Click here to switch to the map view.

The map label for this gene is paaN [H]

Identifier: 119944421

GI number: 119944421

Start: 834744

End: 836795

Strand: Direct

Name: paaN [H]

Synonym: Ping_0649

Alternate gene names: 119944421

Gene position: 834744-836795 (Clockwise)

Preceding gene: 119944417

Following gene: 119944422

Centisome position: 18.31

GC content: 43.57

Gene sequence:

>2052_bases
ATGCAGAAACTACACAGTTACGTTATGGGAAATTGGTATTACGGAAAAAACAAACCGCGAGTAACGTCTAGCGCACTCAC
TAATGAAGGACTTTATGAGCTGGACAGTTCTGGTATTGACAATGCGGCAATGCTTGAATACGGTAGAAAAAAAGGCAGTA
AAGCATTGGCTTCAATGACATTTCTTGAACGAGGAAATATGTTAAAAGAGGTTGCTAAATACATACTGGCTCATAAAGAA
GAGCTCTATGCACTGTCGGCACAGACGGGTGCAACACGTGTTGATTCATGGGTCGATATTGAAGGTGGCGCTGCAACTTT
TTTTAATAATTCAGGTCTTGCTAATCGCGAATTACCCAATGAAACCATCTGGGCAGAAGATGATTTAATCCCGCTATCTA
AAAGTGGCTCATTTGCAGCACGACATATTCTGACTTCAAAACCGGGTGTCGCAATCCATATCAATGCATATAATTTCCCC
TGCTGGGGTATGTTAGAAAAGCTTGCCCCAACCTGGCTTGGTGGAATGGCTGCCATTATTAAACCCGGTTCTGAATCTGC
ATTTTTAACCCAGGCCATGGTTAAAATGATCGTTGAGAGCGGTCTGGTACCAGAAGGGGCCATTCAAGTTGTTTGTGGAT
CTGTTGGTAATTTACTCGATTGTGTTGATTATCAAGATGTCGTCACTTTTACAGGTTCAGCTAAAACCGGGCACATGTTA
CGAGCAACAGATAATCTGATTAAAAAATCAATTCCCTTCACCATGGAAGTTGACTCTATAAACTGCGCTGTCCTTGGCGA
TGATGTCACCATTGACTCACCCGAATTTAAGTTGTTTGTTAAAGAAGTTTGTCGTGAAATGACCATTAAAGCAGGACAAA
AATGTACTGCTATTCGTCGTGCAATGGTGCCGTCCCACCTGCTTAGTGAAGCACGTGATGCAATAAAAATACGCCTTGAA
AGAATAGTGGTCGGTGACCCAAGTATTAAAGACGTTACTATGGGACCGCTTATTAGTCAGTCTCAACTTGATGATGTTAA
AGAAAAAGTAGCTTTACTAAGCCATGATTGTGAGATTGTTACCGGTGGTGATATGTTAAATTTCACGCCACAAGGCTCTG
AAAATGGCGCTTATTTCCCACCCACATTATTAGTCTGTAATGAACCTCAAGCATCGACAACTATTCATGATGTTGAAGCC
TTTGGCCCTGTTTGTACATTAATGCCATACCAGGATCGTGATTCTCTTACTGAGTTAATTGCCCTGGGTAAAGGCAGTCT
TGTTGGCAGTCTTGTGACAGCATCAGGCAGCTTTGCATCAGAAATGGTAAGCCGAATCGGTCATCTGCACGGGCGCTTGC
ATATCCTAAATGCCGAATCATCTAAAGAATCGACAGGTCACGGCTCACCACTGCCGATGTTAATTCATGGTGGTCCTGGC
CGTGCCGGCGGCGGGGAAGAAATGGGCGGGCTACGTGGTATTAAGCACTATATGCAACGTACTGCTATTCAAGGATCACC
AACCATGATTGCGAGTGTAGGCAAAGAATGGGTTCGAGGCGCGCAAACAACAACCGATCTCGTCCATCCTTTTAAGAAAT
ATTTTGAAAATATTGCCGTTGGCGAAAGCTTGAAAACCGCACGGCGTACCATAACAGAAACTGATATTGTTAACTTTGCC
TGTTTAAGTGGCGATCATTTTTATGCGCACATGGATGATATTGCAGCAAAAGAATCGATGTTTGGTCAACGGGTTGCACA
TGGTTATTTTATTATTTCCGCCGCTGCTGGTTTATTTGTTGAAGCCGCTCCTGGTCCTGTTTTAGCAAACTATGGTATGG
AAAGTCTCAGGTTTGTTGAAGCGGTCGCAATTGGCGATACTATTCAGGTAGTATTAACCTGCCAAAAGAAAACTAAAAAG
CGCCAGAAGCTCGAAGAGGACACGCCTCAAGGTGTGGTTGCCTGGGATGTAGAAGTCACTAATCAACATGGTAACCCCGT
TGCCCTTTATACAATACTAACCCTTGTCGCGCGGGAAAAGGGAGACTTTTAA

