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The map label for this gene is uxuB [H]

Identifier: 119943922

GI number: 119943922

Start: 173478

End: 174941

Strand: Reverse

Name: uxuB [H]

Synonym: Ping_0132

Alternate gene names: 119943922

Gene position: 174941-173478 (Counterclockwise)

Preceding gene: 119943923

Following gene: 119943921

Centisome position: 3.84

GC content: 45.15

Gene sequence:

>1464_bases
ATGAAAAACATAGCGAATTCAGAAATAAACGCTCAAGTAATACGTCCTAATTACAATCGAACAGCCCTTAATAGCCGTAT
TGTTCATTTAGGATTTGGTGCCTTCCACCGTGCCCACCAAGCGTTATTTACCAGCGAGATGTTGGAAGAAACAGGTAGCG
ACTGGGGGATTTGTGAAATAAACCTCTTTGGTGGTGAGGAGCTTATAAAACAGCTTAGGGCCCAAGACCACCTTTTTAGC
GTTGCCGAAAAAGGCGCTGATGCTACCCTTGTAAAAATAGCGGGATCTGTCGTTGAATCGCTCCACCCGACACTCGATGG
CCAGCAAGCGGTTCTTGAAAAAATGGCCGAAGAACAAGTTGCGATTGTATCGATGACAATCACAGAAAAAGGCTATTGTG
CCGATCCTGCAACGGGACGTTTAGACGCAAACAATGCGCTTATTAAAGCAGATTTAAGTCATCCAGCAGAGCCAAATTCT
GCCATCGGTTACATCGTTGAAGCCCTGCGAATGAGAAAAGAACGCGGCATCAAACCTTTTACTGTCATGTCTTGTGATAA
CGTCCAGGAAAATGGCCATGTTGCCCGCGCCTCAGTGCTCGGTTTTGCTGCCTTGGTCGATAAAGATCTGGCGGCTTGGA
TTGAAGCTAACGTGACTTTTCCGTCCACTATGGTTGATCGAATTGTCCCTGCAGTAACCGCTGAAACATTATCTGAAATA
GCGGCTTTACTGGGCGTTAACGATCCTTGCGGGATTGCCTGCGAACCTTTCAGACAGTGGGTTATCGAAGACAACTTTGT
TAATGGCCGCCCAGAATGGAACCTTGTAGGAGCAGAGTTTGTACCTGATGTTGTGCCATTTGAAGAAATGAAACTGCGCA
TGCTTAACGGCAGCCATTCTTTCTTAGCTTACTTAGGTTACCTGGGTGGTTATGCGCATATTTCAGATACCATGACCAAT
AAAGATTACCGTAAAGCCGCTTTTGATATGATGATGAAAGCACAAGCACCGTCATTAAAGATGCCTGAAGGGGCGGATTT
AGAAGGCTATGCGAATTTGTTGATTGACCGCTTCACCAACCCAAGCTTAAAACACCAAACTTGGCAAATTGCGATGGATG
GAAGTCAGAAAATTCCGCAACGTATGGGTGGCTCCCTACGTTTTCATTTAGCCAATGGCAGTGATTATAAATGGCTGGCC
ATGGGGATTGCGGGTTGGATGGTTTATATCAGCGGTGAAGACGAAAAAAGTCAAGCAATTGATGTCCGCGACCCGATGCG
CGAACAGTTTCAGGCTATTTATAAGCAACACGGCAAAAATAATTCTGTGATTAAAGCGTTATTAGGGATCGAAGCTGTCT
TTTCTACTGATCTTATTCAAAATAATGAGTTTGTTGAGCAAGTCACACAAGCTTACCAGCTTATTGTAACAAAAGGCGCG
CGCGCTGCCGTCGCATCACTTTAA

Upstream 100 bases:

>100_bases
GTTATTTCTAGGTTACGGTGACTAAAATCATCTGTTCAACAATAAATTTATATATGCCTCGTCGAAAATATATCGGCGCG
ATAAACACAGGAAAGATAAT

Downstream 100 bases:

>100_bases
ATATTTGATATCCCCACGCTGCTGATTGGCGTTGGGGATATTTTTTATGGAGTCATCTATGAAAGCTTTTCTATGTGAAG
ATTTTCTTCTCAACAATAAT

Product: D-mannonate oxidoreductase NAD-binding

Products: NA

Alternate protein names: Fructuronate reductase [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MKNIANSEINAQVIRPNYNRTALNSRIVHLGFGAFHRAHQALFTSEMLEETGSDWGICEINLFGGEELIKQLRAQDHLFS
VAEKGADATLVKIAGSVVESLHPTLDGQQAVLEKMAEEQVAIVSMTITEKGYCADPATGRLDANNALIKADLSHPAEPNS
AIGYIVEALRMRKERGIKPFTVMSCDNVQENGHVARASVLGFAALVDKDLAAWIEANVTFPSTMVDRIVPAVTAETLSEI
AALLGVNDPCGIACEPFRQWVIEDNFVNGRPEWNLVGAEFVPDVVPFEEMKLRMLNGSHSFLAYLGYLGGYAHISDTMTN
KDYRKAAFDMMMKAQAPSLKMPEGADLEGYANLLIDRFTNPSLKHQTWQIAMDGSQKIPQRMGGSLRFHLANGSDYKWLA
MGIAGWMVYISGEDEKSQAIDVRDPMREQFQAIYKQHGKNNSVIKALLGIEAVFSTDLIQNNEFVEQVTQAYQLIVTKGA
RAAVASL

Sequences:

>Translated_487_residues
MKNIANSEINAQVIRPNYNRTALNSRIVHLGFGAFHRAHQALFTSEMLEETGSDWGICEINLFGGEELIKQLRAQDHLFS
VAEKGADATLVKIAGSVVESLHPTLDGQQAVLEKMAEEQVAIVSMTITEKGYCADPATGRLDANNALIKADLSHPAEPNS
AIGYIVEALRMRKERGIKPFTVMSCDNVQENGHVARASVLGFAALVDKDLAAWIEANVTFPSTMVDRIVPAVTAETLSEI
AALLGVNDPCGIACEPFRQWVIEDNFVNGRPEWNLVGAEFVPDVVPFEEMKLRMLNGSHSFLAYLGYLGGYAHISDTMTN
KDYRKAAFDMMMKAQAPSLKMPEGADLEGYANLLIDRFTNPSLKHQTWQIAMDGSQKIPQRMGGSLRFHLANGSDYKWLA
MGIAGWMVYISGEDEKSQAIDVRDPMREQFQAIYKQHGKNNSVIKALLGIEAVFSTDLIQNNEFVEQVTQAYQLIVTKGA
RAAVASL
>Mature_487_residues
MKNIANSEINAQVIRPNYNRTALNSRIVHLGFGAFHRAHQALFTSEMLEETGSDWGICEINLFGGEELIKQLRAQDHLFS
VAEKGADATLVKIAGSVVESLHPTLDGQQAVLEKMAEEQVAIVSMTITEKGYCADPATGRLDANNALIKADLSHPAEPNS
AIGYIVEALRMRKERGIKPFTVMSCDNVQENGHVARASVLGFAALVDKDLAAWIEANVTFPSTMVDRIVPAVTAETLSEI
AALLGVNDPCGIACEPFRQWVIEDNFVNGRPEWNLVGAEFVPDVVPFEEMKLRMLNGSHSFLAYLGYLGGYAHISDTMTN
KDYRKAAFDMMMKAQAPSLKMPEGADLEGYANLLIDRFTNPSLKHQTWQIAMDGSQKIPQRMGGSLRFHLANGSDYKWLA
MGIAGWMVYISGEDEKSQAIDVRDPMREQFQAIYKQHGKNNSVIKALLGIEAVFSTDLIQNNEFVEQVTQAYQLIVTKGA
RAAVASL

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=489, Percent_Identity=64.0081799591002, Blast_Score=649, Evalue=0.0,
Organism=Escherichia coli, GI1788497, Length=484, Percent_Identity=56.4049586776859, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1787823, Length=482, Percent_Identity=54.149377593361, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI48994885, Length=326, Percent_Identity=26.0736196319018, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1790028, Length=261, Percent_Identity=29.8850574712644, Blast_Score=99, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324401, Length=476, Percent_Identity=39.0756302521008, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6320765, Length=476, Percent_Identity=39.0756302521008, Blast_Score=358, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.57 [H]

Molecular weight: Translated: 53628; Mature: 53628

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIANSEINAQVIRPNYNRTALNSRIVHLGFGAFHRAHQALFTSEMLEETGSDWGICEI
CCCCCCCCCCEEEECCCCCCHHHCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
NLFGGEELIKQLRAQDHLFSVAEKGADATLVKIAGSVVESLHPTLDGQQAVLEKMAEEQV
EECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCE
AIVSMTITEKGYCADPATGRLDANNALIKADLSHPAEPNSAIGYIVEALRMRKERGIKPF
EEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCE
TVMSCDNVQENGHVARASVLGFAALVDKDLAAWIEANVTFPSTMVDRIVPAVTAETLSEI
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
AALLGVNDPCGIACEPFRQWVIEDNFVNGRPEWNLVGAEFVPDVVPFEEMKLRMLNGSHS
HHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEECHHHCCCCCCHHHHHHHHCCCCHH
FLAYLGYLGGYAHISDTMTNKDYRKAAFDMMMKAQAPSLKMPEGADLEGYANLLIDRFTN
HHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCC
PSLKHQTWQIAMDGSQKIPQRMGGSLRFHLANGSDYKWLAMGIAGWMVYISGEDEKSQAI
CCCCCCEEEEEECCCHHHHHHCCCCEEEEEECCCCCEEEEEEHEEEEEEECCCCCCCCEE
DVRDPMREQFQAIYKQHGKNNSVIKALLGIEAVFSTDLIQNNEFVEQVTQAYQLIVTKGA
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
RAAVASL
HHHHHCC
>Mature Secondary Structure
MKNIANSEINAQVIRPNYNRTALNSRIVHLGFGAFHRAHQALFTSEMLEETGSDWGICEI
CCCCCCCCCCEEEECCCCCCHHHCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
NLFGGEELIKQLRAQDHLFSVAEKGADATLVKIAGSVVESLHPTLDGQQAVLEKMAEEQV
EECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCE
AIVSMTITEKGYCADPATGRLDANNALIKADLSHPAEPNSAIGYIVEALRMRKERGIKPF
EEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCE
TVMSCDNVQENGHVARASVLGFAALVDKDLAAWIEANVTFPSTMVDRIVPAVTAETLSEI
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
AALLGVNDPCGIACEPFRQWVIEDNFVNGRPEWNLVGAEFVPDVVPFEEMKLRMLNGSHS
HHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEECHHHCCCCCCHHHHHHHHCCCCHH
FLAYLGYLGGYAHISDTMTNKDYRKAAFDMMMKAQAPSLKMPEGADLEGYANLLIDRFTN
HHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCC
PSLKHQTWQIAMDGSQKIPQRMGGSLRFHLANGSDYKWLAMGIAGWMVYISGEDEKSQAI
CCCCCCEEEEEECCCHHHHHHCCCCEEEEEECCCCCEEEEEEHEEEEEEECCCCCCCCEE
DVRDPMREQFQAIYKQHGKNNSVIKALLGIEAVFSTDLIQNNEFVEQVTQAYQLIVTKGA
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
RAAVASL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]