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The map label for this gene is aqpZ [H]

Identifier: 119871183

GI number: 119871183

Start: 5406704

End: 5407531

Strand: Direct

Name: aqpZ [H]

Synonym: Mkms_5156

Alternate gene names: 119871183

Gene position: 5406704-5407531 (Clockwise)

Preceding gene: 119871182

Following gene: 119871184

Centisome position: 94.24

GC content: 69.81

Gene sequence:

>828_bases
ATGCGAGAGCCGACCATGATGCATCGGGTGGCCGCCGAGTTCATCGGAACGTTCTGGCTGGTCTTCGGCGGCTGCGGCAG
CGCGGTGTTCGCCGCCAAGTACACCTCGGCCGACGGATACGCGTTCGGCATCGGGTTCCTCGGCGTCTCGCTCGCCTTCG
GTCTCACGGTGCTCACCGGCGTGTACGCGTTCGGGACGATCTCCGGCGGGCACTTCAACCCCGCGGTCACGCTGGGCGCG
GCACTGGCCCGACGGGTCGAATGGCGTGTGCTGCCGGCCTACTGGCTCACCCAGGTGATCGCCGGCGTGGCGGCCGGACT
CGTCATCTACGTCATCGCCAAGGGGCGTGAGGGGTGGACCGCCACCGGAAACATGGCCGCCAACGGCTACGCCAACCACT
CGCCGGCGGGCTATTCGCTGCTGGCCGTCGTCATCGCCGAGGTCCTGCTGACGGGCATCTTCCTCCTGGTGATCCTCGGC
GCCACCGACACCCGCGCCCCGAAGGGGTTCGCCGGGCTGGCCATCGGGCTGACCCTGACCCTGATCCACCTGATCTCGAT
CCCGATCTCGAACACCTCGGTGAACCCCGCCCGCTCCACCGGCGTGGCGTTCTTCAACGGCAACGAGGCGCCCGCGCAGC
TGTGGGTGTTCTGGATCGCCCCCCTTCTCGGCGCCGCCATCGCCGGCGCGGCCTACCCGTACCTGTTCGGGCGACACGAG
GAACTGGCCGATCGGCCGGTCCGCGACGAAACGCTCGACGCCCAGGTGCGCGCCGAGGACGTCGCGGACGCGCGCCTACG
ACGTGGTCCCGACCCAGAGGTCCGGTAG

Upstream 100 bases:

>100_bases
CGCCCTCCCGGGACATTGCGGTCCGACCACGATTCGGCCGCACCCCCCACATACCGCAGTGATCCGTGTCACGCTCGACC
CAGCGTGAAAGGAGTGGGAC

Downstream 100 bases:

>100_bases
CCGGCCCGGCGCCCACCGGACCGGGTGGGTGGCCGTGACAAGCAGAATTAGGCAAGCTAACATCCTCGCCATGAAGAGAG
CGATCCTGGCGGTTGCCGTC

Product: MIP family channel protein

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MREPTMMHRVAAEFIGTFWLVFGGCGSAVFAAKYTSADGYAFGIGFLGVSLAFGLTVLTGVYAFGTISGGHFNPAVTLGA
ALARRVEWRVLPAYWLTQVIAGVAAGLVIYVIAKGREGWTATGNMAANGYANHSPAGYSLLAVVIAEVLLTGIFLLVILG
ATDTRAPKGFAGLAIGLTLTLIHLISIPISNTSVNPARSTGVAFFNGNEAPAQLWVFWIAPLLGAAIAGAAYPYLFGRHE
ELADRPVRDETLDAQVRAEDVADARLRRGPDPEVR

Sequences:

>Translated_275_residues
MREPTMMHRVAAEFIGTFWLVFGGCGSAVFAAKYTSADGYAFGIGFLGVSLAFGLTVLTGVYAFGTISGGHFNPAVTLGA
ALARRVEWRVLPAYWLTQVIAGVAAGLVIYVIAKGREGWTATGNMAANGYANHSPAGYSLLAVVIAEVLLTGIFLLVILG
ATDTRAPKGFAGLAIGLTLTLIHLISIPISNTSVNPARSTGVAFFNGNEAPAQLWVFWIAPLLGAAIAGAAYPYLFGRHE
ELADRPVRDETLDAQVRAEDVADARLRRGPDPEVR
>Mature_275_residues
MREPTMMHRVAAEFIGTFWLVFGGCGSAVFAAKYTSADGYAFGIGFLGVSLAFGLTVLTGVYAFGTISGGHFNPAVTLGA
ALARRVEWRVLPAYWLTQVIAGVAAGLVIYVIAKGREGWTATGNMAANGYANHSPAGYSLLAVVIAEVLLTGIFLLVILG
ATDTRAPKGFAGLAIGLTLTLIHLISIPISNTSVNPARSTGVAFFNGNEAPAQLWVFWIAPLLGAAIAGAAYPYLFGRHE
ELADRPVRDETLDAQVRAEDVADARLRRGPDPEVR

