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The map label for this gene is sthA [H]

Identifier: 119943911

GI number: 119943911

Start: 155863

End: 157293

Strand: Direct

Name: sthA [H]

Synonym: Ping_0118

Alternate gene names: 119943911

Gene position: 155863-157293 (Clockwise)

Preceding gene: 119943907

Following gene: 119943913

Centisome position: 3.42

GC content: 40.95

Gene sequence:

>1431_bases
ATGTCCACAGTAAAAGATACAACAGTTAAACCTAAACACGATCATTATGATGCTATTGTTATTGGTAGCGGTCCGGGTGG
AGAGGGTGCTGCAATGAAGCTTGCTAAGGGAGGCTTGCGCGTTGCTATTGTAGAAAAATATAAAGATATCGGCGGGGGCT
GTACCCATTGGGGAACCATTCCTTCCAAGGCGTTGCGTCACAGTGTCAGCCAACTTATTGAATTAAAGAAAAACCCATTA
TTTCTTACCAATTACCCTCAGAATAAAACATTTACTTTTAGAGACGTTTTGACTCATACACAAAGTGTGATTGCCAAGCA
GGTAACGATGCGCAGTGGTTTTTATAATCGTAACAATTGCAGTTTATATTTTGGTGGTGCTAACTTTGTTGATAAAAACA
CTGTTTTAATTACCAAAGATGATGGCACAACAGAAACTATTACTGCCAAAGATATTATCATTGCCACGGGATCGCGCCCT
TATCGCCCTGCAGACATTGACTTTACTGCGGCCAATATTTACGACAGTGATACCATTCTTGCCTTAGACCACCATCCGCA
ACACATTGTGATTTATGGGGCAGGTGTTGTGGGTTGTGAATATGCTTCGATATTCAACGGGTTAGGCGTCAAAACAGACT
TAATTAATACTCGGGATAGTTTACTGTCATTTTTAGATACAGAAATGTCCGATGCACTTTCCTATCATTTTAGAAATTCA
GGCATGATCCTGCGCCATGATGAAGAATATGAAAAAGTGGAAAGTACAGAGGAAGGGGTTGTGATCCACTTGAAGTCGGG
TAAAAAGATGAAAGCTGACTGTCTGCTATATGCTAATGGACGCACGGGTAACACGGATAAATTAGCCTTAGAGAATATTG
ATCTAAAACCCGATCCCCGAGGACAGCTCACCGTCAACGAACATTATCAAACCGGGGTCGATAATATTTATGGACTTGGG
GATATCATTGGTTATCCAAGCCTTGCCAGTGCCGCTTATGATCAGGGCCGGATTGCAGCCCACTTTATATTAACCCAAGA
GGGTAAGAAAAAACTGATAAAAGATATTCCAACGGGTATTTATACTATTCCGGAAATTAGCTCCGTAGGTAAAACTGAAC
AGATGTTAACCCAGCAAAAAGTTCCCTATGAGGTGGGACGTGCACTGTTTAAAGATTTAGCACGTTCACAAATTTTAGGC
TCAGAGGTAGGCAGTTTAAAAATACTCTTTCACCGCGAAACAAAAGAGATATTAGGAATTCATTGTTTTGGCGAGCGGGC
AGCTGAAATTATTCATATTGGACAAGCTATCATGGAACAAAAAGGGGAAGGGAATACCATTGAGTATTTTGTTAAGACGA
CCTTTAACTATCCAACCATGGCAGAAGCTTACCGTGTGGCAGCTTTGAATGGTCTAAATAGATTGTTTTAG

Upstream 100 bases:

>100_bases
AACTATTGTATAGCGCACGATTTGTTGTTGGAATGTGTGACAAATGACAGTAATTTGTTAACATAATCTGTTTTTCGTCC
ACCCGAACCCGAGGTCCATC

Downstream 100 bases:

>100_bases
TGCTTCTTTCTGTCAATAACTTATTGTTATAGAAGCGCTTATAAATTATTTTAAAACCCATAAAGAATAATTATTTATGG
GTTTTAATGCCCATCATCAG

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSTVKDTTVKPKHDHYDAIVIGSGPGGEGAAMKLAKGGLRVAIVEKYKDIGGGCTHWGTIPSKALRHSVSQLIELKKNPL
FLTNYPQNKTFTFRDVLTHTQSVIAKQVTMRSGFYNRNNCSLYFGGANFVDKNTVLITKDDGTTETITAKDIIIATGSRP
YRPADIDFTAANIYDSDTILALDHHPQHIVIYGAGVVGCEYASIFNGLGVKTDLINTRDSLLSFLDTEMSDALSYHFRNS
GMILRHDEEYEKVESTEEGVVIHLKSGKKMKADCLLYANGRTGNTDKLALENIDLKPDPRGQLTVNEHYQTGVDNIYGLG
DIIGYPSLASAAYDQGRIAAHFILTQEGKKKLIKDIPTGIYTIPEISSVGKTEQMLTQQKVPYEVGRALFKDLARSQILG
SEVGSLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGEGNTIEYFVKTTFNYPTMAEAYRVAALNGLNRLF

Sequences:

>Translated_476_residues
MSTVKDTTVKPKHDHYDAIVIGSGPGGEGAAMKLAKGGLRVAIVEKYKDIGGGCTHWGTIPSKALRHSVSQLIELKKNPL
FLTNYPQNKTFTFRDVLTHTQSVIAKQVTMRSGFYNRNNCSLYFGGANFVDKNTVLITKDDGTTETITAKDIIIATGSRP
YRPADIDFTAANIYDSDTILALDHHPQHIVIYGAGVVGCEYASIFNGLGVKTDLINTRDSLLSFLDTEMSDALSYHFRNS
GMILRHDEEYEKVESTEEGVVIHLKSGKKMKADCLLYANGRTGNTDKLALENIDLKPDPRGQLTVNEHYQTGVDNIYGLG
DIIGYPSLASAAYDQGRIAAHFILTQEGKKKLIKDIPTGIYTIPEISSVGKTEQMLTQQKVPYEVGRALFKDLARSQILG
SEVGSLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGEGNTIEYFVKTTFNYPTMAEAYRVAALNGLNRLF
>Mature_475_residues
STVKDTTVKPKHDHYDAIVIGSGPGGEGAAMKLAKGGLRVAIVEKYKDIGGGCTHWGTIPSKALRHSVSQLIELKKNPLF
LTNYPQNKTFTFRDVLTHTQSVIAKQVTMRSGFYNRNNCSLYFGGANFVDKNTVLITKDDGTTETITAKDIIIATGSRPY
RPADIDFTAANIYDSDTILALDHHPQHIVIYGAGVVGCEYASIFNGLGVKTDLINTRDSLLSFLDTEMSDALSYHFRNSG
MILRHDEEYEKVESTEEGVVIHLKSGKKMKADCLLYANGRTGNTDKLALENIDLKPDPRGQLTVNEHYQTGVDNIYGLGD
IIGYPSLASAAYDQGRIAAHFILTQEGKKKLIKDIPTGIYTIPEISSVGKTEQMLTQQKVPYEVGRALFKDLARSQILGS
EVGSLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGEGNTIEYFVKTTFNYPTMAEAYRVAALNGLNRLF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=464, Percent_Identity=31.0344827586207, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI50301238, Length=370, Percent_Identity=28.1081081081081, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI22035672, Length=473, Percent_Identity=26.215644820296, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI291045266, Length=476, Percent_Identity=25.2100840336134, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI33519430, Length=454, Percent_Identity=24.0088105726872, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI33519428, Length=454, Percent_Identity=24.0088105726872, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI33519426, Length=454, Percent_Identity=24.0088105726872, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI148277071, Length=488, Percent_Identity=23.7704918032787, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI148277065, Length=454, Percent_Identity=24.0088105726872, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI291045268, Length=351, Percent_Identity=25.9259259259259, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87082354, Length=466, Percent_Identity=69.3133047210301, Blast_Score=689, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=460, Percent_Identity=29.5652173913043, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI87081717, Length=470, Percent_Identity=26.8085106382979, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=28.4738041002278, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=30.1518438177874, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17557007, Length=450, Percent_Identity=26.2222222222222, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI71983429, Length=344, Percent_Identity=26.1627906976744, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71983419, Length=344, Percent_Identity=26.1627906976744, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71982272, Length=496, Percent_Identity=23.7903225806452, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=490, Percent_Identity=27.3469387755102, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6325240, Length=478, Percent_Identity=27.6150627615063, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6325166, Length=483, Percent_Identity=27.7432712215321, Blast_Score=143, Evalue=6e-35,
Organism=Drosophila melanogaster, GI21358499, Length=466, Percent_Identity=31.9742489270386, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24640551, Length=490, Percent_Identity=27.1428571428571, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24640549, Length=479, Percent_Identity=27.348643006263, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24640553, Length=479, Percent_Identity=27.348643006263, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI17737741, Length=484, Percent_Identity=26.2396694214876, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 52523; Mature: 52391

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVKDTTVKPKHDHYDAIVIGSGPGGEGAAMKLAKGGLRVAIVEKYKDIGGGCTHWGTI
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCEEEEEEEHHHHCCCCCCCCCCC
PSKALRHSVSQLIELKKNPLFLTNYPQNKTFTFRDVLTHTQSVIAKQVTMRSGFYNRNNC
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SLYFGGANFVDKNTVLITKDDGTTETITAKDIIIATGSRPYRPADIDFTAANIYDSDTIL
EEEECCCCEECCCEEEEECCCCCCEEEEECEEEEECCCCCCCCCCCCEEEEEECCCCEEE
ALDHHPQHIVIYGAGVVGCEYASIFNGLGVKTDLINTRDSLLSFLDTEMSDALSYHFRNS
EEECCCCEEEEEECCHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHEECCC
GMILRHDEEYEKVESTEEGVVIHLKSGKKMKADCLLYANGRTGNTDKLALENIDLKPDPR
CEEEEECHHHHHHCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCCEEEECCCCCCCCC
GQLTVNEHYQTGVDNIYGLGDIIGYPSLASAAYDQGRIAAHFILTQEGKKKLIKDIPTGI
CCEEECCCHHCCCHHHCCCHHHHCCCCHHHHHCCCCCEEEEEEEECCHHHHHHHHCCCCE
YTIPEISSVGKTEQMLTQQKVPYEVGRALFKDLARSQILGSEVGSLKILFHRETKEILGI
EECCCCHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHEEE
HCFGERAAEIIHIGQAIMEQKGEGNTIEYFVKTTFNYPTMAEAYRVAALNGLNRLF
EEECHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STVKDTTVKPKHDHYDAIVIGSGPGGEGAAMKLAKGGLRVAIVEKYKDIGGGCTHWGTI
CCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCEEEEEEEHHHHCCCCCCCCCCC
PSKALRHSVSQLIELKKNPLFLTNYPQNKTFTFRDVLTHTQSVIAKQVTMRSGFYNRNNC
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SLYFGGANFVDKNTVLITKDDGTTETITAKDIIIATGSRPYRPADIDFTAANIYDSDTIL
EEEECCCCEECCCEEEEECCCCCCEEEEECEEEEECCCCCCCCCCCCEEEEEECCCCEEE
ALDHHPQHIVIYGAGVVGCEYASIFNGLGVKTDLINTRDSLLSFLDTEMSDALSYHFRNS
EEECCCCEEEEEECCHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHEECCC
GMILRHDEEYEKVESTEEGVVIHLKSGKKMKADCLLYANGRTGNTDKLALENIDLKPDPR
CEEEEECHHHHHHCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCCEEEECCCCCCCCC
GQLTVNEHYQTGVDNIYGLGDIIGYPSLASAAYDQGRIAAHFILTQEGKKKLIKDIPTGI
CCEEECCCHHCCCHHHCCCHHHHCCCCHHHHHCCCCCEEEEEEEECCHHHHHHHHCCCCE
YTIPEISSVGKTEQMLTQQKVPYEVGRALFKDLARSQILGSEVGSLKILFHRETKEILGI
EECCCCHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHEEE
HCFGERAAEIIHIGQAIMEQKGEGNTIEYFVKTTFNYPTMAEAYRVAALNGLNRLF
EEECHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]