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The map label for this gene is mutM

Identifier: 119943846

GI number: 119943846

Start: 76031

End: 76843

Strand: Reverse

Name: mutM

Synonym: Ping_0053

Alternate gene names: 119943846

Gene position: 76843-76031 (Counterclockwise)

Preceding gene: 119943847

Following gene: 119943845

Centisome position: 1.69

GC content: 43.05

Gene sequence:

>813_bases
ATGCCAGAATTACCGGAAGTAGAAACCAGCAGAAAAGGGATCAGCCCGCATCTTATTAATAAATCGGTCCAGAATGTTGT
GCTGCGGCATACTCAATTACGCTGGAAAATACCGCAGGATTTATTATCGGACATTAAAGATAAAATATTACTTTCAATCG
ATCGCCGTGCTAAATACCTGCTGTTCAACTTCACCAGTGGCACCTTGTTAATTCACCTGGGCATGTCGGGCAGTTTACGA
ATTTGCCCATTGAATAGCCCGCCAAAAAAACATGACCATGCCGATCTTATTTTCGCAGATTGTTTATTACGCTATACCGA
TCCACGCCGTTTCGGGGCCATTTTATGGTTGGGTTTAACGCCGGAAGACTCGCCTCTATTAAATAAACTCGGTCCTGAGC
CGCTCAATGATGATTTTAATGCGAAGTATTTATACCAGCAGGCGACTAAACGAAAACTGCCGGTAAAACAATTTATTATG
GATCAAAAAGTCGTAACGGGTGTGGGTAATATCTATGCGACGGAAGCCTTATTTAATAGTGGCATCTCGCCAATAAGGGC
GGCCGGCAATATCTCTGAAAAACGCTATCAAATATTAGTTACTGAGATTAAAGAAATTTTACAGCAAGCGATAAAACAAG
GCGGCACCACCCTGAAAGATTTTGTCGGTAGTGATGGTAAACCTGGCTATTTTCAACAGACGCTACAGGTTTATGGTAAA
ACAGGTCAGCAATGCCCTAGCTGCGAAACCCCTTTAAAAGCTGTTAAATTAGCCGCAAGAGCCAGTGTGTATTGTCCGGA
ATGCCAGAGCTAG

Upstream 100 bases:

>100_bases
TACCAAAGCAATTAAGACGACCGACCACCTAGATAAAACAGCATAGATTTTAGCCAAGGAATCAGTACACTGATAATATC
AGTTCAAAGAGAGAATTTTT

Downstream 100 bases:

>100_bases
CTTCCTTGTTGATTGTTTTCATCTAATATACCAGCATAAACGAGCCGTATTGGCCTGCAGTAAGCTTTCGCTTGCGGATG
CTTACCTTAACTTTTATTAG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MPELPEVETSRKGISPHLINKSVQNVVLRHTQLRWKIPQDLLSDIKDKILLSIDRRAKYLLFNFTSGTLLIHLGMSGSLR
ICPLNSPPKKHDHADLIFADCLLRYTDPRRFGAILWLGLTPEDSPLLNKLGPEPLNDDFNAKYLYQQATKRKLPVKQFIM
DQKVVTGVGNIYATEALFNSGISPIRAAGNISEKRYQILVTEIKEILQQAIKQGGTTLKDFVGSDGKPGYFQQTLQVYGK
TGQQCPSCETPLKAVKLAARASVYCPECQS

Sequences:

>Translated_270_residues
MPELPEVETSRKGISPHLINKSVQNVVLRHTQLRWKIPQDLLSDIKDKILLSIDRRAKYLLFNFTSGTLLIHLGMSGSLR
ICPLNSPPKKHDHADLIFADCLLRYTDPRRFGAILWLGLTPEDSPLLNKLGPEPLNDDFNAKYLYQQATKRKLPVKQFIM
DQKVVTGVGNIYATEALFNSGISPIRAAGNISEKRYQILVTEIKEILQQAIKQGGTTLKDFVGSDGKPGYFQQTLQVYGK
TGQQCPSCETPLKAVKLAARASVYCPECQS
>Mature_269_residues
PELPEVETSRKGISPHLINKSVQNVVLRHTQLRWKIPQDLLSDIKDKILLSIDRRAKYLLFNFTSGTLLIHLGMSGSLRI
CPLNSPPKKHDHADLIFADCLLRYTDPRRFGAILWLGLTPEDSPLLNKLGPEPLNDDFNAKYLYQQATKRKLPVKQFIMD
QKVVTGVGNIYATEALFNSGISPIRAAGNISEKRYQILVTEIKEILQQAIKQGGTTLKDFVGSDGKPGYFQQTLQVYGKT
GQQCPSCETPLKAVKLAARASVYCPECQS

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=270, Percent_Identity=53.7037037037037, Blast_Score=301, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_PSYIN (A1SR12)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_941526.1
- ProteinModelPortal:   A1SR12
- SMR:   A1SR12
- STRING:   A1SR12
- GeneID:   4623545
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0053
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- PhylomeDB:   A1SR12
- BioCyc:   PING357804:PING_0053-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 30207; Mature: 30076

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 260-260 BINDING 91-91 BINDING 109-109 BINDING 151-151

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETSRKGISPHLINKSVQNVVLRHTQLRWKIPQDLLSDIKDKILLSIDRRAKYL
CCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCCEEE
LFNFTSGTLLIHLGMSGSLRICPLNSPPKKHDHADLIFADCLLRYTDPRRFGAILWLGLT
EEEECCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECC
PEDSPLLNKLGPEPLNDDFNAKYLYQQATKRKLPVKQFIMDQKVVTGVGNIYATEALFNS
CCCCHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHC
GISPIRAAGNISEKRYQILVTEIKEILQQAIKQGGTTLKDFVGSDGKPGYFQQTLQVYGK
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHCC
TGQQCPSCETPLKAVKLAARASVYCPECQS
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PELPEVETSRKGISPHLINKSVQNVVLRHTQLRWKIPQDLLSDIKDKILLSIDRRAKYL
CCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCCEEE
LFNFTSGTLLIHLGMSGSLRICPLNSPPKKHDHADLIFADCLLRYTDPRRFGAILWLGLT
EEEECCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECC
PEDSPLLNKLGPEPLNDDFNAKYLYQQATKRKLPVKQFIMDQKVVTGVGNIYATEALFNS
CCCCHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHC
GISPIRAAGNISEKRYQILVTEIKEILQQAIKQGGTTLKDFVGSDGKPGYFQQTLQVYGK
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHCC
TGQQCPSCETPLKAVKLAARASVYCPECQS
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA