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The map label for this gene is mtlA [H]

Identifier: 119944744

GI number: 119944744

Start: 1242357

End: 1243766

Strand: Reverse

Name: mtlA [H]

Synonym: Ping_0985

Alternate gene names: 119944744

Gene position: 1243766-1242357 (Counterclockwise)

Preceding gene: 119944745

Following gene: 119944743

Centisome position: 27.28

GC content: 41.49

Gene sequence:

>1410_bases
ATGCTGTCATCACAATCCAAGATTAAAGTACAAAACTTTGGTCGCTTATTGTCAAATATGGTTATGCCAAATATTGGCGC
CTTTATCGCATGGGGTTTAATTACCGCATTATTCATTCCAACGGGGTGGATACCTAACGAAACATTAGCCACCATGGTTG
GGCCGATGATCAAATATATGCTGCCGCTCTTAATTGGTTATACCGGTGGTAAAATTATAGCCGGAGAGCGTGGTGCCGTT
GTAGGTGCAATAGCGACAATGGGTGTGATTGTTGGTACAGATATTCCAATGTTTATGGGTGCGATGATTGTTGGTCCGTT
AGGCGGCCTGGCAATTAAGAAATTTGATGCTGCCATTCACGGTAAAGTGAAAAGTGGTTTTGAAATGTTGGTTAACAACT
TTTCATCCGGTATTATTGGTATGGTGCTGGCGATTATTGCTTACGTAGTGATTGGTCCTGCTGTTAAAATGTTATCGACA
GCCCTTGCTGCTGGTGTTGATGTTTTAGTAGTCAATAACCTGCTTCCTTTGACTTCTATTTTTGTTGAACCGGCAAAGAT
TTTGTTCCTTAATAATGCGATTAACCATGGTATTTTCACGCCGCTGGGTATTGCGCAGTCAGAGTCTCTTGGTCAATCTG
TTTTCTTCTTAATTGAAGCAAACCCGGGTCCAGGTTTAGGTCTTCTTTTAGCCTACATGGTGTTCGGTAAAGGTTCTGCA
AAAGAAACAGCTCCTGGTGCCGTCATTATCCACTTCTTTGGTGGTATCCATGAAATTTACTTCCCTTATGTATTGATGAA
TCCGCGTCTTATCCTATCTGTTATTGCAGGTGGTATGACAGGCGTATTCGTTCTTACTCTATTCGATGCCGGTCTTATCT
CTCCTGCATCTCCTGGTTCTATCTTTGCTGTTTTAGCCATGACGCCTAAAGGCGCATATATGGGTATTCTTCTATCTGTT
GCTGCTGCTGCCGCTGTTTCTTTTGTTGTGGCATCTATTCTGATGAAAACACAAAAAACGGTTGCCGGTGATGAAGTTGC
ACTAGAAGAAGCTGCAAACCAAATGCGCGACATGAAGCAAAGCGCTAAAGGTCAAGCAACAGGAAATGACCGCGTTGATA
TGTCTGCCGTTAAAAAAATCATTGTTGCTTGTGATGCAGGTATGGGTTCAAGTGCAATGGGCGCAAGTCTATTACGCAAA
AAAGTGCAAGCTGCAAATTTAAATATTGAAGTGATTAATACTGCGATCAATGATTTGCCTGGTGATGTTGATATTGTTGT
TACTCATAAAGATTTAACCGACAGAGCACGTAAGCATGCGCCCAATGCACAGCATATTTCATTAACTAATTTCTTAGATA
ATGCGATGTATGACAATTTGGTTAAAGATCTTAAATCGGCTAAAAGCTAG

Upstream 100 bases:

>100_bases
ACGTTCGCTTTTAAAATAATGTGGTACTTTTGCTCGTGAAATTTCAACCTCATTAATTATTTCACCCATTTTGGGTGAAT
GAAGACACTCGGAGCAAATT

Downstream 100 bases:

>100_bases
ATTGAGCAAAAAAGCCTGAAGGTCCTATCTTTCAGGGACTCAAGGCGACTAAATATTAAAGGCTAGATTTTCTAGCCTTT
TTTATATTTAGGGAAATATT

Product: PTS system, mannitol-specific IIABC protein

Products: NA

Alternate protein names: EIICBA-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component; Mannitol-specific phosphotransferase enzyme IIA component; PTS system mannitol-specific EIIA component [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MLSSQSKIKVQNFGRLLSNMVMPNIGAFIAWGLITALFIPTGWIPNETLATMVGPMIKYMLPLLIGYTGGKIIAGERGAV
VGAIATMGVIVGTDIPMFMGAMIVGPLGGLAIKKFDAAIHGKVKSGFEMLVNNFSSGIIGMVLAIIAYVVIGPAVKMLST
ALAAGVDVLVVNNLLPLTSIFVEPAKILFLNNAINHGIFTPLGIAQSESLGQSVFFLIEANPGPGLGLLLAYMVFGKGSA
KETAPGAVIIHFFGGIHEIYFPYVLMNPRLILSVIAGGMTGVFVLTLFDAGLISPASPGSIFAVLAMTPKGAYMGILLSV
AAAAAVSFVVASILMKTQKTVAGDEVALEEAANQMRDMKQSAKGQATGNDRVDMSAVKKIIVACDAGMGSSAMGASLLRK
KVQAANLNIEVINTAINDLPGDVDIVVTHKDLTDRARKHAPNAQHISLTNFLDNAMYDNLVKDLKSAKS

Sequences:

>Translated_469_residues
MLSSQSKIKVQNFGRLLSNMVMPNIGAFIAWGLITALFIPTGWIPNETLATMVGPMIKYMLPLLIGYTGGKIIAGERGAV
VGAIATMGVIVGTDIPMFMGAMIVGPLGGLAIKKFDAAIHGKVKSGFEMLVNNFSSGIIGMVLAIIAYVVIGPAVKMLST
ALAAGVDVLVVNNLLPLTSIFVEPAKILFLNNAINHGIFTPLGIAQSESLGQSVFFLIEANPGPGLGLLLAYMVFGKGSA
KETAPGAVIIHFFGGIHEIYFPYVLMNPRLILSVIAGGMTGVFVLTLFDAGLISPASPGSIFAVLAMTPKGAYMGILLSV
AAAAAVSFVVASILMKTQKTVAGDEVALEEAANQMRDMKQSAKGQATGNDRVDMSAVKKIIVACDAGMGSSAMGASLLRK
KVQAANLNIEVINTAINDLPGDVDIVVTHKDLTDRARKHAPNAQHISLTNFLDNAMYDNLVKDLKSAKS
>Mature_469_residues
MLSSQSKIKVQNFGRLLSNMVMPNIGAFIAWGLITALFIPTGWIPNETLATMVGPMIKYMLPLLIGYTGGKIIAGERGAV
VGAIATMGVIVGTDIPMFMGAMIVGPLGGLAIKKFDAAIHGKVKSGFEMLVNNFSSGIIGMVLAIIAYVVIGPAVKMLST
ALAAGVDVLVVNNLLPLTSIFVEPAKILFLNNAINHGIFTPLGIAQSESLGQSVFFLIEANPGPGLGLLLAYMVFGKGSA
KETAPGAVIIHFFGGIHEIYFPYVLMNPRLILSVIAGGMTGVFVLTLFDAGLISPASPGSIFAVLAMTPKGAYMGILLSV
AAAAAVSFVVASILMKTQKTVAGDEVALEEAANQMRDMKQSAKGQATGNDRVDMSAVKKIIVACDAGMGSSAMGASLLRK
KVQAANLNIEVINTAINDLPGDVDIVVTHKDLTDRARKHAPNAQHISLTNFLDNAMYDNLVKDLKSAKS

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=471, Percent_Identity=69.4267515923567, Blast_Score=645, Evalue=0.0,
Organism=Escherichia coli, GI1789301, Length=467, Percent_Identity=50.9635974304068, Blast_Score=483, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 49089; Mature: 49089

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSSQSKIKVQNFGRLLSNMVMPNIGAFIAWGLITALFIPTGWIPNETLATMVGPMIKYM
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LPLLIGYTGGKIIAGERGAVVGAIATMGVIVGTDIPMFMGAMIVGPLGGLAIKKFDAAIH
HHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
GKVKSGFEMLVNNFSSGIIGMVLAIIAYVVIGPAVKMLSTALAAGVDVLVVNNLLPLTSI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHCHHHHHHH
FVEPAKILFLNNAINHGIFTPLGIAQSESLGQSVFFLIEANPGPGLGLLLAYMVFGKGSA
HHCCHHEEEEECHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCC
KETAPGAVIIHFFGGIHEIYFPYVLMNPRLILSVIAGGMTGVFVLTLFDAGLISPASPGS
CCCCCCEEEEEHHCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCC
IFAVLAMTPKGAYMGILLSVAAAAAVSFVVASILMKTQKTVAGDEVALEEAANQMRDMKQ
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
SAKGQATGNDRVDMSAVKKIIVACDAGMGSSAMGASLLRKKVQAANLNIEVINTAINDLP
HCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHCCC
GDVDIVVTHKDLTDRARKHAPNAQHISLTNFLDNAMYDNLVKDLKSAKS
CCEEEEEECCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLSSQSKIKVQNFGRLLSNMVMPNIGAFIAWGLITALFIPTGWIPNETLATMVGPMIKYM
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LPLLIGYTGGKIIAGERGAVVGAIATMGVIVGTDIPMFMGAMIVGPLGGLAIKKFDAAIH
HHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
GKVKSGFEMLVNNFSSGIIGMVLAIIAYVVIGPAVKMLSTALAAGVDVLVVNNLLPLTSI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHCHHHHHHH
FVEPAKILFLNNAINHGIFTPLGIAQSESLGQSVFFLIEANPGPGLGLLLAYMVFGKGSA
HHCCHHEEEEECHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCC
KETAPGAVIIHFFGGIHEIYFPYVLMNPRLILSVIAGGMTGVFVLTLFDAGLISPASPGS
CCCCCCEEEEEHHCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCC
IFAVLAMTPKGAYMGILLSVAAAAAVSFVVASILMKTQKTVAGDEVALEEAANQMRDMKQ
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
SAKGQATGNDRVDMSAVKKIIVACDAGMGSSAMGASLLRKKVQAANLNIEVINTAINDLP
HCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHCCC
GDVDIVVTHKDLTDRARKHAPNAQHISLTNFLDNAMYDNLVKDLKSAKS
CCEEEEEECCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]