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The map label for this gene is acdA [H]

Identifier: 119871222

GI number: 119871222

Start: 5437186

End: 5438640

Strand: Direct

Name: acdA [H]

Synonym: Mkms_5195

Alternate gene names: 119871222

Gene position: 5437186-5438640 (Clockwise)

Preceding gene: 119871221

Following gene: 119871223

Centisome position: 94.77

GC content: 69.0

Gene sequence:

>1455_bases
GTGCCCCTCGTTTGCGTTCGCGTCGCGATCGGGTGGTTTCACGCGGCCTGCCACGGGCTATCCGACCGCTCGATGACCTT
CGACCTCACGCCCACCAAGGCGCAGCACGATCTCGCTCGGCGCACGCACGAGTTCGCCGAGCAGTGCATCCGTCCGGTGG
CCCTCGAGTACGACCAGCGCCAGGAGTTCCCCTGGCCGGTCCTCGAGGAGGCGGCCCAGCGCGGGTTCTACAGCCCGCTG
TTCTACCGCGACCTGATCGGCGACCCGACCGGGCTCTCGCTGCCGATGTTCATGGAGGAGCTGTTCTGGGGTTGCGCGGG
AATCGGATTGGCCATCGTCATGCCCGCGCTCGCCCTGTCGGCGATCGGCCAGGCCGCCTCGCCCGAACAGATGCTGCAGT
GGGCACCCGAATGCTTCGGCACCCCGGGCGACCTCAAACTCGCCGCTCTGGCGATCTCCGAACCCGAGGGCGGCAGCGAC
GTGCGCAACCTGCGCACCACCGCCCGCCGGGACGGTGACGACTGGATCATCGACGGCCACAAGATGTGGATCGGCAACGG
CGGCATCGCCAACGTCCACGTCGTCAACGCCGTCGTCGACCAGGAACTGGGACACCGCGGCCAGGCGCTGTTCATCGTCC
CCGGTGGCACGCCTGGCCTGGAACTGGTCCGCAAGCTCGACAAGATGGGCTGCCGTGCCTCGCACACCGCGGAACTGAAG
TTCGACGGCGTCCGCATCCCCGGCGACCACCTGCTCGGCGGCGAAGAGAAACTCGAACACAAACTCGCCAAGGCCCGCGA
AGCCGTCGAGGGCGCCCGGAAGTCGGGGTCGGCCGCGCTGGGCACCTTCGAGCAGACCCGCCCCATGGTCGCCGCGCAGG
CGCTCGGGATCGCCCGCGCCGCACTGGAATACATGACCGAGTACGCCAACCGGCGGGAGGCGTTCGGCGCCCCGATCATC
GACAACCAGGGCATCTCGTTCCCCCTCGCGGATCTGGCCACCCAGATCGACGCCGCCCGTCTGCTCACGTGGCGCGCCTC
GTGGATGGCGGCCACCGGTGTGCCCTTCGAGCGCGGCGAGGGGTCGATGTCGAAACTGGCGGCCAGCGAGGTCGCGGTGA
AGGCGACCGAACGGGCCATCCAGACCATGGGCGGATGGGGCTACATCACCGACCATCCGGTCGAGAAGTGGTACCGCGAC
GCCAAGCTCTACACGATCTTCGAGGGCACCAGCGAGATCCAGCGCATGGTGATCTCGCGGGCCCTCGGCGCCGCCGACGG
CGCCCCACCACTGCATGTCGACCTGGAACCGACCGGCGGCCCGCTCAACCGTTACTTCGGCCGCGGCACTGTCCTGCGGG
GCCGCGCGGCCGACCGAGCGCTGTCCGCCAAGGACCGGGTACCGGAATCCGTCATGCGGTTGGCGATGAAAGTGCTTCAG
CCACCGCGTAAGTGA

Upstream 100 bases:

>100_bases
TGAGTCCAGCATCGTCTCGATCCGGTACGACAACGACGACCGCGTCGTCTACGTCACCGTCCGCTGATATCCGCACCACC
GACGAGGGGCACCCACCCGG

Downstream 100 bases:

>100_bases
CCGGGGAGGCCGGATGGCCCAACAGATGAGCGGCATCGTGCACGCCGCATTCGACACCCTGCGCTACGAGCCGACGGCCA
AGCGGATCCGCGTGACGCTC

Product: acyl-CoA dehydrogenase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MPLVCVRVAIGWFHAACHGLSDRSMTFDLTPTKAQHDLARRTHEFAEQCIRPVALEYDQRQEFPWPVLEEAAQRGFYSPL
FYRDLIGDPTGLSLPMFMEELFWGCAGIGLAIVMPALALSAIGQAASPEQMLQWAPECFGTPGDLKLAALAISEPEGGSD
VRNLRTTARRDGDDWIIDGHKMWIGNGGIANVHVVNAVVDQELGHRGQALFIVPGGTPGLELVRKLDKMGCRASHTAELK
FDGVRIPGDHLLGGEEKLEHKLAKAREAVEGARKSGSAALGTFEQTRPMVAAQALGIARAALEYMTEYANRREAFGAPII
DNQGISFPLADLATQIDAARLLTWRASWMAATGVPFERGEGSMSKLAASEVAVKATERAIQTMGGWGYITDHPVEKWYRD
AKLYTIFEGTSEIQRMVISRALGAADGAPPLHVDLEPTGGPLNRYFGRGTVLRGRAADRALSAKDRVPESVMRLAMKVLQ
PPRK

Sequences:

>Translated_484_residues
MPLVCVRVAIGWFHAACHGLSDRSMTFDLTPTKAQHDLARRTHEFAEQCIRPVALEYDQRQEFPWPVLEEAAQRGFYSPL
FYRDLIGDPTGLSLPMFMEELFWGCAGIGLAIVMPALALSAIGQAASPEQMLQWAPECFGTPGDLKLAALAISEPEGGSD
VRNLRTTARRDGDDWIIDGHKMWIGNGGIANVHVVNAVVDQELGHRGQALFIVPGGTPGLELVRKLDKMGCRASHTAELK
FDGVRIPGDHLLGGEEKLEHKLAKAREAVEGARKSGSAALGTFEQTRPMVAAQALGIARAALEYMTEYANRREAFGAPII
DNQGISFPLADLATQIDAARLLTWRASWMAATGVPFERGEGSMSKLAASEVAVKATERAIQTMGGWGYITDHPVEKWYRD
AKLYTIFEGTSEIQRMVISRALGAADGAPPLHVDLEPTGGPLNRYFGRGTVLRGRAADRALSAKDRVPESVMRLAMKVLQ
PPRK
>Mature_483_residues
PLVCVRVAIGWFHAACHGLSDRSMTFDLTPTKAQHDLARRTHEFAEQCIRPVALEYDQRQEFPWPVLEEAAQRGFYSPLF
YRDLIGDPTGLSLPMFMEELFWGCAGIGLAIVMPALALSAIGQAASPEQMLQWAPECFGTPGDLKLAALAISEPEGGSDV
RNLRTTARRDGDDWIIDGHKMWIGNGGIANVHVVNAVVDQELGHRGQALFIVPGGTPGLELVRKLDKMGCRASHTAELKF
DGVRIPGDHLLGGEEKLEHKLAKAREAVEGARKSGSAALGTFEQTRPMVAAQALGIARAALEYMTEYANRREAFGAPIID
NQGISFPLADLATQIDAARLLTWRASWMAATGVPFERGEGSMSKLAASEVAVKATERAIQTMGGWGYITDHPVEKWYRDA
KLYTIFEGTSEIQRMVISRALGAADGAPPLHVDLEPTGGPLNRYFGRGTVLRGRAADRALSAKDRVPESVMRLAMKVLQP
PRK

