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The map label for this gene is yciC [H]

Identifier: 119871338

GI number: 119871338

Start: 5550352

End: 5551359

Strand: Direct

Name: yciC [H]

Synonym: Mkms_5312

Alternate gene names: 119871338

Gene position: 5550352-5551359 (Clockwise)

Preceding gene: 119871336

Following gene: 119871341

Centisome position: 96.74

GC content: 71.43

Gene sequence:

>1008_bases
GTGTCGGCAATCCCGGTCATCGCGTTGACCGGCTATCTGGGTGCCGGTAAGACCAGCCTGCTCAACCATGTGTTGCGGGC
ACCCGATGCCCGGGTGGGCGTGGTGATCAACGACTTCGGTGAACTCAACGTCGACGCCGCGCTGGTGACCGGTCAGGTGG
ACGAACCGGCCTCGATCGCCGGCGGCTGCATCTGCTGCCTACCGGACGAAGGCGGACTCGACGCCGCGCTGGAGAAACTG
GCCGACCCGAAGCTGGGGCTGGACGCGATCATCGTCGAGGCGAGCGGTCTGGCCGACCCTGTCGCGGTCTCGCGGATCAT
CCGCTTCAGCGGCGTGGACCGGGTACGCCCCGGCGGGGTGGTCGACGTCATCGACGCCGCCATGCACTTCGACACCGTCG
ACCGCGGCGGCGCACCGCCCGCCCGCTACGCCGCGGCGTCGCTGGTGGTGGTCAACAAACTCGACCAGATCCCCGACGAC
GACCGTGCCGCCGCCCTCGAGCGCATCGAATCCCGGGTCCGGGAACGGCATCCGGAGGCGCACATCGTCGGCGCCGTCGG
CGGCCGGGTCGACCCGGCTCTGCTCTACGACGTCGCCGACACCGAACTCGCCACCGGGCAGCTGTCCTTCCGCGAACTGC
TGATCGCCGACGACACCCACCATCACGTGCACGCGGTGTCGGTGACGGCGACCAGCGAGGGGTGCGTCGATCCCGGCGCG
CTGTTCGACCTGCTCGAGGATCCGCCCGCGGGGGTGTACCGGCTCAAGGGCACGGTCGCCGTCCGCTATCGGGACCGGGC
CCGCCGCTACGTCGTCAACGTCGTCGGGCCGTCGGTCCACGTCGCGGCCGGGACGCCGGGCTCGGCGAACGTCCTGGTGG
CGATCGGCACCGGATTCGACGTCGACGCGGTCCGTGCGCACGTCGAGGCGGCGTTGCGTCCGTGCGACAAGCCGGTGCCG
ACGGCGGGGCTGCGCCGCCTGCAGCGGTACCGGCGGCTCAGCGCCTAG

Upstream 100 bases:

>100_bases
TCCCACCCCCACAGTCGCGTCATCCCCCGACCCGGAGACCGATGCTAATACCGGTGTCGACGGCCGCGCTTAGACTTCGC
GACGGCGGAAAGGAGGCCAG

Downstream 100 bases:

>100_bases
GTTCCGCGGTGGCCGGCCTCGGCGGGCAGTGGCGGGGGAAGCGGCGTGGTCGGTGTGGGTGTGGCGGGCGCGGGACCGGC
CCCCGGGGAGGCCGGCGCGG

Product: cobalamin synthesis protein, P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MSAIPVIALTGYLGAGKTSLLNHVLRAPDARVGVVINDFGELNVDAALVTGQVDEPASIAGGCICCLPDEGGLDAALEKL
ADPKLGLDAIIVEASGLADPVAVSRIIRFSGVDRVRPGGVVDVIDAAMHFDTVDRGGAPPARYAAASLVVVNKLDQIPDD
DRAAALERIESRVRERHPEAHIVGAVGGRVDPALLYDVADTELATGQLSFRELLIADDTHHHVHAVSVTATSEGCVDPGA
LFDLLEDPPAGVYRLKGTVAVRYRDRARRYVVNVVGPSVHVAAGTPGSANVLVAIGTGFDVDAVRAHVEAALRPCDKPVP
TAGLRRLQRYRRLSA

Sequences:

>Translated_335_residues
MSAIPVIALTGYLGAGKTSLLNHVLRAPDARVGVVINDFGELNVDAALVTGQVDEPASIAGGCICCLPDEGGLDAALEKL
ADPKLGLDAIIVEASGLADPVAVSRIIRFSGVDRVRPGGVVDVIDAAMHFDTVDRGGAPPARYAAASLVVVNKLDQIPDD
DRAAALERIESRVRERHPEAHIVGAVGGRVDPALLYDVADTELATGQLSFRELLIADDTHHHVHAVSVTATSEGCVDPGA
LFDLLEDPPAGVYRLKGTVAVRYRDRARRYVVNVVGPSVHVAAGTPGSANVLVAIGTGFDVDAVRAHVEAALRPCDKPVP
TAGLRRLQRYRRLSA
>Mature_334_residues
SAIPVIALTGYLGAGKTSLLNHVLRAPDARVGVVINDFGELNVDAALVTGQVDEPASIAGGCICCLPDEGGLDAALEKLA
DPKLGLDAIIVEASGLADPVAVSRIIRFSGVDRVRPGGVVDVIDAAMHFDTVDRGGAPPARYAAASLVVVNKLDQIPDDD
RAAALERIESRVRERHPEAHIVGAVGGRVDPALLYDVADTELATGQLSFRELLIADDTHHHVHAVSVTATSEGCVDPGAL
FDLLEDPPAGVYRLKGTVAVRYRDRARRYVVNVVGPSVHVAAGTPGSANVLVAIGTGFDVDAVRAHVEAALRPCDKPVPT
AGLRRLQRYRRLSA

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=359, Percent_Identity=27.0194986072423, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI33469141, Length=359, Percent_Identity=27.0194986072423, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI148727351, Length=359, Percent_Identity=27.0194986072423, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI146231952, Length=359, Percent_Identity=26.7409470752089, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI223941779, Length=359, Percent_Identity=26.4623955431755, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI223941776, Length=358, Percent_Identity=26.536312849162, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI119120938, Length=178, Percent_Identity=30.8988764044944, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI87082430, Length=203, Percent_Identity=26.6009852216749, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788499, Length=227, Percent_Identity=26.431718061674, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324356, Length=198, Percent_Identity=29.2929292929293, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 35129; Mature: 34998

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIPVIALTGYLGAGKTSLLNHVLRAPDARVGVVINDFGELNVDAALVTGQVDEPASIA
CCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCCCCCCHHC
GGCICCLPDEGGLDAALEKLADPKLGLDAIIVEASGLADPVAVSRIIRFSGVDRVRPGGV
CCEEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCH
VDVIDAAMHFDTVDRGGAPPARYAAASLVVVNKLDQIPDDDRAAALERIESRVRERHPEA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEHHHHCCCCCHHHHHHHHHHHHHHHHCCCE
HIVGAVGGRVDPALLYDVADTELATGQLSFRELLIADDTHHHVHAVSVTATSEGCVDPGA
EEEECCCCCCCHHEEEECCCCCCCCCCHHHEEEEEECCCCCEEEEEEEEECCCCCCCHHH
LFDLLEDPPAGVYRLKGTVAVRYRDRARRYVVNVVGPSVHVAAGTPGSANVLVAIGTGFD
HHHHHCCCCCCEEEEECEEEEEEECCCCEEEEEEECCEEEEEECCCCCCEEEEEEECCCC
VDAVRAHVEAALRPCDKPVPTAGLRRLQRYRRLSA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAIPVIALTGYLGAGKTSLLNHVLRAPDARVGVVINDFGELNVDAALVTGQVDEPASIA
CCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCCCCCCHHC
GGCICCLPDEGGLDAALEKLADPKLGLDAIIVEASGLADPVAVSRIIRFSGVDRVRPGGV
CCEEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCH
VDVIDAAMHFDTVDRGGAPPARYAAASLVVVNKLDQIPDDDRAAALERIESRVRERHPEA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEHHHHCCCCCHHHHHHHHHHHHHHHHCCCE
HIVGAVGGRVDPALLYDVADTELATGQLSFRELLIADDTHHHVHAVSVTATSEGCVDPGA
EEEECCCCCCCHHEEEECCCCCCCCCCHHHEEEEEECCCCCEEEEEEEEECCCCCCCHHH
LFDLLEDPPAGVYRLKGTVAVRYRDRARRYVVNVVGPSVHVAAGTPGSANVLVAIGTGFD
HHHHHCCCCCCEEEEECEEEEEEECCCCEEEEEEECCEEEEEECCCCCCEEEEEEECCCC
VDAVRAHVEAALRPCDKPVPTAGLRRLQRYRRLSA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]