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The map label for this gene is fdh [H]

Identifier: 119871224

GI number: 119871224

Start: 5439512

End: 5440690

Strand: Direct

Name: fdh [H]

Synonym: Mkms_5197

Alternate gene names: 119871224

Gene position: 5439512-5440690 (Clockwise)

Preceding gene: 119871223

Following gene: 119871225

Centisome position: 94.81

GC content: 68.45

Gene sequence:

>1179_bases
ATGCGCGCAGTGACCTGGCAGGGCCGACGGAAGGTCTCGGTCGACAACGTGCCGGACCCGATCATCAAGGAGCCGACGGA
CGCCGTCATCCGGGTCACCAGCACCAACATCTGCGGTTCCGACCTGCACCTCTACGAAACGCTCAGCGCGTTCATGAGTC
CCGGCGACATCATCGGCCACGAGGCCATGGGTGTGGTCGAAGAGGTGGGCACCCAGACCGGTGACCTGAAGGTCGGCGAC
CGCGTGGTGATCCCGTTCAACATCTCGTGTGGAACGTGCTGGATGTGCGACCACGGTCTGCAGAGCCAGTGCGAGACCAC
CCAGAACCGGGACCAGGGCACGGGTGCGGCCCTGTTCGGTTTCTCGAAGCTCTACGGCGAGGTGGCCGGCGGACAGGCCG
AGTACCTGCGCGTGCCGCAGGCGCAGTACACCCACATCAAGATCCCCGAGGACGGGCCCGACGAGCGCTTCGTCTACCTG
TCCGACGTGTTGCCCACCGCCTGGCAGGGCGTCGAGTACGCCAACGTGCCCGACGGCGGCACGCTGGTCGTCGTGGGGCT
CGGACCGATCGGCTCGATGGCGTGCCGGATCGCCGCGCACCGCAACAACTGCCGGGTGATCGGCATCGACCTCGTCGAGG
AGCGCCTCGACCGGGCCCGCCCGTACTGCGCCGAGGTGATCGACCTGCGCACGCAGGACGCCGACGCGGTGGTCGCCGAA
CTGACGCAGGGACGCGGCGCCGACTCCGTCATCGACGCGGTGGGAATGGAGGCGCACGGATCCCCCGTCGCCGAAGCCGC
CCAGACCGCCAGTGGCTTCCTGCCCTCGAGCATCGGCCGGGTCGTCATGAAGCATGCGGGTGTGGACCGGCTCGCCGCGC
TGAACTCCGCGATCGCGCTCGTGCGCCGCGGCGGAACGGTATCGCTGTCGGGTGTGTACGGCGGCGCCGCCGATCCGATC
AACATGATGACGCTGTTCGACAAGCAGGTGACGCTGCGGATGGGCCAGGCCAACGTCAAGCGTTGGGTGCCCGACATCCT
GCCGCTGCTGACCGCCGACGATCCGCTGGGCGTCGAGAACTTCGCCACCCACCGGCTGCCGCTCGCCGAGGCGCCGGGCG
CGTACGAGACCTTCCAGAAGAAGCAGGACGGGATGGTCAAGGTGGTGCTCACCCCGTAG

Upstream 100 bases:

>100_bases
CGTCAGGGCCGAGCGGCCGATGACCCAGTGGAGTGAACCCGGCGTTTGACCCGCCACAGAGCGGGCACGCTGACTCGGAC
ACCGAGTTGGAGGAGGACGC

Downstream 100 bases:

>100_bases
CGGCGACGCGGGTGATCAAGCGGGGGTGATTGGCGGACCGCACTGTGGGGTACCTCACCCGCGTGGTTCAGACGTGTCGC
AGGGCGGAGCCCGGGATCGG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MRAVTWQGRRKVSVDNVPDPIIKEPTDAVIRVTSTNICGSDLHLYETLSAFMSPGDIIGHEAMGVVEEVGTQTGDLKVGD
RVVIPFNISCGTCWMCDHGLQSQCETTQNRDQGTGAALFGFSKLYGEVAGGQAEYLRVPQAQYTHIKIPEDGPDERFVYL
SDVLPTAWQGVEYANVPDGGTLVVVGLGPIGSMACRIAAHRNNCRVIGIDLVEERLDRARPYCAEVIDLRTQDADAVVAE
LTQGRGADSVIDAVGMEAHGSPVAEAAQTASGFLPSSIGRVVMKHAGVDRLAALNSAIALVRRGGTVSLSGVYGGAADPI
NMMTLFDKQVTLRMGQANVKRWVPDILPLLTADDPLGVENFATHRLPLAEAPGAYETFQKKQDGMVKVVLTP

Sequences:

>Translated_392_residues
MRAVTWQGRRKVSVDNVPDPIIKEPTDAVIRVTSTNICGSDLHLYETLSAFMSPGDIIGHEAMGVVEEVGTQTGDLKVGD
RVVIPFNISCGTCWMCDHGLQSQCETTQNRDQGTGAALFGFSKLYGEVAGGQAEYLRVPQAQYTHIKIPEDGPDERFVYL
SDVLPTAWQGVEYANVPDGGTLVVVGLGPIGSMACRIAAHRNNCRVIGIDLVEERLDRARPYCAEVIDLRTQDADAVVAE
LTQGRGADSVIDAVGMEAHGSPVAEAAQTASGFLPSSIGRVVMKHAGVDRLAALNSAIALVRRGGTVSLSGVYGGAADPI
NMMTLFDKQVTLRMGQANVKRWVPDILPLLTADDPLGVENFATHRLPLAEAPGAYETFQKKQDGMVKVVLTP
>Mature_392_residues
MRAVTWQGRRKVSVDNVPDPIIKEPTDAVIRVTSTNICGSDLHLYETLSAFMSPGDIIGHEAMGVVEEVGTQTGDLKVGD
RVVIPFNISCGTCWMCDHGLQSQCETTQNRDQGTGAALFGFSKLYGEVAGGQAEYLRVPQAQYTHIKIPEDGPDERFVYL
SDVLPTAWQGVEYANVPDGGTLVVVGLGPIGSMACRIAAHRNNCRVIGIDLVEERLDRARPYCAEVIDLRTQDADAVVAE
LTQGRGADSVIDAVGMEAHGSPVAEAAQTASGFLPSSIGRVVMKHAGVDRLAALNSAIALVRRGGTVSLSGVYGGAADPI
NMMTLFDKQVTLRMGQANVKRWVPDILPLLTADDPLGVENFATHRLPLAEAPGAYETFQKKQDGMVKVVLTP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=282, Percent_Identity=26.241134751773, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI156523966, Length=303, Percent_Identity=25.0825082508251, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4501939, Length=303, Percent_Identity=25.0825082508251, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4501929, Length=271, Percent_Identity=27.6752767527675, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI71565154, Length=271, Percent_Identity=26.9372693726937, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4501933, Length=271, Percent_Identity=26.9372693726937, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI71743840, Length=258, Percent_Identity=27.1317829457364, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI262073058, Length=255, Percent_Identity=28.6274509803922, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786825, Length=403, Percent_Identity=38.7096774193548, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI87082125, Length=254, Percent_Identity=32.6771653543307, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI226510992, Length=371, Percent_Identity=26.6846361185984, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790045, Length=271, Percent_Identity=29.520295202952, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787863, Length=245, Percent_Identity=28.9795918367347, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788073, Length=242, Percent_Identity=28.5123966942149, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788075, Length=383, Percent_Identity=26.3707571801567, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790718, Length=342, Percent_Identity=24.2690058479532, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081918, Length=220, Percent_Identity=30.4545454545455, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788407, Length=205, Percent_Identity=27.3170731707317, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=283, Percent_Identity=27.9151943462898, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=247, Percent_Identity=28.3400809716599, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737897, Length=392, Percent_Identity=25.2551020408163, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17737895, Length=237, Percent_Identity=27.0042194092827, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550770, Length=168, Percent_Identity=30.3571428571429, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45551930, Length=168, Percent_Identity=30.3571428571429, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221457811, Length=168, Percent_Identity=30.3571428571429, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 41956; Mature: 41956

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVTWQGRRKVSVDNVPDPIIKEPTDAVIRVTSTNICGSDLHLYETLSAFMSPGDIIGH
CCCCCCCCCCEEECCCCCCCHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCHHCCH
EAMGVVEEVGTQTGDLKVGDRVVIPFNISCGTCWMCDHGLQSQCETTQNRDQGTGAALFG
HHHHHHHHHCCCCCCEEECCEEEEEEECCCCEEEEECCCCHHHHHHHCCCCCCCCHHHHH
FSKLYGEVAGGQAEYLRVPQAQYTHIKIPEDGPDERFVYLSDVLPTAWQGVEYANVPDGG
HHHHHHHHCCCCHHEEECCCCCCEEEECCCCCCCCCEEEEHHCCHHHHCCCEECCCCCCC
TLVVVGLGPIGSMACRIAAHRNNCRVIGIDLVEERLDRARPYCAEVIDLRTQDADAVVAE
EEEEEECCCCCHHHEEEEECCCCCEEEEHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHH
LTQGRGADSVIDAVGMEAHGSPVAEAAQTASGFLPSSIGRVVMKHAGVDRLAALNSAIAL
HHCCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
VRRGGTVSLSGVYGGAADPINMMTLFDKQVTLRMGQANVKRWVPDILPLLTADDPLGVEN
HCCCCEEEEEECCCCCCCCCHHHHHHCCHHEEEECHHHHHHHHHHHHHHHCCCCCCCCCH
FATHRLPLAEAPGAYETFQKKQDGMVKVVLTP
HHHCCCCCCCCCCHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MRAVTWQGRRKVSVDNVPDPIIKEPTDAVIRVTSTNICGSDLHLYETLSAFMSPGDIIGH
CCCCCCCCCCEEECCCCCCCHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCHHCCH
EAMGVVEEVGTQTGDLKVGDRVVIPFNISCGTCWMCDHGLQSQCETTQNRDQGTGAALFG
HHHHHHHHHCCCCCCEEECCEEEEEEECCCCEEEEECCCCHHHHHHHCCCCCCCCHHHHH
FSKLYGEVAGGQAEYLRVPQAQYTHIKIPEDGPDERFVYLSDVLPTAWQGVEYANVPDGG
HHHHHHHHCCCCHHEEECCCCCCEEEECCCCCCCCCEEEEHHCCHHHHCCCEECCCCCCC
TLVVVGLGPIGSMACRIAAHRNNCRVIGIDLVEERLDRARPYCAEVIDLRTQDADAVVAE
EEEEEECCCCCHHHEEEEECCCCCEEEEHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHH
LTQGRGADSVIDAVGMEAHGSPVAEAAQTASGFLPSSIGRVVMKHAGVDRLAALNSAIAL
HHCCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
VRRGGTVSLSGVYGGAADPINMMTLFDKQVTLRMGQANVKRWVPDILPLLTADDPLGVEN
HCCCCEEEEEECCCCCCCCCHHHHHHCCHHEEEECHHHHHHHHHHHHHHHCCCCCCCCCH
FATHRLPLAEAPGAYETFQKKQDGMVKVVLTP
HHHCCCCCCCCCCHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]