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502183, Length=242, Percent_Identity=35.9504132231405, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI37694062, Length=271, Percent_Identity=32.1033210332103, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI4502179, Length=248, Percent_Identity=33.0645161290323, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI4502181, Length=199, Percent_Identity=31.1557788944724, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI4755125, Length=199, Percent_Identity=31.1557788944724, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI6912506, Length=248, Percent_Identity=30.241935483871, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI157266307, Length=280, Percent_Identity=29.2857142857143, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI22538420, Length=275, Percent_Identity=27.6363636363636, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4502187, Length=279, Percent_Identity=29.7491039426523, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI4826645, Length=275, Percent_Identity=26.5454545454545, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI45446752, Length=192, Percent_Identity=30.2083333333333, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI86792455, Length=235, Percent_Identity=30.6382978723404, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1787101, Length=214, Percent_Identity=57.0093457943925, Blast_Score=223, Evalue=8e-60,
Organism=Escherichia coli, GI1790362, Length=264, Percent_Identity=27.6515151515151, Blast_Score=64, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71993722, Length=262, Percent_Identity=29.3893129770992, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17558372, Length=249, Percent_Identity=30.1204819277108, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6325450, Length=240, Percent_Identity=29.5833333333333, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321054, Length=218, Percent_Identity=28.4403669724771, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24652747, Length=226, Percent_Identity=34.5132743362832, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45551084, Length=226, Percent_Identity=34.5132743362832, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45550503, Length=261, Percent_Identity=27.5862068965517, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24762342, Length=213, Percent_Identity=31.4553990610329, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24762344, Length=265, Percent_Identity=27.9245283018868, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24762346, Length=265, Percent_Identity=27.9245283018868, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24762348, Length=265, Percent_Identity=27.9245283018868, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI20130305, Length=265, Percent_Identity=27.9245283018868, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19922038, Length=275, Percent_Identity=29.8181818181818, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24652751, Length=276, Percent_Identity=30.0724637681159, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17136672, Length=219, Percent_Identity=28.7671232876712, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 29025; Mature: 29025

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREPTMMHRVAAEFIGTFWLVFGGCGSAVFAAKYTSADGYAFGIGFLGVSLAFGLTVLTG
CCCHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
VYAFGTISGGHFNPAVTLGAALARRVEWRVLPAYWLTQVIAGVAAGLVIYVIAKGREGWT
HHHHHCCCCCCCCHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHEEEECCCCCCC
ATGNMAANGYANHSPAGYSLLAVVIAEVLLTGIFLLVILGATDTRAPKGFAGLAIGLTLT
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LIHLISIPISNTSVNPARSTGVAFFNGNEAPAQLWVFWIAPLLGAAIAGAAYPYLFGRHE
HHHHHHCCCCCCCCCCCHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
ELADRPVRDETLDAQVRAEDVADARLRRGPDPEVR
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MREPTMMHRVAAEFIGTFWLVFGGCGSAVFAAKYTSADGYAFGIGFLGVSLAFGLTVLTG
CCCHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
VYAFGTISGGHFNPAVTLGAALARRVEWRVLPAYWLTQVIAGVAAGLVIYVIAKGREGWT
HHHHHCCCCCCCCHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHEEEECCCCCCC
ATGNMAANGYANHSPAGYSLLAVVIAEVLLTGIFLLVILGATDTRAPKGFAGLAIGLTLT
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LIHLISIPISNTSVNPARSTGVAFFNGNEAPAQLWVFWIAPLLGAAIAGAAYPYLFGRHE
HHHHHHCCCCCCCCCCCHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
ELADRPVRDETLDAQVRAEDVADARLRRGPDPEVR
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA