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The map label for this gene is fabG2 [H]

Identifier: 119871036

GI number: 119871036

Start: 5249543

End: 5250328

Strand: Direct

Name: fabG2 [H]

Synonym: Mkms_5009

Alternate gene names: 119871036

Gene position: 5249543-5250328 (Clockwise)

Preceding gene: 119871035

Following gene: 119871042

Centisome position: 91.5

GC content: 69.47

Gene sequence:

>786_bases
GTGAAACTCTCGGGACGCGTCGCGCTGGTGACCGGCGGTGCGTCCGGTATCGGCCGCGCGACCGCCGGTCGACTCGCGGC
CGAGGGCATGCGGGTGTGCGTGCTCGATATCGACGGGCCGGCGACGGAGGCGGTGGCCGAGTCGATCGGTGGGATCGGAT
TACGTTGTGACGTCACTGATCCAGAGCAGGTCGACTCGGCGTTCGATACCTGCGTCGCGGAGTTGGGTGGCGTGGACGTG
GCGTTCCTGAACGCGGGCATCACCATCGACTGGTCGGGGGACATCGGCGCCCTCGACCTGGCTCAGTACCGGAAGTCCGT
CGGCGTCAACGTCGACGGTGTGGTGTTCGGGGTGCGGGCGGCGGTGCGGACCATGCGGACACTCGACCCCGGCGTCGACC
GCGCAATTCTGGCGACCGCGTCTCTGGCAGGGTTGATGCCCTGGCATCCCGACCCGGTCTACTCGCTGGGCAAGCACGGC
GTGGTCGGGTTCATGCGCTCGATCGCCCCGAACCTCGCCGCCGAAGGCATTGCAGTGCACACCATCTGCCCGGGTATCAC
CGAGACCGGGGTGCTCGGCGATCGGCGGTCGCTGGTGGAACGCATCGGCGTGCCTGTGATGGAGCCGGAGATGATCGCCG
ACGCGGTGCTGCTGGCACTCGGCGCCCCGATGTCCGCGGCCGGGACGTGCTGGGTGGCTCAGCACGGAAAGCCGGCCTGG
CCGATGGCATTCGCGCCGGTGGACAGTCCCGACAGCCGGCTCAACGTGCCGGTGAGGGCCCGCTGA

Upstream 100 bases:

>100_bases
GCGGTCGCAGGATTCATCAAGGGCAAGTGGGACAAGACCGATGCCTCCTACATCCGTCCGCTGAAGCTCGACAGCGAGCC
CGTCGAACGGTGGTGAGCGA

Downstream 100 bases:

>100_bases
CCCTCAGGTCGGCGCGAGCGGCGAGGTCGTCGTCGTCGACCAACACCAGCATCTCCTGACCGGGCACGCAGAACATCGTG
ACCAGGAAGCGGCTCCGCGC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MKLSGRVALVTGGASGIGRATAGRLAAEGMRVCVLDIDGPATEAVAESIGGIGLRCDVTDPEQVDSAFDTCVAELGGVDV
AFLNAGITIDWSGDIGALDLAQYRKSVGVNVDGVVFGVRAAVRTMRTLDPGVDRAILATASLAGLMPWHPDPVYSLGKHG
VVGFMRSIAPNLAAEGIAVHTICPGITETGVLGDRRSLVERIGVPVMEPEMIADAVLLALGAPMSAAGTCWVAQHGKPAW
PMAFAPVDSPDSRLNVPVRAR

Sequences:

