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The map label for this gene is parE [C]

Identifier: 119871455

GI number: 119871455

Start: 5663568

End: 5665601

Strand: Direct

Name: parE [C]

Synonym: Mkms_5431

Alternate gene names: 119871455

Gene position: 5663568-5665601 (Clockwise)

Preceding gene: 119871454

Following gene: 119871456

Centisome position: 98.72

GC content: 69.22

Gene sequence:

>2034_bases
TTGAGTTACACCGCCGCCGACATCACCGAACTCGATGATGTCCAGCACACACGCCTGCGGCCGGCGGTGAACCTGGGACT
CGACGTGCTCAACACCGCGCTGCGTGAGCTGATCGACAACGCCATCGAGGAAGTCGCGGATCCCAGCCACGGCGGCTCGG
CGGTGACGATCACCCTGCACGACGACGGTTCGGTCAGCGTCGCCGACGACGGCCGCGGTCTGCCCGTCGACTCCGACCCG
GTGAACGGGAAGAACGGGATCGTCAAGACGCTGGGCACCGCACGGGCCGGCGGGAAGTTCTCCGCCCATACCGATGCCGC
CAGCACCGGGGCCGGTTTGAACGGAATCGGCGCCGCCGCAGCGGTGTTCATCTCCGCGCGCACCGACGTCACCGTGCGCC
GGGCCGGCAAGACCTACCTGCAGAGCTTCGGCCGCGGCTACCCCGGCGTGTTCGAGGGCAAAGACTTCGACCCGGACGCC
CCGTTCACCCGCGCCGACACGCAGAAGCTGCGGGGCACCGGCAACCGCAAGCCCGACGTGCACGGCACCACGGTCCGCAT
CCTGTTCGACCCCGCCGTCGTGCCGGATTCCCAGATCGACATCGGCGAGGTGCTGCTGCGCGCGCACGCCGCGGCCCGGA
TGTCACCCGGCGTGCACCTGAGCGTCATCGACGAAGGCTGGCCCGGCGACGAGGTTGCGCCGGCGTTGCTCGAACCGTTC
ACCGGCCCGTGGGGCACGGACACGCTGCTGGATCTGATGTGCACCGCGGCCGGTACACCCGCGCCCGGCGTGCGCGCGGT
CGTGGAGGGCCGCGGCGAATACACCACCGGTCGCGGCCCCACCCCGTTCCGCTGGTCGCTGACCGCCGGCCCGGCCGAAC
CGGCGACAGTGGCCGCGTTCTGCAACACCGTGCGCACCCCCGGCGGCGGTTCCCATCTGACCGCCGCGATGAAAGGGCTG
TCCGAAGCGCTGGCCGATCGCGCGTCCCGGATGCGGGACCTGGGCCTCGCCAAAGGCGAAGAGGGGCCGGAGGCACAGGA
TTTCGCCGCGGTCACCGCTCTCGCCGTGGACACCCGCGCACCCGATGTCGCCTGGGACTCCCAGGCGAAGACCGCGGTGT
CGTCGCGGTCGCTGAACGTGGCGATGGCCCCCGACGTGGCACGCAGCGTCACCATCTGGGCGGCCAACCCCGCCAACGGC
GACGCGGTTTCGTTGTGGACCAAGCTGGCGCTGGAGTCCGCCAGGGCGCGCCGCAGCGCGGAAGGCGCGAAGGCACGCTC
GCGCGCCGCCTCGAAAGCCAAGGGTCTCGGGACGAACCTGTCGCTGCCGCCCAAACTGCTGCCCAGCCGGGAGACCGGAC
GCGGATCGGGTGCCGAACTGTTCCTGTGTGAGGGCGATTCGGCGCTCGGCACCATCAAGGCGGCGCGTGACGCCACCTTC
CAGGCGGCTTTCCCGCTGAAAGGCAAGCCGCCCAACGTCTACGGCTTCGCGCTGAACAAAGCGCGGGCCAAGGACGAGTT
CGATTCGATCGAACGCATCCTCGGCTGCGGCGTGCGGGACAACTGTGATCCCGAACTGTGCCGGTACGACCGGATTCTGT
TCGCCTCCGACGCCGACCCCGACGGCGGCAACATCAACTCCAGCCTGATCTCGATGTTCCTCGACTTCTACCGTCCGCTG
GTCGAAGCGGGGATGGTGTACGTGACGCTGCCGCCGCTGTTCGTCGTCAAGGACGGCACGCAGCGGATCTACTGCCAGGA
CGAGTCCGAGCGCGACGCCGCCGTGGCCAAGATGAAAGCCACCTCCAAGCGCAAGGTCGAGGTGCAGCGCAACAAGGGCC
TCGGCGAGATGGACGCCGACGACTTCTGGAACACCGTGCTGGATCCACAGCGGCGCACCGTCATTCGCGTGCACCCCGAT
GACAGTGAGAACAAGTTGCACCACACTCTGTTCGGCGGGCCGCCAGAGGGCAGGCGCACGTGGATGGCCGATGTGGCCTC
CCGTGTCGACACCACTGCGCTCGACCTGAGCTAG

Upstream 100 bases:

>100_bases
TTTCGCTCCGATTCTGCAGCGGTGCTCCCACGAAGATGTCGGTGCCGGCGTCTACGATGCCTGCGGCACGCCTGACGGCA
TCGATGAAAAGGATCAGCAG

Downstream 100 bases:

>100_bases
GAGACACACTGTGACCGCGATCATCGAGCAGAACCCCGACCTGGTCCTCGACCAGAGCGCCGACGACTACTGGAACCACT
ACCAGCTGACCTTCGCGCTC

Product: DNA topoisomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 677; Mature: 676

Protein sequence:

>677_residues
MSYTAADITELDDVQHTRLRPAVNLGLDVLNTALRELIDNAIEEVADPSHGGSAVTITLHDDGSVSVADDGRGLPVDSDP
VNGKNGIVKTLGTARAGGKFSAHTDAASTGAGLNGIGAAAAVFISARTDVTVRRAGKTYLQSFGRGYPGVFEGKDFDPDA
PFTRADTQKLRGTGNRKPDVHGTTVRILFDPAVVPDSQIDIGEVLLRAHAAARMSPGVHLSVIDEGWPGDEVAPALLEPF
TGPWGTDTLLDLMCTAAGTPAPGVRAVVEGRGEYTTGRGPTPFRWSLTAGPAEPATVAAFCNTVRTPGGGSHLTAAMKGL
SEALADRASRMRDLGLAKGEEGPEAQDFAAVTALAVDTRAPDVAWDSQAKTAVSSRSLNVAMAPDVARSVTIWAANPANG
DAVSLWTKLALESARARRSAEGAKARSRAASKAKGLGTNLSLPPKLLPSRETGRGSGAELFLCEGDSALGTIKAARDATF
QAAFPLKGKPPNVYGFALNKARAKDEFDSIERILGCGVRDNCDPELCRYDRILFASDADPDGGNINSSLISMFLDFYRPL
VEAGMVYVTLPPLFVVKDGTQRIYCQDESERDAAVAKMKATSKRKVEVQRNKGLGEMDADDFWNTVLDPQRRTVIRVHPD
DSENKLHHTLFGGPPEGRRTWMADVASRVDTTALDLS

Sequences:

>Translated_677_residues
MSYTAADITELDDVQHTRLRPAVNLGLDVLNTALRELIDNAIEEVADPSHGGSAVTITLHDDGSVSVADDGRGLPVDSDP
VNGKNGIVKTLGTARAGGKFSAHTDAASTGAGLNGIGAAAAVFISARTDVTVRRAGKTYLQSFGRGYPGVFEGKDFDPDA
PFTRADTQKLRGTGNRKPDVHGTTVRILFDPAVVPDSQIDIGEVLLRAHAAARMSPGVHLSVIDEGWPGDEVAPALLEPF
TGPWGTDTLLDLMCTAAGTPAPGVRAVVEGRGEYTTGRGPTPFRWSLTAGPAEPATVAAFCNTVRTPGGGSHLTAAMKGL
SEALADRASRMRDLGLAKGEEGPEAQDFAAVTALAVDTRAPDVAWDSQAKTAVSSRSLNVAMAPDVARSVTIWAANPANG
DAVSLWTKLALESARARRSAEGAKARSRAASKAKGLGTNLSLPPKLLPSRETGRGSGAELFLCEGDSALGTIKAARDATF
QAAFPLKGKPPNVYGFALNKARAKDEFDSIERILGCGVRDNCDPELCRYDRILFASDADPDGGNINSSLISMFLDFYRPL
VEAGMVYVTLPPLFVVKDGTQRIYCQDESERDAAVAKMKATSKRKVEVQRNKGLGEMDADDFWNTVLDPQRRTVIRVHPD
DSENKLHHTLFGGPPEGRRTWMADVASRVDTTALDLS
>Mature_676_residues
SYTAADITELDDVQHTRLRPAVNLGLDVLNTALRELIDNAIEEVADPSHGGSAVTITLHDDGSVSVADDGRGLPVDSDPV
NGKNGIVKTLGTARAGGKFSAHTDAASTGAGLNGIGAAAAVFISARTDVTVRRAGKTYLQSFGRGYPGVFEGKDFDPDAP
FTRADTQKLRGTGNRKPDVHGTTVRILFDPAVVPDSQIDIGEVLLRAHAAARMSPGVHLSVIDEGWPGDEVAPALLEPFT
GPWGTDTLLDLMCTAAGTPAPGVRAVVEGRGEYTTGRGPTPFRWSLTAGPAEPATVAAFCNTVRTPGGGSHLTAAMKGLS
EALADRASRMRDLGLAKGEEGPEAQDFAAVTALAVDTRAPDVAWDSQAKTAVSSRSLNVAMAPDVARSVTIWAANPANGD
AVSLWTKLALESARARRSAEGAKARSRAASKAKGLGTNLSLPPKLLPSRETGRGSGAELFLCEGDSALGTIKAARDATFQ
AAFPLKGKPPNVYGFALNKARAKDEFDSIERILGCGVRDNCDPELCRYDRILFASDADPDGGNINSSLISMFLDFYRPLV
EAGMVYVTLPPLFVVKDGTQRIYCQDESERDAAVAKMKATSKRKVEVQRNKGLGEMDADDFWNTVLDPQRRTVIRVHPDD
SENKLHHTLFGGPPEGRRTWMADVASRVDTTALDLS

