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The map label for this gene is iscA [H]

Identifier: 119945070

GI number: 119945070

Start: 1644900

End: 1645211

Strand: Direct

Name: iscA [H]

Synonym: Ping_1326

Alternate gene names: 119945070

Gene position: 1644900-1645211 (Clockwise)

Preceding gene: 119945069

Following gene: 119945071

Centisome position: 36.08

GC content: 38.14

Gene sequence:

>312_bases
ATGACAGAACCAGCTGCAAAACATGTTGCTGCTTTTCTATCTAATCGCGGTAAAGGGATTGGTTTACGGTTAGGGGTTAA
AACATCGGGTTGTTCCGGTATGTCTTATGTAATCGAGTTCGTTGATGTGCTTAATGATGACGACCAAGTATTTATCGATA
AAGGCGTCAAAGTCGTTGTTGATAAAAAAAGTCTCCTTTACATTGACGGTACCGAATTAGATTTTGTTAAAGAAGGCCTA
AATGAGGGCTTTGAATTTAATAACCCTAATATAGACGGTGAGTGTGGTTGCGGTGAAAGTTTTAATGTTTAA

Upstream 100 bases:

>100_bases
CACCCGAACGCATAAAAGCGGTTTGGCAGGTATCATCTTGATGATATTTGCCAATATTGAATATTTGAATTAATAACTGG
AGTCAATTTTGGCTATCACA

Downstream 100 bases:

>100_bases
CACTTAAATTTAATCCTTTAACCCGTTATACTGATAAATCGTATTTTTACTGAGGAATTATGTTTACATTTTTCCTCTTT
TTTTTAGGGAACTGTTGTGA

Product: iron-sulfur cluster assembly protein IscA

Products: NA

Alternate protein names: Iron-sulfur cluster assembly protein [H]

Number of amino acids: Translated: 103; Mature: 102

Protein sequence:

>103_residues
MTEPAAKHVAAFLSNRGKGIGLRLGVKTSGCSGMSYVIEFVDVLNDDDQVFIDKGVKVVVDKKSLLYIDGTELDFVKEGL
NEGFEFNNPNIDGECGCGESFNV

Sequences:

>Translated_103_residues
MTEPAAKHVAAFLSNRGKGIGLRLGVKTSGCSGMSYVIEFVDVLNDDDQVFIDKGVKVVVDKKSLLYIDGTELDFVKEGL
NEGFEFNNPNIDGECGCGESFNV
>Mature_102_residues
TEPAAKHVAAFLSNRGKGIGLRLGVKTSGCSGMSYVIEFVDVLNDDDQVFIDKGVKVVVDKKSLLYIDGTELDFVKEGLN
EGFEFNNPNIDGECGCGESFNV

Specific function: Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that iscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transi

COG id: COG0316

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesB/iscA family [H]

Homologues:

Organism=Homo sapiens, GI52426768, Length=103, Percent_Identity=42.7184466019417, Blast_Score=103, Evalue=2e-23,
Organism=Homo sapiens, GI160420328, Length=83, Percent_Identity=42.1686746987952, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788877, Length=103, Percent_Identity=69.9029126213592, Blast_Score=149, Evalue=4e-38,
Organism=Escherichia coli, GI1787974, Length=103, Percent_Identity=45.6310679611651, Blast_Score=102, Evalue=5e-24,
Organism=Escherichia coli, GI1786351, Length=105, Percent_Identity=38.0952380952381, Blast_Score=63, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193209025, Length=103, Percent_Identity=34.9514563106796, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25146411, Length=103, Percent_Identity=34.9514563106796, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323001, Length=103, Percent_Identity=37.8640776699029, Blast_Score=83, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24642263, Length=103, Percent_Identity=41.747572815534, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000361
- InterPro:   IPR016092
- InterPro:   IPR017870
- InterPro:   IPR011302 [H]

Pfam domain/function: PF01521 Fe-S_biosyn [H]

EC number: NA

Molecular weight: Translated: 11124; Mature: 10992

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: PS01152 HESB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPAAKHVAAFLSNRGKGIGLRLGVKTSGCSGMSYVIEFVDVLNDDDQVFIDKGVKVVV
CCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCEEEE
DKKSLLYIDGTELDFVKEGLNEGFEFNNPNIDGECGCGESFNV
ECCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEPAAKHVAAFLSNRGKGIGLRLGVKTSGCSGMSYVIEFVDVLNDDDQVFIDKGVKVVV
CCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCEEEE
DKKSLLYIDGTELDFVKEGLNEGFEFNNPNIDGECGCGESFNV
ECCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA