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The map label for this gene is mtlA [H]

Identifier: 119943881

GI number: 119943881

Start: 118212

End: 120098

Strand: Direct

Name: mtlA [H]

Synonym: Ping_0088

Alternate gene names: 119943881

Gene position: 118212-120098 (Clockwise)

Preceding gene: 119943878

Following gene: 119943882

Centisome position: 2.59

GC content: 40.59

Gene sequence:

>1887_bases
ATGCTGTCATCACAATCCAAGATTAAAGTACAAAACTTTGGTCGCTTATTGTCAAATATGGTTATGCCAAATATTGGCGC
CTTTATCGCATGGGGTTTAATTACCGCATTATTTATTCCAACGGGGTGGATACCTAACGAAACATTAGCCACCATGGTTG
GGCCGATGATCAAATATATGCTGCCGCTCTTAATTGGTTATACCGGTGGTAAAATTATAGCCGGAGAGCGTGGTGCCGTT
GTAGGTGCAATAGCGACAATGGGTGTGATTGTTGGTACAGATATTCCAATGTTTATGGGTGCGATGATTGTTGGTCCGTT
AGGCGGCCTGGCAATTAAGAAATTTGATGCTGCCATTCACGGTAAAGTGAAAAGCGGTTTTGAAATGTTGGTTAACAACT
TTTCATCCGGTATTATTGGTATGGTGCTAGCGATTATTGCTTACGTAGTGATTGGTCCTGCTGTTAAAATGTTATCGACA
GCCCTTGCTGCTGGTGTTGATGTTTTAGTGGTCAATAACCTGCTTCCTTTGACTTCTATTTTTGTTGAACCGGCAAAGAT
TTTGTTCCTTAATAATGCGATTAACCATGGTATTTTTACGCCGCTGGGTATTGCGCAGTCAGAGTCTCTTGGTCAATCTG
TTTTCTTCTTAATTGAAGCAAACCCAGGTCCAGGTTTAGGTCTTCTTTTAGCCTACATGGTGTTCGGTAAAGGTTCTGCA
AAAGAAACAGCTCCTGGTGCCGTCATTATCCACTTCTTTGGTGGTATCCATGAAATTTACTTCCCTTATGTATTGATGAA
TCCGCGTCTTATCCTATCTGTTATTGCAGGTGGTATGACAGGCGTATTCGTTCTTACTCTATTCGATGCCGGTCTTATCT
CTCCTGCATCTCCTGGTTCTATCTTTGCTGTTTTAGCCATGACGCCTAAAGGCGCATATATGGGTATTCTTCTATCTGTT
GCTGCTGCTGCCGCTGTTTCTTTTGTTGTGGCATCTATTCTGATGAAAACACAAAAAACGGTTGCCGGTGATGAAGTTGC
ACTGGAAGAAGCTGCAAACCAAATGCGCGACATGAAGCAAAGCGCTAAAGGTCAAGCAACAGGAAATGACCGCGTTGATA
TGTCTGCCGTTAAAAAAATCATTGTTGCTTGTGATGCAGGTATGGGTTCAAGTGCAATGGGCGCAAGTCTATTACGCAAA
AAAGTGCAAGCTGCAAATTTAAATATTGAAGTGATTAATACTGCGATCAATGATTTACCCGGTGATGTTGATATTGTTGT
TACTCATAAAGATTTAACCGACAGAGCACGTAAGCATGCGCCCAATGCACAGCATATTTCATTAACTAATTTCTTAGATA
ATGCGATGTATGACAATTTGGTGAAAGATCTTAAATCTGCCGGTAATGCACCTGCTGCAAATGCACCAGAAGGTGATGCA
AAAAAGTCTGAAGGTCCTTTGAAATTAACCGATAAAAATATCTTCTTAGGGCTTAAACCTGCAACCAAGGAAGAGGCGAT
TAAATTTGCTGGTGAGCAGTTGATTGCTTTGAATTATGTTGAGCCTGAATATCTACAGGGTATGTTTGATAGAGAAAAAT
TAGTATCAACTTATTTAGGTGAATCGATAGCGGTTCCTCACGGTACTATTGAGACAAAAAAACATGTTCTTAAAACCGGT
ATCGTATTTTGTCAGTACCCGGCAGGTATTCAGTGGGGTGAAGATGAAGACGATGTTGCAATTCTGGTTATTGGTATTGC
AGCGCAGGGTGATCAACATATTCATGTGATCACCGCCATCACCAATGCACTTGATGATGAAGAAGCAATAGAATGTTTAA
AAACAACAGTTAATAAAGAAGATGTACTGAAAATTTTAAATAACTAG

Upstream 100 bases:

>100_bases
GCATATGCTTTTGAAATAATATGGTAGATTCAGTGGAGAAAGTTTAACCTCATTAATTATTTCACCCATTTTAGGTGAAG
AAAGACACTCGGAGCAAATT

Downstream 100 bases:

>100_bases
AAGCTTCTTAAGGTAGCTGCTTCGATTGAGGTGGCCGATTAAATATTCGAGGCTAGATTTTCTAGCCTTTTTTAATTTTA
GGGAAATATTTATTATGAAA

Product: PTS system, mannitol-specific IIABC protein

Products: NA

Alternate protein names: EIICBA-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component; Mannitol-specific phosphotransferase enzyme IIA component; PTS system mannitol-specific EIIA component [H]

Number of amino acids: Translated: 628; Mature: 628

Protein sequence:

>628_residues
MLSSQSKIKVQNFGRLLSNMVMPNIGAFIAWGLITALFIPTGWIPNETLATMVGPMIKYMLPLLIGYTGGKIIAGERGAV
VGAIATMGVIVGTDIPMFMGAMIVGPLGGLAIKKFDAAIHGKVKSGFEMLVNNFSSGIIGMVLAIIAYVVIGPAVKMLST
ALAAGVDVLVVNNLLPLTSIFVEPAKILFLNNAINHGIFTPLGIAQSESLGQSVFFLIEANPGPGLGLLLAYMVFGKGSA
KETAPGAVIIHFFGGIHEIYFPYVLMNPRLILSVIAGGMTGVFVLTLFDAGLISPASPGSIFAVLAMTPKGAYMGILLSV
AAAAAVSFVVASILMKTQKTVAGDEVALEEAANQMRDMKQSAKGQATGNDRVDMSAVKKIIVACDAGMGSSAMGASLLRK
KVQAANLNIEVINTAINDLPGDVDIVVTHKDLTDRARKHAPNAQHISLTNFLDNAMYDNLVKDLKSAGNAPAANAPEGDA
KKSEGPLKLTDKNIFLGLKPATKEEAIKFAGEQLIALNYVEPEYLQGMFDREKLVSTYLGESIAVPHGTIETKKHVLKTG
IVFCQYPAGIQWGEDEDDVAILVIGIAAQGDQHIHVITAITNALDDEEAIECLKTTVNKEDVLKILNN

Sequences:

>Translated_628_residues
MLSSQSKIKVQNFGRLLSNMVMPNIGAFIAWGLITALFIPTGWIPNETLATMVGPMIKYMLPLLIGYTGGKIIAGERGAV
VGAIATMGVIVGTDIPMFMGAMIVGPLGGLAIKKFDAAIHGKVKSGFEMLVNNFSSGIIGMVLAIIAYVVIGPAVKMLST
ALAAGVDVLVVNNLLPLTSIFVEPAKILFLNNAINHGIFTPLGIAQSESLGQSVFFLIEANPGPGLGLLLAYMVFGKGSA
KETAPGAVIIHFFGGIHEIYFPYVLMNPRLILSVIAGGMTGVFVLTLFDAGLISPASPGSIFAVLAMTPKGAYMGILLSV
AAAAAVSFVVASILMKTQKTVAGDEVALEEAANQMRDMKQSAKGQATGNDRVDMSAVKKIIVACDAGMGSSAMGASLLRK
KVQAANLNIEVINTAINDLPGDVDIVVTHKDLTDRARKHAPNAQHISLTNFLDNAMYDNLVKDLKSAGNAPAANAPEGDA
KKSEGPLKLTDKNIFLGLKPATKEEAIKFAGEQLIALNYVEPEYLQGMFDREKLVSTYLGESIAVPHGTIETKKHVLKTG
IVFCQYPAGIQWGEDEDDVAILVIGIAAQGDQHIHVITAITNALDDEEAIECLKTTVNKEDVLKILNN
>Mature_628_residues
MLSSQSKIKVQNFGRLLSNMVMPNIGAFIAWGLITALFIPTGWIPNETLATMVGPMIKYMLPLLIGYTGGKIIAGERGAV
VGAIATMGVIVGTDIPMFMGAMIVGPLGGLAIKKFDAAIHGKVKSGFEMLVNNFSSGIIGMVLAIIAYVVIGPAVKMLST
ALAAGVDVLVVNNLLPLTSIFVEPAKILFLNNAINHGIFTPLGIAQSESLGQSVFFLIEANPGPGLGLLLAYMVFGKGSA
KETAPGAVIIHFFGGIHEIYFPYVLMNPRLILSVIAGGMTGVFVLTLFDAGLISPASPGSIFAVLAMTPKGAYMGILLSV
AAAAAVSFVVASILMKTQKTVAGDEVALEEAANQMRDMKQSAKGQATGNDRVDMSAVKKIIVACDAGMGSSAMGASLLRK
KVQAANLNIEVINTAINDLPGDVDIVVTHKDLTDRARKHAPNAQHISLTNFLDNAMYDNLVKDLKSAGNAPAANAPEGDA
KKSEGPLKLTDKNIFLGLKPATKEEAIKFAGEQLIALNYVEPEYLQGMFDREKLVSTYLGESIAVPHGTIETKKHVLKTG
IVFCQYPAGIQWGEDEDDVAILVIGIAAQGDQHIHVITAITNALDDEEAIECLKTTVNKEDVLKILNN