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=384, Percent_Identity=40.3645833333333, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI4557231, Length=427, Percent_Identity=34.192037470726, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI187960098, Length=411, Percent_Identity=33.8199513381995, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI4501859, Length=406, Percent_Identity=32.7586206896552, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI4501857, Length=393, Percent_Identity=29.7709923664122, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI7656849, Length=409, Percent_Identity=29.0953545232274, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI226958412, Length=402, Percent_Identity=30.8457711442786, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI226958414, Length=374, Percent_Identity=32.3529411764706, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI21361497, Length=311, Percent_Identity=30.2250803858521, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI76496475, Length=320, Percent_Identity=30.3125, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI4557235, Length=320, Percent_Identity=30.3125, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI48976061, Length=409, Percent_Identity=23.960880195599, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI211971008, Length=409, Percent_Identity=23.960880195599, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI38505218, Length=302, Percent_Identity=26.4900662251656, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4503943, Length=384, Percent_Identity=24.21875, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI7669494, Length=295, Percent_Identity=25.4237288135593, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=27.9373368146214, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1786223, Length=272, Percent_Identity=26.8382352941176, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17534899, Length=410, Percent_Identity=35.8536585365854, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17570075, Length=404, Percent_Identity=36.3861386138614, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17569725, Length=406, Percent_Identity=34.4827586206897, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17508101, Length=379, Percent_Identity=32.9815303430079, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17506239, Length=387, Percent_Identity=32.0413436692506, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17538396, Length=393, Percent_Identity=31.8066157760814, Blast_Score=165, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17533517, Length=397, Percent_Identity=28.463476070529, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71990804, Length=275, Percent_Identity=34.5454545454545, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17505929, Length=414, Percent_Identity=28.743961352657, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17551932, Length=281, Percent_Identity=31.3167259786477, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI71985184, Length=374, Percent_Identity=26.7379679144385, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17531909, Length=259, Percent_Identity=30.5019305019305, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32563615, Length=213, Percent_Identity=34.2723004694836, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982178, Length=302, Percent_Identity=26.8211920529801, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17534353, Length=318, Percent_Identity=23.5849056603774, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985192, Length=358, Percent_Identity=24.3016759776536, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17531913, Length=99, Percent_Identity=40.4040404040404, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562446, Length=347, Percent_Identity=23.6311239193084, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24660351, Length=421, Percent_Identity=36.8171021377672, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI21356377, Length=389, Percent_Identity=34.9614395886889, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24646207, Length=392, Percent_Identity=35.4591836734694, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24666513, Length=274, Percent_Identity=37.5912408759124, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI21355753, Length=392, Percent_Identity=30.8673469387755, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI281363737, Length=326, Percent_Identity=30.6748466257669, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI19920834, Length=325, Percent_Identity=26.7692307692308, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 52775; Mature: 52644

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00073 ACYL_COA_DH_2 ; PS00697 DNA_LIGASE_A1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVCVRVAIGWFHAACHGLSDRSMTFDLTPTKAQHDLARRTHEFAEQCIRPVALEYDQR
CCEEEEHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHC
QEFPWPVLEEAAQRGFYSPLFYRDLIGDPTGLSLPMFMEELFWGCAGIGLAIVMPALALS
CCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIGQAASPEQMLQWAPECFGTPGDLKLAALAISEPEGGSDVRNLRTTARRDGDDWIIDGH
HHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEECCE
KMWIGNGGIANVHVVNAVVDQELGHRGQALFIVPGGTPGLELVRKLDKMGCRASHTAELK
EEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEE
FDGVRIPGDHLLGGEEKLEHKLAKAREAVEGARKSGSAALGTFEQTRPMVAAQALGIARA
ECCEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHH
ALEYMTEYANRREAFGAPIIDNQGISFPLADLATQIDAARLLTWRASWMAATGVPFERGE
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCC
GSMSKLAASEVAVKATERAIQTMGGWGYITDHPVEKWYRDAKLYTIFEGTSEIQRMVISR
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHH
ALGAADGAPPLHVDLEPTGGPLNRYFGRGTVLRGRAADRALSAKDRVPESVMRLAMKVLQ
HHCCCCCCCCEEEEECCCCCHHHHHCCCCCEEECCHHHHHHHHHHCCHHHHHHHHHHHHC
PPRK
CCCC
>Mature Secondary Structure 
PLVCVRVAIGWFHAACHGLSDRSMTFDLTPTKAQHDLARRTHEFAEQCIRPVALEYDQR
CEEEEHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHC
QEFPWPVLEEAAQRGFYSPLFYRDLIGDPTGLSLPMFMEELFWGCAGIGLAIVMPALALS
CCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIGQAASPEQMLQWAPECFGTPGDLKLAALAISEPEGGSDVRNLRTTARRDGDDWIIDGH
HHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEECCE
KMWIGNGGIANVHVVNAVVDQELGHRGQALFIVPGGTPGLELVRKLDKMGCRASHTAELK
EEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEE
FDGVRIPGDHLLGGEEKLEHKLAKAREAVEGARKSGSAALGTFEQTRPMVAAQALGIARA
ECCEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHH
ALEYMTEYANRREAFGAPIIDNQGISFPLADLATQIDAARLLTWRASWMAATGVPFERGE
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCC
GSMSKLAASEVAVKATERAIQTMGGWGYITDHPVEKWYRDAKLYTIFEGTSEIQRMVISR
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHH
ALGAADGAPPLHVDLEPTGGPLNRYFGRGTVLRGRAADRALSAKDRVPESVMRLAMKVLQ
HHCCCCCCCCEEEEECCCCCHHHHHCCCCCEEECCHHHHHHHHHHCCHHHHHHHHHHHHC
PPRK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]