score=437, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=31.9783197831978, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17560914, Length=359, Percent_Identity=32.033426183844, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17560912, Length=359, Percent_Identity=32.033426183844, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI71982617, Length=290, Percent_Identity=26.551724137931, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71982625, Length=290, Percent_Identity=26.551724137931, Blast_Score=111, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6320438, Length=380, Percent_Identity=31.5789473684211, Blast_Score=203, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=30.7065217391304, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6323954, Length=261, Percent_Identity=29.8850574712644, Blast_Score=109, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24662918, Length=390, Percent_Identity=57.1794871794872, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI17136286, Length=404, Percent_Identity=31.1881188118812, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17137420, Length=380, Percent_Identity=28.4210526315789, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24653280, Length=372, Percent_Identity=24.7311827956989, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653276, Length=372, Percent_Identity=24.7311827956989, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653278, Length=372, Percent_Identity=24.7311827956989, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43263; Mature: 43132

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKFYQQINQQIEQVKNDGLYKSERIITSAQQALVSIASGEQVLNFCANNYLGLANHPE
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCHH
LIAAAKKGLDQQGFGMASVRFICGTQDKHKALEAKLSGFLGMEDTILYTSCFDANTGLFE
HHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHH
TILNADDAIISDALNHASIIDGVRLCKAKRFRYANNNMAELEEQLIAAEKAGARNTLIVT
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEE
DGVFSMDGVVANLPAICDLADKYDALVMVDDSHAVGFMGANGRGTHEYHNVMGRIDIITG
CCCCCCCCHHHCCCHHHHHHCCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHEEEEC
TLGKAMGGASGGYTAGKKEVIDWLRQRSRPYLFSNSLAPAIVAASIEVLDLLAKSHALRE
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
KLWENSAHFRRRMTEAGFTMGGSDHAIIPIMLGDAKIAAEFAERALLKKVYVVAFSFPVV
HHHCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHEECCCC
PKDQARIRTQMSAAHTTKQLDYAIDVFIEVGKEMGLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNKFYQQINQQIEQVKNDGLYKSERIITSAQQALVSIASGEQVLNFCANNYLGLANHPE
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCHH
LIAAAKKGLDQQGFGMASVRFICGTQDKHKALEAKLSGFLGMEDTILYTSCFDANTGLFE
HHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHH
TILNADDAIISDALNHASIIDGVRLCKAKRFRYANNNMAELEEQLIAAEKAGARNTLIVT
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEE
DGVFSMDGVVANLPAICDLADKYDALVMVDDSHAVGFMGANGRGTHEYHNVMGRIDIITG
CCCCCCCCHHHCCCHHHHHHCCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHEEEEC
TLGKAMGGASGGYTAGKKEVIDWLRQRSRPYLFSNSLAPAIVAASIEVLDLLAKSHALRE
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
KLWENSAHFRRRMTEAGFTMGGSDHAIIPIMLGDAKIAAEFAERALLKKVYVVAFSFPVV
HHHCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHEECCCC
PKDQARIRTQMSAAHTTKQLDYAIDVFIEVGKEMGLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]