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=635, Percent_Identity=66.7716535433071, Blast_Score=834, Evalue=0.0,
Organism=Escherichia coli, GI1789301, Length=467, Percent_Identity=50.9635974304068, Blast_Score=483, Evalue=1e-137,
Organism=Escherichia coli, GI1788494, Length=140, Percent_Identity=38.5714285714286, Blast_Score=108, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 66325; Mature: 66325

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSSQSKIKVQNFGRLLSNMVMPNIGAFIAWGLITALFIPTGWIPNETLATMVGPMIKYM
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LPLLIGYTGGKIIAGERGAVVGAIATMGVIVGTDIPMFMGAMIVGPLGGLAIKKFDAAIH
HHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
GKVKSGFEMLVNNFSSGIIGMVLAIIAYVVIGPAVKMLSTALAAGVDVLVVNNLLPLTSI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHCHHHHHHH
FVEPAKILFLNNAINHGIFTPLGIAQSESLGQSVFFLIEANPGPGLGLLLAYMVFGKGSA
HHCCHHEEEEECHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCC
KETAPGAVIIHFFGGIHEIYFPYVLMNPRLILSVIAGGMTGVFVLTLFDAGLISPASPGS
CCCCCCEEEEEHHCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCC
IFAVLAMTPKGAYMGILLSVAAAAAVSFVVASILMKTQKTVAGDEVALEEAANQMRDMKQ
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SAKGQATGNDRVDMSAVKKIIVACDAGMGSSAMGASLLRKKVQAANLNIEVINTAINDLP
HCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHCCC
GDVDIVVTHKDLTDRARKHAPNAQHISLTNFLDNAMYDNLVKDLKSAGNAPAANAPEGDA
CCEEEEEECCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
KKSEGPLKLTDKNIFLGLKPATKEEAIKFAGEQLIALNYVEPEYLQGMFDREKLVSTYLG
CCCCCCEEEECCCEEEECCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHC
ESIAVPHGTIETKKHVLKTGIVFCQYPAGIQWGEDEDDVAILVIGIAAQGDQHIHVITAI
CCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEHH
TNALDDEEAIECLKTTVNKEDVLKILNN
HHHCCHHHHHHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure
MLSSQSKIKVQNFGRLLSNMVMPNIGAFIAWGLITALFIPTGWIPNETLATMVGPMIKYM
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LPLLIGYTGGKIIAGERGAVVGAIATMGVIVGTDIPMFMGAMIVGPLGGLAIKKFDAAIH
HHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
GKVKSGFEMLVNNFSSGIIGMVLAIIAYVVIGPAVKMLSTALAAGVDVLVVNNLLPLTSI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHCHHHHHHH
FVEPAKILFLNNAINHGIFTPLGIAQSESLGQSVFFLIEANPGPGLGLLLAYMVFGKGSA
HHCCHHEEEEECHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCC
KETAPGAVIIHFFGGIHEIYFPYVLMNPRLILSVIAGGMTGVFVLTLFDAGLISPASPGS
CCCCCCEEEEEHHCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCC
IFAVLAMTPKGAYMGILLSVAAAAAVSFVVASILMKTQKTVAGDEVALEEAANQMRDMKQ
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SAKGQATGNDRVDMSAVKKIIVACDAGMGSSAMGASLLRKKVQAANLNIEVINTAINDLP
HCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHCCC
GDVDIVVTHKDLTDRARKHAPNAQHISLTNFLDNAMYDNLVKDLKSAGNAPAANAPEGDA
CCEEEEEECCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
KKSEGPLKLTDKNIFLGLKPATKEEAIKFAGEQLIALNYVEPEYLQGMFDREKLVSTYLG
CCCCCCEEEECCCEEEECCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHC
ESIAVPHGTIETKKHVLKTGIVFCQYPAGIQWGEDEDDVAILVIGIAAQGDQHIHVITAI
CCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEHH
TNALDDEEAIECLKTTVNKEDVLKILNN
HHHCCHHHHHHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]