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The map label for this gene is mdtL [H]

Identifier: 119944316

GI number: 119944316

Start: 693556

End: 694758

Strand: Reverse

Name: mdtL [H]

Synonym: Ping_0543

Alternate gene names: 119944316

Gene position: 694758-693556 (Counterclockwise)

Preceding gene: 119944325

Following gene: 119944314

Centisome position: 15.24

GC content: 46.47

Gene sequence:

>1203_bases
ATGCGCAAAAATATATTACCGATGTTGATGTCGATGGTGGTTTTAAGCCCGCTTGCCATCGATATCTATCTGCCTTCAAT
GCCGGCAATGGCCGCAGAATTTAATGTTTCATCCAGCGAAATACAGTCAACCTTAGTATTGTTTTTATTCGCAATGGGGG
TAGGACAAATATTAATTGGTCCACTCGCGGATCGTTTTGGTAGACGCCCTATTGCACTCGCCGGAATGGTACTTTACGTG
GCAAGCAGTTTGCTGGCGGCGAATGTTATAGAGTTCCACTGGCTACAATTTGCGCGGGTATTACAGGGGCTTGCGGCATG
CGCCACTTCGATAGTGGTCTTTAGTGCGGTACGTGACAGTTATACGGCCAAACAAGGTGCCTATTATTACAGTTATCTCA
ACGGAGTTATCTGCGTGATTCCGGCATTGGCACCCACCCTGGGCGGATTGCTTGCCTTGCAGTTTGGCTGGCGTTCAACC
TTTGTATTTATGGCGCTTTATGCACTGCTTATATTATTTATTTCCCTGTTGCACTTACCGGAGACTCGCCCCAAAAATAC
TGACAGCGACGGTCTATTATATAGCTGGGCTCGTTTTAAACCTGTCCTGCAGGATGCCCATTTTATCTTTTACGCTTTAA
CCTGCATGGTCGGTATGGCGTCCATTTTAACCTACGTTTCCTATGCACCTGACTGGTTAATAAGGCATTTAGGGGTTTCC
GAATTAACTTTTAGTGCTTTATTTGCTGTGAATGCCGTGGTTAATATCAGCGCATGTTTTGTAGCCCCTCTGGTGATTAA
ACGTTTTGGTAACCGTGCCACTGTGTTGATTGCTTTGCTGACCCTAATAACCTCAGCCGCCCTGCAGTTTGTTGCACAGC
ACCTTGGACTTGACAGCGGTATCAGCGCAGCATTTGCATTTATGCTGCCTATGATGCTGTTATGCGTTGGTTTTGCATTA
TTACTTGGGCCTGCTACCAGTATGGCCTTATCTGCATTTGACGAACGCGCGGGAACAGCAGCGGCGATATTAGGCTGCAT
TCAGATGAGTGGTGCAGCATTGTTAGCCGGCTTGATTCAGCAAACTAACTTAACTGCCCCCTATGCTTTGATTGTATTAA
TGGGCGGATTGAGCAGCAGTTTATTACTGGTCATGTTAATGCCGCGTTTTAATCACTGGCATCAGGAGCCCCTCCTACAA
TAA

Upstream 100 bases:

>100_bases
CAAAAGGAAATTCAGTTCTGAAATCATACCATTATGATTCATAACTAACCTTGGGTAAACTACCTCAGATAATCAATGTG
TTAACTATTTGAGTCTTATA

Downstream 100 bases:

>100_bases
GGACTCGCGCAACTTCAATCATCTCTGGCATTTAATGGTTGTTTATAAGGGATTATCTAGTGTCTTTACATCTAGTGCAC
TGATAATAAATAACGCCATT

Product: drug resistance transporter, Bcr/CflA subfamily protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MRKNILPMLMSMVVLSPLAIDIYLPSMPAMAAEFNVSSSEIQSTLVLFLFAMGVGQILIGPLADRFGRRPIALAGMVLYV
ASSLLAANVIEFHWLQFARVLQGLAACATSIVVFSAVRDSYTAKQGAYYYSYLNGVICVIPALAPTLGGLLALQFGWRST
FVFMALYALLILFISLLHLPETRPKNTDSDGLLYSWARFKPVLQDAHFIFYALTCMVGMASILTYVSYAPDWLIRHLGVS
ELTFSALFAVNAVVNISACFVAPLVIKRFGNRATVLIALLTLITSAALQFVAQHLGLDSGISAAFAFMLPMMLLCVGFAL
LLGPATSMALSAFDERAGTAAAILGCIQMSGAALLAGLIQQTNLTAPYALIVLMGGLSSSLLLVMLMPRFNHWHQEPLLQ

Sequences:

>Translated_400_residues
MRKNILPMLMSMVVLSPLAIDIYLPSMPAMAAEFNVSSSEIQSTLVLFLFAMGVGQILIGPLADRFGRRPIALAGMVLYV
ASSLLAANVIEFHWLQFARVLQGLAACATSIVVFSAVRDSYTAKQGAYYYSYLNGVICVIPALAPTLGGLLALQFGWRST
FVFMALYALLILFISLLHLPETRPKNTDSDGLLYSWARFKPVLQDAHFIFYALTCMVGMASILTYVSYAPDWLIRHLGVS
ELTFSALFAVNAVVNISACFVAPLVIKRFGNRATVLIALLTLITSAALQFVAQHLGLDSGISAAFAFMLPMMLLCVGFAL
LLGPATSMALSAFDERAGTAAAILGCIQMSGAALLAGLIQQTNLTAPYALIVLMGGLSSSLLLVMLMPRFNHWHQEPLLQ
>Mature_400_residues
MRKNILPMLMSMVVLSPLAIDIYLPSMPAMAAEFNVSSSEIQSTLVLFLFAMGVGQILIGPLADRFGRRPIALAGMVLYV
ASSLLAANVIEFHWLQFARVLQGLAACATSIVVFSAVRDSYTAKQGAYYYSYLNGVICVIPALAPTLGGLLALQFGWRST
FVFMALYALLILFISLLHLPETRPKNTDSDGLLYSWARFKPVLQDAHFIFYALTCMVGMASILTYVSYAPDWLIRHLGVS
ELTFSALFAVNAVVNISACFVAPLVIKRFGNRATVLIALLTLITSAALQFVAQHLGLDSGISAAFAFMLPMMLLCVGFAL
LLGPATSMALSAFDERAGTAAAILGCIQMSGAALLAGLIQQTNLTAPYALIVLMGGLSSSLLLVMLMPRFNHWHQEPLLQ

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790146, Length=397, Percent_Identity=30.9823677581864, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI87082312, Length=343, Percent_Identity=29.7376093294461, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788509, Length=368, Percent_Identity=25.5434782608696, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI48994889, Length=194, Percent_Identity=32.9896907216495, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1787065, Length=342, Percent_Identity=26.0233918128655, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790794, Length=260, Percent_Identity=24.6153846153846, Blast_Score=75, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324264, Length=169, Percent_Identity=30.7692307692308, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322071, Length=170, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43206; Mature: 43206

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKNILPMLMSMVVLSPLAIDIYLPSMPAMAAEFNVSSSEIQSTLVLFLFAMGVGQILIG
CCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
PLADRFGRRPIALAGMVLYVASSLLAANVIEFHWLQFARVLQGLAACATSIVVFSAVRDS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTAKQGAYYYSYLNGVICVIPALAPTLGGLLALQFGWRSTFVFMALYALLILFISLLHLP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ETRPKNTDSDGLLYSWARFKPVLQDAHFIFYALTCMVGMASILTYVSYAPDWLIRHLGVS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCHH
ELTFSALFAVNAVVNISACFVAPLVIKRFGNRATVLIALLTLITSAALQFVAQHLGLDSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ISAAFAFMLPMMLLCVGFALLLGPATSMALSAFDERAGTAAAILGCIQMSGAALLAGLIQ
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QTNLTAPYALIVLMGGLSSSLLLVMLMPRFNHWHQEPLLQ
HCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRKNILPMLMSMVVLSPLAIDIYLPSMPAMAAEFNVSSSEIQSTLVLFLFAMGVGQILIG
CCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
PLADRFGRRPIALAGMVLYVASSLLAANVIEFHWLQFARVLQGLAACATSIVVFSAVRDS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTAKQGAYYYSYLNGVICVIPALAPTLGGLLALQFGWRSTFVFMALYALLILFISLLHLP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ETRPKNTDSDGLLYSWARFKPVLQDAHFIFYALTCMVGMASILTYVSYAPDWLIRHLGVS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCHH
ELTFSALFAVNAVVNISACFVAPLVIKRFGNRATVLIALLTLITSAALQFVAQHLGLDSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ISAAFAFMLPMMLLCVGFALLLGPATSMALSAFDERAGTAAAILGCIQMSGAALLAGLIQ
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QTNLTAPYALIVLMGGLSSSLLLVMLMPRFNHWHQEPLLQ
HCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]