>Translated_261_residues
MKLSGRVALVTGGASGIGRATAGRLAAEGMRVCVLDIDGPATEAVAESIGGIGLRCDVTDPEQVDSAFDTCVAELGGVDV
AFLNAGITIDWSGDIGALDLAQYRKSVGVNVDGVVFGVRAAVRTMRTLDPGVDRAILATASLAGLMPWHPDPVYSLGKHG
VVGFMRSIAPNLAAEGIAVHTICPGITETGVLGDRRSLVERIGVPVMEPEMIADAVLLALGAPMSAAGTCWVAQHGKPAW
PMAFAPVDSPDSRLNVPVRAR
>Mature_261_residues
MKLSGRVALVTGGASGIGRATAGRLAAEGMRVCVLDIDGPATEAVAESIGGIGLRCDVTDPEQVDSAFDTCVAELGGVDV
AFLNAGITIDWSGDIGALDLAQYRKSVGVNVDGVVFGVRAAVRTMRTLDPGVDRAILATASLAGLMPWHPDPVYSLGKHG
VVGFMRSIAPNLAAEGIAVHTICPGITETGVLGDRRSLVERIGVPVMEPEMIADAVLLALGAPMSAAGTCWVAQHGKPAW
PMAFAPVDSPDSRLNVPVRAR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI31542939, Length=225, Percent_Identity=32, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI224922801, Length=184, Percent_Identity=33.1521739130435, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI40254992, Length=223, Percent_Identity=30.0448430493274, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI4758504, Length=209, Percent_Identity=33.9712918660287, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI142976729, Length=223, Percent_Identity=26.9058295964126, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI83715985, Length=184, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=191, Percent_Identity=33.5078534031414, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI87082100, Length=199, Percent_Identity=32.1608040201005, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789378, Length=193, Percent_Identity=29.0155440414508, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789057, Length=188, Percent_Identity=32.4468085106383, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1787905, Length=247, Percent_Identity=26.3157894736842, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=206, Percent_Identity=33.9805825242718, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17555706, Length=238, Percent_Identity=32.3529411764706, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI25147288, Length=191, Percent_Identity=32.4607329842932, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17538480, Length=203, Percent_Identity=28.0788177339901, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=232, Percent_Identity=27.1551724137931, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=222, Percent_Identity=29.7297297297297, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=200, Percent_Identity=28.5, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=208, Percent_Identity=27.8846153846154, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=207, Percent_Identity=26.5700483091787, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=207, Percent_Identity=25.6038647342995, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=228, Percent_Identity=26.7543859649123, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=203, Percent_Identity=29.5566502463054, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=207, Percent_Identity=25.1207729468599, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=211, Percent_Identity=27.9620853080569, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=192, Percent_Identity=30.2083333333333, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=204, Percent_Identity=26.9607843137255, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=196, Percent_Identity=30.6122448979592, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737361, Length=200, Percent_Identity=32, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355319, Length=193, Percent_Identity=28.4974093264249, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI116007234, Length=233, Percent_Identity=32.1888412017167, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24663911, Length=245, Percent_Identity=29.3877551020408, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641232, Length=233, Percent_Identity=31.3304721030043, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281364494, Length=238, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571387, Length=236, Percent_Identity=27.9661016949153, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221331218, Length=267, Percent_Identity=25.4681647940075, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24665243, Length=267, Percent_Identity=25.4681647940075, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI23397609, Length=193, Percent_Identity=28.4974093264249, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24648944, Length=229, Percent_Identity=27.0742358078603, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24665247, Length=268, Percent_Identity=25.3731343283582, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221331216, Length=268, Percent_Identity=25.3731343283582, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI116007236, Length=232, Percent_Identity=25, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639444, Length=236, Percent_Identity=29.2372881355932, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24649181, Length=228, Percent_Identity=26.7543859649123, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581726, Length=223, Percent_Identity=26.457399103139, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24665264, Length=209, Percent_Identity=25.8373205741627, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24641388, Length=235, Percent_Identity=28.936170212766, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26860; Mature: 26860

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSGRVALVTGGASGIGRATAGRLAAEGMRVCVLDIDGPATEAVAESIGGIGLRCDVTD
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCEEEECCCC
PEQVDSAFDTCVAELGGVDVAFLNAGITIDWSGDIGALDLAQYRKSVGVNVDGVVFGVRA
HHHHHHHHHHHHHHHCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHH
AVRTMRTLDPGVDRAILATASLAGLMPWHPDPVYSLGKHGVVGFMRSIAPNLAAEGIAVH
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCEEEE
TICPGITETGVLGDRRSLVERIGVPVMEPEMIADAVLLALGAPMSAAGTCWVAQHGKPAW
EECCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCC
PMAFAPVDSPDSRLNVPVRAR
CEEECCCCCCCCCCCCCEECC
>Mature Secondary Structure
MKLSGRVALVTGGASGIGRATAGRLAAEGMRVCVLDIDGPATEAVAESIGGIGLRCDVTD
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCEEEECCCC
PEQVDSAFDTCVAELGGVDVAFLNAGITIDWSGDIGALDLAQYRKSVGVNVDGVVFGVRA
HHHHHHHHHHHHHHHCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHH
AVRTMRTLDPGVDRAILATASLAGLMPWHPDPVYSLGKHGVVGFMRSIAPNLAAEGIAVH
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCEEEE
TICPGITETGVLGDRRSLVERIGVPVMEPEMIADAVLLALGAPMSAAGTCWVAQHGKPAW
EECCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCC
PMAFAPVDSPDSRLNVPVRAR
CEEECCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]