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The map label for this gene is aroE

Identifier: 119943864

GI number: 119943864

Start: 99340

End: 100158

Strand: Reverse

Name: aroE

Synonym: Ping_0071

Alternate gene names: 119943864

Gene position: 100158-99340 (Counterclockwise)

Preceding gene: 119943865

Following gene: 119943863

Centisome position: 2.2

GC content: 39.8

Gene sequence:

>819_bases
ATGGATAACTATGCCGTCTTTGGCAATCCAATTAAACAAAGTAAGTCCCCCTTTATTCACACTTTATTTGCACAGCAAAC
ACAAGAAAAGATAGTTTACAGTGCAATTGAACCAGCAACAGATGATTTTAAAACTGCTTTAAAAGACTTTTTTTTAGAAC
AAGGAAAAGGTTGTAATATTACAGCCCCCTTTAAAGAGCAGGCATACCAATACGCACAACAGTTAACAGAACGGGCAGCA
TTGGCCGGTGCGGTAAATACTTTGAAATTAACCGATGACGGTATTATCATTGGGGATAATACCGATGGCGCTGGATTGGT
ATTAGATCTTAAGAACAATAATGTAACGCTTAAGGGGTCTCGTATTTTGTTAATTGGAGCAGGAGGAGCTGCTCGAGGAG
TCTGTGGACCGTTATTAGCTGAACACCCAAAAGAGCTGATAATCGCGAACCGTACCTTTTCAAAAGCACAAACCCTCACA
ACAATATTCACAAAACTAGGCAATATATCTGCTTGTGAATTTTCAGAATTATCAGGTGAGTTCGATTTAATCATCAATTC
AACATCTGCGAGTTTACATGGTGAAGTGCCTCTAATCGGTACTAAATTGATTCGACCTGAAACTACAATATACGACATGA
TGTATAGCGCACAAGTAACCCCCTTTAATGCCTGGGCAAAAGAGCAGGGTGCAAAATTTATCCTTGACGGGTTGGGTATG
TTAGTTGGACAAGCAGCAGAAAGTTTTGCGATTTGGCGTGGAGTAAAGCCTGATGCGAAACAAGTGTTAAATGAATTACG
TCATCATTTAGCGACTTAG

Upstream 100 bases:

>100_bases
TGCGATAGCTAACTGTCTTGTGCACGGTAAATTTTCACTGGTAATTTTAAAATGTGAAATTATCTGTTATTTAAAAATCA
TCAACTATTTTGGAGTCCAC

Downstream 100 bases:

>100_bases
TAAATAACACCAAATTGGTTAATGAAGCTTCTATTTGAACAAAGAAAAATAGATAACAAATTATTGGATTTGCTATAAGT
AATCAGGAAATTTTAAATCG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MDNYAVFGNPIKQSKSPFIHTLFAQQTQEKIVYSAIEPATDDFKTALKDFFLEQGKGCNITAPFKEQAYQYAQQLTERAA
LAGAVNTLKLTDDGIIIGDNTDGAGLVLDLKNNNVTLKGSRILLIGAGGAARGVCGPLLAEHPKELIIANRTFSKAQTLT
TIFTKLGNISACEFSELSGEFDLIINSTSASLHGEVPLIGTKLIRPETTIYDMMYSAQVTPFNAWAKEQGAKFILDGLGM
LVGQAAESFAIWRGVKPDAKQVLNELRHHLAT

Sequences:

>Translated_272_residues
MDNYAVFGNPIKQSKSPFIHTLFAQQTQEKIVYSAIEPATDDFKTALKDFFLEQGKGCNITAPFKEQAYQYAQQLTERAA
LAGAVNTLKLTDDGIIIGDNTDGAGLVLDLKNNNVTLKGSRILLIGAGGAARGVCGPLLAEHPKELIIANRTFSKAQTLT
TIFTKLGNISACEFSELSGEFDLIINSTSASLHGEVPLIGTKLIRPETTIYDMMYSAQVTPFNAWAKEQGAKFILDGLGM
LVGQAAESFAIWRGVKPDAKQVLNELRHHLAT
>Mature_272_residues
MDNYAVFGNPIKQSKSPFIHTLFAQQTQEKIVYSAIEPATDDFKTALKDFFLEQGKGCNITAPFKEQAYQYAQQLTERAA
LAGAVNTLKLTDDGIIIGDNTDGAGLVLDLKNNNVTLKGSRILLIGAGGAARGVCGPLLAEHPKELIIANRTFSKAQTLT
TIFTKLGNISACEFSELSGEFDLIINSTSASLHGEVPLIGTKLIRPETTIYDMMYSAQVTPFNAWAKEQGAKFILDGLGM
LVGQAAESFAIWRGVKPDAKQVLNELRHHLAT

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=272, Percent_Identity=51.1029411764706, Blast_Score=265, Evalue=2e-72,
Organism=Escherichia coli, GI1787983, Length=261, Percent_Identity=30.2681992337165, Blast_Score=105, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320332, Length=280, Percent_Identity=28.2142857142857, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_PSYIN (A1SR30)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_941544.1
- ProteinModelPortal:   A1SR30
- SMR:   A1SR30
- STRING:   A1SR30
- GeneID:   4626625
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0071
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   DQYVVFG
- PhylomeDB:   A1SR30
- ProtClustDB:   PRK00258
- BioCyc:   PING357804:PING_0071-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29480; Mature: 29480

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: ACT_SITE 65-65

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNYAVFGNPIKQSKSPFIHTLFAQQTQEKIVYSAIEPATDDFKTALKDFFLEQGKGCNI
CCCCEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCE
TAPFKEQAYQYAQQLTERAALAGAVNTLKLTDDGIIIGDNTDGAGLVLDLKNNNVTLKGS
ECCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCCCEEEEEECCCCEEEECC
RILLIGAGGAARGVCGPLLAEHPKELIIANRTFSKAQTLTTIFTKLGNISACEFSELSGE
EEEEEECCCCCCCCHHHHHHHCCHHEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHCCCC
FDLIINSTSASLHGEVPLIGTKLIRPETTIYDMMYSAQVTPFNAWAKEQGAKFILDGLGM
EEEEEECCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHH
LVGQAAESFAIWRGVKPDAKQVLNELRHHLAT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDNYAVFGNPIKQSKSPFIHTLFAQQTQEKIVYSAIEPATDDFKTALKDFFLEQGKGCNI
CCCCEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCE
TAPFKEQAYQYAQQLTERAALAGAVNTLKLTDDGIIIGDNTDGAGLVLDLKNNNVTLKGS
ECCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCCCEEEEEECCCCEEEECC
RILLIGAGGAARGVCGPLLAEHPKELIIANRTFSKAQTLTTIFTKLGNISACEFSELSGE
EEEEEECCCCCCCCHHHHHHHCCHHEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHCCCC
FDLIINSTSASLHGEVPLIGTKLIRPETTIYDMMYSAQVTPFNAWAKEQGAKFILDGLGM
EEEEEECCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHH
LVGQAAESFAIWRGVKPDAKQVLNELRHHLAT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA