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The map label for this gene is ubiH [H]

Identifier: 119944380

GI number: 119944380

Start: 789589

End: 790809

Strand: Direct

Name: ubiH [H]

Synonym: Ping_0607

Alternate gene names: 119944380

Gene position: 789589-790809 (Clockwise)

Preceding gene: 119944379

Following gene: 119944381

Centisome position: 17.32

GC content: 43.24

Gene sequence:

>1221_bases
ATGGATAAAAATAGTGATTATGACCTTGTTATTGTCGGGGCAGGTATTGTTGGCAGTCTGCTTGCTTATGCCTTATTAAA
GCGCAGTCCAACGCTGAGGGTTGCCCTTGTCGATGAAAACCCGAAACCAGCATCAGGCAGCAAAAGCTCTATTCCGGGGT
TTGATGCGCGCAGTATTGCGCTAAGCGCAGGCACCTGCGATATACTCGATGACTTGGGTTTTTGGGCGGATATTAAAGCG
CATGCCCAGCCGATTGAAGAGATACATATCTCTGATCGCGGTTGTTTCGGGAAATTAGATTTATGCGCTAAAGATGAGCC
TCAAGCATTTGGTTATGTGCTCGAACTGCATCAAATTGGCTGCGCGCTTAACAAACGATTAGATAAGTTAACACAATTAG
CGCGTTTTTATGATTCACGTATTACCAAAATTGAAAAACAGCCAGAGCAGACCCTTTGTCATCTTTTTGATAATACTATT
CTGACGGCTAAATTATGTGTCGCAGCAGATGGAGCAAACAGTTCGACCCGTCATCTGCTGTCGATCCCCTCACAATCTTT
TGATTATGAATGTACTGCGATTATTGCTAATGTGCGTTGTTCTAAGCCGCATCTTAATAAGGCGTTTGAGCGTTTTACCG
AATTTGGTCCTATTGCCTTATTACCCTTAACGGATAATCGTTACTCATTAGTTTGGTCGGTGGCAAGTGGTGATGCTGCC
CGTTTATGCGCATTAAATGACGAACATTTCCTAAGTGAACTGCAGAATGCTTTTGGCTATCTGGCAGGCGTGTTTACTGC
GGCTGGAAAACGGGACAGCTACCCGCTGAAATTGACAAAAACGACACAACCTTTTGCCCACAGAGGTGTTTGTATTGGTA
ATGCTGCTCATTGTCTGCACCCTGTGATGGGGCAGGGATTTAACTTAGGGATGCGTGATTTGTTTGTATTATCTTCCATT
ATCAGTGAGTTGCAGGACCCTCAAAAAATAGGTGGTTTTGATATGCTGAATCGTTATTGGTTAGCGCGAGAGAGCGACCA
TAATAATACCATCAGTCTCACGGATTCAGTCGTGCGTATTTTTAATAATAACCATTGGCCGATTATACTGGGACGAAATG
TTGTCTTACAGGCGATGCGTTATTTATCCGATTTATCAGTTCCTATTATAAAACAGGCGAAAGGGCAGTTTCCATTACTC
AGTAGAGATACAAACAAATGA

Upstream 100 bases:

>100_bases
GATGATGTCTTAGTGACTCAAAGTGGCGCTGAAGTGTTAAGCGCGGATGTCCCTAAGAGTATTAATGAAATTGAAGCATT
AATGGCCAATGTAACTGTCT

Downstream 100 bases:

>100_bases
TGCAATCATACGACTTAACCATAGTAGGTGGCGGAATTGTCGGGCTGACGTTGGCAGCCTCCCTCGCAGACAGAGCATTA
TCGATTGCGCTGATTGAAAC

Product: 2-octaprenyl-6-methoxyphenol hydroxylase UbiH

Products: H2O; 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MDKNSDYDLVIVGAGIVGSLLAYALLKRSPTLRVALVDENPKPASGSKSSIPGFDARSIALSAGTCDILDDLGFWADIKA
HAQPIEEIHISDRGCFGKLDLCAKDEPQAFGYVLELHQIGCALNKRLDKLTQLARFYDSRITKIEKQPEQTLCHLFDNTI
LTAKLCVAADGANSSTRHLLSIPSQSFDYECTAIIANVRCSKPHLNKAFERFTEFGPIALLPLTDNRYSLVWSVASGDAA
RLCALNDEHFLSELQNAFGYLAGVFTAAGKRDSYPLKLTKTTQPFAHRGVCIGNAAHCLHPVMGQGFNLGMRDLFVLSSI
ISELQDPQKIGGFDMLNRYWLARESDHNNTISLTDSVVRIFNNNHWPIILGRNVVLQAMRYLSDLSVPIIKQAKGQFPLL
SRDTNK

Sequences:

>Translated_406_residues
MDKNSDYDLVIVGAGIVGSLLAYALLKRSPTLRVALVDENPKPASGSKSSIPGFDARSIALSAGTCDILDDLGFWADIKA
HAQPIEEIHISDRGCFGKLDLCAKDEPQAFGYVLELHQIGCALNKRLDKLTQLARFYDSRITKIEKQPEQTLCHLFDNTI
LTAKLCVAADGANSSTRHLLSIPSQSFDYECTAIIANVRCSKPHLNKAFERFTEFGPIALLPLTDNRYSLVWSVASGDAA
RLCALNDEHFLSELQNAFGYLAGVFTAAGKRDSYPLKLTKTTQPFAHRGVCIGNAAHCLHPVMGQGFNLGMRDLFVLSSI
ISELQDPQKIGGFDMLNRYWLARESDHNNTISLTDSVVRIFNNNHWPIILGRNVVLQAMRYLSDLSVPIIKQAKGQFPLL
SRDTNK
>Mature_406_residues
MDKNSDYDLVIVGAGIVGSLLAYALLKRSPTLRVALVDENPKPASGSKSSIPGFDARSIALSAGTCDILDDLGFWADIKA
HAQPIEEIHISDRGCFGKLDLCAKDEPQAFGYVLELHQIGCALNKRLDKLTQLARFYDSRITKIEKQPEQTLCHLFDNTI
LTAKLCVAADGANSSTRHLLSIPSQSFDYECTAIIANVRCSKPHLNKAFERFTEFGPIALLPLTDNRYSLVWSVASGDAA
RLCALNDEHFLSELQNAFGYLAGVFTAAGKRDSYPLKLTKTTQPFAHRGVCIGNAAHCLHPVMGQGFNLGMRDLFVLSSI
ISELQDPQKIGGFDMLNRYWLARESDHNNTISLTDSVVRIFNNNHWPIILGRNVVLQAMRYLSDLSVPIIKQAKGQFPLL
SRDTNK

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=403, Percent_Identity=27.2952853598015, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI32967307, Length=341, Percent_Identity=29.0322580645161, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1789274, Length=379, Percent_Identity=39.8416886543536, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1789273, Length=394, Percent_Identity=28.6802030456853, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1786883, Length=396, Percent_Identity=27.5252525252525, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI25146631, Length=427, Percent_Identity=25.7611241217799, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321694, Length=454, Percent_Identity=23.568281938326, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19920760, Length=452, Percent_Identity=24.5575221238938, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.- [C]

Molecular weight: Translated: 44811; Mature: 44811

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKNSDYDLVIVGAGIVGSLLAYALLKRSPTLRVALVDENPKPASGSKSSIPGFDARSIA
CCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEE
LSAGTCDILDDLGFWADIKAHAQPIEEIHISDRGCFGKLDLCAKDEPQAFGYVLELHQIG
EECCCHHHHHHCCCHHHHHHHHCCHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
CALNKRLDKLTQLARFYDSRITKIEKQPEQTLCHLFDNTILTAKLCVAADGANSSTRHLL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHEEEEEEEEECCCCCCCCEEE
SIPSQSFDYECTAIIANVRCSKPHLNKAFERFTEFGPIALLPLTDNRYSLVWSVASGDAA
ECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCE
RLCALNDEHFLSELQNAFGYLAGVFTAAGKRDSYPLKLTKTTQPFAHRGVCIGNAAHCLH
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCEEECCHHHHHH
PVMGQGFNLGMRDLFVLSSIISELQDPQKIGGFDMLNRYWLARESDHNNTISLTDSVVRI
HHHCCCCCCCHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHEECCCCCCEEEHHHHHHHH
FNNNHWPIILGRNVVLQAMRYLSDLSVPIIKQAKGQFPLLSRDTNK
HCCCCCEEEECCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MDKNSDYDLVIVGAGIVGSLLAYALLKRSPTLRVALVDENPKPASGSKSSIPGFDARSIA
CCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEE
LSAGTCDILDDLGFWADIKAHAQPIEEIHISDRGCFGKLDLCAKDEPQAFGYVLELHQIG
EECCCHHHHHHCCCHHHHHHHHCCHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
CALNKRLDKLTQLARFYDSRITKIEKQPEQTLCHLFDNTILTAKLCVAADGANSSTRHLL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHEEEEEEEEECCCCCCCCEEE
SIPSQSFDYECTAIIANVRCSKPHLNKAFERFTEFGPIALLPLTDNRYSLVWSVASGDAA
ECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCE
RLCALNDEHFLSELQNAFGYLAGVFTAAGKRDSYPLKLTKTTQPFAHRGVCIGNAAHCLH
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCEEECCHHHHHH
PVMGQGFNLGMRDLFVLSSIISELQDPQKIGGFDMLNRYWLARESDHNNTISLTDSVVRI
HHHCCCCCCCHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHEECCCCCCEEEHHHHHHHH
FNNNHWPIILGRNVVLQAMRYLSDLSVPIIKQAKGQFPLLSRDTNK
HCCCCCEEEECCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-octaprenyl-6-methoxyphenol; O2 [C]

Specific reaction: 2-octaprenyl-6-methoxyphenol + O2 = H2O + 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]