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The map label for this gene is folK [H]

Identifier: 119943960

GI number: 119943960

Start: 221555

End: 222049

Strand: Direct

Name: folK [H]

Synonym: Ping_0173

Alternate gene names: 119943960

Gene position: 221555-222049 (Clockwise)

Preceding gene: 119943959

Following gene: 119943961

Centisome position: 4.86

GC content: 38.79

Gene sequence:

>495_bases
ATGGCAGCCGTTTTTATTGGCGTCGGCTCCAGTATCAACCGATCTGAGAATATTCGTTTAGGTATTGCGGCATTACAAGC
TGAGTTTGGTGAGTTACTGCTTTCTCCTCTTTACGAAAGTGAAGCTGTTGGTTTTTCAGGGGTTAATTTTTACAATTTAG
TGGTTAAATTGCATACTGAGCAAAATATTGTCGAATTAATTAAAAAACTTAAAGGCATAGAGAAGCAGCATGGCCGCCCG
GAAAAGTCATCTAAGTTTACCCCAAGAACCTTAGATTTAGATTTACTTTTATACGACCAGCAGATAGATCCTGATATTGA
TTTACCGCGCGGCGAAATTTTAAAAAATGCATTTGTATTAAAACCCTTATCCGAGTTAGCACCAACATTAAGACACCCTG
TTCTGGGTGAAACCTATCAAGCCTTGTGGCGGAATTATCCGCAACAAAAGCAAAAATTGTGGAAAGTATCAAAACAGCTT
CCCGATCATTATTGA

Upstream 100 bases:

>100_bases
CGGAGTTTGCAGTGCCCTGGGTTAAAGTGAGACTACATAAACCCGGGGCTTTGCCAAAGGCACAAAGTTTAGGGGTACAG
ATTGAGCGTGGTGTTCGTTA

Downstream 100 bases:

>100_bases
TCACTTTATTTTATATATGAGATAAAAATGTCCGAACTTCAAATTGTTGTATTAGCTTTAATTCAGGGATTAACTGAATT
TTTACCTATTTCCAGCTCAG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MAAVFIGVGSSINRSENIRLGIAALQAEFGELLLSPLYESEAVGFSGVNFYNLVVKLHTEQNIVELIKKLKGIEKQHGRP
EKSSKFTPRTLDLDLLLYDQQIDPDIDLPRGEILKNAFVLKPLSELAPTLRHPVLGETYQALWRNYPQQKQKLWKVSKQL
PDHY

Sequences:

>Translated_164_residues
MAAVFIGVGSSINRSENIRLGIAALQAEFGELLLSPLYESEAVGFSGVNFYNLVVKLHTEQNIVELIKKLKGIEKQHGRP
EKSSKFTPRTLDLDLLLYDQQIDPDIDLPRGEILKNAFVLKPLSELAPTLRHPVLGETYQALWRNYPQQKQKLWKVSKQL
PDHY
>Mature_163_residues
AAVFIGVGSSINRSENIRLGIAALQAEFGELLLSPLYESEAVGFSGVNFYNLVVKLHTEQNIVELIKKLKGIEKQHGRPE
KSSKFTPRTLDLDLLLYDQQIDPDIDLPRGEILKNAFVLKPLSELAPTLRHPVLGETYQALWRNYPQQKQKLWKVSKQLP
DHY

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18637; Mature: 18506

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVFIGVGSSINRSENIRLGIAALQAEFGELLLSPLYESEAVGFSGVNFYNLVVKLHTE
CEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCC
QNIVELIKKLKGIEKQHGRPEKSSKFTPRTLDLDLLLYDQQIDPDIDLPRGEILKNAFVL
HHHHHHHHHHHCHHHHCCCCCCCCCCCCCEECEEEEEECCCCCCCCCCCHHHHHHHHHHH
KPLSELAPTLRHPVLGETYQALWRNYPQQKQKLWKVSKQLPDHY
CCHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AAVFIGVGSSINRSENIRLGIAALQAEFGELLLSPLYESEAVGFSGVNFYNLVVKLHTE
EEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCC
QNIVELIKKLKGIEKQHGRPEKSSKFTPRTLDLDLLLYDQQIDPDIDLPRGEILKNAFVL
HHHHHHHHHHHCHHHHCCCCCCCCCCCCCEECEEEEEECCCCCCCCCCCHHHHHHHHHHH
KPLSELAPTLRHPVLGETYQALWRNYPQQKQKLWKVSKQLPDHY
CCHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]