Upstream 100 bases:

>100_bases
GAAGTTTTAACGTTCAGATGAAAAATAAGTTTTAACCTTAAAAAGTGACAACGCACAATAGGGCAATAAGATTTCATTCA
TAATCAATAGGAATAAAATA

Downstream 100 bases:

>100_bases
TGATTATCCCCAACAGATAATTATTATTTTAAACAGCTAATCATTATCGATTAGCTGTTTTTTTTACTTCAAAAAAAATA
TTAAAAACCGCCTCAATATT

Product: bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase

Products: NA

Alternate protein names: Phenylacetic acid degradation protein paaZ [H]

Number of amino acids: Translated: 683; Mature: 683

Protein sequence:

>683_residues
MQKLHSYVMGNWYYGKNKPRVTSSALTNEGLYELDSSGIDNAAMLEYGRKKGSKALASMTFLERGNMLKEVAKYILAHKE
ELYALSAQTGATRVDSWVDIEGGAATFFNNSGLANRELPNETIWAEDDLIPLSKSGSFAARHILTSKPGVAIHINAYNFP
CWGMLEKLAPTWLGGMAAIIKPGSESAFLTQAMVKMIVESGLVPEGAIQVVCGSVGNLLDCVDYQDVVTFTGSAKTGHML
RATDNLIKKSIPFTMEVDSINCAVLGDDVTIDSPEFKLFVKEVCREMTIKAGQKCTAIRRAMVPSHLLSEARDAIKIRLE
RIVVGDPSIKDVTMGPLISQSQLDDVKEKVALLSHDCEIVTGGDMLNFTPQGSENGAYFPPTLLVCNEPQASTTIHDVEA
FGPVCTLMPYQDRDSLTELIALGKGSLVGSLVTASGSFASEMVSRIGHLHGRLHILNAESSKESTGHGSPLPMLIHGGPG
RAGGGEEMGGLRGIKHYMQRTAIQGSPTMIASVGKEWVRGAQTTTDLVHPFKKYFENIAVGESLKTARRTITETDIVNFA
CLSGDHFYAHMDDIAAKESMFGQRVAHGYFIISAAAGLFVEAAPGPVLANYGMESLRFVEAVAIGDTIQVVLTCQKKTKK
RQKLEEDTPQGVVAWDVEVTNQHGNPVALYTILTLVAREKGDF

Sequences:

>Translated_683_residues
MQKLHSYVMGNWYYGKNKPRVTSSALTNEGLYELDSSGIDNAAMLEYGRKKGSKALASMTFLERGNMLKEVAKYILAHKE
ELYALSAQTGATRVDSWVDIEGGAATFFNNSGLANRELPNETIWAEDDLIPLSKSGSFAARHILTSKPGVAIHINAYNFP
CWGMLEKLAPTWLGGMAAIIKPGSESAFLTQAMVKMIVESGLVPEGAIQVVCGSVGNLLDCVDYQDVVTFTGSAKTGHML
RATDNLIKKSIPFTMEVDSINCAVLGDDVTIDSPEFKLFVKEVCREMTIKAGQKCTAIRRAMVPSHLLSEARDAIKIRLE
RIVVGDPSIKDVTMGPLISQSQLDDVKEKVALLSHDCEIVTGGDMLNFTPQGSENGAYFPPTLLVCNEPQASTTIHDVEA
FGPVCTLMPYQDRDSLTELIALGKGSLVGSLVTASGSFASEMVSRIGHLHGRLHILNAESSKESTGHGSPLPMLIHGGPG
RAGGGEEMGGLRGIKHYMQRTAIQGSPTMIASVGKEWVRGAQTTTDLVHPFKKYFENIAVGESLKTARRTITETDIVNFA
CLSGDHFYAHMDDIAAKESMFGQRVAHGYFIISAAAGLFVEAAPGPVLANYGMESLRFVEAVAIGDTIQVVLTCQKKTKK
RQKLEEDTPQGVVAWDVEVTNQHGNPVALYTILTLVAREKGDF
>Mature_683_residues
MQKLHSYVMGNWYYGKNKPRVTSSALTNEGLYELDSSGIDNAAMLEYGRKKGSKALASMTFLERGNMLKEVAKYILAHKE
ELYALSAQTGATRVDSWVDIEGGAATFFNNSGLANRELPNETIWAEDDLIPLSKSGSFAARHILTSKPGVAIHINAYNFP
CWGMLEKLAPTWLGGMAAIIKPGSESAFLTQAMVKMIVESGLVPEGAIQVVCGSVGNLLDCVDYQDVVTFTGSAKTGHML
RATDNLIKKSIPFTMEVDSINCAVLGDDVTIDSPEFKLFVKEVCREMTIKAGQKCTAIRRAMVPSHLLSEARDAIKIRLE
RIVVGDPSIKDVTMGPLISQSQLDDVKEKVALLSHDCEIVTGGDMLNFTPQGSENGAYFPPTLLVCNEPQASTTIHDVEA
FGPVCTLMPYQDRDSLTELIALGKGSLVGSLVTASGSFASEMVSRIGHLHGRLHILNAESSKESTGHGSPLPMLIHGGPG
RAGGGEEMGGLRGIKHYMQRTAIQGSPTMIASVGKEWVRGAQTTTDLVHPFKKYFENIAVGESLKTARRTITETDIVNFA
CLSGDHFYAHMDDIAAKESMFGQRVAHGYFIISAAAGLFVEAAPGPVLANYGMESLRFVEAVAIGDTIQVVLTCQKKTKK
RQKLEEDTPQGVVAWDVEVTNQHGNPVALYTILTLVAREKGDF

