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The map label for this gene is pepP [H]

Identifier: 119944379

GI number: 119944379

Start: 788277

End: 789596

Strand: Direct

Name: pepP [H]

Synonym: Ping_0606

Alternate gene names: 119944379

Gene position: 788277-789596 (Clockwise)

Preceding gene: 119944378

Following gene: 119944380

Centisome position: 17.29

GC content: 41.06

Gene sequence:

>1320_bases
ATGGTAATGACTGAATTTCAACAACGCAGAGCCTCTTTTTTTACAAAGATGCAAAATAATAGTCTGGCTATTTTTCCGGC
AGCGGAAGAAAAGATACGCAGTAAAGATACTGAATATCCTTTCCGGCAAAATAGTGACTTTTATTATTTAACGGGTTTTA
ATGAGCCGGATGCTTATTTGCTGATTATCAATAAGTGTGGTGAGCAGCAAACAGTTTTATTTAATCGAAAAAAAGATAAA
AATGCGGAAATTTGGCATGGTCTGCGCATGGGACAAAGTGCCGCCGTGAGTACACTTGGTTTTGATCTGGCTTATGATGT
TCTCGAATTTGAAGAGCAACTGCAGGGCTTTATTGGTGACTTTTCTGTGCTTTATTATCCCGTTTTTAATGCGCCCGAAT
TGGAAAAACGCTTAAGTTCTGTGATTAACTTAATGCGGGCAGATCGCAGCAAAGGACAGGCTGCGCCTACGCAGTTTATT
GATAACCTTGCCATTGTGCATGAAATGCGTCTAATTAAATCTGAAAATGAAATGGCATTGATGTCTGATGCGGCTGAAAT
TTCAGCGGCGGGGCACATCAGAGCCATGCAGCTTTGTCATCCAGGCATGTGGGAATACCAGTTAGAAGCAGAAATTCGCT
ACGAATTTGCTCAACAGGGTGCGACGAATGTTGCTTATAACAGTATCGTTGCTGGTGGCCATCATGCTTGTATTTTACAT
TACACGGAAAATAATCAACAGTTACATGATGGGGATCTGGTCTTAATTGATGCCGGTGCTGAATATAAGGGCTATGCAGG
TGATATCACCCGAACCTTTCCTGTTAATGGTATTTTTTCTGAGCATCAGGCAAAACTATATCAACTGGTTTTGAATATTC
AAGTAAGTGCGATTAATCAGGTAAAGCCCGGTGTTGCCTTGGCCGATATTAATAAAAGTGCCGTTAAGAAAATGATTGAG
GGTCTGCTTGAATTGGGGATTGTAGAAGGAGACAGTGAGCAGCTGATAAAGGATCAGGCTCATAAAGAGTTTTATATGCA
TGGTCTGGGTCATTATTTAGGATTAGATGTGCATGATGTAGGCTTATACGGTACTGCTGAACATCCCCGTTTACTCGAAG
CAGGTATGGTGATCACCATTGAGCCTGGTATATATATCAGTGAAAATGCTAACGTCGATGATGTTTGGAAGGGCATTGGT
ATTCGCATCGAAGATGATGTCTTAGTGACTCAAAGTGGCGCTGAAGTGTTAAGCGCGGATGTCCCTAAGAGTATTAATGA
AATTGAAGCATTAATGGCCAATGTAACTGTCTATGGATAA

Upstream 100 bases:

>100_bases
TGTTGAGTATCTTCGTGTTGGCGCAATGCTTTGCTTTAATACTTTTTCACGTAACCCCAACACACCCATTTCAAAAACCC
TTCACTAGGATTAATAATTA

Downstream 100 bases:

>100_bases
AAATAGTGATTATGACCTTGTTATTGTCGGGGCAGGTATTGTTGGCAGTCTGCTTGCTTATGCCTTATTAAAGCGCAGTC
CAACGCTGAGGGTTGCCCTT

Product: peptidase M24

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MVMTEFQQRRASFFTKMQNNSLAIFPAAEEKIRSKDTEYPFRQNSDFYYLTGFNEPDAYLLIINKCGEQQTVLFNRKKDK
NAEIWHGLRMGQSAAVSTLGFDLAYDVLEFEEQLQGFIGDFSVLYYPVFNAPELEKRLSSVINLMRADRSKGQAAPTQFI
DNLAIVHEMRLIKSENEMALMSDAAEISAAGHIRAMQLCHPGMWEYQLEAEIRYEFAQQGATNVAYNSIVAGGHHACILH
YTENNQQLHDGDLVLIDAGAEYKGYAGDITRTFPVNGIFSEHQAKLYQLVLNIQVSAINQVKPGVALADINKSAVKKMIE
GLLELGIVEGDSEQLIKDQAHKEFYMHGLGHYLGLDVHDVGLYGTAEHPRLLEAGMVITIEPGIYISENANVDDVWKGIG
IRIEDDVLVTQSGAEVLSADVPKSINEIEALMANVTVYG

Sequences:

>Translated_439_residues
MVMTEFQQRRASFFTKMQNNSLAIFPAAEEKIRSKDTEYPFRQNSDFYYLTGFNEPDAYLLIINKCGEQQTVLFNRKKDK
NAEIWHGLRMGQSAAVSTLGFDLAYDVLEFEEQLQGFIGDFSVLYYPVFNAPELEKRLSSVINLMRADRSKGQAAPTQFI
DNLAIVHEMRLIKSENEMALMSDAAEISAAGHIRAMQLCHPGMWEYQLEAEIRYEFAQQGATNVAYNSIVAGGHHACILH
YTENNQQLHDGDLVLIDAGAEYKGYAGDITRTFPVNGIFSEHQAKLYQLVLNIQVSAINQVKPGVALADINKSAVKKMIE
GLLELGIVEGDSEQLIKDQAHKEFYMHGLGHYLGLDVHDVGLYGTAEHPRLLEAGMVITIEPGIYISENANVDDVWKGIG
IRIEDDVLVTQSGAEVLSADVPKSINEIEALMANVTVYG
>Mature_439_residues
MVMTEFQQRRASFFTKMQNNSLAIFPAAEEKIRSKDTEYPFRQNSDFYYLTGFNEPDAYLLIINKCGEQQTVLFNRKKDK
NAEIWHGLRMGQSAAVSTLGFDLAYDVLEFEEQLQGFIGDFSVLYYPVFNAPELEKRLSSVINLMRADRSKGQAAPTQFI
DNLAIVHEMRLIKSENEMALMSDAAEISAAGHIRAMQLCHPGMWEYQLEAEIRYEFAQQGATNVAYNSIVAGGHHACILH
YTENNQQLHDGDLVLIDAGAEYKGYAGDITRTFPVNGIFSEHQAKLYQLVLNIQVSAINQVKPGVALADINKSAVKKMIE
GLLELGIVEGDSEQLIKDQAHKEFYMHGLGHYLGLDVHDVGLYGTAEHPRLLEAGMVITIEPGIYISENANVDDVWKGIG
IRIEDDVLVTQSGAEVLSADVPKSINEIEALMANVTVYG

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=411, Percent_Identity=36.2530413625304, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI149589008, Length=468, Percent_Identity=29.9145299145299, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI260593665, Length=378, Percent_Identity=32.010582010582, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI260593663, Length=456, Percent_Identity=28.2894736842105, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1789275, Length=429, Percent_Identity=48.951048951049, Blast_Score=430, Evalue=1e-121,
Organism=Escherichia coli, GI1788728, Length=270, Percent_Identity=32.2222222222222, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1790282, Length=300, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17508215, Length=470, Percent_Identity=31.2765957446809, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI71989583, Length=378, Percent_Identity=27.2486772486773, Blast_Score=139, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6321118, Length=450, Percent_Identity=31.1111111111111, Blast_Score=189, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6320922, Length=440, Percent_Identity=29.0909090909091, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI19920384, Length=453, Percent_Identity=35.3200883002208, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI21357079, Length=447, Percent_Identity=32.4384787472036, Blast_Score=210, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49010; Mature: 49010

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMTEFQQRRASFFTKMQNNSLAIFPAAEEKIRSKDTEYPFRQNSDFYYLTGFNEPDAYL
CCCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCCCCCCCEEEEECCCCCCEEE
LIINKCGEQQTVLFNRKKDKNAEIWHGLRMGQSAAVSTLGFDLAYDVLEFEEQLQGFIGD
EEEECCCCCEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FSVLYYPVFNAPELEKRLSSVINLMRADRSKGQAAPTQFIDNLAIVHEMRLIKSENEMAL
CEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
MSDAAEISAAGHIRAMQLCHPGMWEYQLEAEIRYEFAQQGATNVAYNSIVAGGHHACILH
HHCHHHHHHCCCCEEEECCCCCCCEEEEEHHHHHHHHHCCCCHHHHHHEECCCCEEEEEE
YTENNQQLHDGDLVLIDAGAEYKGYAGDITRTFPVNGIFSEHQAKLYQLVLNIQVSAINQ
EECCCCEEECCCEEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHEEEEEHHC
VKPGVALADINKSAVKKMIEGLLELGIVEGDSEQLIKDQAHKEFYMHGLGHYLGLDVHDV
CCCCEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
GLYGTAEHPRLLEAGMVITIEPGIYISENANVDDVWKGIGIRIEDDVLVTQSGAEVLSAD
CEECCCCCCCHHHCCEEEEECCCEEEECCCCHHHHHHCCCEEEECCEEEECCCCHHHHCC
VPKSINEIEALMANVTVYG
CCCHHHHHHHHHHHEEECC
>Mature Secondary Structure
MVMTEFQQRRASFFTKMQNNSLAIFPAAEEKIRSKDTEYPFRQNSDFYYLTGFNEPDAYL
CCCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCCCCCCCEEEEECCCCCCEEE
LIINKCGEQQTVLFNRKKDKNAEIWHGLRMGQSAAVSTLGFDLAYDVLEFEEQLQGFIGD
EEEECCCCCEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FSVLYYPVFNAPELEKRLSSVINLMRADRSKGQAAPTQFIDNLAIVHEMRLIKSENEMAL
CEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
MSDAAEISAAGHIRAMQLCHPGMWEYQLEAEIRYEFAQQGATNVAYNSIVAGGHHACILH
HHCHHHHHHCCCCEEEECCCCCCCEEEEEHHHHHHHHHCCCCHHHHHHEECCCCEEEEEE
YTENNQQLHDGDLVLIDAGAEYKGYAGDITRTFPVNGIFSEHQAKLYQLVLNIQVSAINQ
EECCCCEEECCCEEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHEEEEEHHC
VKPGVALADINKSAVKKMIEGLLELGIVEGDSEQLIKDQAHKEFYMHGLGHYLGLDVHDV
CCCCEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
GLYGTAEHPRLLEAGMVITIEPGIYISENANVDDVWKGIGIRIEDDVLVTQSGAEVLSAD
CEECCCCCCCHHHCCEEEEECCCEEEECCCCHHHHHHCCCEEEECCEEEECCCCHHHHCC
VPKSINEIEALMANVTVYG
CCCHHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]