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The map label for this gene is purE [H]

Identifier: 119943866

GI number: 119943866

Start: 100832

End: 101341

Strand: Reverse

Name: purE [H]

Synonym: Ping_0073

Alternate gene names: 119943866

Gene position: 101341-100832 (Counterclockwise)

Preceding gene: 119943867

Following gene: 119943865

Centisome position: 2.22

GC content: 45.1

Gene sequence:

>510_bases
TTGACTAAACCTTTTGTAGCCATATTAATGGGCTCAGATTCTGATCTGCCTGTTATGCAAGGTACGATTGAGATATTAAA
ATCTTTTTCTATCGCTTTTGAAGTTAAAGTAACTTCAGCACACCGTACTCCAGCTGCGACACATGCATATGTAACCGATG
CAGAAAATCGTGGTTGTAAAGTATTTATCTGTGCCGCCGGTCTTGCCGCGCACTTAGCCGGCGCTGTTGCTGGAATAACA
ACACGACCCATTATTGGCGTGCCAATTGACTGTGGCCCCTTAAACGGCCAAGATGCATTATTGTCAACGGTAATGATGCC
TGCCGGTGTACCGGTTGCAACTGTTGCAATTGGCAGTGCAGGCGCAAAAAATGCAGCTTATCTTGCAGCGCAAATTCTTG
CGGTTGCCGATGACGAGCTGGCAAAACGCGTCAAAGAAAATCGTGCTGAAAATGCGCAAGCTGTTATTGCAAAAGATGCT
GCATTACAGCTTAAATTAGCAAGCCTATAA

Upstream 100 bases:

>100_bases
CATAATATGTCCAAAAAAAGGATGTGGTTACCGAGGCAAGCCTATATAATAATTGTTTTTTCGCTAAATTTTTAACCTAC
AACCCAAAGAGGGAAGAACC

Downstream 100 bases:

>100_bases
CGGATTTGTTACTTTTGTTGAAACAAAGTGAATTAAATGACGCCCTGAAGATACTTAAATCTCAAGGCGTTATTGCATAC
CCCACTGAGTCTGTTTTTGG

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MTKPFVAILMGSDSDLPVMQGTIEILKSFSIAFEVKVTSAHRTPAATHAYVTDAENRGCKVFICAAGLAAHLAGAVAGIT
TRPIIGVPIDCGPLNGQDALLSTVMMPAGVPVATVAIGSAGAKNAAYLAAQILAVADDELAKRVKENRAENAQAVIAKDA
ALQLKLASL

Sequences:

>Translated_169_residues
MTKPFVAILMGSDSDLPVMQGTIEILKSFSIAFEVKVTSAHRTPAATHAYVTDAENRGCKVFICAAGLAAHLAGAVAGIT
TRPIIGVPIDCGPLNGQDALLSTVMMPAGVPVATVAIGSAGAKNAAYLAAQILAVADDELAKRVKENRAENAQAVIAKDA
ALQLKLASL
>Mature_168_residues
TKPFVAILMGSDSDLPVMQGTIEILKSFSIAFEVKVTSAHRTPAATHAYVTDAENRGCKVFICAAGLAAHLAGAVAGITT
RPIIGVPIDCGPLNGQDALLSTVMMPAGVPVATVAIGSAGAKNAAYLAAQILAVADDELAKRVKENRAENAQAVIAKDAA
LQLKLASL

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=151, Percent_Identity=47.682119205298, Blast_Score=103, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6324702, Length=163, Percent_Identity=46.6257668711656, Blast_Score=139, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17279; Mature: 17148

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPFVAILMGSDSDLPVMQGTIEILKSFSIAFEVKVTSAHRTPAATHAYVTDAENRGCK
CCCCEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEEECCCCCCCE
VFICAAGLAAHLAGAVAGITTRPIIGVPIDCGPLNGQDALLSTVMMPAGVPVATVAIGSA
EEEECCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCC
GAKNAAYLAAQILAVADDELAKRVKENRAENAQAVIAKDAALQLKLASL
CCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCEEEEEEECC
>Mature Secondary Structure 
TKPFVAILMGSDSDLPVMQGTIEILKSFSIAFEVKVTSAHRTPAATHAYVTDAENRGCK
CCCEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEEECCCCCCCE
VFICAAGLAAHLAGAVAGITTRPIIGVPIDCGPLNGQDALLSTVMMPAGVPVATVAIGSA
EEEECCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCC
GAKNAAYLAAQILAVADDELAKRVKENRAENAQAVIAKDAALQLKLASL
CCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]