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The map label for this gene is htrA [H]

Identifier: 119871028

GI number: 119871028

Start: 5241264

End: 5242289

Strand: Direct

Name: htrA [H]

Synonym: Mkms_5001

Alternate gene names: 119871028

Gene position: 5241264-5242289 (Clockwise)

Preceding gene: 119871027

Following gene: 119871030

Centisome position: 91.36

GC content: 71.93

Gene sequence:

>1026_bases
ATGGGCATGCTCCGTACTCGTTGGCTGTCCGTGCTCTCGGTCGTGTTGGCCGCGCTACTCGCACTGGTGGGCCCGTTCTC
CCCGGCCACCTCGAGCGCCGCACCCGCTGATCCGATCGCGGCGGCGGCCACCGTCGAGCCCGCCGTGGCGCGCATCGACA
CCGAGATCGACTACCAGAGCGCGATCGGTACCGGCACCGGCATCGTGCTCGACCCCGGCGGTCAGGTGCTGACGAACTTC
CACGTCGTCCAGGGCGCCGACCGGGTCAACGTCGCCGTCGCGGGCCGGTCGTATCCGGCCGAACTCGTCGGCTACGACCG
TGGCCGCGACATCGCGGTGATCCAGTTGCTCGGGGCGGGCGGTCTGCCGGTGGCCCCGATCGGCGACTCCGCGGCGCTGG
CGGCGGGTGAGCCCGTCGTCGCCCTCGGCAACGCGCAGGGCTCCGCTGCCCCGCTGACCCGGGAGGTCGGCAGCGTCACC
GCCTTCGGGCGGACGGTCCAGGCCGAAGACTCGCTGACCGGCAGCTCCGACGAACTGACCGGGTTGATCGAGTTCGCCGC
ACCCGTGCGGGCCGGCGATTCGGGTGGACCGGTCGTCAACAGCGCGGGCCAGGTCGTCGGCATCACCACCGCGGCCTCGG
TGAACTACCGGATGGGCCCCGGGGGTAAGGGCTTCGCGATCCCGATCAACGAGGCGGTCGGCGTCGCGAACCAGATCCGG
TCGCGGATTCCGTCGGACACCGTCCACATCGGCCCGCCCGCGCTGCTCGGCGTCGGCGTGCGGACCGCACCTAGCGACGT
GCCCGGGGTCCTCATCCAGGAGGTGCTGCGCGGCGGACCCGCCGAAGCGGCCGGTTTGATGGACCGCGACGTGCTGATCG
CGATCAACGGCAACCGCCTCACCTCGGCCACCCAACTGACCTACACGCTGGACCGGTTCTACCCCGGCGACGTCGTGGAC
GTCACGTGGATCGACGGCTTCGGCCAGGAGCGCACCGCGAAGGCGACGCTGGCACCCGGCCCCTAG

Upstream 100 bases:

>100_bases
TCGAAGACTGAGGTCAGCGCCCTTTCGTCGACACCACGCGGTCTGATCGCGAACAATGTGAGCAGAACCCGAGTTACAAA
ACCTCGTCGAAGGGCAATTC

Downstream 100 bases:

>100_bases
GGTCGACCGCCGCGCAGCAGTTGTTCCAGCCCGGCGATCGCCAGATCGAGTTCGAACTCGAACTGCCCCTCGTCCGGTCG
GGGCGCGCTGTCGAGCACCA

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MGMLRTRWLSVLSVVLAALLALVGPFSPATSSAAPADPIAAAATVEPAVARIDTEIDYQSAIGTGTGIVLDPGGQVLTNF
HVVQGADRVNVAVAGRSYPAELVGYDRGRDIAVIQLLGAGGLPVAPIGDSAALAAGEPVVALGNAQGSAAPLTREVGSVT
AFGRTVQAEDSLTGSSDELTGLIEFAAPVRAGDSGGPVVNSAGQVVGITTAASVNYRMGPGGKGFAIPINEAVGVANQIR
SRIPSDTVHIGPPALLGVGVRTAPSDVPGVLIQEVLRGGPAEAAGLMDRDVLIAINGNRLTSATQLTYTLDRFYPGDVVD
VTWIDGFGQERTAKATLAPGP

Sequences:

>Translated_341_residues
MGMLRTRWLSVLSVVLAALLALVGPFSPATSSAAPADPIAAAATVEPAVARIDTEIDYQSAIGTGTGIVLDPGGQVLTNF
HVVQGADRVNVAVAGRSYPAELVGYDRGRDIAVIQLLGAGGLPVAPIGDSAALAAGEPVVALGNAQGSAAPLTREVGSVT
AFGRTVQAEDSLTGSSDELTGLIEFAAPVRAGDSGGPVVNSAGQVVGITTAASVNYRMGPGGKGFAIPINEAVGVANQIR
SRIPSDTVHIGPPALLGVGVRTAPSDVPGVLIQEVLRGGPAEAAGLMDRDVLIAINGNRLTSATQLTYTLDRFYPGDVVD
VTWIDGFGQERTAKATLAPGP
>Mature_340_residues
GMLRTRWLSVLSVVLAALLALVGPFSPATSSAAPADPIAAAATVEPAVARIDTEIDYQSAIGTGTGIVLDPGGQVLTNFH
VVQGADRVNVAVAGRSYPAELVGYDRGRDIAVIQLLGAGGLPVAPIGDSAALAAGEPVVALGNAQGSAAPLTREVGSVTA
FGRTVQAEDSLTGSSDELTGLIEFAAPVRAGDSGGPVVNSAGQVVGITTAASVNYRMGPGGKGFAIPINEAVGVANQIRS
RIPSDTVHIGPPALLGVGVRTAPSDVPGVLIQEVLRGGPAEAAGLMDRDVLIAINGNRLTSATQLTYTLDRFYPGDVVDV
TWIDGFGQERTAKATLAPGP

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=266, Percent_Identity=30.4511278195489, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI24308541, Length=265, Percent_Identity=29.0566037735849, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI22129776, Length=290, Percent_Identity=28.2758620689655, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI7019477, Length=258, Percent_Identity=29.8449612403101, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789630, Length=350, Percent_Identity=29.4285714285714, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789629, Length=278, Percent_Identity=31.294964028777, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786356, Length=251, Percent_Identity=31.0756972111554, Blast_Score=88, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24646839, Length=298, Percent_Identity=27.1812080536913, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 34355; Mature: 34224

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMLRTRWLSVLSVVLAALLALVGPFSPATSSAAPADPIAAAATVEPAVARIDTEIDYQS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCHHHHHHCCCCCHHH
AIGTGTGIVLDPGGQVLTNFHVVQGADRVNVAVAGRSYPAELVGYDRGRDIAVIQLLGAG
HCCCCCEEEECCCCCEEEEEEEEECCCEEEEEEECCCCCHHHEECCCCCCEEEEEEECCC
GLPVAPIGDSAALAAGEPVVALGNAQGSAAPLTREVGSVTAFGRTVQAEDSLTGSSDELT
CCCCCCCCCCCEECCCCCEEEEECCCCCCCCHHHHHCCEECCCCEEECCCCCCCCCHHHH
GLIEFAAPVRAGDSGGPVVNSAGQVVGITTAASVNYRMGPGGKGFAIPINEAVGVANQIR
EEEEECCCCCCCCCCCCEECCCCCEEEEEEEEEEEEEECCCCCEEEEECHHHHHHHHHHH
SRIPSDTVHIGPPALLGVGVRTAPSDVPGVLIQEVLRGGPAEAAGLMDRDVLIAINGNRL
HHCCCCEEECCCCHHEECCCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCCEEEEECCCEE
TSATQLTYTLDRFYPGDVVDVTWIDGFGQERTAKATLAPGP
CCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCEEECCCCC
>Mature Secondary Structure 
GMLRTRWLSVLSVVLAALLALVGPFSPATSSAAPADPIAAAATVEPAVARIDTEIDYQS
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCHHHHHHCCCCCHHH
AIGTGTGIVLDPGGQVLTNFHVVQGADRVNVAVAGRSYPAELVGYDRGRDIAVIQLLGAG
HCCCCCEEEECCCCCEEEEEEEEECCCEEEEEEECCCCCHHHEECCCCCCEEEEEEECCC
GLPVAPIGDSAALAAGEPVVALGNAQGSAAPLTREVGSVTAFGRTVQAEDSLTGSSDELT
CCCCCCCCCCCEECCCCCEEEEECCCCCCCCHHHHHCCEECCCCEEECCCCCCCCCHHHH
GLIEFAAPVRAGDSGGPVVNSAGQVVGITTAASVNYRMGPGGKGFAIPINEAVGVANQIR
EEEEECCCCCCCCCCCCEECCCCCEEEEEEEEEEEEEECCCCCEEEEECHHHHHHHHHHH
SRIPSDTVHIGPPALLGVGVRTAPSDVPGVLIQEVLRGGPAEAAGLMDRDVLIAINGNRL
HHCCCCEEECCCCHHEECCCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCCEEEEECCCEE
TSATQLTYTLDRFYPGDVVDVTWIDGFGQERTAKATLAPGP
CCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]