Specific function: Phenylacetic acid aerobic catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI153266822, Length=430, Percent_Identity=24.6511627906977, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI115387104, Length=457, Percent_Identity=24.945295404814, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI25777724, Length=477, Percent_Identity=23.6897274633124, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI25777728, Length=447, Percent_Identity=23.9373601789709, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI12007648, Length=276, Percent_Identity=25.7246376811594, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI25777730, Length=401, Percent_Identity=22.9426433915212, Blast_Score=70, Evalue=9e-12,
Organism=Homo sapiens, GI4507229, Length=283, Percent_Identity=25.0883392226148, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI21361176, Length=373, Percent_Identity=23.8605898123324, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI25777732, Length=406, Percent_Identity=21.9211822660099, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI1787653, Length=684, Percent_Identity=62.5730994152047, Blast_Score=867, Evalue=0.0,
Organism=Escherichia coli, GI1786504, Length=464, Percent_Identity=28.2327586206897, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1787684, Length=458, Percent_Identity=25.764192139738, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1789015, Length=419, Percent_Identity=23.6276849642005, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87082295, Length=301, Percent_Identity=25.9136212624585, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI87081896, Length=424, Percent_Identity=25.7075471698113, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788042, Length=444, Percent_Identity=23.4234234234234, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1787715, Length=355, Percent_Identity=25.6338028169014, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787558, Length=407, Percent_Identity=24.3243243243243, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1787250, Length=364, Percent_Identity=21.7032967032967, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081926, Length=310, Percent_Identity=20.9677419354839, Blast_Score=62, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI25143874, Length=464, Percent_Identity=25.2155172413793, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI25143876, Length=462, Percent_Identity=25.1082251082251, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71995606, Length=395, Percent_Identity=26.0759493670886, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71995613, Length=394, Percent_Identity=26.3959390862944, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17551164, Length=459, Percent_Identity=23.0936819172113, Blast_Score=80, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562198, Length=291, Percent_Identity=25.085910652921, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17534119, Length=374, Percent_Identity=25.1336898395722, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25144435, Length=315, Percent_Identity=24.1269841269841, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI32564736, Length=315, Percent_Identity=23.8095238095238, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI133930964, Length=451, Percent_Identity=23.5033259423503, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323822, Length=370, Percent_Identity=25.9459459459459, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6323821, Length=366, Percent_Identity=25.1366120218579, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320917, Length=448, Percent_Identity=22.9910714285714, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6324950, Length=373, Percent_Identity=25.201072386059, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281362580, Length=416, Percent_Identity=25, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI62472918, Length=416, Percent_Identity=25, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI62472926, Length=416, Percent_Identity=25, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI62472936, Length=416, Percent_Identity=25, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21356737, Length=416, Percent_Identity=25, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI20129399, Length=428, Percent_Identity=25.2336448598131, Blast_Score=81, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR002539
- InterPro:   IPR011966 [H]

Pfam domain/function: PF00171 Aldedh; PF01575 MaoC_dehydratas [H]

EC number: NA

Molecular weight: Translated: 73930; Mature: 73930

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLHSYVMGNWYYGKNKPRVTSSALTNEGLYELDSSGIDNAAMLEYGRKKGSKALASMT
CCHHHHHHHCCEEECCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHH
FLERGNMLKEVAKYILAHKEELYALSAQTGATRVDSWVDIEGGAATFFNNSGLANRELPN
HHHHCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCC
ETIWAEDDLIPLSKSGSFAARHILTSKPGVAIHINAYNFPCWGMLEKLAPTWLGGMAAII
CCCCCCCCCEECCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEEE
KPGSESAFLTQAMVKMIVESGLVPEGAIQVVCGSVGNLLDCVDYQDVVTFTGSAKTGHML
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEECCCCCCCEE
RATDNLIKKSIPFTMEVDSINCAVLGDDVTIDSPEFKLFVKEVCREMTIKAGQKCTAIRR
HHHHHHHHHCCCCEEEECCEEEEEECCCEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHH
AMVPSHLLSEARDAIKIRLERIVVGDPSIKDVTMGPLISQSQLDDVKEKVALLSHDCEIV
HHHHHHHHHHHHHHHHEEEEEEEECCCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCEEE
TGGDMLNFTPQGSENGAYFPPTLLVCNEPQASTTIHDVEAFGPVCTLMPYQDRDSLTELI
ECCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHCCCEEEECCCCCHHHHHHHH
ALGKGSLVGSLVTASGSFASEMVSRIGHLHGRLHILNAESSKESTGHGSPLPMLIHGGPG
HHCCCCHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEEECCCC
RAGGGEEMGGLRGIKHYMQRTAIQGSPTMIASVGKEWVRGAQTTTDLVHPFKKYFENIAV
CCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GESLKTARRTITETDIVNFACLSGDHFYAHMDDIAAKESMFGQRVAHGYFIISAAAGLFV
CHHHHHHHHHHHHHHCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHCCEEEEEECCCEEE
EAAPGPVLANYGMESLRFVEAVAIGDTIQVVLTCQKKTKKRQKLEEDTPQGVVAWDVEVT
ECCCCCEEECCCHHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHCCCCCCEEEEEEEEE
NQHGNPVALYTILTLVAREKGDF
CCCCCEEHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQKLHSYVMGNWYYGKNKPRVTSSALTNEGLYELDSSGIDNAAMLEYGRKKGSKALASMT
CCHHHHHHHCCEEECCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHH
FLERGNMLKEVAKYILAHKEELYALSAQTGATRVDSWVDIEGGAATFFNNSGLANRELPN
HHHHCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCC
ETIWAEDDLIPLSKSGSFAARHILTSKPGVAIHINAYNFPCWGMLEKLAPTWLGGMAAII
CCCCCCCCCEECCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEEE
KPGSESAFLTQAMVKMIVESGLVPEGAIQVVCGSVGNLLDCVDYQDVVTFTGSAKTGHML
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEECCCCCCCEE
RATDNLIKKSIPFTMEVDSINCAVLGDDVTIDSPEFKLFVKEVCREMTIKAGQKCTAIRR
HHHHHHHHHCCCCEEEECCEEEEEECCCEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHH
AMVPSHLLSEARDAIKIRLERIVVGDPSIKDVTMGPLISQSQLDDVKEKVALLSHDCEIV
HHHHHHHHHHHHHHHHEEEEEEEECCCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCEEE
TGGDMLNFTPQGSENGAYFPPTLLVCNEPQASTTIHDVEAFGPVCTLMPYQDRDSLTELI
ECCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHCCCEEEECCCCCHHHHHHHH
ALGKGSLVGSLVTASGSFASEMVSRIGHLHGRLHILNAESSKESTGHGSPLPMLIHGGPG
HHCCCCHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEEECCCC
RAGGGEEMGGLRGIKHYMQRTAIQGSPTMIASVGKEWVRGAQTTTDLVHPFKKYFENIAV
CCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GESLKTARRTITETDIVNFACLSGDHFYAHMDDIAAKESMFGQRVAHGYFIISAAAGLFV
CHHHHHHHHHHHHHHCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHCCEEEEEECCCEEE
EAAPGPVLANYGMESLRFVEAVAIGDTIQVVLTCQKKTKKRQKLEEDTPQGVVAWDVEVT
ECCCCCEEECCCHHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHCCCCCCEEEEEEEEE
NQHGNPVALYTILTLVAREKGDF
CCCCCEEHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]