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The map label for this gene is acdA [H]

Identifier: 119871305

GI number: 119871305

Start: 5513209

End: 5514366

Strand: Direct

Name: acdA [H]

Synonym: Mkms_5278

Alternate gene names: 119871305

Gene position: 5513209-5514366 (Clockwise)

Preceding gene: 119871304

Following gene: 119871306

Centisome position: 96.1

GC content: 72.71

Gene sequence:

>1158_bases
GTGGCTGAGGCCTTCGTGTTCACCGAGGAGCAGCGGCAGCTGCGGGATGCGGTGCGGGGCTTCTGCTCCGACCACTTCGA
CGAGCAGACCGTGCGCCGGATCATGGAGTCCGATCCGGCGCACGATCCGGCGCTGTGGGCGCGGCTCGGATCGGAACTCG
GCGTGCTCGGTCTGTCGGTGTCCGAAGCCGACGGCGGCGCCGGTGGCGACCTCGTCGACCAGGCGGTCGCGGTCGAGGAG
TTCGGCGCGTCGCTGGTGTGCGGACCACTGTTCGGGACGGTCTACCTCGCGATACCCGCCCTGGTCGCCGCCTCGGCCGG
GCCGGCGCGCGACCGCCTGCTCGCCGACCTCGTCGAGGGCACCCGCACCGCGGCGTTCGCCGTCGCTGACCGCGCCGGCG
CCTTCGTCCCCGATGCGGTCGGCGTGACGGTCGAGGGTGACGCGCTGACGGGCACGCTCGCGCAGGTCGTCGACGGCGCC
GTCGCCGACGTGCTGCTCGTCGCCGCGAAGGGGTCCGACGGGGTGGGCCTCTACGCGGTCGACACGGGCGCCGAGGGTCT
GGAACGCACCCCGTTGGTCACGCTCGACCTCACCCGCACCCAGGCGTCCTTCACGTTGTCGGGCGCGCCCGCCACGCTGA
TCGCCGGACCGGATGAGGCGGCCAGGGTCATCCAGCACGCACTGCACGTGGGTTCGGCGCTGCTGGCCGTCGAACAGGTC
GGCGCCGCGCAGCACCTGCTCGACATCGCAGTCGAGTACGCGAAGTCGCGGCTGCAGTTCGGGCGTCCGATCGGATCGTT
CCAGGCGGTCAAACACCGGCTGGCCGACATGCTGGTCGACGCCGAACACGCGCGCTCGACGGCCTATCACGCGGTGTGGG
CGCTGACCAACGGGTCCGACGACGCCGCGCTGGCGACGGCGATCGCCCAGGCCGTGTGCTCGGCCGCGCTCAGCCGGATC
GCCGCGGACACCATCCAGGTGCTCGGCGGTATCGGGTTCACGTGGGAGCACCAGGCGCACCTGTACTTCAAGCGGGCGAC
CACCGACGCGACGTTGCTCGGCACCGCCGAAGAGCACCGCGCCCGCGTCGCCGACCTGGTACTCGACACCGCGACACCCG
AACGCCTCCCGCGGGTGGCCGCCGGAGTCCCCGGCTGA

Upstream 100 bases:

>100_bases
GGCACCTCGGACGTCATGCGGAACATCCTGGGCGAGCGGGTGCTCGGTCTGCCGGGTGATCTGCGTGCCGATGCGGGGAT
GCCGTGGAAGGAGGTGCCGC

Downstream 100 bases:

>100_bases
GTCGACACCCGGCACGGGTGCCGGGGAATCGCTATGCTGGCGCCTTTCCCCCTGAGGACGGGAGGCGCCATGTCGACTGG
GAGCGGACACATCCGGTTGA

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MAEAFVFTEEQRQLRDAVRGFCSDHFDEQTVRRIMESDPAHDPALWARLGSELGVLGLSVSEADGGAGGDLVDQAVAVEE
FGASLVCGPLFGTVYLAIPALVAASAGPARDRLLADLVEGTRTAAFAVADRAGAFVPDAVGVTVEGDALTGTLAQVVDGA
VADVLLVAAKGSDGVGLYAVDTGAEGLERTPLVTLDLTRTQASFTLSGAPATLIAGPDEAARVIQHALHVGSALLAVEQV
GAAQHLLDIAVEYAKSRLQFGRPIGSFQAVKHRLADMLVDAEHARSTAYHAVWALTNGSDDAALATAIAQAVCSAALSRI
AADTIQVLGGIGFTWEHQAHLYFKRATTDATLLGTAEEHRARVADLVLDTATPERLPRVAAGVPG

Sequences:

>Translated_385_residues
MAEAFVFTEEQRQLRDAVRGFCSDHFDEQTVRRIMESDPAHDPALWARLGSELGVLGLSVSEADGGAGGDLVDQAVAVEE
FGASLVCGPLFGTVYLAIPALVAASAGPARDRLLADLVEGTRTAAFAVADRAGAFVPDAVGVTVEGDALTGTLAQVVDGA
VADVLLVAAKGSDGVGLYAVDTGAEGLERTPLVTLDLTRTQASFTLSGAPATLIAGPDEAARVIQHALHVGSALLAVEQV
GAAQHLLDIAVEYAKSRLQFGRPIGSFQAVKHRLADMLVDAEHARSTAYHAVWALTNGSDDAALATAIAQAVCSAALSRI
AADTIQVLGGIGFTWEHQAHLYFKRATTDATLLGTAEEHRARVADLVLDTATPERLPRVAAGVPG
>Mature_384_residues
AEAFVFTEEQRQLRDAVRGFCSDHFDEQTVRRIMESDPAHDPALWARLGSELGVLGLSVSEADGGAGGDLVDQAVAVEEF
GASLVCGPLFGTVYLAIPALVAASAGPARDRLLADLVEGTRTAAFAVADRAGAFVPDAVGVTVEGDALTGTLAQVVDGAV
ADVLLVAAKGSDGVGLYAVDTGAEGLERTPLVTLDLTRTQASFTLSGAPATLIAGPDEAARVIQHALHVGSALLAVEQVG
AAQHLLDIAVEYAKSRLQFGRPIGSFQAVKHRLADMLVDAEHARSTAYHAVWALTNGSDDAALATAIAQAVCSAALSRIA
ADTIQVLGGIGFTWEHQAHLYFKRATTDATLLGTAEEHRARVADLVLDTATPERLPRVAAGVPG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=382, Percent_Identity=27.2251308900524, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI4557233, Length=368, Percent_Identity=26.3586956521739, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4501857, Length=388, Percent_Identity=23.1958762886598, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI226958414, Length=342, Percent_Identity=26.9005847953216, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4557231, Length=391, Percent_Identity=23.0179028132992, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI187960098, Length=391, Percent_Identity=23.0179028132992, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI76496475, Length=364, Percent_Identity=24.7252747252747, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4557235, Length=364, Percent_Identity=24.7252747252747, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4501859, Length=360, Percent_Identity=22.2222222222222, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786223, Length=124, Percent_Identity=29.0322580645161, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538396, Length=386, Percent_Identity=26.1658031088083, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17508101, Length=388, Percent_Identity=22.1649484536082, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17570075, Length=394, Percent_Identity=23.6040609137056, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17506239, Length=383, Percent_Identity=22.976501305483, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17569725, Length=399, Percent_Identity=22.3057644110276, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17505929, Length=320, Percent_Identity=27.8125, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356377, Length=382, Percent_Identity=24.6073298429319, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=26.1780104712042, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24646207, Length=353, Percent_Identity=24.0793201133144, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24660351, Length=394, Percent_Identity=23.8578680203046, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666513, Length=379, Percent_Identity=21.8997361477573, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 39871; Mature: 39740

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAFVFTEEQRQLRDAVRGFCSDHFDEQTVRRIMESDPAHDPALWARLGSELGVLGLSV
CCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEE
SEADGGAGGDLVDQAVAVEEFGASLVCGPLFGTVYLAIPALVAASAGPARDRLLADLVEG
ECCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
TRTAAFAVADRAGAFVPDAVGVTVEGDALTGTLAQVVDGAVADVLLVAAKGSDGVGLYAV
CHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEE
DTGAEGLERTPLVTLDLTRTQASFTLSGAPATLIAGPDEAARVIQHALHVGSALLAVEQV
CCCCCCCCCCCEEEEEEECCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
GAAQHLLDIAVEYAKSRLQFGRPIGSFQAVKHRLADMLVDAEHARSTAYHAVWALTNGSD
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCC
DAALATAIAQAVCSAALSRIAADTIQVLGGIGFTWEHQAHLYFKRATTDATLLGTAEEHR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEEEECCCCEEEECCHHHHH
ARVADLVLDTATPERLPRVAAGVPG
HHHHHHHHCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
AEAFVFTEEQRQLRDAVRGFCSDHFDEQTVRRIMESDPAHDPALWARLGSELGVLGLSV
CCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEE
SEADGGAGGDLVDQAVAVEEFGASLVCGPLFGTVYLAIPALVAASAGPARDRLLADLVEG
ECCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
TRTAAFAVADRAGAFVPDAVGVTVEGDALTGTLAQVVDGAVADVLLVAAKGSDGVGLYAV
CHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEE
DTGAEGLERTPLVTLDLTRTQASFTLSGAPATLIAGPDEAARVIQHALHVGSALLAVEQV
CCCCCCCCCCCEEEEEEECCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
GAAQHLLDIAVEYAKSRLQFGRPIGSFQAVKHRLADMLVDAEHARSTAYHAVWALTNGSD
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCC
DAALATAIAQAVCSAALSRIAADTIQVLGGIGFTWEHQAHLYFKRATTDATLLGTAEEHR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEEEECCCCEEEECCHHHHH
ARVADLVLDTATPERLPRVAAGVPG
HHHHHHHHCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]