Specific function: Topoisomerase IV Is Essential For Chromosome Segregation. It Has Relaxation Of Supercoiled DNA Activity. Performs The Decatenation Events Required During The Replication Of A Circular DNA Molecule. [C]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1789408, Length=676, Percent_Identity=29.2899408284024, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI48994957, Length=606, Percent_Identity=27.2277227722772, Blast_Score=158, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 71694; Mature: 71563

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYTAADITELDDVQHTRLRPAVNLGLDVLNTALRELIDNAIEEVADPSHGGSAVTITLH
CCCCCCCHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEE
DDGSVSVADDGRGLPVDSDPVNGKNGIVKTLGTARAGGKFSAHTDAASTGAGLNGIGAAA
CCCCEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
AVFISARTDVTVRRAGKTYLQSFGRGYPGVFEGKDFDPDAPFTRADTQKLRGTGNRKPDV
EEEEECCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCC
HGTTVRILFDPAVVPDSQIDIGEVLLRAHAAARMSPGVHLSVIDEGWPGDEVAPALLEPF
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHCCC
TGPWGTDTLLDLMCTAAGTPAPGVRAVVEGRGEYTTGRGPTPFRWSLTAGPAEPATVAAF
CCCCCHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHH
CNTVRTPGGGSHLTAAMKGLSEALADRASRMRDLGLAKGEEGPEAQDFAAVTALAVDTRA
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHEEECCCC
PDVAWDSQAKTAVSSRSLNVAMAPDVARSVTIWAANPANGDAVSLWTKLALESARARRSA
CCCCCCCHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
EGAKARSRAASKAKGLGTNLSLPPKLLPSRETGRGSGAELFLCEGDSALGTIKAARDATF
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEHHCCCCE
QAAFPLKGKPPNVYGFALNKARAKDEFDSIERILGCGVRDNCDPELCRYDRILFASDADP
EEECCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCEEEECCCCC
DGGNINSSLISMFLDFYRPLVEAGMVYVTLPPLFVVKDGTQRIYCQDESERDAAVAKMKA
CCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCEEEEECCCCEEEECCCCCHHHHHHHHHH
TSKRKVEVQRNKGLGEMDADDFWNTVLDPQRRTVIRVHPDDSENKLHHTLFGGPPEGRRT
CCCCEEEEHHCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHH
WMADVASRVDTTALDLS
HHHHHHHHHCCCEECCC
>Mature Secondary Structure 
SYTAADITELDDVQHTRLRPAVNLGLDVLNTALRELIDNAIEEVADPSHGGSAVTITLH
CCCCCCHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEE
DDGSVSVADDGRGLPVDSDPVNGKNGIVKTLGTARAGGKFSAHTDAASTGAGLNGIGAAA
CCCCEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
AVFISARTDVTVRRAGKTYLQSFGRGYPGVFEGKDFDPDAPFTRADTQKLRGTGNRKPDV
EEEEECCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCC
HGTTVRILFDPAVVPDSQIDIGEVLLRAHAAARMSPGVHLSVIDEGWPGDEVAPALLEPF
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHCCC
TGPWGTDTLLDLMCTAAGTPAPGVRAVVEGRGEYTTGRGPTPFRWSLTAGPAEPATVAAF
CCCCCHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHH
CNTVRTPGGGSHLTAAMKGLSEALADRASRMRDLGLAKGEEGPEAQDFAAVTALAVDTRA
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHEEECCCC
PDVAWDSQAKTAVSSRSLNVAMAPDVARSVTIWAANPANGDAVSLWTKLALESARARRSA
CCCCCCCHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
EGAKARSRAASKAKGLGTNLSLPPKLLPSRETGRGSGAELFLCEGDSALGTIKAARDATF
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEHHCCCCE
QAAFPLKGKPPNVYGFALNKARAKDEFDSIERILGCGVRDNCDPELCRYDRILFASDADP
EEECCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCEEEECCCCC
DGGNINSSLISMFLDFYRPLVEAGMVYVTLPPLFVVKDGTQRIYCQDESERDAAVAKMKA
CCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCEEEEECCCCEEEECCCCCHHHHHHHHHH
TSKRKVEVQRNKGLGEMDADDFWNTVLDPQRRTVIRVHPDDSENKLHHTLFGGPPEGRRT
CCCCEEEEHHCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHH
WMADVASRVDTTALDLS
HHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA